17-ketosteroids and Body-Weight

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Age Determination by Skeleton; Anthropometry; Body Height; Body Weight; Child; Dermatoglyphics; Facial Expression; Female; Gigantism; Glucose Tolerance Test; Humans; Insulin; Intellectual Disability; Male; Metyrapone; Neurologic Manifestations; Pituitary-Adrenal Function Tests; Psychological Tests; Voice

Topics: 17-Ketosteroids; Administration, Topical; Adult; Aerosols; Aged; Anti-Inflammatory Agents; Asthma; Beclomethasone; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Humans; Hydrocortisone; Hydroxysteroids; Lung; Male; Middle Aged; Spirometry; Steroids; Substance-Related Disorders

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Analysis of Variance; Antipsychotic Agents; Benztropine; Body Weight; Butyrophenones; Calcium; Female; Glycine; Humans; Magnesium; Middle Aged; Phenelzine; Phenothiazines; Placebos; Potassium; Psychiatric Status Rating Scales; Schizophrenia; Sodium; Tryptophan

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Asthma; Blood Glucose; Body Weight; Clinical Trials as Topic; Female; Glucocorticoids; Humans; Male; Middle Aged; Potassium; Prednisone; Pregnatrienes; Pyrazoles; Sodium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Age Determination by Skeleton; Antibody Formation; Blood Proteins; Body Height; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Female; Follow-Up Studies; Growth; Growth Disorders; Growth Hormone; Humans; Hypopituitarism; Insulin; Iodine; Long-Term Care; Male; Metyrapone; Pituitary Function Tests; Protein Binding; Radioimmunoassay; Skinfold Thickness

A study involving an injectable contraceptive regimen utilizing 2 commercially available hormonal preparations, medroxyprogesterone acetate (Depo-Provera, The Upjohn Company) and estradiol-17 beta-cyclopentylpropionate (Depo-Estradiol Cypionate, The Upjohn Company), is described. 90 multigravidas received intramuscular injections of 50 mg of medroxyprogesterone acetate and 10 mg of estradiol-17 beta-cyclopentylpropionate as a contraceptive every 5 weeks, for a total of 1155 periods. The injections were found to be safe and completely effective. In 15% of the therapeutic cycles, bleeding did not appear for a period of 30 or more days. In 14%, bleeding and/or spotting lasted for longer than 9 days during a 30 day period. The incidence of aminorrhea increased somewhat after the first 10 months of treatment. Endometrial biopsies showed a "suppressed" endometrium. Adrenal pituitary responsiveness to metyrapone was found to be normal in 17 of 21 patients tested. Although almost half of the patients presented some complaints during the study, these were mostly transient and minor in nature. Headache was the complaint most frequently observed (14%), but it was generally limited to 1 cycle. The monthly injectable contraceptive regimen may be useful in a particular population of patients who, for various reasons, cannot tolerate or cannot be relied upon to take oral contraceptives. The authors believe that because of the high incidence of alterations in the bleeding pattern while on the therapeutic regimen, as well as the frequent occurrence of aminorrhea following discontinuation of therapy, the use of such a contraceptive regimen in the general population might not be desirable.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Amenorrhea; Body Weight; Clinical Trials as Topic; Contraceptive Agents; Delayed-Action Preparations; Endometrium; Estradiol; Female; Humans; Injections, Intramuscular; Medroxyprogesterone; Menstruation Disturbances; Pituitary-Adrenal Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Bipolar Disorder; Blood Pressure; Body Temperature; Body Weight; Brain; Clinical Trials as Topic; Drug Synergism; Electroencephalography; Factor Analysis, Statistical; Female; Humans; Menstruation; Norepinephrine; Placebos; Psychiatric Status Rating Scales; Pulse; Reserpine; Respiration; Serotonin; Sodium; Tranylcypromine; Tryptophan; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Aged; Androgens; Arteriosclerosis Obliterans; Body Temperature; Body Weight; Chlorpromazine; Clinical Trials as Topic; Exercise Test; Foot; Humans; Hyperemia; Intermittent Claudication; Male; Middle Aged; Placebos; Plethysmography; Pulse; Skin Diseases; Testosterone; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aldosterone; Body Weight; Clinical Trials as Topic; Cushing Syndrome; Female; Humans; Hyperaldosteronism; Hypopituitarism; Male; Metyrapone; Middle Aged; Natriuresis; Pituitary-Adrenal System; Potassium; Secretory Rate

In a previous study we demonstrated that, in children affected with isolated GH deficiency, an acute high-dose human recombinant GH (hrGH) treatment increases the 11-deoxycortisol and induces an IGF-I responsiveness to ACTH. The aim of the present study was to reevaluate, in the same children, the adrenal and IGF-I responsiveness to ACTH after a chronic replacement-dose GH therapy. Ten children (seven males and three females, mean age 7 years) affected with isolated GH deficiency underwent a synthetic ACTH 1-17 test before and after sc administration of human recombinant GH at a dose of 0.6 UI/kg/week for 3 months. After therapy, the 11-deoxycortisol responsiveness to ACTH significantly decreased compared with that observed after acute treatment (P < 0.001), and so it returned to baseline. No differences were detected in the responsiveness to ACTH of cortisol, dehydroepiandrosterone-sulphate, D4-androstenedione, and 17-hydroxyprogesterone. On the other hand, the chronic treatment induced an IGF-I responsiveness to ACTH (P < 0.001). In conclusion, our study demonstrates that, in isolated GH deficiency, replacement doses of hrGH do not modify the adrenal steroid basal levels or its responsiveness to ACTH, whereas both replacement and high doses of hrGH induce an IGF-I responsiveness to ACTH.

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Body Height; Body Weight; Child; Child, Preschool; Cohort Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Growth Disorders; Growth Hormone; Humans; Male; Peptide Fragments; Recombinant Proteins; Reference Values

Previous work has demonstrated that dehydroepiandrosterone (DHEA) strongly inhibits growth and de novo cholesterol (CH) biosynthesis in preneoplastic rat liver. Administration of a mixture of 4 ribo- or deoxyribonucleosides of adenine, guanine, cytosine and uracil/thymine, prevents growth inhibition but not inhibition of CH synthesis. The purpose of this paper was to identify the site of inhibition of CH synthesis by DHEA. Persistent nodules (PNs) were induced, in diethylnitrosamine-initiated male F344 rats, by 'resistant hepatocyte' protocol. Fifteen weeks after initiation, nodule bearing rats and normal controls received a diet containing 0.6% DHEA for 3 weeks. They were then killed. 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity and mRNA levels were 18- and 14-fold higher, respectively in nodules than in normal liver. DHEA strongly inhibited HMGR activity in both tissues in vivo, but had a slight effect on HMGR activity, when added in vitro to the reaction mixture for determination of this activity. In vivo DHEA treatment caused a 65% decrease in the level of HMGR mRNA in PNs, which, however, does not seem to completely account for the decrease in HMGR activity (83%). Low density lipoprotein receptor (LDL-R) mRNA level underwent a slight decrease in PNs, with respect to control liver, which did not lead to a significant decrease in 125I-LDL binding to LDL-R. DHEA treatment caused 30% and 24% increases in LDL-R expression and 125I-LDL binding, respectively, in nodules. These observations indicate that in addition to HMGR gene expression, increased influx of LDL into preneoplastic cells may contribute to the deregulation of mevalonate synthesis by DHEA. The observation that HMGR activity and gene expression were still 3- to 5-fold higher in PNs of DHEA-treated rats than in control liver, and previous findings of preneoplastic liver cell growth in the presence of relatively low CH synthesis, suggest that even relatively low levels of mevalonate are sufficient for the growth of preneoplastic liver cells.

Topics: 17-Ketosteroids; Animals; Body Weight; Cholesterol; Dehydroepiandrosterone; Gene Expression; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Liver; Liver Neoplasms, Experimental; Male; Mevalonic Acid; Precancerous Conditions; Rats; Rats, Inbred F344; Receptors, LDL

Liver metabolites and in vitro enzyme activities were measured in Sprague-Dawley rats pair-fed the standard NIH diet with or without 0.6% (wt/wt) dehydroepiandrosterone (DHEA) for 16 d. Absorption of DHEA from the gut was confirmed by a 300-fold increase in urine 17-ketosteroids in DHEA-treated animals. Of the liver metabolites measured only 6-phosphogluconate was significantly changed, increasing by less than a factor of two in the DHEA-treated animals, 38.7 +/- 2.2 nmol/g, above the value in the pair-fed controls, 22.5 +/- 2.5 nmol/g. Contrary to the in vitro findings that DHEA inhibits glucose-6-phosphate dehydrogenase (EC 1.1.1.49), thus leading to the hypothesis that DHEA inhibits fat synthesis by diminishing the availability of NADPH, the [NADP+]/[NADPH] ratios calculated from the 6-phosphogluconate dehydrogenase (EC 1.1.1.44), isocitrate dehydrogenase (EC 1.1.1.42) and malic enzyme (EC 1.1.1.40) redox couples were no more oxidized in the DHEA-treated animals than in the control animals. Malic enzyme and isocitrate dehydrogenase activities were 620 and 25% higher in DHEA-treated animals than in pair-fed controls. There was no change in the measured activity of glucose-6-phosphate dehydrogenase or 6-phosphogluconate dehydrogenase. These data give no support to the hypothesis that administration of DHEA per os results in decreased cytoplasmic NADPH in liver.

Topics: 17-Ketosteroids; Animals; Body Weight; Dehydroepiandrosterone; Diet; Food; Gluconates; Glucosephosphate Dehydrogenase; Isocitrate Dehydrogenase; Liver; Malate Dehydrogenase; Male; NADP; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Rats; Rats, Inbred Strains

Adult male Long-Evans rats were intermittently exposed to 2450 MHz CW microwaves at an average power density of 0.5 mW/cm2 for 90 days. The resulting SAR was 0.14 W/kg (range 0.11 to 0.18 W/kg). The animals were exposed 7 h/day, 7 days/wk, for a total of 630 h in a monopole-above-ground radiation chamber while housed in Plexiglas holding cages. Daily measures of body mass and food and water intake indicated no statistically significant effects of microwave exposure. Monthly assessment of reactivity to electric footshock, levels of cholinesterase and sulfhydryl groups in blood, and 17-ketosteroids in urine revealed no reliable differences between 14 sham-exposed and 14 microwave-exposed rats. After the 90 days of exposure, seven rats, randomly chosen from each group, were assessed for open-field behavior, shuttlebox performance, and schedule-controlled (IRT schedule) lever pressing for food pellets. Statistically significant differences between microwave-exposed and sham-exposed rats were observed in shuttlebox performances and lever pressing. Post mortem measures of mass of several organs and microscopic examination of adrenal tissue revealed no differences between the two groups of animals.

Topics: 17-Ketosteroids; Animals; Avoidance Learning; Behavior, Animal; Body Weight; Cholinesterases; Drinking; Eating; Male; Microwaves; Rats; Sulfhydryl Compounds

Topics: 17-Ketosteroids; Adolescent; Adult; Androstenedione; Body Weight; Female; Humans; Hydrocortisone; Menstruation; Sports; Steroids; Testosterone; Thyroxine; Triiodothyronine

Serum testosterone, follicle-stimulating hormone, luteinising hormone, and dihydro-epiandrosterone concentrations rose significantly in seven men studied during recovery from a severe exacerbation of chronic obstructive airways disease. Urinary 17-ketosteroids also rose significantly though serum androstenedione and prolactin concentrations did not. Our findings suggest that hypoxia in this condition suppresses the hypothalamus or pituitary or both and that such suppression is reversible. In view of previous reports of increase in total body potassium and intracellular water with recovery from cor pulmonale, we also carried out metabolic studies on our patients. Low body potassium concentrations in cor pulmonale fell further with recovery, in part reflecting a fall in lean body tissue. Intracellular water appeared to increase on recovery despite a fall in other lean body mass indices (the simplest and most reliable being skinfold thickness). We suspect this result to be spurious and due to problems with equilibration in isotope dilution. Alternatively it may reflect waterlogging of cells. A false figure for intracellular water could be responsible for an unexpectedly low estimated intracellular potassium concentration on recovery. Our results cast doubt on isotope dilution methods for measuring body water compartments in disease states likely to cause changes in cell permeability.

Topics: 17-Ketosteroids; Adult; Body Water; Body Weight; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Middle Aged; Potassium; Pulmonary Heart Disease; Testosterone

The plasma concentrations of total testosterone, free testosterone index, androstenedione, 17 beta-estradiol, luteinizing hormone, follicle-stimulating hormone, prolactin, and urinary 17-ketosteroid and 17-ketogenic steroid excretion were measured in 48 nonhirsute and 119 hirsute patients. Hormone data were compared within and between groups according to whether the menstrual cycles were eumenorrheic, amenorrheic, or oligomenorrheic. Eleven hirsute women treated with prednisone were followed for 6 months. It was concluded that: (1) androstenedione, testosterone, free testosterone index, and adrenal androgens alone or in combination play a role in the pathogenesis of the hirsutism observed in eumenorrheic women and in the amenorrhea and oligomenorrhea of both hirsute and nonhirsute women; (2) body weight correlated with adrenal adrogens (17-ketosteroids) in nonhirsute women and with androstenedione in hirsute women; (3) prednisone significantly suppressed androstenedione and 17-ketosteroids (p less than 0.05), with a decline of testosterone to 65% and luteinizing hormone to 51% of pretreatment values, with favorable clinical effects on the hirsutism, menstrual dysfunction, and infertility; (4) concentrations of 17 beta-estradiol were lower in amenorrheic than in eumenorrheic and oligomenorrheic women of both groups.

Topics: 17-Ketosteroids; Adult; Amenorrhea; Androgens; Androstenedione; Body Weight; Estradiol; Female; Follicle Stimulating Hormone; Glucocorticoids; Hirsutism; Humans; Infertility, Female; Luteinizing Hormone; Menstruation Disturbances; Prednisone; Prolactin; Testosterone

Topics: 17-Ketosteroids; Air Pollutants; Animals; Body Weight; Central Nervous System; Dose-Response Relationship, Drug; Ethylmercury Compounds; Female; Humans; Immunity; Rats; Time Factors; Volatilization

We have previously reported increased testosterone and androstenedione concentrations and decreased sex hormone binding globulin (SHBG) concentrations in the plasma of massively obese women. We now report that these plasma hormone concentrations return to normal in twelve of the same women after substantial weight reduction and these changes are associated with more normal menstrual cycles. We conclude that body weight and fat are important determinants of sex steroid secretion and binding and thus influence menstrual function.

Topics: 17-Ketosteroids; Adult; Androstenedione; Body Weight; Estrogens; Female; Humans; Menstruation; Obesity; Sex Hormone-Binding Globulin; Testosterone

Studies were made of steroid metabolites excreted in the urine of 17 obese girls 11.4 to 16.8 yr and 17 normal girls 11 to 17 yr. Creatinine excretion (muscle mass), total body water (or deuterium space), lean body mass and body fat were determined in the obese girls. Extracellular volume (corrected bromide space) was also measured and by difference with body water, intracellular water or soft tissue cell mass was calculated. In normal girls 24-h creatinine excretion was determined, but body water was predicted from height and weight. It was found, as in previous studies, that the obese girls had excess muscle mass and soft tissue cell mass for height. The excess growth of muscle, lean tissue, and body length in obese girls correlated with increments in oxosteroid (17 ketosteroid) excretion. The overall weight increase correlated with increased excretion of corticosteroid metabolites--a finding of interest since a physiological Cushing's syndrome was postulated for fat girls many years ago. When the normal and obese girls were divided by age at 14 yr and the subgroups compared (normal obese) the younger girls showed differences with respect to height, weight, total body water, fat and percentage fat. Differences in steroid metabolites were not found. In older girls the same findings were made again, but here it was clear that the increments in body size, particularly muscle mass, correlated with augmented oxosteroid excretion. Evidence is cited that these findings are not just related to a larger steroid pool in obese girls.

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Body Composition; Body Water; Body Weight; Child; Creatinine; Female; Humans; Obesity; Pregnanes; Puberty

Topics: 17-Ketosteroids; Adolescent; Adult; Anorexia Nervosa; Body Weight; Female; Gonadotropin-Releasing Hormone; Humans; Hydrocortisone; Insulin; Pituitary Hormones, Anterior; Thyrotropin-Releasing Hormone; Triiodothyronine

Long-Evans male adult rats were exposed for 16 weeks to 915-MHz CW microwaves at an average power density of 5 mW/cm2. The resulting dose rate was 2.46 (+/- 0.29 SEM) mW/g. The animals were exposed eight hours a day, five days a week, for a total of 640 h in a monopole-above ground radiation chamber while housed in Plexiglas cages. Daily measures of body mass and of food and water intake indicated no statistically significant effects of microwave irradiation. Measures by activity wheels and stabilimetric platforms of spontaneous locomotion indicate than mean activity levels increased about 25% after microwave exposure, but the findings are doubtful statistical significance (Ps < .10 but > .05). Studies of blood sampled after 2, 6, 10, and 14 weeks of exposure revealed alterations of free sulfhydryls. Measures of levels of urinary 17-ketosteroids at weeks 1, 5, 9, and 12 of exposure, and measures of brain hypothalamic tissue, and of mass of adrenals, heart, and liver at the end of the 16-week period, revealed no significant differences between irradiated and control animals. Cortical EEGs sampled after conclusion of microwave exposures also revealed no significant differences.

Topics: 17-Ketosteroids; Activity Cycles; Adrenal Glands; Animals; Blood Cells; Body Weight; Brain; Cholinesterases; Drinking; Eating; Electroencephalography; Heart; Hypothalamus; Liver; Male; Microwaves; Motor Activity; Organ Size; Radiation Dosage; Rats; Time Factors

During a population-based screening project for breast cancer, almost 15,000 women aged 50 years and over have provided a 12 h (overnight) sample of urine for research purposes. In 3,789 women the excretion of 11-desoxy-17-oxosteroids (DOOS) and creatinine was measured. Results were analysed in terms of urinary concentrations and of a ratio between DOOS and creatinine. Age had an effect on DOOS, creatinine and their ratio. Body weight and body surface area had an effect on creatinine excretion and therefore on the ratio. The following variables did not have an appreciable effect on the above-mentioned ratio: a family history of breast cancer, parity and age at first pregnancy, menopause and oestrogenic drugs, and parenchymal pattern of the breast as observed on the xeromammogram. Breast cancer was found at first screening in 106 out of 14,697 women. In 100 of these cases DOOS and creatinine were measured. Excretion values expressed as the ratio between the two, allowing for body surface area, did not differ materially from those of 100 age-matched controls. These results lead the authors to the conclusion that the determination of androgen metabolite excretion in women over 50 years of age is of no help in selecting a group at high risk of breast cancer.

Topics: 17-Ketosteroids; Adult; Age Factors; Body Height; Body Weight; Breast; Breast Neoplasms; Creatinine; Female; Humans; Maternal Age; Menopause; Middle Aged; Parity; Pregnancy

Responses to the changes in dietary sodium and posture were investigated in 9 young clinically healthy Japanese males who customarily consumed a larger amount of salt than North Americans or Europeans of mixed white ethnic background. Plasma renin activity (PRA), plasma aldosterone concentration (PAC), and urinary aldosterone excretion rate (AER) differed at each end of 3- to 4-day spans on a "control", a high-salt and a low-salt diet and of furosemide administration. PRA and PAC, also determined during the upright position following the supine blood sampling, increased after only 1 hour of standing in each condition (p less than 0.05 or more). PRA and PAC were well correlated in all 4 conditions, regardless of the posture (r = 0.806, p less than 0.001). There were also highly significant correlations between the "supine" PRA or PAC and the preceding 24-hour AER (r = 0.869, p less than 0.001) for PRA; r = 0.855, p less than 0.001 for PAC). Correlation coefficients between PRA and PAC in 9 individual subjects ranged from 0.823 to 0.987. The estimates of constant and slope of the regression line between PRA and PAC varied from subject to subject. The renin-aldosterone axis in response to changes in dietary sodium and posture must be individually assessed.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aldosterone; Body Weight; Creatinine; Diet, Sodium-Restricted; Electrolytes; Furosemide; Hematocrit; Humans; Japan; Male; Natriuresis; Posture; Renin; Sodium Chloride

Poor drug compliance may cause a decreased survival of children with malignancies. Children who fail to take their medications are not receiving optimum amounts of chemotherapy and suboptimal therapy causes a shortened survival in children with cancer. This is a study of prednisone compliance in 52 children with cancer during three distinct phases of therapy. The patients were either known to be taking prednisone (on-therapy group), off prednisone (off-therapy group), or their compliance was unknown (unknown group). Evaluation of prednisone compliance was attempted by measuring hemoglobin level changes, weight changes, and random urinary 17-ketogenic steroids. The results obtained show that while hemoglobin and weight changes are not helpful, a random urine 17-ketogenic steroid assay is able to differentiate clearly those patients who are taking their prednisone. By the use of this assay it was found that 33% of patients who by protocol and instruction were supposed to be receiving prednisone were not complying. Separate analysis of adolescents revealed an even more alarming 59% noncompliance rate. This striking level of noncompliance strongly suggests that the survival of patients may be threatened by noncompliance.

Topics: 17-Ketosteroids; Adolescent; Body Weight; Child; Child, Preschool; Female; Hemoglobins; Humans; Infant; Leukemia; Male; Patient Compliance; Prednisone; Prognosis

The effectiveness of therapy with cyproterone acetate and ethinyl estradiol was studied in 103 women. Acne and seborrhea responded best with 91.7 and 93.3% respectively, including complete and partial therapeutic success. For hirsutism complete remission and partial improvement were found in 75.3% of the treated women. Under therapy, body weight did not change in 51.9%, while 24.7% of the patients gained weight and 23.4% lost weight. The cycle length remained normal after therapy in 35.8%. Normalization or improvement was found in 54.7%. In 6.3% no improvement was noted after therapy and in 3.2% cycle irregularity developed in women with previous undisturbed pattern. According to BBT, improvement of the functional capacity of the reproductive system was found in 32.9% of the patients. Only 3% of the women studied demonstrated a deterioration. The 17-ketosteroid excretion was diminished in 35.3% after therapy and remained unchanged in 64.7%. The therapeutic regimen used for the study was well tolerated and good cycle control was obtained.

Topics: 17-Ketosteroids; Acne Vulgaris; Adolescent; Adult; Body Temperature; Body Weight; Cyproterone; Dermatitis, Seborrheic; Ethinyl Estradiol; Female; Hirsutism; Humans; Menstruation; Menstruation Disturbances; Remission, Spontaneous

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex; Androgens; Body Weight; Brain Diseases; Female; Humans; Hypothalamus; Male; Puberty; Syndrome

A unique syndrome in a three-year-old American Indian girl was characterized by signs and symptoms of mineralocorticoid excess in the absence of excessive secretion of any known sodium-retaining steroids. Hypertension and hypokalemic alkalosis were corrected by spironolactone or a low sodium diet. Plasma renin activity was suppressed but the secretion of aldosterone was undetectable and was not stimulated by salt depletion. There was no evidence of abnormal accumulation of aldosterone precursors and metabolism of a tracer dose of the hormone was normal. Secretion rates of cortisol, corticosterone, deoxycorticosterone, deoxycortisol and aldosterone were very low and did not increase normally with ACTH administration. However ACTH administration aggravated hypertension and hypokalemia. Dexamethasone did not improve hypertension. Despite low secretion of glucocorticoids and mineralocorticoids, the patient showed no addisonian features and survived severe illness. Secretion of a factor of adrenocortical origin was suggested by the exacerbation of the syndrome of ACTH. The unidentified factor appears to be both a potent glucocorticoid and mineralocorticoid.

Topics: 17-Ketosteroids; Aldosterone; Blood Pressure; Body Weight; Child, Preschool; Chlorothiazide; Dexamethasone; Female; Humans; Hydrocortisone; Hydroxysteroids; Hypertension; Mineralocorticoids; Potassium; Renin; Sodium; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Birth Weight; Body Height; Body Weight; Child Development; Child, Preschool; Follow-Up Studies; Humans; Infant, Newborn; Infant, Premature; Male

In a series of 146 school girls and nurses in the serum levels of growth hormone (GH), follicle stimulating hormone (FSH), and luteinizing hormone (LH) were determined in the afternoon after 4-5 hours' fast. Blood specimens of the menstruating girls were taken on the 7th to 10th day from the beginning of the preceding menstrual bleeding. From the 24-hour urines collected on the previous day the excretion of total oestrogens, 17-ketosteroids and 17-hydrocorticosteroids was determined. The series was grouped according to skeletal age which varied from 8.0 years to the adult stage. In the girls aged 11-13 years the GH curve showed a significant rise parallel with the mean height curve. The FSH values at the early age of 8-9 years corresponded to the follicular phase of adult women. The LH level increased syteeply up to the 15th year of bone age and mean values of adults were found to be about three times those of childhood. The excretion of total oestrogens and 17-ketosteroids increased steadily up to the full maturity of skeletal age. In the oldest group of girls the excretion was about four times that of the group aged 8-9 years. The hormonal maturation seems to continue until late puberty. The 17-OHCS, on the other hand, reached the adult level in the group with a bone age of 13 years. The excretion of 17-OHCS shows a steep rise from the age of 11 to 12 years and this acceleration of excretion perhaps exceeds the increase in surface area.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Age Determination by Skeleton; Age Factors; Animals; Body Height; Body Surface Area; Body Weight; Child; Estrogens; Female; Follicle Stimulating Hormone; Growth Hormone; Guinea Pigs; Humans; Luteinizing Hormone; Menstruation; Ovulation; Puberty; Rabbits; Radioimmunoassay; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Age Determination by Skeleton; Age Factors; Alkaline Phosphatase; Body Height; Body Weight; Child; Female; Growth Hormone; Humans; Menarche; Puberty

The excretion of 7 individual 17-oxosteroids and 7 individual corticosteroids in 24 h urine samples from 62 normal infants, children and adolescents, based on an accurate and specific paper chromatographic method for their separation and quantitation, is reported. The excretion of the 11-deoxy-17-oxosteroids gradually increases from 7 years of age and the increase becomes more rapid 2 or 3 years before the clinical signs of puberty appear. The rise continues throughout puberty and beyond it until the adult level is reached. The increase far exceeds that which would be accounted for by the growth of the individual. The increase in the excretion of the 11-oxy-17-oxosteroids with age is much more gradual. Androgens favour the formation of 5alpha metabolites and the 5alpha:5beta ratio of the total 5alpha 17-oxosteroids and the total 5beta 17-oxosteroids shows a statistically significant increase with age. In addition, a relatively high 5alpha:5beta ratio is noted in male infants, which is likely to be related to their relatively high plasma testosterone levels. The excretion of the 17-hydroxycorticosteroids and the alpha-ketolic metabolites of cortisol gradually rises with age and correlates with body weight. The alpha-ketolic metabolites of corticosterone are relatively high in infancy, but after the age of 4 years their excretion also correlates with body weight. An increase in the 5alpha:5beta ratio of allo-THF to THF is noted at puberty similar to that found with the 5alpha:5beta ratios of the 17-oxosteroids.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Age Factors; Androsterone; Body Height; Body Weight; Child; Child, Preschool; Corticosterone; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Hydrocortisone; Infant; Male; Puberty; Sex Factors

The effect of Danazol, a synthetic 2,3 isoxazol derivative of 17 alpha-ethinyl testosterone, was assessed in three girls and two boys with sexual precocity. Progression of sexual development ceased during administration of Danazol; the effect upon growth rate and skeletal maturation was equivocal. Serum estrogen and progesterone concentrations in the girls were lower during treatment; serum testosterone and dehydroepiandrosterone levels in the boys were also lower. Serum and urinary luteinizing hormone concentrations were inconsistently suppressed. No effect upon follicle-stimulating hormone levels could be demonstrated. Although Danazol appears to inhibit sexual development, this study indicates that the pituitary-gonadal axis is not completely suppressed. Growth rate is not reverted to normal, and virilization may occur among girls. Because undesirable side effects may outweight desirable results, careful consideration is recommended before Danazol is prescribed in the management of sexual precocity.

Topics: 17-Ketosteroids; Age Determination by Skeleton; Androgens; Body Height; Body Weight; Bone Development; Child; Child, Preschool; Danazol; Estrogens; Female; Gonadotropins; Growth; Humans; Male; Pregnadienes; Progesterone; Puberty, Precocious

Three children with Fanconi's anemia belonging to a family where 6 children had the disease were investigated. One child had growth hormone deficiency, a second child showed subnormal response of testosterone to gonadotropin stimulation and the third child had a missing insulin release following arginine. This report shows that growth hormone deficiency is not necessarily liniked with Fanconi's anemia when it occurs in a family. Multiple endocrine insufficiencies do no appear to be part of the disease.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Anemia, Aplastic; Arginine; Blood Glucose; Body Height; Body Weight; Child; Child, Preschool; Endocrine Glands; Fanconi Anemia; Growth Hormone; Humans; Hydrocortisone; Insulin; Insulin Secretion; Islets of Langerhans; Luteinizing Hormone; Male; Metyrapone; Pituitary Gland, Anterior; Testis; Testosterone; Thyroxine; Urea

The authors note that previous data on the role of biological factors in homosexuality have been suggestive rather than definitive. They investigated hormonal metabolism in heterosexual and homosexual men and found no indication of disturbed functioning in the homosexual subjects. The authors discuss problems with research in this area, suggesting the need for larger samples, attention to the factor of diurnal variations in hormonal secretion, and methodological refinements.

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex; Adult; Androstenedione; Androsterone; Body Weight; Etiocholanolone; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Homosexuality; Humans; Luteinizing Hormone; Male; Pituitary Gland; Testis; Testosterone

Twenty-four female rats consisting of 6 sets of litters were used for the experiment. After weaning, rats were divided into 4 groups and fed with 10, 18, 27 and 36% casein diet. Effect of protein nutrition on aging was examined from the anthropometric and biochemical viewpoint. The difference of growth in body weight, and that of the urinary excretion of creatinine and 17-ketosteroids observed in the early period of growing disappeared by the end of growth period. From 1 year after birth, serum alkaline phosphatase activity and serum cholesterol were also measured. However, effect of protein nutrition on these parameters was not clear due to the scatter of data. The difference in diet did not affect life span in the present experiments, but the effect of the variance of litters on it seemed to be significant between the rats fed 18% casein diet and those fed 10% casein diet. Rats fed high-protein diet had a great number of lesions in the kidney and hypophysis, and often an incidence of tumors.

Topics: 17-Ketosteroids; Aging; Alkaline Phosphatase; Animals; Body Weight; Cholesterol; Creatinine; Dietary Proteins; Female; Longevity; Rats

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Age Determination by Skeleton; Arginine; Body Height; Body Weight; Child; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Immunoassay; Insulin; Lesch-Nyhan Syndrome; Male; Radioimmunoassay; Somatomedins; Stimulation, Chemical; Testosterone; Thyroid Function Tests

Topics: 17-Ketosteroids; Adrenal Glands; Animals; Blood Pressure; Body Weight; Cholesterol; Corticosterone; Fatty Acids, Nonesterified; Heart; Hypertension; Kidney; Male; Organ Size; Rats; Rodent Diseases; Spleen; Thymus Gland

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Amenorrhea; Androsterone; Body Weight; Breast Neoplasms; Castration; Contraceptives, Oral; Dexamethasone; Estrogens; Etiocholanolone; Female; Hirsutism; Humans; Hypophysectomy; Luteinizing Hormone; Menstruation; Middle Aged; Obesity; Ovarian Diseases; Starvation

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Age Determination by Skeleton; Androgens; Body Surface Area; Body Weight; Child; Child, Preschool; Chromatography, Paper; Corticosterone; Female; Humans; Hydrocortisone; Infant; Male; Obesity; Puberty

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Androsterone; Body Surface Area; Body Weight; Bone Development; Deficiency Diseases; Etiocholanolone; Female; Humans; Hydroxycorticosteroids; Male; Obesity; Pregnanediol; Pregnanetriol; Progestins

Topics: 17-Ketosteroids; Age Factors; Alkaline Phosphatase; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Caseins; Creatinine; Dietary Proteins; Estrus; Female; Growth; Hydroxyproline; Longevity; Mammary Neoplasms, Experimental; Pregnancy; Protein Deficiency; Rats; Spleen; Tail; Time Factors

Topics: 17-Ketosteroids; Body Height; Body Weight; Child; Estrogens; Humans; Leydig Cell Tumor; Male; Pregnanetriol; Puberty, Precocious; Testicular Neoplasms; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Body Height; Body Weight; Child, Preschool; Dermatoglyphics; Fibroblasts; Genes; Humans; Infant; Infant, Newborn; Karyotyping; Klinefelter Syndrome; Lymphocytes; Male; Microscopy, Fluorescence; Sex Chromatin

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Diseases; Body Height; Body Weight; Cortisone; Cushing Syndrome; Female; Fludrocortisone; Humans; Hydrocortisone; Hyperplasia; Metyrapone; Mitotane

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Age Factors; Aged; Body Height; Body Weight; Creatinine; Female; Humans; Middle Aged; Obesity

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Androgens; Androstanes; Androstenedione; Animals; Body Weight; Carbon Isotopes; Hydroxysteroids; Hypophysectomy; Lipids; Male; Pituitary Gland; Rats; Sebaceous Glands; Sebum; Testis; Testosterone

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotropic Hormone; Body Weight; Bone Development; Child; Child, Preschool; Cushing Syndrome; Desoxycorticosterone; Diagnosis, Differential; Diagnostic Errors; Fludrocortisone; Glucocorticoids; Growth Disorders; Growth Hormone; Humans; Hydrocortisone; Infant; Infant, Newborn; Insulin; Male; Methylprednisolone; Metyrapone; Mineralocorticoids; Pituitary-Adrenal Function Tests

During a 28-week study, vasectomy and vasoligation of immature male Wistar rats revealed that there was a significant decrease in urinary 17-ketosteroid in the vasectomized group at week 15; at week 28 there were significant decreases in the weights of the testes of the test groups, as compared to those receiving sham operations, with maximum alterations in the vasectomized rats. Small, soft discolored testes with cysts in the cauda epididymis and vas deferens regions occurred frequently in the test groups. The output of 17-ketosteroid in the urine and the findings in the testes indicate significant alterations in the morphology and function of the testes and suggest the need for caution and extensive investigations in man before recommending vasectomy as a simple, innocuous, "physiologic" means to ensure conception control.

Topics: 17-Ketosteroids; Animals; Body Weight; Cysts; Epididymis; Genital Diseases, Male; Leukocyte Count; Ligation; Male; Organ Size; Rats; Testicular Diseases; Testis; Vas Deferens; Vasectomy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Biopsy; Blood Cells; Body Height; Body Weight; Fibroblasts; Gonadotropins; Humans; Hypogonadism; Karyotyping; Male; Mosaicism; Mouth Mucosa; Sex Chromatin; Sex Chromosome Aberrations; Skin; Syndrome; Testis; Testosterone

Topics: 17-Ketosteroids; Androgen Antagonists; Androstenes; Animals; Body Weight; Castration; Depression, Chemical; Dihydrotestosterone; Female; Fluoxymesterone; Imides; Male; Organ Size; Oxazoles; Phthalic Acids; Phthalimides; Prostate; Rats; Seminal Vesicles; Testis; Testosterone; Uterus

Topics: 17-Ketosteroids; Animal Feed; Animals; Body Composition; Body Weight; Calcium; Cold Temperature; Environmental Exposure; Epididymis; Humidity; Intestine, Small; Kidney; Liver; Male; Organ Size; Phosphorus; Proteins; Swine; Testis

Topics: 17-Ketosteroids; Adult; Blood Glucose; Body Composition; Body Water; Body Weight; Female; Glucose Tolerance Test; Humans; Insulin; Lipids; Male; Middle Aged; Muscles; Obesity; Oxygen Consumption; Physical Education and Training; Potassium; Succinate Dehydrogenase; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Body Weight; Circadian Rhythm; Female; Humans; Hypothalamo-Hypophyseal System; Metyrapone; Middle Aged; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Aldosterone; Body Weight; Female; Humans; Hydrocortisone; Male; Middle Aged; Natriuresis; Potassium; Pregnanetriol; Radioimmunoassay; Secretory Rate; Stimulation, Chemical; Tritium

Topics: 17-Ketosteroids; Abdomen; Adaptation, Physiological; Adult; Arm; Back; Body Height; Body Temperature Regulation; Body Weight; Breast; Clothing; Cold Temperature; Endocrine Glands; Female; Foot; Hot Temperature; Humans; Leg; Male; Rectum; Seasons; Sex Factors; Skin Temperature; Skinfold Thickness; Thigh; Tongue; Urine

Topics: 17-Ketosteroids; Asthenia; Balneology; Body Weight; Climate; Dairy Products; Diet Therapy; Electric Stimulation Therapy; Emotions; Exercise Therapy; Health Resorts; Humans; Hydrotherapy; Physical Therapy Modalities; Sleep; Ultraviolet Therapy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Animals; Body Weight; Catecholamines; Crowding; Drinking Behavior; Haplorhini; Housing, Animal; Male; Population Density; Social Dominance; Social Isolation; Species Specificity; Stress, Physiological

Topics: 17-Ketosteroids; Animals; Body Weight; Cyclohexanecarboxylic Acids; Erythrocyte Count; Growth Substances; Hematopoiesis; Liver; Liver Glycogen; Male; Organ Size; Rats; Stimulation, Chemical

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adult; Amenorrhea; Anorexia Nervosa; Blood Pressure; Blood Urea Nitrogen; Body Weight; Carbon Dioxide; Chlorine; Dexamethasone; Female; Follicle Stimulating Hormone; Glucose Tolerance Test; Humans; Hypopituitarism; Luteinizing Hormone; Male; Metyrapone; Middle Aged; Sodium

Topics: 17-Ketosteroids; Androgens; Androstenedione; Animals; Body Weight; Chromatography, Gas; Guinea Pigs; Male; Organ Size; Testis; Testosterone; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Body Height; Body Weight; Child; Estrogens; Female; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Hypogonadism; Intellectual Disability; Metyrapone; Obesity; Puberty, Precocious

Topics: 17-Ketosteroids; Adult; Anthropometry; Body Surface Area; Body Weight; Chromatography, Thin Layer; Creatinine; Female; Humans; Male; Sex Factors

Topics: 17-Ketosteroids; Age Factors; Androstanes; Animals; Antibody Formation; Body Weight; Carbon Isotopes; Chromatography, Thin Layer; Hydroxyprogesterones; In Vitro Techniques; Male; Monoamine Oxidase; Organ Size; Pregnenolone; Progesterone; Rats; Serotonin; Testis; Testosterone; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Body Weight; Child; Chromatography, Paper; Corticosterone; Humans; Hydrocortisone; Puberty

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenalectomy; Body Height; Body Weight; Child; Child, Preschool; Cushing Syndrome; Dexamethasone; Dwarfism; Female; Growth Hormone; Humans; Hydrocortisone; Ketosteroids; Male; Obesity; Postoperative Complications; Steroids

Topics: 17-Ketosteroids; Adult; Blood Glucose; Body Weight; Cholesterol; Creatinine; Glucose Tolerance Test; Growth Hormone; Humans; Hydrocortisone; Hydroxycorticosteroids; Insulin; Iodine; Iodine Isotopes; Thyroid Gland

Topics: 17-Ketosteroids; Adolescent; Body Height; Body Weight; Bone Development; Child; Female; Growth; Humans; Male; Obesity; Puberty

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Age Factors; Alkaline Phosphatase; Body Height; Body Weight; Bone Development; Child; Estrogens; Female; Gonadotropins, Pituitary; Humans; Menarche; Puberty; Thyroid Function Tests; Thyroxine; Thyroxine-Binding Proteins

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Androgens; Androsterone; Body Weight; Cholesterol; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Laparotomy; Sex Characteristics

Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Animals; Body Weight; Chemotherapy, Cancer, Regional Perfusion; Dehydroepiandrosterone; Glucuronates; Guinea Pigs; Half-Life; Hydrocortisone; Kidney; Liver; Liver Circulation; Mononuclear Phagocyte System; Pregnenolone; Progesterone; Sulfates; Sulfoglycosphingolipids; Tritium

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Blood Glucose; Body Height; Body Weight; Child; Child, Preschool; Growth; Growth Disorders; Growth Hormone; Humans; Hydrocortisone; Infant; Infant Nutrition Disorders; Insulin; Maternal Deprivation; Nutrition Disorders; Pituitary Gland; Psychosocial Deprivation; Thyroid Function Tests

Topics: 17-Ketosteroids; Androstanes; Animals; Body Weight; Carbon Isotopes; Cricetinae; Crystallization; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Male; Mice; NADP; Organ Size; Pregnenolone; Progesterone; Rats; Testis; Testosterone; Tritium

Topics: 17-Ketosteroids; Adrenal Glands; Anabolic Agents; Animals; Arteries; Arteriosclerosis; Aspartate Aminotransferases; Blood Glucose; Blood Urea Nitrogen; Body Weight; Cholesterol; Corticosterone; Fatty Acids, Nonesterified; Female; Heart; Hypertension; Islets of Langerhans; Kidney; Male; Organ Size; Ovary; Pancreas; Rats; Renal Artery; Testis; Thymus Gland; Triglycerides

Topics: 17-Ketosteroids; Aging; Androgens; Androstanes; Animals; Animals, Newborn; Body Weight; Chromatography, Paper; Chromatography, Thin Layer; Crystallization; Heparin; Hydroxyprogesterones; In Vitro Techniques; Male; Organ Size; Progesterone; Prostate; Radioisotope Dilution Technique; Rats; Seminal Vesicles; Testis; Testosterone; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Administration, Oral; Adolescent; Adult; Aged; Androstanes; Biological Assay; Body Weight; Cortisone; Dexamethasone; Female; Gonadotropins; Humans; Hydrocortisone; Hypogonadism; Injections, Intravenous; Klinefelter Syndrome; Male; Metyrapone; Middle Aged; Obesity; Radioisotope Dilution Technique; Testosterone; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Body Weight; Electrophoresis; Female; Glucose Tolerance Test; Humans; Iodine Isotopes; Obesity; Sodium Chloride; Water; Water-Electrolyte Balance

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Analysis of Variance; Androgen Antagonists; Androstanes; Androsterone; Animals; Anthropometry; Body Weight; Dihydrotestosterone; Drug Antagonism; Female; Fetal Diseases; Fetus; Hypospadias; Male; Organ Size; Pregnancy; Pregnancy Complications; Pregnanes; Rats; Sterols; Testosterone; Urethra; Virilism

Topics: 17-Ketosteroids; Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Body Weight; Female; Humans; Mental Health; Socioeconomic Factors

Topics: 17-Ketosteroids; Animals; Body Weight; Cell Differentiation; Depression, Chemical; Ear, External; Estradiol; Female; Injections, Subcutaneous; Male; Progesterone; Rabbits; Regeneration; Sex Factors; Stimulation, Chemical

Topics: 17-Ketosteroids; Body Weight; Chromosome Aberrations; Cytogenetics; Dermatoglyphics; Estrogens; Gynecomastia; Humans; Intellectual Disability; Karyotyping; Klinefelter Syndrome; Male; Mosaicism; Puberty

Topics: 17-Ketosteroids; Body Temperature; Body Weight; Creatinine; Glucocorticoids; Heart Rate; Hot Temperature; Humans; Hydrocortisone; Kidney; Male; Methods; Mining; Physical Exertion; Potassium; Sodium; Sweating; Temperature; Water-Electrolyte Balance

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Body Weight; Child; Child, Preschool; Emotions; Female; Humans; Infant; Obesity; Pregnancy; Psychophysiologic Disorders; Twins

Topics: 17-Ketosteroids; Adult; Androgen-Insensitivity Syndrome; Body Weight; Castration; Cell Nucleus; Color Vision Defects; Creatinine; Dihydrotestosterone; Estrogens; Eunuchism; Humans; Hypogonadism; Intellectual Disability; Male; Nitrogen; Olfaction Disorders; Phosphates; Receptors, Drug; Sex Chromosome Aberrations; Stimulation, Chemical; Testosterone

Topics: 17-Ketosteroids; Androstanes; Animals; Body Weight; Deer; Epididymis; Fructose; Horns; Male; Organ Size; Pituitary Gland; Prostate; Semen; Seminal Vesicles; Spermatozoa; Testis; Testosterone

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Androstanes; Body Height; Body Surface Area; Body Weight; Chromatography, Gas; Creatinine; Female; Heterozygote; Humans; Male; Metabolism, Inborn Errors; Mixed Function Oxygenases; Pregnanediol; Pregnanetriol; Steroids; Urine

Topics: 17-Ketosteroids; Acetazolamide; Action Potentials; Adult; Aldosterone; Biopsy; Body Weight; Electromyography; Glucose Tolerance Test; Humans; Hyperthyroidism; Hypokalemia; Insulin; Male; Muscles; Paralyses, Familial Periodic; Potassium; Sodium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Adrenocorticotropic Hormone; Adult; Body Weight; Creatinine; Depression, Chemical; Dexamethasone; Female; Humans; Injections, Intramuscular; Ketosteroids; Metabolism; Obesity; Polycystic Ovary Syndrome; Pregnanes; Stimulation, Chemical; Time Factors; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Body Height; Body Surface Area; Body Weight; Circadian Rhythm; Creatinine; Endopeptidases; Humans; Male; Pituitary-Adrenal System; Steroids; Stress, Physiological; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aged; Body Weight; Catheterization; Dexamethasone; Female; Hirsutism; Humans; Middle Aged; Phlebography; Prednisone; Testosterone; Veins; Virilism

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Anthropometry; Body Height; Body Surface Area; Body Weight; Creatinine; Extraversion, Psychological; Humans; Male; Neurotic Disorders; Personality; Personality Inventory; Psychotic Disorders; Skinfold Thickness; Somatotypes

Topics: 17-Ketosteroids; Androstanes; Animals; Biotransformation; Body Weight; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Estriol; Estrogens; Estrone; Female; Hydroxysteroid Dehydrogenases; Hyperthyroidism; Hypothyroidism; In Vitro Techniques; Mixed Function Oxygenases; Organ Size; Ovary; Rats; Stereoisomerism; Stimulation, Chemical; Thyroid Gland; Triiodothyronine

Topics: 17-Ketosteroids; Aldosterone; Blood Volume; Body Weight; Feces; Humans; Hydrocortisone; Male; Natriuresis; Oxytocin; Renin; Sodium; Vasopressins; Water Deprivation; Water-Electrolyte Balance

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Acids; Adrenal Glands; Age Factors; Androstanes; Animals; Body Weight; Castration; Dehydroepiandrosterone; Female; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Organ Size; Ovary; Pregnenolone; Progesterone; Rats; Stimulation, Chemical; Vitamin A; Vitamin A Deficiency; Weaning

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Body Weight; Estriol; Female; Humans; Hyperemesis Gravidarum; Kidney Failure, Chronic; Maternal-Fetal Exchange; Metyrapone; Obstetric Labor, Premature; Pituitary-Adrenal System; Placenta Previa; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Complications, Cardiovascular; Pregnancy in Diabetics; Pregnanediol; Pregnanetriol; Rupture; Thrombosis; Uterine Hemorrhage

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Body Weight; Chorionic Gonadotropin; Dehydroepiandrosterone; Dexamethasone; Estrogens; Female; Humans; Hyperemesis Gravidarum; Metyrapone; Pituitary-Adrenal System; Pregnancy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Birth Weight; Body Weight; Humans; Infant, Newborn; Infant, Premature; Pituitary-Adrenal Function Tests; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Birth Weight; Body Weight; Humans; Infant; Infant, Newborn; Infant, Premature; Pituitary-Adrenal Function Tests; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Body Weight; Diabetes Mellitus; Female; Humans; Obesity

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adult; Body Weight; Cholesterol; Diabetes Complications; Diabetes Mellitus; Diet; Fatty Acids, Nonesterified; Growth Hormone; Humans; Hyperlipidemias; Insulin; Lipids; Lipoproteins; Male; Phospholipids; Triglycerides; Xanthomatosis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Body Weight; Corticosterone; Creatinine; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Metyrapone; Middle Aged; Mixed Function Oxygenases; Obesity; Secretory Rate; Starvation

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Aldosterone; Body Height; Body Weight; Child; Child, Preschool; Dehydration; Female; Fluorometry; Humans; Hydrocortisone; Hyperkalemia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Melanins; Pigmentation Disorders; Seizures; Sodium Chloride; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Animals; Antifungal Agents; Body Weight; Female; Glucuronidase; Kidney; Liver; Pesticides; Rats; Sulfatases; Uterus

Topics: 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Animals; Body Weight; Bone and Bones; Chromatography; Dehydroepiandrosterone; Desoxycorticosterone; Estrogens; Female; Hydrocortisone; Hypertrophy; Hypophysectomy; Kidney; Liver; Menopause; Muscles; Organ Size; Pituitary Gland; Rats

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Aldosterone; Ammonium Chloride; Angiotensin II; Bicarbonates; Body Height; Body Weight; Catecholamines; Child; Chlorides; Diet; Female; Glucose Tolerance Test; Humans; Hyperaldosteronism; Hyperplasia; Juxtaglomerular Apparatus; Kidney Diseases; Kidney Function Tests; Metyrapone; Microscopy, Electron; Muscles; Norepinephrine; Pituitary-Adrenal Function Tests; Potassium; Renin; Serum Albumin; Sodium; Spironolactone; Triamterene; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Age Determination by Skeleton; Body Height; Body Weight; Child; Female; Gonadotropins; Gonads; Growth Hormone; Humans; Hypoglycemia; Insulin; Male; Metyrapone; Pituitary Gland; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Thalassemia; Thyroid Gland

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Blood Glucose; Blood Pressure; Body Height; Body Weight; Cushing Syndrome; Diabetes Complications; Diabetes Mellitus; Fasting; Female; Fluorometry; Glucocorticoids; Glucose Tolerance Test; Humans; Insulin; Islets of Langerhans; Male; Middle Aged

Topics: 17-Ketosteroids; Adolescent; Age Determination by Skeleton; Age Factors; Androgens; Body Height; Body Weight; Bone Development; Child; Child, Preschool; Dehydroepiandrosterone; Endocrine System Diseases; Epiphyses, Slipped; Female; Femur; Hand; Hip Injuries; Humans; Male; Nitriles; Obesity; Puberty; Sex Factors; Wrist

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Body Temperature; Body Weight; Calcium; Diet; Diuresis; Fever; Humans; Hypothermia, Induced; Leukocytosis; Magnesium; Male; Nitrogen; Phosphorus; Potassium; Pregnanetriol; Sodium; Sweat; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Animals; Body Weight; Citrates; Follicle Stimulating Hormone; Fructose; Genitalia, Male; Gonadotropins, Pituitary; Histocytochemistry; Luteinizing Hormone; Male; Organ Size; Pituitary Gland; Sheep; Statistics as Topic; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Ascorbic Acid; Body Height; Body Weight; Child; Creatinine; Female; Humans; Male; Nicotinic Acids; Palmitic Acids; Pantothenic Acid; Pyridoxine; Riboflavin; Tryptophan; Vitamins; Xanthurenates

Topics: 17-Ketosteroids; Acid Phosphatase; Alkaline Phosphatase; Androgen Antagonists; Body Weight; Gonadotropins, Pituitary; Gynecomastia; Hemoglobinometry; Humans; Male; Prostatic Neoplasms; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Aged; Body Weight; Chromatography, Gas; Diabetes Mellitus; Endometrium; Estrogens; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Uterine Neoplasms

Topics: 17-Ketosteroids; Androgens; Animals; Body Weight; Cattle; Female; Growth; Male; Organ Size; Pregnancy; Testis; Testosterone; Twins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Body Height; Body Weight; Child; Estrogens; Gonadotropins; Humans; Male

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Body Weight; Diet, Reducing; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Obesity; Thyroid Gland

Topics: 17-Ketosteroids; Acidosis; Adolescent; Adrenal Cortex Hormones; Adult; Bicarbonates; Body Weight; Cholesterol; Diet, Reducing; Female; Humans; Ketones; Male; Middle Aged; Obesity; Respiratory Function Tests; Sodium; Starvation; Uric Acid

Topics: 17-Ketosteroids; Adult; Amino Acids; Body Height; Body Weight; Creatinine; Diet; Humans; Lysine; Male; Methionine; Nitrogen; Protein Deficiency; Tryptophan; Urea

Topics: 17-Ketosteroids; Acetates; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Blood Glucose; Body Weight; Desoxycorticosterone; Electrolytes; Hematocrit; Leukocyte Count; Leukocytes; Male; Photometry; Pituitary-Adrenal Function Tests; Prednisone; Spectrum Analysis; Swine; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Blood Glucose; Body Weight; Electrolytes; Hematocrit; Leukocyte Count; Leukocytes; Male; Nitrogen; Physical Exertion; Pituitary-Adrenal Function Tests; Prednisone; Swine; Temperature; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Blood Glucose; Body Weight; Electrolytes; Hematocrit; Leukocyte Count; Leukocytes; Male; Pituitary-Adrenal Function Tests; Swine; Thyroid Function Tests; Thyroid Gland; Thyroidectomy; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Adipose Tissue; Adolescent; Adult; Body Composition; Body Weight; Cushing Syndrome; Extracellular Space; Female; Follow-Up Studies; Humans; Hydrocortisone; Male; Middle Aged; Potassium; Radioisotope Dilution Technique

Topics: 17-Ketosteroids; Adult; Alpha-Globulins; Beta-Globulins; Blood Pressure; Blood Protein Electrophoresis; Body Weight; Coronary Disease; gamma-Globulins; Humans; Hypercholesterolemia; Male; Middle Aged; Phospholipids; Serum Albumin; Uric Acid

Topics: 17-Ketosteroids; Blood Coagulation Tests; Body Weight; Contraceptives, Oral; Family Planning Services; Female; Humans; Menstruation Disturbances; Mestranol; Norethindrone; Vaginal Smears

Topics: 17-Ketosteroids; Body Weight; Ethnology; Fluids and Secretions; Social Conditions; Statistics as Topic; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood Coagulation; Blood Platelets; Body Height; Body Weight; Cottonseed Oil; Emulsions; Fats; Fibrinogen; Fluids and Secretions; Humans; Injections, Intravenous; Liver; Oils; Pharmacology; Physiology; Schizophrenia; Toxicology; Urine

Topics: 17-Ketosteroids; Aging; Amino Acids; Basal Metabolism; Body Height; Body Weight; Child; Creatine; Creatinine; Diet; Female; Humans; Metabolism; Nitrogen; Sex; Urine

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Body Composition; Body Height; Body Weight; Child; Child Behavior Disorders; Chorionic Gonadotropin; Fluids and Secretions; Gonadotropins; Growth; Humans; Neurotic Disorders; Psychopharmacology; Schizophrenia; Schizophrenia, Childhood; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Balneology; Body Weight; Exercise Therapy; Humans; Obesity; Urine

Topics: 17-Ketosteroids; Adenocarcinoma; Androsterone; Biomedical Research; Body Weight; Carcinoma; Carcinoma, Squamous Cell; Emphysema; Etiocholanolone; Fluids and Secretions; Humans; Liver Function Tests; Lung Neoplasms; Metabolism; Pregnanediol; Pulmonary Emphysema; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aged; Blood Glucose; Body Weight; Diabetes Complications; Duodenal Ulcer; Endopeptidases; Eosinophils; Female; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Stomach Ulcer; Stress, Physiological

Topics: 17-Ketosteroids; Adolescent; Alkaline Phosphatase; Blood Pressure Determination; Blood Protein Electrophoresis; Body Height; Body Weight; Child; Growth; Humans; Iron; Male; Somatotypes

Topics: 17-Ketosteroids; Adolescent; Aging; Appetite; Aspartate Aminotransferases; Body Weight; Bone and Bones; Child; Dwarfism; Growth; Liver; Nandrolone; Norethandrolone; Propionates; Sex Characteristics; Urine

Topics: 17-Ketosteroids; Anabolic Agents; Biomedical Research; Body Weight; Calcium; Calcium, Dietary; Humans; Metabolism; Nitrogen; Pharmacology; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aging; Androsterone; Blood Chemical Analysis; Body Height; Body Weight; Chemistry Techniques, Analytical; Cortisone; Dehydroepiandrosterone; Etiocholanolone; Female; Glucocorticoids; Humans; Hydrocortisone

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anorexia Nervosa; Basal Metabolism; Blood Chemical Analysis; Blood Pressure; Blood Pressure Determination; Body Weight; Genetics, Medical; Humans; Hypopituitarism; Urine

Topics: 17-Ketosteroids; Animals; Body Weight; Buffaloes; Electrocardiography; Eosinophils; Erythrocyte Count; Hypophysectomy; Leukocyte Count; Lymphocytes; Rats; Research; Surgery, Oral; Tooth Extraction; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Basal Metabolism; Biomedical Research; Body Weight; Corticosterone; Diet; Pituitary-Adrenal Function Tests; Respiration; Starvation; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adipose Tissue; Adrenal Glands; Adrenocorticotropic Hormone; Biomedical Research; Body Composition; Body Height; Body Weight; Creatine; Creatinine; Dexamethasone; Humans; Obesity; Pharmacology; Physiology; Urine

Topics: 17-Ketosteroids; Anal Canal; Androgens; Biological Assay; Body Weight; Castration; Chorionic Gonadotropin; Female; Gonadotropins, Pituitary; Humans; Injections, Subcutaneous; Male; Orchiectomy; Ovary; Parabiosis; Pharmacology; Prostate; Rats; Seminal Vesicles; Testis; Testosterone

Topics: 17-Ketosteroids; Adolescent; Aspartate Aminotransferases; Biomedical Research; Blood; Blood Cell Count; Blood Proteins; Body Weight; Ceruloplasmin; Child; Cholesterol; Coenzyme A; Electrolytes; Hemoglobins; Humans; Metabolism; Pantothenic Acid; Pharmacology; Pituitary-Adrenal Function Tests; Serum Albumin; Serum Globulins; Urine

Topics: 17-Ketosteroids; Abdomen; Adipose Tissue; Adolescent; Age Determination by Skeleton; Anthropometry; Body Composition; Body Height; Body Weight; Buttocks; Child; Humans; Obesity; Potassium; Potassium Isotopes; Radiometry; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Blood Chemical Analysis; Blood Pressure; Body Weight; Body Weights and Measures; Cushing Syndrome; Dexamethasone; Glucose Tolerance Test; Humans; Hydrocortisone; Metabolism; Obesity; Urine

Topics: 17-Ketosteroids; Adolescent; Biomedical Research; Body Fluids; Body Height; Body Weight; Body Weights and Measures; Child; Fluids and Secretions; Geriatrics; Humans; Infant; Urine; Weather

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Blood; Body Weight; Drug Therapy; Humans; Obesity; Starvation; Urine

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Amenorrhea; Body Height; Body Weight; Cushing Syndrome; Female; Fludrocortisone; Humans; Obesity; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Body Weight; Diethylstilbestrol; Female; Humans; Male; Organ Size

Topics: 17-Ketosteroids; Body Fluids; Body Weight; Body Weights and Measures; Down Syndrome; Intellectual Disability; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aging; Body Height; Body Weight; Glucocorticoids; Healthy Volunteers; Humans; Sex Characteristics; Steroids

Topics: 17-Ketosteroids; Androgens; Biological Transport; Body Weight; Body Weights and Measures