17-ketosteroids and Atrophy

A 35-yr-old woman had Cushing's syndrome, amenorrhea, and elevated and nonsuppressible levels of urinary and plasma cortisol and urinary 17-hydroxycorticosteroids. An ovarian carcinoma with extensive metastases was found. Tumor concentrations of ACTH were much lower than those in any previously reported patient with the ectopic ACTH syndrome. Cortisol levels obtained from the venous effluent of tumor-involved ovaries were higher than that in peripheral plasma obtained at the same time. Transient postoperative normalization of plasma and urinary cortisol followed partial tumor removal. Electron microscopic study of the tumor revealed a cell type consistent with steroid-secreting cells. Postmortem examination revealed atrophy of both adrenal glands and no pituitary adenoma.

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Atrophy; Cushing Syndrome; Dexamethasone; Female; Humans; Hydrocortisone; Hydroxysteroids; Ovarian Neoplasms

Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Atrophy; Carcinoma; Child; Female; Humans; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Atrophy; Female; Gonadotropins; Humans; Hypertrophy; Ovarian Cysts; Ovarian Diseases; Ovary; Ovulation; Staining and Labeling

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adolescent; Adult; Atrophy; Back; Child; Female; Humans; Lumbosacral Region; Male; Obesity; Sex Factors; Skin; Skin Diseases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Atrophy; Chronic Disease; Estrogens; Gonadotropins, Pituitary; Gynecomastia; Hemochromatosis; Humans; Liver Cirrhosis; Male; Testicular Diseases; Thyroid Function Tests

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Atrophy; Female; Humans; Indomethacin; Pituitary-Adrenal Function Tests; Skin Diseases; Urticaria

Topics: 17-Ketosteroids; Atrophy; Female; Humans; Liver Cirrhosis; Male; Testis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Anemia, Sickle Cell; Atrophy; Biopsy; Cortisone; Humans; Hypopituitarism; Male; Osmolar Concentration; Pituitary Function Tests; Pituitary Gland, Posterior; Testis; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma, Mucinous; Aged; Atrophy; Breast Neoplasms; Estrogens; Gynecomastia; Humans; Karyotyping; Klinefelter Syndrome; Male; Prostate

Topics: 17-Ketosteroids; Adult; Atrophy; Chronic Disease; Fructose; Gonadotropins; Hepatitis; Humans; Libido; Liver Cirrhosis; Liver Diseases; Male; Middle Aged; Spermatozoa; Testicular Diseases

Topics: 17-Ketosteroids; Adenocarcinoma; Atrophy; Chorionic Gonadotropin; Clomiphene; Diagnosis; Drug Therapy; Endometriosis; Endometrium; Female; Follicle Stimulating Hormone; Genital Diseases, Female; Gonadotropins; Humans; Hyperplasia; Infertility; Infertility, Female; Ovulation; Pathology; Polycystic Ovary Syndrome; Stilbenes; Toxicology; Urine; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Atrophy; Hepatitis; Liver Cirrhosis; Metyrapone; Mineralocorticoid Receptor Antagonists; Pathology; Pharmacology; Pituitary-Adrenal Function Tests

Ataxia-telangiectasia is a syndrome of progressive cerebellar ataxia and other neurological manifestations associated with conjunctival and cutaneous telangiectases and with recurrent sino-pulmonary infections. Immunological and endocrine abnormalities occur. Two girls with this disease are described. The first had only minor respiratory infections; her serum proteins and immunity responses appeared normal. The second had recurrent pulmonary infections and bronchiectasis; she also exhibited sclerodermatous changes, poor development of secondary sexual characteristics with low urinary excretion of 17-ketosteroids, and lymphopenia. Autopsy at 17 years showed bilateral ovarian dysgerminomata and excessive cutaneous collagen as well as atrophy, and perhaps hypoplasia, of adrenals, thymus, spleen and lymphoid tissue (after steroid therapy). The cerebellum exhibited cortical degeneration. Both lungs were fibrotic with old and recent bronchopneumonia and bronchiectasis. The left lung was studied by injection of a latex preparation; no arteriovenous aneurysms were found, but the smaller pulmonary vessels showed some unusual morphological characteristics.

Topics: 17-Ketosteroids; Adolescent; Ataxia; Ataxia Telangiectasia; Atrophy; Blood Protein Electrophoresis; Bronchiectasis; Cerebellar Diseases; Child; Conjunctiva; Dysgerminoma; Eosinophils; Female; Genetics, Medical; Humans; Hypogonadism; Immunoelectrophoresis; Infant; Infant, Newborn; Leukocyte Count; Lymphocytes; Neoplasms, Germ Cell and Embryonal; Neurologic Manifestations; Ovarian Neoplasms; Pathology; Pulmonary Circulation; Pulmonary Fibrosis; Scleroderma, Systemic; Telangiectasis; Urine

Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Aged; Amenorrhea; Atrophy; Breast Diseases; Estrogens; Female; Gonadotropins; Humans; Surgical Procedures, Operative; Urine; Urography

Topics: 17-Ketosteroids; Atrophy; Humans; Leprosy; Male; Steroids; Testis