17-ketosteroids and Asthma

Forty-two perennial asthmatic children were selected for a 12-wk study using beclomethasone dipropionate. The groups included 21 steroid-dependent children (Group I) and 21 patients (Group II) whose disease was of sufficient severity that corticosteroid therapy was contemplated. All children received the drug in a dose of 100 mug 4 times daily. During the study, oral prednisone was withdrawn from the steroid-dependent children while other therapy was essentially unchanged. Group II children underwent a double-blind trial, receiving beclomethasone for 6 wk and placebo for 6 wk. Objective assessment of adrenal and pulmonary function was obtained at regular intervals. For the latter, total lung capacity and its subdivisions, airways resistance, maximum expiratory flow volume, and oxygen tension, were measured in both groups. In Group II static elastic recoil was measured also. For most tests the results were statistically significant. In both groups, 18 of 21 patients demonstrated an excellent clinical response, no evidence of adrenal suppression, and improvement in pulmonary function. Forty of 42 patients were followed for another 12 wk, and 19 of each group did well. After 20-24 wk of therapy, 16% of patients harbored monilia in their oropharynx, and 1 patient had clinical monilial stomatitis. Within the limits of the time of the study, beclomethasone dipropionate appeared to provide adequate clinical control in many chronic, severe, steroid-dependent and nonsteroid-dependent asthmatic children.

Topics: 17-Ketosteroids; Adolescent; Adult; Aerosols; Asthma; Beclomethasone; Candidiasis, Oral; Child; Clinical Trials as Topic; Female; Humans; Hydrocortisone; Male; Methylprednisolone; Respiratory Function Tests

Beclomethasone dipropionate is a topically active corticosteroid used as an adjuvant in the control of chronic asthma when given by inhalation as an aerosol. It is not intended for treatment of acute attacks. It appears that the main difference between beclomethasone dipropionate and other corticosteroids previously used by inhalation is its high topical activity together with a lower systemic activity due to metabolic inactivation of the swallowed portion of the dose. Clinical experience has shown that at doses of 200 to 600mug daily, beclomethasone dipropionate inhaler is preferable to oral corticosteroids, because of lack of side-effects, when adult patients and children who are inadequately controlled by full doses of sodium cromoglycate and bronchodilators, are first considered to need maintenance corticosteroids. Inhaled beclomethasone dipropionate can allow a worthwhile reduction in maintenance doses of systemic corticosteroids in many patients already receiving these drugs and can replace systemic steroids entirely in some patients, particularly when their initial dose of steroids is less than 10mg daily of prednisone or its equivalent. Substitution should be attempted when the patient's asthma is well controlled on their usual doses of systemic steroids and full doses of other adjuvant therapy. Withdrawal of systemic corticosteroids should be performed slowly and carefully. Because recovery from impaired adrenocortical function caused by prolonged systemic steroid therapy is usually slow, special care is necessary for 9 to 12 months after transfer to beclomethasone dipropionate aerosol until the hypothalamo-pituitary-adrenal axis has sufficiently recovered to cope with emergencies such as trauma, surgery, severe infections or an acute attack of asthma. It is essential that additional therapy including high doses of systemic corticosteroids be used immediately to control any acute exacerbation of asthma which occurs during maintenance therapy with beclomethasone dipropionate aerosol. Tests of adrenal function suggest that beclomethasone dipropionate at dosages of 400 to 800 mug daily has little or no adverse effect. The most common side-effect associated with the continuous use of beclomethasone dipropionate inhaler has been oropharyngeal candidiasis, which appears to be dose-related and more common in women than in men. Systemic steroid withdrawal effects, like being generally unwell, and exacerbation of underlying allergic diseases such as aller

Topics: 17-Ketosteroids; Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aerosols; Asthma; Beclomethasone; Child; Clinical Trials as Topic; Drug Evaluation; Forced Expiratory Volume; Half-Life; Humans; Hydrocortisone; Kinetics; Methylprednisolone; Middle Aged; Substance-Related Disorders

Topics: 17-Ketosteroids; Administration, Topical; Adult; Aerosols; Aged; Anti-Inflammatory Agents; Asthma; Beclomethasone; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Humans; Hydrocortisone; Hydroxysteroids; Lung; Male; Middle Aged; Spirometry; Steroids; Substance-Related Disorders

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Asthma; Blood Glucose; Body Weight; Clinical Trials as Topic; Female; Glucocorticoids; Humans; Male; Middle Aged; Potassium; Prednisone; Pregnatrienes; Pyrazoles; Sodium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Insufficiency; Adult; Aged; Asthma; Circadian Rhythm; Female; Humans; Male; Middle Aged

The Tohoku University method of fasting therapy was performed on 380 patients. The clinical results revealed an efficacy rate of 87%. With regard to psychosomatic diseases, irritable colon syndrome, neurocirculatory asthenia, mild diabetes mellitus, obesity and borderline hypertension were good indications for this therapy. In order to clarify the therapeutic mechanism, several clinical examinations were administered before, during and after therapy. EEG data was analysed according to the power spectral method. The peak frequency decreased as fasting progressed, while it increased as re-fed continued. Percent energy of alpha waves after fasting therapy was significantly higher than that of the pre-fasting stage. The dexamethasone suppression rate of urine 17-OHCS after fasting therapy was significantly lower than that of the pre-fasting stage. It seems that ketone nutrition may work as a strong stressor in the brain cell, temporarily placing all biological mechanisms in a stress state and then activating the natural healing power inherent to the human body, thereby bringing about homeostasis.

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Asthma; Child; Colonic Diseases, Functional; Dexamethasone; Diabetes Mellitus; Electroencephalography; Fasting; Female; Headache; Humans; Hypertension; Hyperventilation; Male; Middle Aged; Obesity; Psychophysiologic Disorders

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androgens; Asthma; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Pulmonary Circulation; Remission, Spontaneous

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Asthma; Autonomic Nervous System; Blood Pressure; Child; Electroencephalography; Humans; Methacholine Compounds; Parasympathetic Nervous System; Thyroid Function Tests; Thyroid Gland

15 adult chronic asthmatic patients who were on daily maintenance dose of oral steroid for at least 6 months were studied. Following an investigation period of 2 weeks, the patients were started on BDA, 100 microgram four times daily. The daily oral steroid dose, which averaged 12 mg of prednisone or its equivalent, was gradually reduced by about 1 mg per day. The trial lasted 8 weeks, at the end of which, ten patients were as good or better on BDA than on oral steroids. Two patients had to return to oral corticosteroid therapy before the trial ended and three patients were unable to discontinue their oral steroid treatment. The lack of systemic effects of BDA was demonstrated by the appearance of symptoms which were apparently previously suppressed by the oral steroids and the excretion of normal amounts of 17-OHCS in the urine in some to the patients who had evidence of adrenal suppression while on oral steroids.

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aerosols; Asthma; Beclomethasone; Chronic Disease; Humans; Respiratory Function Tests; Substance-Related Disorders

In addition to the usual mangement of asthma the introduction of Beclomethasone-dipropionate aerosol can be considered as a progress in the long-term treatment of asthma, because in most cases oral and parenteral application of corticosteroids is no longer necessary. According to the results of many authors the wellknown side effects of steriod therapy have so far not been observed. We report our experiences with Beclomethasone in the treatment of 19 chronically asthmatic children.

Topics: 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Aerosols; Asthma; Beclomethasone; Child; Child, Preschool; Cortisone; Female; Humans; Long-Term Care; Male; Respiration

Topics: 17-Ketosteroids; Adult; Aged; Asthma; Female; Humans; Male; Middle Aged; Saliva; Salivary Glands

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Antibodies; Antibody Specificity; Asthma; Bronchitis; Creatinine; Drug Hypersensitivity; Female; Humans; Immune Sera; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin G; Iodine Radioisotopes; Male; Radioimmunoassay

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Air Pollution; alpha 1-Antitrypsin; Asthma; Bronchitis; Chronic Disease; Coal Mining; Cystic Fibrosis; Diagnosis, Differential; Humans; Lung Diseases, Obstructive; Occupational Diseases; Pulmonary Emphysema; Respiratory Hypersensitivity; Respiratory Tract Infections; Rural Population; Smoking; Socioeconomic Factors; Urban Population

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Administration, Topical; Adrenal Glands; Adult; Anti-Inflammatory Agents; Asthma; Beclomethasone; Circadian Rhythm; Dexamethasone; Humans; Hydrocortisone; Male; Methylprednisolone; Respiratory Therapy; Time Factors

Topics: 17-Ketosteroids; Adolescent; Adult; Asthma; Bronchial Neoplasms; Cushing Syndrome; Female; Glucocorticoids; Humans; Hydroxycorticosteroids; Male; Middle Aged; Nephritis; Rheumatic Fever; Sarcoidosis; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyrotropin-Releasing Hormone; Triiodothyronine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Asthma; Child; Humans; Skin Tests; Spirometry; Vital Capacity

Topics: 17-Ketosteroids; Adrenal Glands; Asthma; Carotid Body; Humans; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Acute Disease; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Asthma; Child; Creatinine; Eosinophilia; Eosinophils; Glucocorticoids; Humans; Male; Pituitary-Adrenal Function Tests; Uric Acid

Topics: 17-Ketosteroids; Altitude; Asthma; Blood Flow Velocity; Body Temperature Regulation; Hernia, Diaphragmatic; Humans; Pressure; Respiration; Sinusitis; Spirometry; Vascular Diseases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Asthma; Bronchography; Bronchoscopy; Chloramphenicol; Eosinophils; Erythromycin; Humans; Skin Tests; Sputum; Troleandomycin

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Asthma; Child; Cortisone; Female; Humans; Male; Metyrapone; Middle Aged; Pituitary Gland; Pituitary-Adrenal Function Tests; Prednisone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Asthma; Body Surface Area; Child; Child, Preschool; Depression, Chemical; Female; Growth; Humans; Infant; Male; Metyrapone; Pituitary-Adrenal Function Tests; Prednisone; Stimulation, Chemical; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Asthma; Female; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Asthma; Child; Chromatography; Electrophoresis; Female; Humans; Male

Topics: 17-Ketosteroids; Adolescent; Adult; Asthma; Cytochromes; Female; Humans; Hypersensitivity; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Adult; Asthma; Female; Humans; Injections, Intramuscular; Male; Staphylococcal Infections

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumatoid; Asthma; Female; Humans; Male; Middle Aged; Myasthenia Gravis; Nephrosis; Purpura; Urticaria

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Age Factors; Asthma; Body Temperature; Circadian Rhythm; Corticosterone; Glucocorticoids; Humans; Hydrocortisone; Infusions, Parenteral; Male; Middle Aged; Pyrogens; Rest; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Asthma; Child; Female; Humans; Male

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Animals; Asthma; Autonomic Nervous System; Blood Vessels; Cerebral Cortex; Circadian Rhythm; Climate; Conditioning, Psychological; Emotions; Endocrine Glands; Estrus; Female; Guinea Pigs; Homeostasis; Humans; Hypersensitivity; Hypothalamus; Infections; Menopause; Menstruation; Muscle, Smooth; Parasympathetic Nervous System; Physical Exertion; Pregnancy; Psychophysiologic Disorders; Respiration; Serotonin; Sympathetic Nervous System; Uterus

Topics: 17-Ketosteroids; Adolescent; Asthma; Autonomic Nervous System; Catecholamines; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Norepinephrine; Phenylacetates; Pituitary-Adrenal Function Tests; Reflex, Abnormal; Skin Manifestations; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Alopecia Areata; Arthritis, Rheumatoid; Asthma; Breast Neoplasms; Child; Child, Preschool; Colitis, Ulcerative; Cortisone; Endocrine System Diseases; Female; Humans; Hydrocortisone; Male; Middle Aged; Multiple Sclerosis

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Asthma; Child, Preschool; Female; Humans; Hydrocortisone; Hypersensitivity; Infant; Male; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Respiratory Function Tests; Skin Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Asthma; Collagen Diseases; Female; Hodgkin Disease; Humans; Lymphadenitis; Metyrapone; Middle Aged; Nephrosis, Lipoid; Pituitary-Adrenal Function Tests; Skin Diseases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Arthritis, Juvenile; Asthma; Child; Child, Preschool; Fluprednisolone; Humans; Prednisone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Asthma; Bronchitis; Child; Chronic Disease; Colitis, Ulcerative; Emphysema; Female; Humans; Lupus Erythematosus, Discoid; Male; Methylprednisolone; Nephrosis; Prednisone; Pregnanes; Triamcinolone

Topics: 17-Ketosteroids; Adult; Asthma; Female; Humans; Lung Abscess; Male; Middle Aged; Potassium; Sodium

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Asthma; Blood Glucose; Body Temperature Regulation; Brain Diseases; Calcium; Child; Child, Preschool; Chlorides; Cholesterol; Epinephrine; Female; Glucose; Humans; Hypothalamus; Infant; Insulin; Male; Nicotinic Acids; Parasympathetic Nervous System; Phosphorus; Photosensitivity Disorders; Potassium; Reflex, Abnormal; Serum Albumin; Serum Globulins; Ultraviolet Rays

Topics: 17-Ketosteroids; Adrenal Glands; Asthma; Humans

Topics: 17-Ketosteroids; Adrenal Glands; Asthma; Atmospheric Pressure; Humans

Topics: 17-Ketosteroids; Adrenal Insufficiency; Asthma; Humans

Topics: 17-Ketosteroids; Addison Disease; Adrenal Glands; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Asthma; Carcinoma, Bronchogenic; Coccidioidomycosis; Cushing Syndrome; Diabetes Mellitus; Ethinyl Estradiol; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypopituitarism; Hypotension; Myocardial Infarction; Neurotic Disorders; Pituitary Neoplasms; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aerosols; Asthma; Biomedical Research; Dexamethasone; Humans; Isoproterenol; Placebos; Toxicology; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aerosols; Asthma; Dexamethasone; Humans; Pharmacology; Phosphates; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Toxicology; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Asthma; Child; Chorion; Chorionic Gonadotropin; Gonadotropins; Pharmacology; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Asthma; Metyrapone; Mineralocorticoid Receptor Antagonists; Pharmacology; Pituitary Diseases; Pituitary Gland

Topics: 17-Ketosteroids; Adolescent; Adult; Asthma; Blood Chemical Analysis; Cholesterol; Copper; Eosinophils; Estrogens; Geriatrics; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Iodides; Iodine; Iron; Leukocyte Count; Phosphoric Monoester Hydrolases; Testosterone; Thyroid Function Tests; Uric Acid

Topics: 17-Ketosteroids; Asthma; Female; Pregnancy; Pregnancy Complications; Urine

Topics: 17-Ketosteroids; Asthma; Endopeptidases; Eosinophils; Humans; Myocardial Infarction

Topics: 17-Ketosteroids; Adrenal Cortex Function Tests; Agranulocytosis; Animals; Asthma; Behavior, Animal; Biological Transport; Social Behavior

Topics: 17-Ketosteroids; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Anemia; Anemia, Aplastic; Asthma; Cerebral Cortex; Child; Dexamethasone; Humans; Nephrotic Syndrome; Prednisolone; Rheumatic Fever

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Asthma; Child; Dermatomyositis; Dexamethasone; Encephalitis; Humans; Nephrotic Syndrome; Prednisolone; Rheumatic Fever

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Function Tests; Asthma; Cholesterol; Humans; Hypoglycemia; Pancreatic Diseases

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Asthma; Plasma; Urinary Tract; Zinc

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Animals; Asthma; Behavior, Animal; Social Behavior; Steroids

Topics: 17-Ketosteroids; Asthma; Body Fluids; Humans; Research Design; Rhinitis, Allergic, Seasonal; Steroids

Topics: 17-Ketosteroids; Asthma; Biological Phenomena; Desensitization, Immunologic; Physiological Phenomena; Steroids; Urine

Topics: 17-Ketosteroids; Asthma; Bronchitis; Dyspnea; Humans; Steroids; Urinary Tract; Urine

Topics: 17-Ketosteroids; Asthma; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Asthma

Topics: 17-Ketosteroids; Asthma; Body Fluids; Bronchitis; Gonads; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androgens; Asthma; Biological Transport; Body Fluids; Steroids