17-ketosteroids has been researched along with Arthritis--Rheumatoid* in 53 studies
1 review(s) available for 17-ketosteroids and Arthritis--Rheumatoid
Article | Year |
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Low adrenal androgenic-anabolic steroids in women with rheumatoid arthritis (RA): gas-liquid chromatographic studies of RA patients and matched normal control women indicating decreased 11-deoxy-17-ketosteroid excretion.
Using GLC, multiple adrenal corticosteroid urinary metabolites, including androgenic-anabolic, glucocorticoid, pregnanediol, and pregnanetriol, were measured in eight ambulatory female RA patients and eight matched normal control subjects on baseline, ACTH-, and metyrapone-stimulation days under carefully monitored clinical research center protocol. Neither group had been treated previously with any steroid hormones. The 11-deoxy-17-KS metabolites, derived from adrenal androgenic-anabolic steroids, and comprising androsterone, etiocholanolone, and DHA, were significantly lower in RA patients on baseline (P less than .001), ACTH (P less than .005)-, and metyrapone (P less than .02)-stimulation days. To the contrary, the 11-oxy-17-KS metabolites, derived mainly from glucocorticoids, showed some lowered excretion at baseline (P less than .05), but none on ACTH- or metyrapone-stimulation. RA patients had lower tetrahydrocortisone (P less than .001) and tetrahydro-11-deoxycortisol (P less than .01) excretion at baseline, but not during ACTH- or metyrapone-stimulation, than control subjects. Pregnanetriol excretion was lower (P less than .005) in RA patients than control subjects only during ACTH-stimulation. No difference was found between groups in tetrahydrocortisol or pregnanediol excretion on any day studied. Under conditions of oral metyrapone administration (750 mg every four hours for seven doses) each control subject increased their DHA excretion, but no RA patient showed an increase over baseline excretion (P less than .02). Except for 11-deoxy-17-KS, no difference was found in the other metabolites studied during metyrapone stimulation, ie, pregnanediol, pregnanetriol, tetrahydro-11-deoxycortisol, and tetrahydrocortisol. The 24-hour oral metyrapone test provided a greater stimulus to total 11-deoxy-17-KS excretion than an eight-hour intravenous ACTH test in control and particularly RA (P less than .01) subjects even though the DHA excretion decreased in the RA groups. Our findings of lower adrenal androgenic-anabolic metabolite excretion in female RA patients than normal matched control subjects under various conditions and other supportive androgenic hormone and metabolite studies reviewed in the English reports suggest an abnormality of adrenal androgen synthesis or metabolism in RA, whether it be a primary predisposing or secondary factor in disease. The recognized female sex preponderance and age-specific patterns of occurrence of RA are consiste Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Anabolic Agents; Androgens; Androsterone; Arthritis, Rheumatoid; Calorimetry; Chromatography, Gas; Cortodoxone; Dehydroepiandrosterone; Etiocholanolone; Female; Glucocorticoids; Humans; Metyrapone; Middle Aged; Pregnanediol; Pregnanetriol | 1984 |
52 other study(ies) available for 17-ketosteroids and Arthritis--Rheumatoid
Article | Year |
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Study on the inactivation mechanism of androgens in rheumatoid arthritis: excretory rate of free and conjugated 17-ketosteroids.
Unconjugated, sulpho- and glucurono-conjugated androgen hormone metabolites have been determined in the urine of patients with rheumatoid arthritis. An increase in the excretory rate of unconjugated 5 beta-reduced 17-ketosteroids and a decrease in that of 17-ketosteroid conjugates, especially in dehydroepiandrosterone sulphate and in the sum of dehydroepiandrosterone, etiocholanolone and androsterone glucuronoside were observed. In contrast to unconjugated metabolites, there was less significant change in the 5 beta-metabolite conjugates in urine. Corticosteroid treatment resulted in an additional decrease of metabolite excretion by patients. Further study is necessary to determine the causative factors in the altered steroid pattern observed in this severe, non-endocrine disease. Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Androgens; Arthritis, Rheumatoid; Female; Glucuronates; Humans; Sulfuric Acids | 1979 |
Adrenocortical response upon repeated stimulation with corticotrophin in patients lacking endogenous corticotrophin secretion.
Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Arthritis, Rheumatoid; Female; Humans; Hydrocortisone; Hypophysectomy; Hypopituitarism; Male; Prednisone; Stimulation, Chemical | 1977 |
[Comparison of clinical effects of gold thioglucose and gold sodium thiomalate].
Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Evaluation Studies as Topic; Female; Glucose; Gold; Humans; Male; Middle Aged; Thiomalates | 1972 |
Comparison of effects of corticotrophin and corticosteroids on pituitary-adrenal function.
Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Androstanes; Arthritis; Arthritis, Rheumatoid; Chronic Disease; Circadian Rhythm; Dehydroepiandrosterone; Delayed-Action Preparations; Female; Glucocorticoids; Humans; Hydrocortisone; Hypothalamus; Insulin; Male; Middle Aged; Pituitary Gland; Prednisolone; Psoriasis | 1971 |
[Some parallels of neuro-humoral and metabolic indices in diseases inhibiting and intensifying the development of atherosclerosis].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adult; Arteriosclerosis; Arthritis, Rheumatoid; Cholelithiasis; Cholesterol; Coronary Disease; Cushing Syndrome; Epinephrine; Fibrinolysis; Heparin; Humans; Lipoproteins; Liver Cirrhosis; Middle Aged; Neuraminic Acids; Norepinephrine; Pulse | 1971 |
[Studies on the steroid-saving effect of oxyphenbutazone].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Arthritis, Rheumatoid; Cortisone; Humans; Hydrocortisone; Oxyphenbutazone; Pituitary Gland; Prednisolone | 1971 |
[Cortisone withdrawal syndrome in progressive chronic polyarthritis and its management].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Arthritis, Rheumatoid; Cortisone; Humans; Peptides; Prednisolone; Substance Withdrawal Syndrome | 1970 |
[Problems of corticoid therapy in pregnancy].
Topics: 17-Ketosteroids; Adult; Arthritis, Rheumatoid; Betamethasone; Estrogens; Female; Fetal Diseases; Hirsutism; Humans; Placenta Diseases; Pregnancy; Pregnancy Complications; Pregnanediol; Triamcinolone | 1970 |
[Pituitary and adrenal functional reserve in children with rheumatoid arthritis].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Child; Female; Humans; Male; Pituitary-Adrenal Function Tests | 1969 |
The action of prolactin on the adrenocortical function.
Topics: 17-Ketosteroids; Adrenal Insufficiency; Animals; Arthritis, Rheumatoid; Female; Humans; Injections, Intramuscular; Middle Aged; Pituitary-Adrenal Function Tests; Prolactin; Sheep; Time Factors | 1969 |
Joint stiffness--its characterisation and significance.
Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Aged; Arthritis, Rheumatoid; Biomechanical Phenomena; Child; Child, Preschool; Circadian Rhythm; Collagen; Connective Tissue; Elasticity; Electromyography; Female; Humans; Joint Diseases; Joints; Knee Joint; Male; Middle Aged; Movement; Movement Disorders; Muscles; Osteoarthritis; Pressure; Relaxation; Sclerosis; Sex Factors; Synovial Fluid; Temperature | 1969 |
[Hormonal changes and clinical effects produced in patients treated with a delyed-action preparation of synthetic ACTH].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumatoid; Asthma; Female; Humans; Male; Middle Aged; Myasthenia Gravis; Nephrosis; Purpura; Urticaria | 1968 |
Metabolism of tetrahydrocortisone in health and disease.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Amyotrophic Lateral Sclerosis; Arthritis, Rheumatoid; Chemistry, Clinical; Diabetes Mellitus; Diabetic Retinopathy; Female; Glucuronates; Humans; Hydrocortisone; Liver Cirrhosis; Male; Middle Aged; Multiple Sclerosis; Pregnanes; Tritium | 1968 |
Low-dosage glucocorticoid therapy. An appraisal of its safety and mode of action in clinical disorders, including rheumatoid arthritis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Alopecia Areata; Arthritis, Rheumatoid; Asthma; Breast Neoplasms; Child; Child, Preschool; Colitis, Ulcerative; Cortisone; Endocrine System Diseases; Female; Humans; Hydrocortisone; Male; Middle Aged; Multiple Sclerosis | 1967 |
The effect of ACTH on hormone excretion in patients with rheumatoid arthritis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Gonadotropins, Pituitary; Hormones; Humans; Male; Middle Aged; Urine | 1967 |
The determination of the urinary excretion of 11-oxy-17-ketosteroids in normal human individuals and in patients with rheumatoid arthritis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged | 1967 |
Comparative metabolism in vivo of [4-14C]cortisol in synovial fluid in the normal, rheumatoid and osteoarthritis knee.
Topics: 17-Ketosteroids; Adult; Arthritis, Rheumatoid; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Glucuronates; Humans; Hydrocortisone; In Vitro Techniques; Injections, Intra-Articular; Male; Middle Aged; Osteoarthritis; Radioisotope Dilution Technique; Sulfates; Synovial Fluid | 1967 |
[On the effects of salicylic-humic acid baths].
Topics: 17-Ketosteroids; Adult; Arthritis, Rheumatoid; Baths; Female; Humans; Humic Substances; Male; Middle Aged; Salicylates; Skin Absorption; Solutions | 1967 |
Response to metyrapone in children with rheumatic diseases.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Arthritis, Rheumatoid; Child; Child, Preschool; Female; Humans; Male; Metyrapone; Rheumatic Fever | 1966 |
Scientific assessment of the results of physical treatment--measurement of stiffness.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Humans; Muscle Contraction; Muscles; Periodicity; Sleep | 1966 |
ON THE PROBLEM OF THE INTERFERENCE OF CHLOROQUINE WITH THE REGULATORY MECHANISMS IN MAN.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Chloroquine; Drug Therapy; Fluids and Secretions; Humans; Hydroxyproline; Joint Diseases; Leukopenia; Lupus Erythematosus, Systemic; Male; Pharmacology; Potassium; Rheumatic Fever; Sodium; Spondylitis; Spondylitis, Ankylosing; Urine | 1965 |
PITUITARY-ADRENOCORTICAL RESERVE DURING CORTICOSTEROID THERAPY: A REPORT ON THE METHOPYRAPONE TEST IN TEN PATIENTS TAKING LONG-CONTINUED SMALL DOSES.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Prednisolone; Urine | 1964 |
CORTISOL TOLERANCE IN RHEUMATIC DISEASES.
Topics: 17-Ketosteroids; Aldosterone; Arthritis; Arthritis, Rheumatoid; Cortisone; Drug Tolerance; Humans; Hydrocortisone; Lupus Erythematosus, Systemic; Prednisolone; Rheumatic Diseases; Sclerosis; Spondylitis; Spondylitis, Ankylosing; Urine | 1964 |
EFFECT OF CORTICOSTEROIDS ON URINARY 5-BETA AND 5-ALPHA C19 STEROIDS IN MAN.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Androsterone; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Castration; Dexamethasone; Drug Therapy; Etiocholanolone; Familial Mediterranean Fever; Female; Humans; Male; Metabolism; Nephrosis; Orchiectomy; Ovary; Prednisone; Testosterone; Urine | 1964 |
[EXAMINATION OF THE HYPOTHALAMUS AND ADRENAL GLANDS IN THE COURSE OF CHRONIC POLYARTHRITIS FOLLOWING PROLONGED CORTICOTHERAPY].
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Drug Therapy; Hypothalamus; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary-Adrenal Function Tests; Toxicology; Urine | 1964 |
METYRAPONE AND ACUTE ADRENAL INSUFFICIENCY.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Arthritis; Arthritis, Rheumatoid; Female; Hydrocortisone; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary-Adrenal Function Tests; Pregnancy; Pregnancy Complications; Toxicology; Urine | 1964 |
[ADRENOCORTICAL AND PITUITARY FUNCTION FOLLOWING PROTRACTED PREDNISOLONE TREATMENT].
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Cortisone; Metyrapone; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Prednisolone; Urine | 1964 |
ACTIVATION OF SUBCLINICAL RHEUMATIC ACTIVITY BY METOPIRONE ADMINISTRATION IN RHEUMATIC HEART DISEASE AND RHEUMATOID ARTHRITIS.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Conjunctiva; Diagnosis; Erythrocyte Aggregation; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Pharmacology; Rheumatic Fever; Rheumatic Heart Disease; Urine | 1964 |
CORTICOSTEROIDS IN RHEUMATOID ARTHRITIS. STUDIES ON ALDOSTERONE, 17-HYDROXYCORTICOSTEROID, AND 17-KETOSTEROID RESPONSE TO CORTICOTROPIN IN MALE PATIENTS WITH RHEUMATOID ARTHRITIS.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aldosterone; Arthritis; Arthritis, Rheumatoid; Blood; Glucocorticoids; Humans; Urine | 1963 |
[Studies on urinary 17-ketosteroids in rheumatoid arthritis].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Body Fluids; Humans; Urinary Tract | 1961 |
[Steroid excretion during chloroquine therapy of rheumatoid arthritis].
Topics: 17-Ketosteroids; Arthritis, Rheumatoid; Chloroquine; Steroids | 1960 |
[Fractionation of urinary 17-ketosteroids in inflammatory rheumatisms and in gout].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Gout; Hormones; Humans; Rheumatic Fever | 1959 |
Studies on adrenal cortical activity in patients with rheumatoid arthritis: the diurnal pattern and twenty-four hour levels of urinary total 17-hydroxycorticosteroids and 17-ketosteroids.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Hormones; Humans | 1959 |
[Studies on the adrenal cortical activity in patients with rheumatoid arthritis: daily pattern & value of urinary excretion of total 17-hydroxycorticosteroids & 17-ketosteroids in 24 hours].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Hormones; Humans; Hydroxycorticosteroids; Ketosteroids; Periodicity | 1959 |
[Effect of treatment by mild insulin-induced hypoglycemia on urinary excretion of neutral 17-ketosteroids; research on mechanism of insulin-induced hypoglycemia].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Humans; Hypoglycemia; Insulin; Thromboangiitis Obliterans | 1958 |
[Urinary elimination of 17-ketosteroids in arthrosis and spondylosis after Herculane sulphurous thermal therapy].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Balneology; Humans; Joint Diseases; Osteoarthritis; Spinal Osteophytosis; Spondylosis; Steroids; Sulfur | 1957 |
[Elimination of 17-ketosteroids in rheumatic diseases].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Humans; Rheumatic Diseases; Spondylitis; Spondylitis, Ankylosing; Steroids; Urine | 1956 |
Urinary excretion of 17-hydroxy-20-oxosteroids in normal health and in rheumatoid arthritis.
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Humans; Steroids; Urine | 1955 |
17-ketosteroid excretion in two unusual forms of rheumatoid disease.
Topics: 17-Ketosteroids; Arthritis, Rheumatoid; Humans; Sjogren's Syndrome; Spondylitis; Spondylitis, Ankylosing; Steroids | 1954 |
[Elimination of urinary 17-ketosteroids in rheumatoid arthritis: 16 cases].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Steroids; Urinary Tract; Urine | 1954 |
[On the mechanism of action of stimulating therapy, with special reference to oral gold therapy with aurubin. V. 17-Ketosteroid excretion during aurubin therapy,].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Gold; Steroids | 1954 |
[Excretion of beta-17-ketosteroids in polyarthritis after ACTH infusion].
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Body Fluids; Urine | 1954 |
[Neutral 17-ketosteroids curve during cryotherapy of rheumatoid arthritis].
Topics: 17-Ketosteroids; Arthritis, Rheumatoid; Cryosurgery; Cryotherapy; Gold; Steroids; Urine | 1953 |
[Urinary elimination of neutral 17-ketosteroids in rheumatoid arthritis during steroid therapy].
Topics: 17-Ketosteroids; Androgens; Arthritis; Arthritis, Rheumatoid; Body Fluids; Cortisone; Pregnenolone; Progesterone; Steroids; Urine | 1953 |
[On determination of 17-ketosteroids fractions in polyarthritis].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Body Fluids; Steroids | 1953 |
[The urinary elimination of steroid hormones (11-hydroxycorticoids, 17-ketosteroids) during the administration of phenylbutazone].
Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Analgesics; Arthritis; Arthritis, Rheumatoid; Body Fluids; Phenylbutazone; Steroids; Urine | 1953 |
Gold therapy and neutral 17-ketosteroid excretion in rheumatoid arthritis.
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Gold; Hydrogen-Ion Concentration; Steroids | 1952 |
[Rheumatoid arthritis; total urinary excretion of neutral 17-ketosteroids].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Steroids | 1951 |
[Effect of artificial pyrexia on urinary elimination of 11-oxysteroids and 17-ketosteroids].
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Epilepsy; Fats; Fever; Hyperthermia, Induced; Steroids | 1951 |
17-ketosteroid excretion in rheumatoid arthritis.
Topics: 17-Ketosteroids; Arthritis; Arthritis, Rheumatoid; Humans | 1950 |
[Elimination of 17-ketosteroids in rheumatoid arthritis].
Topics: 17-Ketosteroids; Androgens; Arthritis; Arthritis, Rheumatoid; Biological Transport; Body Fluids; Humans; Urine | 1950 |
Excretion of 17-ketosteroids in ankylosing spondylarthritis and in rheumatoid arthritis; a preliminary report.
Topics: 17-Ketosteroids; Adrenal Glands; Androgens; Arthritis; Arthritis, Rheumatoid; Humans; Spine; Spondylitis, Ankylosing; Steroids; Urine | 1947 |