17-ketosteroids and Anemia--Aplastic

Topics: 17-Ketosteroids; Adolescent; Anemia, Aplastic; Child; Child, Preschool; Female; Humans; Male; Pituitary Hormones, Anterior

Three children with Fanconi's anemia belonging to a family where 6 children had the disease were investigated. One child had growth hormone deficiency, a second child showed subnormal response of testosterone to gonadotropin stimulation and the third child had a missing insulin release following arginine. This report shows that growth hormone deficiency is not necessarily liniked with Fanconi's anemia when it occurs in a family. Multiple endocrine insufficiencies do no appear to be part of the disease.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Anemia, Aplastic; Arginine; Blood Glucose; Body Height; Body Weight; Child; Child, Preschool; Endocrine Glands; Fanconi Anemia; Growth Hormone; Humans; Hydrocortisone; Insulin; Insulin Secretion; Islets of Langerhans; Luteinizing Hormone; Male; Metyrapone; Pituitary Gland, Anterior; Testis; Testosterone; Thyroxine; Urea

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Anemia, Aplastic; Blood Glucose; Bone Development; Child; Growth Hormone; Humans; Insulin; Male; Syndrome; Testosterone; Thyroxine

Topics: 17-Ketosteroids; Anemia, Aplastic; Animals; Cells; Culture Techniques; Cytoplasm; Erythrocytes; Esterases; Guanidines; HeLa Cells; Hemosiderosis; Histocytochemistry; Histological Techniques; Humans; Hypopituitarism; Lipid Metabolism; Liver; Liver Glycogen; Mice; Microscopy, Electron; Mitochondria; Nucleic Acids; Protein Binding; Protein Denaturation; Proteins; Rats; Reticulocytes; Staining and Labeling; Tissue Preservation

Topics: 17-Ketosteroids; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Anemia; Anemia, Aplastic; Asthma; Cerebral Cortex; Child; Dexamethasone; Humans; Nephrotic Syndrome; Prednisolone; Rheumatic Fever