17-ketosteroids and Alopecia

Treatment of virilization symptoms in 230 patients is reported. 68 patients were treated with Planovin (4 mg megestrol acetate and .05 mg ethinyl estradiol), 77 with SH81041 (100 mg Cyproterone acetate for 10 days and .05 mg ethinyl estradiol for 21 days), and 85 were treated first and Planovin and then with SH81041. Acne, seborrhea, hirsutism, and alopecia improved under treatment with each preparation; results were similar with acne and alopecia, while SH81041 was somewhat more effective than Planovin in treating seborrhea and hirsutism. Therapeutic results obtained during treatment with SH81041 in acne and alopecia are retained during Planovin treatment, but seborrhea and hirsutism become worse again. Successful treatment was independent of the severity of hirsutism and the duration of of treatment. Side effects included breakthrough bleeding and sweating.

Topics: 17-Ketosteroids; Acne Vulgaris; Adolescent; Adult; Alopecia; Androgen Antagonists; Clinical Trials as Topic; Cyproterone; Dermatitis, Seborrheic; Ethinyl Estradiol; Female; Hirsutism; Humans; Megestrol; Virilism

Virilism in females is often associated with menstrual disorders. There is an evident correlation between the severity of virilism, the level of androgens and the degree of menstrual disorder. A study was carried out between January 1978 and December 1980 on 75 women with various degrees of virilism. The majority of women with severe hirsutism and male-type alopecia were found in the group with amenorrhoea. Furthermore, the four cases with the full-blown picture of severe virilism were found exclusively in this group. Clarification of the virilizing manifestations on the basis of a determination of the basic hormonal status (including the steroid fractions), the dexamethasone suppression test (including the HCG stimulation test) and the oestrogen-gestagen suppression test, diagnostic laparoscopy and phlebography of the adrenal gland is discussed and the methods evaluated.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Alopecia; Amenorrhea; Dexamethasone; Female; Follicle Stimulating Hormone; Hirsutism; Humans; Luteinizing Hormone; Phlebography; Prolactin; Testosterone; Virilism

Cyproterone acetate, combined with ethinyl estradiol, was administered to 60 women (mean age: 25 years) suffering from hirsutism, acne and alopecia for 3--39 months. The rate of success was 94% for acne, 85% for hirsutism and 55% for alopecia. These results are comparable to those already reported. No correlation was found between the degree of the disease or plasma levels of testosterone, androstenedione, respectively urinary 17-cetosteroids, and the effectiveness of the treatment. Side effects were rare and identical in frequency and nature to those encountered during treatment with estrogen-containing contraceptives.

Topics: 17-Ketosteroids; Acne Vulgaris; Adult; Alopecia; Androstenedione; Cyproterone; Female; Hirsutism; Humans; Testosterone

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Alopecia; Animals; Antibody Specificity; Autoimmune Diseases; Child; Chromosome Aberrations; Diabetes Complications; Female; Fluorescent Antibody Technique; Graves Disease; Humans; Long-Acting Thyroid Stimulator; Male; Middle Aged; Pedigree; Sheep; Thyroid Gland; Thyroiditis, Autoimmune

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Alopecia; Deafness; Dermatoglyphics; Follicle Stimulating Hormone; Growth Hormone; Humans; Hydrocortisone; Hypogonadism; Intelligence; Luteinizing Hormone; Male; Metyrapone; Pedigree; Pituitary-Adrenal Function Tests; Syndrome; Testosterone; Thyroid Function Tests

Topics: 17-Ketosteroids; Alopecia; Female; Hirsutism; Humans; Male; Testosterone

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Alopecia; Female; Hirsutism; Humans; Leydig Cell Tumor; Ovarian Neoplasms; Ovary; Sertoli-Leydig Cell Tumor; Testosterone; Vaginal Smears; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Alopecia; Estrogens; Female; Gonadotropins; Humans; Menstruation

Topics: 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Alopecia; Androstanes; Breast Diseases; Chemistry, Clinical; Chorionic Gonadotropin; Chromatography, Paper; Dehydroepiandrosterone; Dermatitis, Seborrheic; Female; Follicle Stimulating Hormone; Humans; Klinefelter Syndrome; Male; Middle Aged; Radiation Injuries; Testis; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abdomen; Adrenocortical Hyperfunction; Alopecia; Animals; Asthenia; Dexamethasone; Dog Diseases; Dogs; Feeding and Eating Disorders; Female; Glucocorticoids; Glucose Tolerance Test; Humans; Hyperplasia; Hypertrophy; Liver Diseases; Male; Obesity; Pituitary-Adrenal Function Tests; Radiography; Thirst; Thyrotropin

Topics: 17-Ketosteroids; Adult; Age Factors; Alopecia; Androgens; Androsterone; Chromatography; Etiocholanolone; Female; Humans; Male; Middle Aged; Sex Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Alopecia; Estrogens; Female; Glucocorticoids; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Acne Vulgaris; Adrenocortical Hyperfunction; Alopecia; Chromatography; Female; Hirsutism; Humans; Hypertrichosis; Staphylococcal Infections; Urine

Topics: 17-Ketosteroids; Alopecia; Arteriosclerosis; Hirsutism; Hypercholesterolemia; Hypertrichosis; Obesity; Toxicology; Triparanol; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Alopecia; Asthenia; Hyperthyroidism; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary Gland; Pituitary-Adrenal Function Tests; Rheumatic Heart Disease

Topics: 17-Ketosteroids; Alopecia; Contraceptive Agents, Female; Drug Therapy; Estradiol Congeners; Estrogens; Female; Hair; Hirsutism; Humans; Hypertrichosis

Topics: 17-Ketosteroids; Alopecia; Alopecia Areata; Chemical Fractionation; Chromatography; Dose Fractionation, Radiation; Humans