17-ketosteroids and Adrenal-Cortex-Diseases

Under analysis are results of an examination of 56 patients with hormonally non-active tumors of the adrenals, 48 of them were operated upon. In 20 patients (35%) they had clinical manifestations, 16 patients (28%) had an elevated level of the 17-HCS and 17-CS excretion in the 24-hours urine. Morphological investigations of the tumors in 20 patients have revealed clear cell adenomas of the cortical layer of the adrenal, in 19 patients--tumoral cysts, in 3 patients--true cysts, in 1 case-myelolipoma, in 1 case--ganglioneuromyelolipoma, in 4 cases--hormonally non-active carcinomas of the adrenal cortex. The authors propose to designate the new formations described as hormonally non-active tumors of the adrenals. In view of the absence of absolute methods for the identification of malignancy of the tumors the operative treatment of them is proposed.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Diseases; Adrenal Cortex Neoplasms; Adrenal Glands; Adult; Aged; Cysts; Humans; Intraoperative Complications; Middle Aged; Tomography, X-Ray Computed; Ultrasonography

A generation ago, the determination of urinary 17-hydroxycorticoids was the best available laboratory procedure for assessing adrenocortical function. Today, the plasma cortisol concentration, measured by radioimmunoassay, is a much more specific and reliable parameter, particularly in combination with simple functional tests, which are also suitable for ambulatory patients. The most appropriate tests of adrenocortical function for the diagnosis or exclusion of Cushing's syndrome or of primary and secondary adrenocortical failure are briefly described. Substitution therapy in patients with adrenocortical insufficiency must be evaluated by clinical criteria and not by steroid analysis.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Diseases; Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocorticotropic Hormone; Cushing Syndrome; Dexamethasone; Humans; Hydrocortisone; Radioimmunoassay

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Diagnostic Services; Humans; Hydroxycorticosteroids

Topics: 17-Ketosteroids; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Medulla; Adult; Cushing Syndrome; Dexamethasone; Epinephrine; Female; Humans; Middle Aged; Norepinephrine; Pheochromocytoma

1. Results of tests for the diagnosis of Cushings syndrome of varoius aetiologies are discussed for twenty-five patients in whom the pathology was established by operation or autopsy. 2. Control values for the urinary excretion of free cortisol, 17-OHCS, Porter-Silber chromogens (P-SC) and 17-OS and plasma levels of P-SC are compared with those for normal subjects. 3. The results indicated that urinary values are within the normal range for some patients with Cushing's syndrome. 4. Plasma levels of P-SC in the morning were within the normal range for the majority and elevated for the rest. 5. Some patients showed day-night variation of plasma P-SC but evening values were above the normal range. 6. The expected response for low dosage dexamethasone was found in all patients tested but unexpected responses followed high dosage in some. 7. Plasma 11-OHCS in the five patients tested failed to respond to insulin induced hypoglycaemia. 8. Metyrapone administration and corticotrophin infusion tests had limited usefulness in establishing the aetiology of the disease. The 17-OHCS excretion became raised in the response to corticotrophin and the evaluation was prolonged beyond normal responsiveness.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Diseases; Adrenal Cortex Function Tests; Adult; Aged; Cushing Syndrome; Diagnosis, Differential; Evaluation Studies as Topic; Female; Humans; Hydrocortisone; Male; Middle Aged

In order to establish a more reliable profile of the function of the adrenal cortex, a study has been made of this simultaneous estimation of plasma and urinary unconjugated cortisol by competitive protein binding (CPB) radioassay. Both plasma and urinary cortisol were measured by CPB radioassay after solvent extraction. Normal ranges were found for plasma and urinary cortisol. The samples obtained in the morning (8:00 am) established a normal plasma cortisol range of 9.0-21.6 mug% with a mean of 15.3. range for urinary unconjugated cortisol was 12.0-41.5 mug/day (mean 26.9). Dexamethasone suppression and adrenocorticotrophic hormone stimulation of plasma and urinary cortisol were tested with individuals having normal and abnormal adrenal cortical function. RESULTS INDICATED A GOOD CLINICOPATHOLOGICAL CORRELATION. It was concluded that plasma and urinary unconjugated cortisol are reliable laboratory tests for adrenocortical function and would be the methods of choice rather than urinary 17-ketogenic steroids.

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Diseases; Adrenal Cortex Function Tests; Adrenalectomy; Adrenocorticotropic Hormone; Binding, Competitive; Circadian Rhythm; Depression, Chemical; Dexamethasone; Female; Humans; Hydrocortisone; Male; Middle Aged; Quality Control; Radioligand Assay; Secretory Rate; Stimulation, Chemical

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Diseases; Adrenal Gland Diseases; Adult; Child; Child, Preschool; Dexamethasone; Female; Humans; Infant; Middle Aged; Pregnancy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Androsterone; Cortisone; Dehydroepiandrosterone; Humans; Hydrochlorothiazide; Pharmacology; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Adrenal Glands; DDT; Humans; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenocorticotropic Hormone; Humans; Iatrogenic Disease

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Glucocorticoids; Humans

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Diabetes Mellitus; Humans

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Dose Fractionation, Radiation; Humans; Prednisone; Rheumatic Diseases

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congenital; Familial Mediterranean Fever; Fever; Humans; Hyperplasia; Hypertrophy; Male; Medical Records

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Body Fluids; Cushing Syndrome; Hormones; Humans; Hyperplasia

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congenital; Chorionic Gonadotropin; Female; Gonadotropins; Hormones; Humans

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Diagnosis, Differential; Endocrine System Diseases; Humans; Musculoskeletal Diseases

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Chemical Fractionation; Chromatography; Humans

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Chromatography

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Chemical Fractionation; Chromatography; Cysts; Female; Gynecology; Humans; Ovarian Cysts; Ovary

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Insufficiency; Humans

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Cortex Neoplasms; Child; Humans; Neoplasms; Puberty; Puberty, Precocious; Sexual Maturation

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Child; Dwarfism; Humans; Hydroxysteroids; Infant; Obesity; Puberty; Puberty, Precocious; Sexual Maturation

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Humans

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Disease; Female; Hirsutism; Humans; Ovary

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Ketosteroids

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Cushing Syndrome; Hormones; Hydrocortisone

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Blood Glucose; Cholesterol; Choline; Humans; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Cortex Hormones; Female; Humans; Hydrocortisone; Steroids; Urine; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Bronchi; Hyperplasia; Hypertrophy; Neoplasms; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Hyperplasia; Hypertrophy; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Chromatography; Cortisone; Disorders of Sex Development; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Disease; Female; Hair; Hair Diseases; Hirsutism; Humans; Ovarian Diseases; Ovary; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congenital; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Body Fluids; Cushing Syndrome; Humans; Neoplasms; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Body Fluids; Cortisone; Hyperplasia; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Body Fluids; Humans; Steroids