17-hydroxy-4-7-10-13-15-19-docosahexaenoic-acid has been researched along with Acute-Lung-Injury* in 1 studies
1 other study(ies) available for 17-hydroxy-4-7-10-13-15-19-docosahexaenoic-acid and Acute-Lung-Injury
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Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury.
Acute lung injury (ALI) is a severe illness with excess mortality and no specific therapy. Protective actions were recently uncovered for docosahexaenoic acid-derived mediators, including D-series resolvins. Here, we used a murine self-limited model of hydrochloric acid-induced ALI to determine the effects of aspirin-triggered resolvin D1 (AT-RvD1; 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid) on mucosal injury. RvD1 and its receptor ALX/FPR2 were identified in murine lung after ALI. AT-RvD1 (~0.5-5 μg kg(-1)) decreased peak inflammation, including bronchoalveolar lavage fluid (BALF) neutrophils by ~75%. Animals treated with AT-RvD1 had improved epithelial and endothelial barrier integrity and decreased airway resistance concomitant with increased BALF epinephrine levels. AT-RvD1 inhibited neutrophil-platelet heterotypic interactions by downregulating both P-selectin and its ligand CD24. AT-RvD1 also significantly decreased levels of BALF pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, Kupffer cells, and tumor necrosis factor-α, and decreased nuclear factor-κB-phosphorylated p65 nuclear translocation. Taken together, these findings indicate that AT-RvD1 displays potent mucosal protection and promotes catabasis after ALI. Topics: Acute Lung Injury; Adaptor Proteins, Signal Transducing; Airway Resistance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Blood-Air Barrier; Disease Models, Animal; Docosahexaenoic Acids; Epinephrine; Inflammation; Inflammation Mediators; Leukocytes; Macrophages, Alveolar; Male; Mice; Neutrophils; Pulmonary Edema; Receptors, Formyl Peptide; Respiratory Mucosa; Transcription Factor RelA | 2013 |