17-18-epoxy-5-8-11-14-eicosatetraenoic-acid and Obesity

17,18-Epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP) are bioactive epoxides produced from n-3 polyunsaturated fatty acid eicosapentaenoic acid and docosahexaenoic acid, respectively. However, these epoxides are quickly metabolized into less active diols by soluble epoxide hydrolase (sEH). We have previously demonstrated that an sEH inhibitor,

Topics: Adipogenesis; Adipose Tissue, Brown; Animals; Anti-Obesity Agents; Arachidonic Acids; Benzoates; Blood Glucose; Carnitine O-Palmitoyltransferase; Diet, High-Fat; Epoxide Hydrolases; Fatty Acids; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenylurea Compounds