16-16-dimethylprostaglandin-e2 and Fetal-Death

Estradiol and progesterone levels in maternal plasma after administration of 16, 16-dimethyl-PGE2 p-benzaldehyde semicarbazone ester (16,16-PGE2) 6 hourly for abortion were studied in 27 women in the second trimester of pregnancy and in 49 patients with fetal death in utero. Basal maternal plasma levels of estradiol and progesterone measured before prostaglandin injection were significantly lower in cases of fetal death in utero than in the other subjects. After 16,16-PGE2 injection, plasma levels of estradiol and progesterone fell more rapidly and to a greater extent in cases of fetal death in utero than those with normal pregnancy at corresponding gestations; the decline of plasma estradiol levels was quicker and more marked than that of progesterone. Thus, 16,16-PGE2 appears to exert a differential effect on estradiol and progesterone biosynthesis.. Estradiol and progesterone levels in maternal plasma after administration of 16, 16-dimethyl-prostaglandin E2 (PGE2) p-benzaldehyde semicarbazone ester (16, 16-PGE2) every 6 hours for abortion were studied in 27 women in the 2nd trimester of pregnancy and in 49 patients with fetal death in utero. Basal maternal plasma levels of estradiol and progesterone measured before PG injection were significantly lower in cases of fetal death in utero than in the other subjects. After, 16, 16-PGE2 injection, plasma levels of estradiol and progesterone fell more rapidly and to a greater extent in cases of fetal death in utero than in those with normal pregnancies at corresponding gestations; the decline of plasma estradiol levels was quicker and more marked than that of progesterone. Thus, 16, 16-PGE2 appears to exert a differential effect on estradiol and progesterone biosynthesis.

Topics: 16,16-Dimethylprostaglandin E2; Abortion, Missed; Abortion, Therapeutic; Estradiol; Female; Fetal Death; Humans; Kinetics; Pregnancy; Progesterone; Prostaglandins E, Synthetic