16-16-dimethylprostaglandin-e2 and Carcinoma

16-16-dimethylprostaglandin-e2 has been researched along with Carcinoma* in 2 studies

Other Studies

2 other study(ies) available for 16-16-dimethylprostaglandin-e2 and Carcinoma

ArticleYear
Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin.
    British journal of cancer, 1985, Volume: 52, Issue:2

    WHT/Ht mice transplanted s.c. with NC carcinoma were treated with 16,16-dimethyl prostaglandin E2 methyl ester (di-me-PGE2) and/or indomethacin. Each primary tumour was excised under anaesthesia 3 weeks after transplantation, weighed and extracted for prostaglandins. Mouse survival time and tumour recurrence were measured. Di-me-PGE2 10 micrograms, injected at the tumour site on alternate days from day 1 to 19, indomethacin 2.5 mg kg-1 daily by mouth, or both drugs together resulted in lighter tumours (respectively 45, 45 and 52% less, n = 18 to 20 per group, P less than 0.02) compared with vehicle-treated controls. Indomethacin reduced the tumour prostaglandin yield, but the biological activity in extracts of tumours from mice given di-me-PGE2 was high. The median survival time was longer in mice receiving indomethacin alone (61 days from tumour transplantation compared with 50 days in controls P less than 0.02). Di-me-PGE2 alone had little or no effect on survival (median 48 days) but counteracted the increase with indomethacin (di-me-PGE2 + indomethacin, 49 days median survival). There were no obvious effects of the treatments on tumour recurrence at the excision site, but there was a higher incidence of involved lymph nodes in mice given di-me-PGE2.

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Carcinoma; Indomethacin; Male; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Prostaglandins; Prostaglandins E, Synthetic

1985
Prostaglandin analogs as inhibitors of tumor cell DNA synthesis.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1981, Volume: 166, Issue:4

    Topics: 16,16-Dimethylprostaglandin E2; Carcinoma; Cells, Cultured; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Melanoma; Neoplasms, Experimental; Prostaglandins A, Synthetic; Prostaglandins E, Synthetic; Structure-Activity Relationship; Time Factors

1981