15-ketoprostaglandin-e2 and Leukemia--Myeloid--Acute

15-ketoprostaglandin-e2 has been researched along with Leukemia--Myeloid--Acute* in 1 studies

Other Studies

1 other study(ies) available for 15-ketoprostaglandin-e2 and Leukemia--Myeloid--Acute

Article	Year
Metabolism of prostaglandin E2 by human HL-60 leukemia cells. Agents and actions, 1987, Volume: 21, Issue:3-4 The metabolic fate of prostaglandin E2 (PGE2) was examined in human HL-60 leukemia cells. Cytosolic fractions obtained from dimethylformamide treated HL-60 granulocytes rapidly convert exogonous PGE2 to 15-keto-PGE2. The strict requirement for NAD coupled with other characteristics of the reaction indicate that the enzyme is the NAD-dependent 15-prostaglandin dehydrogenase (15-PGDH). When intact cells are incubated with 3H-PGE2, both 15-keto-PGE2 and its subsequent metabolite, 13,14-dihydro-15-keto-PGE2 are produced. Thus, HL-60 cells express two enzymes of the major prostaglandin catabolic pathway, 15-PGDH and ketoprostaglandin delta 13-reductase. Topics: Cell Line; Dinoprostone; Humans; Hydroxyprostaglandin Dehydrogenases; Leukemia, Myeloid, Acute; Prostaglandins E	1987

Article

Year

Metabolism of prostaglandin E2 by human HL-60 leukemia cells.

Agents and actions, 1987, Volume: 21, Issue:3-4

The metabolic fate of prostaglandin E2 (PGE2) was examined in human HL-60 leukemia cells. Cytosolic fractions obtained from dimethylformamide treated HL-60 granulocytes rapidly convert exogonous PGE2 to 15-keto-PGE2. The strict requirement for NAD coupled with other characteristics of the reaction indicate that the enzyme is the NAD-dependent 15-prostaglandin dehydrogenase (15-PGDH). When intact cells are incubated with 3H-PGE2, both 15-keto-PGE2 and its subsequent metabolite, 13,14-dihydro-15-keto-PGE2 are produced. Thus, HL-60 cells express two enzymes of the major prostaglandin catabolic pathway, 15-PGDH and ketoprostaglandin delta 13-reductase.

Topics: Cell Line; Dinoprostone; Humans; Hydroxyprostaglandin Dehydrogenases; Leukemia, Myeloid, Acute; Prostaglandins E

1987