15-keto-13-14-dihydroprostaglandin-f2alpha has been researched along with Heart-Arrest* in 2 studies
2 other study(ies) available for 15-keto-13-14-dihydroprostaglandin-f2alpha and Heart-Arrest
| Article | Year |
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Differences in cerebral reperfusion and oxidative injury after cardiac arrest in pigs.
An investigation of the free radical scavenger sodium 2-sulfophenyl-N-tert-butyl nitrone (S-PBN) and the weak vasodilatator Tris buffer mixture (TBM) on cerebral cortical blood flow (CCBF) and the jugular bulb concentration of two eicosanoids, indicators of oxidative stress and inflammation, was undertaken in 30 anaesthetized piglets during cardiopulmonary resuscitation (CPR) and after restoration of spontaneous circulation (ROSC).. Thirty animals were subjected to 8 min of untreated circulatory arrest followed by 8 min of closed-chest CPR. During CPR, the animals were randomized to receive 60 mg/kg S-PBN, 1 mmol/kg TBM or 2 ml/kg normal saline (n = 10 in each group). Systemic haemodynamic variables, CCBF and jugular bulb plasma concentrations of 8-iso-PGF2alpha and 15-keto-dihydro-PGF2alpha were measured.. The CCBF during reperfusion after ROSC was greater in the TBM group than in the S-PBN group, the regression coefficient between CCBF and mean arterial blood pressure being lower in the S-PBN group than in the TBM group. The jugular bulb plasma concentration of 8-iso-PGF2alpha during the first 30 min after ROSC was greater in the TBM group than in the S-PBN group. Administration of TBM after vasopressin did not attenuate the pressor effect of vasopressin.. Administration of S-PBN during CPR results in less cerebral oxidative stress, possibly by promoting normal distribution of cerebral blood flow. Topics: Animals; Blood Pressure; Brain; Cardiopulmonary Resuscitation; Cerebrovascular Circulation; Dinoprost; F2-Isoprostanes; Female; Heart Arrest; Hydrogen-Ion Concentration; Male; Oxidative Stress; Reperfusion Injury; Swine | 2003 |
Development of a novel biomarker of free radical damage in reperfusion injury after cardiac arrest.
In a porcine model of cardiopulmonary resuscitation (CPR), we investigated changes in the plasma levels of 8-iso-PGF(2alpha), a marker for oxidative injury, and 15-keto-dihydro-PGF(2alpha), an inflammatory response indicator during the post-resuscitation period after cardiac arrest. Twelve piglets were subjected to either 2 or 5 min (VF2 and VF5 group) of ventricular fibrillation (VF) followed by 5 min of closed-chest CPR. Six piglets without cardiac arrest were used as controls. In VF5 group, 8-iso-PGF(2alpha) in the jugular bulb plasma (draining the brain) increased four-fold. Jugular bulb 8-iso-PGF(2alpha) in the control group remained unchanged. The 15-keto-dihydro-PGF(2alpha) also increased four-fold in the VF5 group. Thus, 8-iso-PGF(2alpha) and 15-keto-dihydro-PGF(2alpha) measurements in jugular bulb plasma may be used as biomarkers for quantification of free radical catalyzed oxidative brain injury and inflammatory response in reperfusion injury. Topics: Animals; Biomarkers; Cardiopulmonary Resuscitation; Dinoprost; Disease Models, Animal; F2-Isoprostanes; Female; Free Radicals; Heart Arrest; Jugular Veins; Male; Molecular Structure; Myocardial Reperfusion Injury; Swine; Ventricular Fibrillation | 2000 |