15-hydroxy-5-8-11-13-eicosatetraenoic-acid has been researched along with Head-and-Neck-Neoplasms* in 4 studies
4 other study(ies) available for 15-hydroxy-5-8-11-13-eicosatetraenoic-acid and Head-and-Neck-Neoplasms
| Article | Year |
|---|---|
Comparison of arachidonic acid metabolism by normal, precancerous and neoplastic epithelial cell lines of the upper aerodigestive tract.
Topics: Arachidonic Acid; Carcinoma, Squamous Cell; Cell Line; Dinoprostone; Epithelial Cells; Head and Neck Neoplasms; Humans; Hydroxyeicosatetraenoic Acids; Keratinocytes; Leukotriene B4; Mucous Membrane; Palatine Tonsil; Precancerous Conditions; Reference Values; Trachea; Tumor Cells, Cultured | 1997 |
Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Arachidonic Acids; Carcinoma, Squamous Cell; Dinoprostone; Female; Head and Neck Neoplasms; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Middle Aged; Neoplasm Staging; Reference Values; Saliva | 1997 |
Arachidonic acid metabolites in cutaneous carcinomas. Evidence suggesting that elevated levels of prostaglandins in basal cell carcinomas are associated with an aggressive growth pattern.
There is evidence suggesting a role of eicosanoids in the growth of certain tumors. In this study, tissue samples were collected from basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Both BCCs and SCCs contained more prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) than normal epidermis. In vitro incubation of tumor samples with arachidonic acid also resulted in PGE2 and PGF2 alpha formation. Basal cell carcinomas exhibiting a histologically aggressive growth pattern contained higher levels of prostaglandins than those with a nonaggressive growth pattern, both in vivo and after in vitro incubation. Lipoxygenase products (12- and 15-hydroxyeicosatetraenoic acid) were present in smaller amounts than cyclo-oxygenase products (PGE2 and PGF2 alpha) in vivo. Compared with normal epidermis, SCCs and, particularly, BCCs produced smaller amounts of 12-hydroxyeicosatetraenoic acid during in vitro incubation with arachidonic acid. The levels of lipoxygenase products were not related to the tumor growth pattern. These results indicate that excessive prostaglandin levels in BCCs may be associated with an aggressive growth pattern. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acids; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chromatography, High Pressure Liquid; Dinoprost; Dinoprostone; Head and Neck Neoplasms; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Mice; Prostaglandins; Prostaglandins E; Prostaglandins F; Rabbits; Radioimmunoassay; Skin Neoplasms | 1986 |
Biosynthesis of prostaglandins and hydroxy fatty acids in primary squamous carcinomas of head and neck in humans.
The metabolism of [14C]arachidonic acid into cyclooxygenase and lipoxygenase products by homogenates of primary squamous carcinomas of head and neck in 12 patients was studied in vitro. The lipoxygenase pathway was predominant in all samples. The major metabolites were 12-hydroxy-5,8,11-14-eicosatetraenoic acid, (12-HETE) and 15-HETE. 5-HETE, 5,12-diHETE, 8-HETE and 9-HETE were also detected. The cyclooxygenase products detected were in the following order: PGE2 greater than PGF2 alpha greater than TxB2 greater than 15-keto-PGE2 greater than 6-keto-PGF1 alpha greater than PGD2. Literature review of the biological activities of these oxygenated metabolites of arachidonic acid suggest important modulatory roles in the pathophysiology of head and neck cancer. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Hydroxy Acids; Hydroxyeicosatetraenoic Acids; Prostaglandins | 1985 |