Compounds > 15-hydroxy-5-8-11-13-eicosatetraenoic-acid

15-hydroxy-5-8-11-13-eicosatetraenoic-acid and Gastroenteritis

15-hydroxy-5-8-11-13-eicosatetraenoic-acid has been researched along with Gastroenteritis* in 1 studies

Other Studies

1 other study(ies) available for 15-hydroxy-5-8-11-13-eicosatetraenoic-acid and Gastroenteritis

Article	Year
LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis. Nature communications, 2015, Apr-15, Volume: 6 Liver receptor homologue-1 (LRH-1) is a nuclear receptor involved in the repression of inflammatory processes in the hepatointestinal tract. Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involving STAT6. We show that loss-of-function of LRH-1 in macrophages impedes IL-13-induced macrophage polarization due to impaired generation of 15-HETE PPARγ ligands. The incapacity to generate 15-HETE metabolites is at least partially caused by the compromised regulation of CYP1A1 and CYP1B1. Mice with LRH-1-deficient macrophages are, furthermore, highly susceptible to gastrointestinal and systemic Candida albicans infection. Altogether, these results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13-induced 15-HETE/PPARγ axis. Topics: Animals; Blotting, Western; Candida albicans; Candidiasis; Chromatin Immunoprecipitation; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gastroenteritis; Humans; Hydroxyeicosatetraenoic Acids; Interleukin-13; Macrophages; Macrophages, Peritoneal; Mice; Phagocytosis; Phenotype; PPAR gamma; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; STAT6 Transcription Factor	2015

Article

Year

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis.

Nature communications, 2015, Apr-15, Volume: 6

Liver receptor homologue-1 (LRH-1) is a nuclear receptor involved in the repression of inflammatory processes in the hepatointestinal tract. Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involving STAT6. We show that loss-of-function of LRH-1 in macrophages impedes IL-13-induced macrophage polarization due to impaired generation of 15-HETE PPARγ ligands. The incapacity to generate 15-HETE metabolites is at least partially caused by the compromised regulation of CYP1A1 and CYP1B1. Mice with LRH-1-deficient macrophages are, furthermore, highly susceptible to gastrointestinal and systemic Candida albicans infection. Altogether, these results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13-induced 15-HETE/PPARγ axis.

Topics: Animals; Blotting, Western; Candida albicans; Candidiasis; Chromatin Immunoprecipitation; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gastroenteritis; Humans; Hydroxyeicosatetraenoic Acids; Interleukin-13; Macrophages; Macrophages, Peritoneal; Mice; Phagocytosis; Phenotype; PPAR gamma; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; STAT6 Transcription Factor

2015