15-hydroxy-5-8-11-13-eicosatetraenoic-acid and Esophageal-Diseases

The pathogenesis of eosinophilic esophagitis (EoE) involves Th2-mediated eosinophil recruitment and degranulation into the esophagus. However, measuring serum Th2 cytokines, eosinophils, and eosinophil-derived products does not reliably distinguish EoE from control populations. Non-invasive methods to diagnose EoE are lacking. We evaluated the diagnostic value of a novel candidate biomarker of EoE: 15(S)-hydroxyeicosatetraenoic acid (HETE). We used immunoassay to measure 15(S)-HETE and cytokine profiles in patients undergoing endoscopy with known or suspected EoE. 31 subjects were enrolled, 16 with EoE, and 15 with an alternate diagnosis. 15(S)-HETE was elevated in the EoE group compared to non-EoE group. The sensitivity and specificity of 15(S)-HETE to be used as a non-invasive marker is 50% and 80%, respectively. 15(S)-HETE may aid in the diagnosis of EoE.

Topics: Area Under Curve; Biomarkers; Biopsy; Cell Count; Child; Cytokines; Diagnosis, Differential; Eosinophilic Esophagitis; Eosinophils; Esophageal Diseases; Esophagoscopy; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Sensitivity and Specificity