Zhongguo shi yan xue ye xue za zhi, 2022, Volume: 30, Issue:3
To investigate the expression of PD-L1 and PD-1 in pathological tissue of patients newly diagnosed with diffuse large B-cell lymphoma (DLBCL).. Data of DLBCL patients who visited the Department of Hematology, Peking University Third Hospital from May 2014 to March 2017 were collected, and a total of 21 patients with pathological tissue sections which were still available at the initial treatment were selected. The patients were divided into complete remission (CR) group and refractory relapse (RR) group according to clinical outcome. The expression and proportion of PD-1 and PD-L1 in pathological tissue sections were detected by multiplex fluorescence immunohistochemical staining, and the differences in the expression of different molecular markers in different clinical characteristics and different prognosis were compared using non-parametric test.. The increased expression ratio of PD-L1 to PD-1 in pathological tissue sections of newly diagnosed DLBCL patients is associated with poor prognostic clinical characteristics.. 初治弥漫大B细胞淋巴瘤患者病理组织中PD-L1与PD-1的表达情况.. 探索初治弥漫大B细胞淋巴瘤（DLBCL）患者病理组织中程序性死亡配体-1（PD-L1）与程序性死亡受体-1（PD-1）的表达情况.. 收集2014年5月至2017年3月于北京大学第三医院血液内科就诊的DLBCL患者资料，选取现仍可获取初治时病理组织切片的患者21例。将患者依临床结局分为完全缓解及难治复发两组。采用多重荧光免疫组化染色的方法检测患者病理组织切片中PD-1、PD-L1表达情况及其表达比例，应用非参数检验比较不同分子标志物表达在不同临床特点组及不同预后组间的差异.. 初治DLBCL患者病理组织切片中PD-L1与PD-1的表达比例增高与不良预后临床特征相关.. 血小板铺展的主要影响因素.. 探索血小板铺展的主要影响因素，为相关疾病研究奠定基础.. 与10和100 μg/ml的纤维蛋白原组相比，在包被了30 μg/ml纤维蛋白原的载玻片上粘附的血小板数目最优；另外，在凝血酶、ADP和U46619的刺激下，血小板铺展与刺激剂浓度呈正相关(ADP: r=0.925， U46619: r=0.937). Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; B7-H1 Antigen; Biomarkers, Tumor; Blood Platelets; Fibrinogen; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred C57BL; Neoplasm Recurrence, Local; Platelet Adhesiveness; Prognosis; Programmed Cell Death 1 Receptor; Thrombin | 2022 |