15-hydroperoxy-5-8-11-13-eicosatetraenoic-acid and Parkinson-Disease

Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated by complexes of 15-lipoxygenase (15-LOX) and a scaffold protein, phosphatidylethanolamine (PE)-binding protein (PEBP)1. As the Ca

Topics: Animals; Arachidonate 15-Lipoxygenase; Disease Models, Animal; Female; Ferroptosis; Group VI Phospholipases A2; Humans; Iron; Leukotrienes; Lipid Metabolism; Lipid Peroxides; Lipids; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Parkinson Disease; Phosphatidylethanolamine Binding Protein; Phospholipases; Phospholipids; Rats; Rats, Inbred Lew