15-deoxy-delta(12-14)-prostaglandin-j2 and Fever

15-deoxy-delta(12-14)-prostaglandin-j2 has been researched along with Fever* in 2 studies

Other Studies

2 other study(ies) available for 15-deoxy-delta(12-14)-prostaglandin-j2 and Fever

ArticleYear
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atherosclerosis; Fever; Humans; Intramolecular Oxidoreductases; Mice; Mice, Knockout; Microsomes; Pain; Prostaglandin-E Synthases; Stroke

2008
A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Feb-11, Volume: 24, Issue:6

    Fever is an important part of the host defense response, yet fever can be detrimental if it is uncontrolled. We provide the first evidence that 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2), an endogenous ligand for peroxisome proliferator-activated receptor gamma (PPARgamma), can attenuate the febrile response to lipopolysaccharide (LPS) in rats via an action on the brain. Furthermore, we show that PPARgamma is expressed in the hypothalamus, an important locus in the brain for fever generation. In addition, 15d-PGJ2 and its synthesizing enzyme (PGD2 synthase) were present in rat cerebrospinal fluid, and their levels were enhanced in response to systemic injection of LPS. The antipyretic effect of 15d-PGJ2 was associated with reduction in LPS-stimulated cyclooxygenase-2 expression in the hypothalamus but not in p44/p42 mitogen-activated protein kinase phosphorylation or in the expression of the PPARgamma. Thus it is likely that there is a parallel induction of an endogenous prostanoid pathway in the brain capable of limiting deleterious actions of the proinflammatory prostaglandin E2-dependent pathway.

    Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Brain; Cyclooxygenase 2; Disease Models, Animal; Fever; Hypothalamus; Intramolecular Oxidoreductases; Isoenzymes; Lipocalins; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Transcription Factors

2004