15-deoxy-delta(12-14)-prostaglandin-j2 and Arthralgia

Painful conditions of the temporomandibular joint (TMJ) are challenging to manage and most attempts often result in unsatisfactory outcomes. In such context, nanocarrier systems, such as polymeric micelles, have been showing encouraging results in solving therapeutic limitations. Poloxamers are widely used, especially PL 407, because of their high biocompatibility and approval by the Food and Drug Administration (FDA) for clinical use. 15-deoxy-

Topics: Animals; Anti-Inflammatory Agents; Arthralgia; Biological Availability; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Drug Carriers; Drug Compounding; Formaldehyde; Inflammation Mediators; Injections, Intra-Articular; Leukocytes; Male; Micelles; Poloxamer; Prostaglandin D2; Rats, Wistar; Temporomandibular Joint; Temporomandibular Joint Disorders; Tissue Distribution