14-hydroxydocosahexaenoate and Cardiovascular-Diseases

Cardiovascular disease, a major cause of mortality and morbidity, exhibits sexual dimorphism since the onset of cardiovascular disease occurs later in women than in men. The loss of cardioprotection in older women may be due to an increase in arterial stiffness after menopause. Free fatty acid metabolites of polyunsaturated fatty acids, called oxylipins, are known to impact vessel function and may be responsible for the vascular benefits of polyunsaturated fatty acids. The objectives of this study were to compare the plasma oxylipin profiles of young females (20-55 years), older females (55. Higher 12-lipoxygenase oxylipin plasma concentrations associated with lower arterial stiffness in premenopausal females may be an important contributing factor to sex differences in cardiovascular disease. Registration: URL: https://www.clinicaltrials.gov; Unique identifiers: NCT01661543, NCT01562171, NCT01890330, NCT02571114 and NCT02317588.

Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Age Factors; Aged; Ankle Brachial Index; Biomarkers; Cardiovascular Diseases; Docosahexaenoic Acids; Eicosapentaenoic Acid; Female; Health Status Disparities; Heart Disease Risk Factors; Humans; Male; Menopause; Middle Aged; Obesity; Oxylipins; Pulse Wave Analysis; Risk Assessment; Sex Factors; Up-Regulation; Vascular Stiffness; Young Adult