14,15-epoxy-5,8,11-eicosatrienoic acid has been researched along with Hypertension in 14 studies
14,15-epoxy-5,8,11-eicosatrienoic acid: RN given refers to cpd without isomeric designation
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Taken together, these data support the concept that renal microvascular 11,12-EET activity and levels may not properly offset the enhanced angiotensin II renal vasoconstriction during angiotensin II hypertension." | 7.71 | Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid. ( Capdevila, JH; Falck, JR; Imig, JD; Wei, S; Zhao, X, 2001) |
| "Taken together, these data support the concept that renal microvascular 11,12-EET activity and levels may not properly offset the enhanced angiotensin II renal vasoconstriction during angiotensin II hypertension." | 3.71 | Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid. ( Capdevila, JH; Falck, JR; Imig, JD; Wei, S; Zhao, X, 2001) |
| "Preeclampsia is a serious complication of pregnancy characterized by the development of vasospasm, hypertension and often associated with proteinuria after the 20th week of gestation." | 1.46 | The role of soluble epoxide hydrolase in preeclampsia. ( Joiakim, A; Kim, H; Park, JA; Putt, DA; Santos, JM; Taylor, RN, 2017) |
| " 1,3-dicyclohexylurea (DCU), a potent sEH inhibitor, lowers systemic blood pressure in spontaneously hypertensive rats when dosed intraperitoneally." | 1.35 | Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. ( Chiang, PC; Fujiwara, H; Ghosh, S; Roberds, SL; Selbo, JG; Wahlstrom, JL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Imig, JD | 4 |
| Jankiewicz, WK | 1 |
| Khan, AH | 1 |
| Campbell, WB | 1 |
| Schmitz, JM | 1 |
| Falck, JR | 4 |
| Santos, JM | 1 |
| Park, JA | 1 |
| Joiakim, A | 1 |
| Putt, DA | 1 |
| Taylor, RN | 1 |
| Kim, H | 1 |
| Yang, C | 1 |
| Yang, J | 1 |
| Xu, X | 1 |
| Yan, S | 1 |
| Pan, S | 1 |
| Pan, X | 1 |
| Zhang, C | 1 |
| Leung, GP | 1 |
| Sporková, A | 1 |
| Husková, Z | 1 |
| Škaroupková, P | 1 |
| Rami Reddy, N | 1 |
| Sadowski, J | 1 |
| Červenka, L | 1 |
| Pidkovka, N | 1 |
| Rao, R | 1 |
| Mei, S | 1 |
| Gong, Y | 1 |
| Harris, RC | 1 |
| Wang, WH | 1 |
| Capdevila, JH | 2 |
| Ghosh, S | 1 |
| Chiang, PC | 1 |
| Wahlstrom, JL | 1 |
| Fujiwara, H | 1 |
| Selbo, JG | 1 |
| Roberds, SL | 1 |
| Ma, YH | 1 |
| Schwartzman, ML | 1 |
| Roman, RJ | 1 |
| Yu, Z | 2 |
| Huse, LM | 2 |
| Adler, P | 1 |
| Graham, L | 2 |
| Ma, J | 1 |
| Zeldin, DC | 2 |
| Kroetz, DL | 2 |
| Xu, F | 1 |
| Morisseau, C | 1 |
| Draper, AJ | 1 |
| Newman, JW | 1 |
| Parker, C | 1 |
| Engler, MM | 1 |
| Hammock, BD | 1 |
| Zhao, X | 1 |
| Wei, S | 1 |
| Catella, F | 1 |
| Lawson, JA | 1 |
| Fitzgerald, DJ | 1 |
| FitzGerald, GA | 1 |
| Lin, WK | 1 |
| Wong, PY | 1 |
2 reviews available for 14,15-epoxy-5,8,11-eicosatrienoic acid and Hypertension
| Article | Year |
|---|---|
Orally Active Epoxyeicosatrienoic Acid Analogs.
Topics: 8,11,14-Eicosatrienoic Acid; Administration, Oral; Animals; Blood Pressure; Cardiovascular Diseases; | 2017 |
Epoxyeicosatrienoic acids, hypertension, and kidney injury.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antihypertensive Agents; Disease Models, Animal; Disease Progr | 2015 |
12 other studies available for 14,15-epoxy-5,8,11-eicosatrienoic acid and Hypertension
| Article | Year |
|---|---|
Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiovascular Diseases; Cytochrome P-450 En | 2020 |
The role of soluble epoxide hydrolase in preeclampsia.
Topics: 8,11,14-Eicosatrienoic Acid; Adult; Antihypertensive Agents; Blood Pressure; Epoprostenol; Epoxide H | 2017 |
Vasodilatory effect of 14,15-epoxyeicosatrienoic acid on mesenteric arteries in hypertensive and aged rats.
Topics: 8,11,14-Eicosatrienoic Acid; Aging; Animals; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vasc | 2014 |
Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimenta
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Disease Progression; Dose-Response Relationship | 2017 |
Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Ant | 2013 |
Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Administration, Oral; Animals; Blood Pressure; Chromatography, Liquid; | 2008 |
Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytoch | 1994 |
Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Hyper | 2000 |
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Blood Pressure; Cytosol; Eicosanoids; Enzym | 2000 |
Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II; Animals; Arterioles; Cytochrome P-450 CYP2J2; Cytochrom | 2001 |
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Dogs; Fatty Acids, Unsaturated; Female; Gas Chromatography-Mas | 1990 |
Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antihypertensive Agents; Blood Pressure; Diterpenes; Dose-Resp | 1990 |