14,15-epoxy-5,8,11-eicosatrienoic acid has been researched along with Disease Models, Animal in 21 studies
14,15-epoxy-5,8,11-eicosatrienoic acid: RN given refers to cpd without isomeric designation
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In chronic heart failure, the lung endothelial permeability response to angiotensin II or thapsigargin-induced store depletion is ablated, although the mechanisms are not understood." | 3.73 | Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. ( Alvarez, DF; King, JA; Townsley, MI, 2005) |
| "The effect of AUDA on airway remodeling was related to the downregulation of extracellular-regulated protein kinases (Erk1/2), c-Jun N-terminal kinases (JNK) and signal transducer and activator of transcription 3 (STAT3)." | 1.56 | Inhibition of soluble epoxide hydrolase attenuates airway remodeling in a chronic asthma model. ( Guan, Y; Jia, YL; Jiang, JX; Liu, Q; Shen, HJ; Shen, J; Xie, QM; Zhang, LH; Zhu, YL, 2020) |
| "The role of 14, 15-EET in breast cancer cell adhesion, invasion was explored by adhesion and Transwell assays." | 1.48 | 14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling. ( Deng, XF; Huang, Y; Jia, M; Luo, J; Wang, YQ; Yao, JF; Zheng, XD; Zhu, JH, 2018) |
| "Patients recovering from aneurysmal subarachnoid hemorrhage (SAH) are at risk for developing delayed cerebral ischemia (DCI)." | 1.42 | Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage. ( Alkayed, NJ; Anderson, VC; Borkar, RN; Cetas, JS; Dogan, A; Fairbanks, SL; Liu, JJ; Martini, RP; Nelson, JW; Raskin, JS; Siler, DA; Wang, RK; Ward, JP; Zuloaga, KL, 2015) |
| "One of the prominent features of Alzheimer's disease is the excessive accumulation of the protein amyloid beta (Aβ) in certain areas of the brain leading to neurodegeneration." | 1.37 | Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. ( Harder, DR; Narayanan, J; Sarkar, P, 2011) |
| " 1,3-dicyclohexylurea (DCU), a potent sEH inhibitor, lowers systemic blood pressure in spontaneously hypertensive rats when dosed intraperitoneally." | 1.35 | Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. ( Chiang, PC; Fujiwara, H; Ghosh, S; Roberds, SL; Selbo, JG; Wahlstrom, JL, 2008) |
| "The hyperemia was specific to EETs since we did not observe it to be induced by other vasodilators such as nitric oxide or prostacyclin." | 1.33 | Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). ( Dunn, BE; Dunn, LK; Falck, JR; Gruenloh, SK; Jacobs, ER; Medhora, M; Reddy, DS, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 12 (57.14) | 24.3611 |
| 2020's | 4 (19.05) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, H | 1 |
| Tang, J | 1 |
| Chen, H | 1 |
| Gu, W | 1 |
| Geng, H | 1 |
| Wang, L | 1 |
| Wang, Y | 2 |
| Jiang, JX | 1 |
| Guan, Y | 1 |
| Shen, HJ | 1 |
| Jia, YL | 1 |
| Shen, J | 1 |
| Zhang, LH | 1 |
| Liu, Q | 1 |
| Zhu, YL | 1 |
| Xie, QM | 1 |
| Wu, J | 1 |
| Zhao, Y | 1 |
| Fan, Z | 1 |
| Chen, Q | 1 |
| Chen, J | 1 |
| Sun, Y | 1 |
| Jiang, X | 1 |
| Xiao, Q | 1 |
| Imig, JD | 3 |
| Jankiewicz, WK | 1 |
| Khan, AH | 1 |
| Luo, J | 1 |
| Yao, JF | 1 |
| Deng, XF | 1 |
| Zheng, XD | 1 |
| Jia, M | 1 |
| Wang, YQ | 1 |
| Huang, Y | 1 |
| Zhu, JH | 1 |
| Chen, X | 1 |
| Li, Z | 1 |
| Zhang, B | 1 |
| Hu, R | 1 |
| Li, J | 2 |
| Feng, M | 1 |
| Yao, W | 1 |
| Zhang, C | 1 |
| Wan, L | 1 |
| Zhang, Y | 2 |
| Siler, DA | 1 |
| Martini, RP | 1 |
| Ward, JP | 1 |
| Nelson, JW | 1 |
| Borkar, RN | 1 |
| Zuloaga, KL | 1 |
| Liu, JJ | 1 |
| Fairbanks, SL | 1 |
| Raskin, JS | 1 |
| Anderson, VC | 1 |
| Dogan, A | 1 |
| Wang, RK | 1 |
| Alkayed, NJ | 3 |
| Cetas, JS | 1 |
| Chen, G | 1 |
| Xu, R | 1 |
| Zhang, S | 1 |
| Wang, P | 1 |
| Edin, ML | 1 |
| Zeldin, DC | 1 |
| Wang, DW | 1 |
| Alánová, P | 1 |
| Husková, Z | 1 |
| Kopkan, L | 1 |
| Sporková, A | 1 |
| Jíchová, Š | 1 |
| Neckář, J | 1 |
| Klevstig, M | 1 |
| Kolář, F | 1 |
| Rami Reddy, N | 1 |
| Falck, JR | 4 |
| Sadowski, J | 1 |
| Nishiyama, A | 1 |
| Kramer, HJ | 1 |
| Melenovský, V | 1 |
| Červenková, L | 1 |
| Kujal, P | 1 |
| Vernerová, Z | 1 |
| Červenka, L | 1 |
| Kandhi, S | 1 |
| Froogh, G | 1 |
| Qin, J | 1 |
| Luo, M | 1 |
| Wolin, MS | 1 |
| Huang, A | 1 |
| Sun, D | 1 |
| Guan, H | 1 |
| Liu, H | 1 |
| Zhao, L | 1 |
| Li, L | 1 |
| Tan, P | 1 |
| Mi, B | 1 |
| Li, F | 1 |
| Motoki, A | 1 |
| Merkel, MJ | 2 |
| Packwood, WH | 1 |
| Cao, Z | 2 |
| Liu, L | 2 |
| Iliff, J | 1 |
| Van Winkle, DM | 2 |
| Packwood, W | 1 |
| Young, J | 1 |
| Planagumà, A | 1 |
| Pfeffer, MA | 1 |
| Rubin, G | 1 |
| Croze, R | 1 |
| Uddin, M | 1 |
| Serhan, CN | 1 |
| Levy, BD | 1 |
| Gross, GJ | 2 |
| Baker, JE | 1 |
| Hsu, A | 1 |
| Wu, HE | 1 |
| Nithipatikom, K | 2 |
| Sarkar, P | 1 |
| Narayanan, J | 1 |
| Harder, DR | 1 |
| Dunn, LK | 1 |
| Gruenloh, SK | 1 |
| Dunn, BE | 1 |
| Reddy, DS | 1 |
| Jacobs, ER | 1 |
| Medhora, M | 1 |
| Alvarez, DF | 1 |
| King, JA | 1 |
| Townsley, MI | 1 |
| Ghosh, S | 1 |
| Chiang, PC | 1 |
| Wahlstrom, JL | 1 |
| Fujiwara, H | 1 |
| Selbo, JG | 1 |
| Roberds, SL | 1 |
| Gauthier, KM | 1 |
| Moore, J | 1 |
| Hammock, BD | 1 |
| Campbell, WB | 1 |
1 review available for 14,15-epoxy-5,8,11-eicosatrienoic acid and Disease Models, Animal
| Article | Year |
|---|---|
Epoxyeicosatrienoic acids, hypertension, and kidney injury.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antihypertensive Agents; Disease Models, Animal; Disease Progr | 2015 |
20 other studies available for 14,15-epoxy-5,8,11-eicosatrienoic acid and Disease Models, Animal
| Article | Year |
|---|---|
14,15-EET Reduced Brain Injury from Cerebral Ischemia and Reperfusion via Suppressing Neuronal Parthanatos.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Brain Injuries; Brain Ischemia; Disease Models, Animal; Glucos | 2021 |
Inhibition of soluble epoxide hydrolase attenuates airway remodeling in a chronic asthma model.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage | 2020 |
Soluble epoxide hydrolase inhibitor protects against blood-brain barrier dysfunction in a mouse model of type 2 diabetes via the AMPK/HO-1 pathway.
Topics: 8,11,14-Eicosatrienoic Acid; AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Diabetes M | 2020 |
Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiovascular Diseases; Cytochrome P-450 En | 2020 |
14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Moveme | 2018 |
Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.
Topics: 8,11,14-Eicosatrienoic Acid; Analgesics; Animals; Cerebral Hemorrhage; Disease Models, Animal; Gabap | 2019 |
Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage.
Topics: 8,11,14-Eicosatrienoic Acid; Aged; Animals; Brain Ischemia; Disease Models, Animal; Female; Humans; | 2015 |
CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.
Topics: 8,11,14-Eicosatrienoic Acid; Alanine Transaminase; Animals; Aspartate Aminotransferases; Catalase; C | 2015 |
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Administration, Oral; Animals; Blood Pressure; Blood Pressure Monitorin | 2015 |
EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterial Pressure; Disease Models, Animal; Dose-Response Relat | 2016 |
Epoxyeicosanoids prevent intervertebral disc degeneration in vitro and in vivo.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Hydrogen P | 2017 |
Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Disease Models, Animal; Enzyme Inhibitors; Epoxide | 2008 |
Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Epoxid | 2010 |
Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4.
Topics: 8,11,14-Eicosatrienoic Acid; Acute Disease; Animals; Anticholesteremic Agents; Cell Line; Disease Mo | 2010 |
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
Topics: 8,11,14-Eicosatrienoic Acid; Analgesics, Opioid; Animals; Disease Models, Animal; GTP-Binding Protei | 2010 |
Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain.
Topics: 8,11,14-Eicosatrienoic Acid; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Br | 2011 |
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Capillaries; Chick Embryo; Chorioallantoic Membrane; Culture T | 2005 |
Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcimycin; Calcium Channels; Calcium-Transporting ATPases; Di | 2005 |
Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Administration, Oral; Animals; Blood Pressure; Chromatography, Liquid; | 2008 |
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Blood Pressure; Cardiovascular Agents; Coronary Ci | 2008 |