13-cis-retinal has been researched along with Breast-Neoplasms* in 1 studies
1 other study(ies) available for 13-cis-retinal and Breast-Neoplasms
| Article | Year |
|---|---|
Growth factors and hormones which affect survival, growth, and differentiation of the MCF-7 stem cells and their descendants.
The human breast tumor cell line was separated by Percoll density gradient centrifugation into six different subpopulations, A to F, one of which (E) appears to contain the stem cells on the basis of several criteria (M. Resnicoff et al. 1987, Proc. Natl. Acad. Sci. USA 84, 7295. We now analyzed the response of the isolated subpopulations to insulin, thrombin, PGF2 alpha, estradiol, and 13-cis-retinal. We demonstrate that the first two growth factors stimulate [3H]thymidine incorporation in the more differentiated subpopulations (D and F), while PGF2 alpha has mitogenic activity in subpopulations C and D. In the absence of any added growth factor, estradiol has the extreme and transient capacity of allowing the stem cell to detach from the tissue culture dish and to grow in suspension as multicellular aggregates (MCF-7/SE cells). 13-cis-Retinal acts as a negative modulator of differentiation and protects the cells from the inhibitory and differentiation activity of Na-butyrate. Topics: Breast Neoplasms; Butyrates; Butyric Acid; Cell Differentiation; Cell Division; Cell Survival; Culture Media; Dinoprost; Diterpenes; DNA; Estradiol; Hormones; Humans; Insulin; Neoplastic Stem Cells; Retinaldehyde; Retinoids; Thrombin; Tumor Cells, Cultured | 1989 |