Compounds > 12-o-tetradeca-2-4-6-8-tetranoylphorbol-13-acetate

12-o-tetradeca-2-4-6-8-tetranoylphorbol-13-acetate and Carcinoma--Squamous-Cell

12-o-tetradeca-2-4-6-8-tetranoylphorbol-13-acetate has been researched along with Carcinoma--Squamous-Cell* in 1 studies

Other Studies

1 other study(ies) available for 12-o-tetradeca-2-4-6-8-tetranoylphorbol-13-acetate and Carcinoma--Squamous-Cell

ArticleYear
The effects of interferon-beta on phorbol ester or calcium ionophore-induced intercellular adhesion molecule-I expression in epidermal carcinoma cells.
    The Journal of dermatology, 1992, Volume: 19, Issue:2

    Keratinocyte intercellular adhesion molecule (ICAM)-I expression is induced by interferon (IFN)-gamma. It has been previously reported that IFN-beta suppresses IFN-gamma-induced ICAM-I expression in A431 cells, a human squamous cell carcinoma cell line. In this study, the suppression mechanisms were investigated at the post second messenger level. Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and calcium ionophore (A23187) induce ICAM-I expression in A431 cells. ICAM-I expression induced by either was not suppressed with cotreatment with IFN-beta. Furthermore, IFN-beta did not inhibit the translocation of protein kinase C (PKC) by TPA. It appears that the pathways involved in ICAM-I expression induced by activation of PKC or increased in intracellular Ca++ are not affected by IFN-beta.

    Topics: Calcimycin; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Line; Enzyme Activation; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interferon-beta; Keratinocytes; Protein Kinase C; Second Messenger Systems; Skin Neoplasms; Tetradecanoylphorbol Acetate

1992