12-hydroxy-5-8-10-14-eicosatetraenoic-acid and Schizophrenia

The model presented here suggests that a defect in a selenium transport protein may be a necessary but not sufficient precondition for a sub-type of schizophrenia--a type of schizophrenia that has been characterized by negative symptoms, brain damage, and a lack of primarily paranoid ideation. A defective selenium transport protein and consequent low levels of selenium might adversely affect multiple enzyme systems. Selenium-enzyme interreactions are discussed and the effect of selenium on arachidonic acid and its metabolites, especially 12-HPETE, are examined in light of the presented model. If the proffered model is essentially correct, selenoprotein P, a hypothesized selenium transport protein, is a likely candidate for a protein involved in the etiology of a form of schizophrenia.

Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Carrier Proteins; Dopamine; Enzymes; Glutathione Peroxidase; Humans; Hydroxyeicosatetraenoic Acids; Models, Biological; Proteins; Rats; Schizophrenia; Schizophrenic Psychology; Selenium; Selenium-Binding Proteins; Selenoprotein P; Selenoproteins; Ubiquinone