12-hydroxy-5-8-10-14-eicosatetraenoic-acid has been researched along with Granuloma* in 4 studies
4 other study(ies) available for 12-hydroxy-5-8-10-14-eicosatetraenoic-acid and Granuloma
Article | Year |
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Macrophages isolated from liver granulomas of murine Schistosoma mansoni synthesize predominantly TxA2 during the acute and chronic phases of infection.
Macrophages isolated from liver granulomas of mice infected with Schistosoma mansoni for 8 or 20 wk synthesize predominantly thromboxane A2 with smaller amounts of the PGE2 and PGI2. There is no physiologic production of leukotrienes, as determined by RIA and HPLC. Thromboxane A2 is the predominant arachidonic acid metabolite whether the cells are stimulated by a phagocytic stimuli such as zymosan or the exogenous substrates arachidonic acid and PGH2. These data indicate that the predominant arachidonate enzymatic activity in these cells is thromboxane synthase. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Acute Disease; Animals; Arachidonic Acid; Arachidonic Acids; Chronic Disease; Granuloma; Hydroxyeicosatetraenoic Acids; Liver Diseases; Macrophage Activation; Macrophages; Mice; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Schistosomiasis mansoni; SRS-A; Thromboxane A2; Thromboxane-A Synthase | 1988 |
Production of superoxide anion, prostaglandins, and hydroxyeicosatetraenoic acids by macrophages from hypersensitivity-type (Schistosoma mansoni egg) and foreign body-type granulomas.
Macrophages isolated from hypersensitivity (Schistosoma mansoni egg) and foreign body- (Sephadex bead) type granulomas were evaluated with regard to superoxide anion (O2-) production and arachidonic acid metabolism. Granuloma macrophages from schistosome-infected mice were examined during both the acute and modulated phases of the disease. In addition, the populations were characterized phenotypically by measurement of Ia antigen expression. Based on differences in the parameters studied at least three different macrophage populations could be identified in acute, modulated, and foreign body-type lesions, respectively. Macrophages from acute lesions (8-week granuloma macrophages) produced significant amounts of O2-, prostaglandins, and monohydroxyeicosatetraenoic acids without the addition of an exogenous stimulus. These cells also showed a high degree of Ia expression. In contrast, macrophages from modulated (20-week granuloma macrophages) and foreign body (foreign body granuloma macrophages) lesions required stimulation with phorbol ester to evoke significant O2- production and minimally metabolized arachidonic acid. However, 20-week and foreign body granuloma macrophages could be distinguished by their high and low degrees of Ia expression, respectively. The role of lymphokines and other intercellular signals in determining macrophage activation states within granulomas is discussed. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acids; Cells, Cultured; Female; Foreign-Body Reaction; Granuloma; Histocompatibility Antigens Class II; Hypersensitivity; Macrophages; Mice; Mice, Inbred CBA; Prostaglandins; Schistosoma mansoni; Schistosomiasis; Superoxides | 1983 |
Indomethacin inhibits the in vivo formation of the lipoxygenase product HETE (12-hydroxy-5,8,10,14-eicosatetraenoic acid) during granulomatous inflammation in the rat.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acids; Carrageenan; Granuloma; Indomethacin; Inflammation; Lipoxygenase Inhibitors; Male; Prostaglandins E; Rats; Time Factors | 1980 |
'In vivo' models to study interactions between the arachidonate cascade and granulomatous inflammation.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acids; Disease Models, Animal; Fatty Acids; Granuloma; Inflammation; Prostaglandins E | 1980 |