12-hydroxy-5-8-10-14-eicosatetraenoic-acid has been researched along with Diabetic-Angiopathies* in 2 studies
2 other study(ies) available for 12-hydroxy-5-8-10-14-eicosatetraenoic-acid and Diabetic-Angiopathies
| Article | Year |
|---|---|
12S-hydroxyeicosatetraenoic acid levels link to coronary artery disease in Type 2 diabetic patients.
12(S)-Hydroxyeicosatetraenoic acid (12(S)-HETE) is a metabolite of arachidonic acid. 12(S)-HETE is involved in the pathogenesis of atherosclerosis and diabetes. However, the correlation between 12(S)-HETE and coronary artery disease (CAD) in the diabetic patient is unclear.. The study investigated the relationship between 12(S)-HETE and CAD in Type 2 diabetes (T2D).. Plasma 12(S)- HETE levels were detected by enzyme-linked immunosorbent assay in 103 healthy controls (control), 109 diabetic patients without CAD (diabetic), and 152 diabetic patients with CAD (diabetic-CAD).. 12(S)-HETE levels were higher in both diabetic and diabetic-CAD groups compared to control and in the diabetic-CAD group compared to the diabetic group. In the multiple linear stepwise regression analysis, 12(S)-HETE levels correlated independently with CAD, systolic blood pressure, and glycated hemoglobin.. These results indicate that 12(S)-HETE levels are increased in diabetic patients with CAD, suggesting a role for atherosclerosis in T2D. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Aged; Blood Pressure; Case-Control Studies; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Middle Aged; Regression Analysis; Risk Factors | 2013 |
12-Lipoxygenase products increase monocyte:endothelial interactions.
In summary, we suggest that hyperglycemia causes upregulation of 12-lipoxygenase activity. The increased production of 12-LO products, 12(S) and 15(S)-HETE, activates monocyte integrins which result in enhanced adhesion of monocytes to endothelium. The binding of monocytes to endothelium is a key early event in development of atherosclerosis. Upregulation of this process by vascular cells exposed to chronic elevations in glucose may be one explanation for the accelerated atherosclerosis observed in patients with Type 2 diabetes. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate 12-Lipoxygenase; Arteriosclerosis; Cell Adhesion; Cell Communication; Cells, Cultured; Diabetic Angiopathies; Endothelium, Vascular; Glucose; Humans; Hydroxyeicosatetraenoic Acids; Hyperglycemia; Lipoxygenase Inhibitors; Monocytes; Signal Transduction | 1999 |