Compounds > 12-hydroxy-5-8-10-14-eicosatetraenoic-acid

12-hydroxy-5-8-10-14-eicosatetraenoic-acid and Cognition-Disorders

12-hydroxy-5-8-10-14-eicosatetraenoic-acid has been researched along with Cognition-Disorders* in 1 studies

Other Studies

1 other study(ies) available for 12-hydroxy-5-8-10-14-eicosatetraenoic-acid and Cognition-Disorders

Article	Year
Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment. Annals of neurology, 2005, Volume: 58, Issue:4 The 12/15 lipoxygenase (12/15LOX) enzyme is increased in pathologically affected frontal and temporal regions of Alzheimer's disease (AD) brains compared with controls. Herein, we measured 12(S)-HETE and 15(S)-HETE levels, products of 12/15LOX, in cerebrospinal fluid (CSF) of normal individuals, subjects with mild cognitive impairment (MCI) and AD. Compared with controls, there was a significant increase of both metabolites in CSF from AD and MCI, which correlated with lipid peroxidation and tau protein levels. These results suggest that the activation of this enzyme occurs early in the course of AD, before the onset of overt dementia, thereby implicating 12/15LOX-mediated lipid peroxidation in the pathogenesis of AD. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aged; Alzheimer Disease; Apolipoproteins E; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Case-Control Studies; Cognition Disorders; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Statistics as Topic; tau Proteins	2005

Article

Year

Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment.

Annals of neurology, 2005, Volume: 58, Issue:4

The 12/15 lipoxygenase (12/15LOX) enzyme is increased in pathologically affected frontal and temporal regions of Alzheimer's disease (AD) brains compared with controls. Herein, we measured 12(S)-HETE and 15(S)-HETE levels, products of 12/15LOX, in cerebrospinal fluid (CSF) of normal individuals, subjects with mild cognitive impairment (MCI) and AD. Compared with controls, there was a significant increase of both metabolites in CSF from AD and MCI, which correlated with lipid peroxidation and tau protein levels. These results suggest that the activation of this enzyme occurs early in the course of AD, before the onset of overt dementia, thereby implicating 12/15LOX-mediated lipid peroxidation in the pathogenesis of AD.

Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aged; Alzheimer Disease; Apolipoproteins E; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Case-Control Studies; Cognition Disorders; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Statistics as Topic; tau Proteins

2005