11-dehydrocorticosterone has been researched along with Myocardial-Infarction* in 1 studies
1 other study(ies) available for 11-dehydrocorticosterone and Myocardial-Infarction
| Article | Year |
|---|---|
11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI.
We have previously demonstrated that neutrophil recruitment to the heart following myocardial infarction (MI) is enhanced in mice lacking 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) that regenerates active glucocorticoid within cells from intrinsically inert metabolites. The present study aimed to identify the mechanism of regulation. In a mouse model of MI, neutrophil mobilization to blood and recruitment to the heart were higher in 11β-HSD1-deficient ( Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Bone Marrow Cells; Cells, Cultured; Chemokine CXCL2; Chemokine CXCL5; Corticosterone; Fibroblasts; Male; Mice; Mice, Knockout; Microfilament Proteins; Muscle Proteins; Myocardial Infarction; Neutrophils | 2017 |