11-12-epoxy-5-8-14-eicosatrienoic-acid has been researched along with Diabetic-Nephropathies* in 1 studies
1 other study(ies) available for 11-12-epoxy-5-8-14-eicosatrienoic-acid and Diabetic-Nephropathies
| Article | Year |
|---|---|
Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice.
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play important and diverse roles in the cardiovascular system. The anti-inflammatory, anti-apoptotic, pro-angiogenic, and anti-hypertensive properties of EETs in the cardiovascular system suggest a beneficial role for EETs in diabetic nephropathy. This study investigated the effects of endothelial specific overexpression of CYP2J2 epoxygenase on diabetic nephropathy in streptozotocin-induced diabetic mice. Endothelial CYP2J2 overexpression attenuated renal damage as measured by urinary microalbumin and glomerulosclerosis. These effects were associated with inhibition of TGF-β/Smad signaling in the kidney. Indeed, overexpression of CYP2J2 prevented TGF-β1-induced renal tubular epithelial-mesenchymal transition in vitro. These findings highlight the beneficial roles of the CYP epoxygenase-EET system in the pathogenesis of diabetic nephropathy. Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Epithelial-Mesenchymal Transition; Gene Expression; Kidney; Kidney Function Tests; Mice; Mice, Transgenic; Signal Transduction; Smad Proteins; Streptozocin; Transforming Growth Factor beta1 | 2011 |