10-propargyl-10-deazaaminopterin has been researched along with T-Cell Lymphoma in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (26.92) | 29.6817 |
| 2010's | 13 (50.00) | 24.3611 |
| 2020's | 6 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Karasuno, T; Sata, H; Sawada, K; Yasumi, M | 1 |
| Califano, A; Casadei, B; Douglass, E; George, C; Kinahan, C; Ma, H; Mangone, M; Marchi, E; Montanari, F; Murty, VV; O'Connor, OA; Scotto, L | 1 |
| Harrop, S; Prince, HM; van der Weyden, C | 1 |
| Cairo, MS; Dhir, A; Hill, B; Waite, ES; Xavier, AC | 1 |
| Admojo, L; Bazargan, A; Bhurani, M; Coyle, L; Dickinson, M; Dunlop, L; Giri, P; Gutta, N; Hawkes, E; Hua, M; Irving, I; Kennedy, G; Khoo, L; Kipp, D; Lindsay, J; McCormack, C; McQuillan, A; Moreton, S; Panicker, S; Prince, HM; Quach, H; Radeski, D; Scott, A; Trotman, J; Twigger, R; Van Der Weyden, C; Yeung, J; Yuen, S; Zimet, A | 1 |
| Vose, JM | 1 |
| Ohshima, K; Okamura, M; Tabata, C; Tabata, R; Takei, Y | 1 |
| Shinohara, MM; Shustov, A; Tarabadkar, ES; Ware, O | 1 |
| Dasanu, CA; Shimanovsky, A | 1 |
| Mangone, M; Marchi, E; O'Connor, OA; Zullo, K | 1 |
| Amengual, JE; Bates, SE; Bhagat, G; Cremers, S; Deng, C; Jain, S; Jirau-Serrano, X; Karan, C; O'Connor, OA; Olive, KP; Palermo, CF; Realubit, R; Sastra, SA; Scotto, L; Thomas, T; Wei, Y; Zhang, Y; Zullo, KM | 1 |
| Amengual, JE; Cooke, L; Cremers, S; Duong, J; Guo, Y; Jirau-Serrano, X; Mahadevan, D; Mangone, M; Mao, Y; Nandakumar, R; O'Connor, OA; Scotto, L; Zullo, KM | 1 |
| Duvic, M | 1 |
| Chihara, D; Davis, RE; Fanale, MA; Fayad, LE; Fowler, NH; Hagemeister, FB; Hosing, C; Lee, HJ; Medeiros, LJ; Miranda, RN; Nastoupil, LJ; Neelapu, SS; Nieto, YL; Noorani, M; Oki, Y; Rodriguez, MA; Romaguera, JE; Samaniego, F; Turturro, F; Wang, M; Westin, JR | 1 |
| Casanova, M; Medina-Pérez, A; Quero, C; Rueda, A | 1 |
| Gumbs, AA; MacGregor-Cortelli, B; Neylon, E; O'Connor, OA; Patterson, M; Zain, J | 1 |
| Horwitz, SM | 1 |
| Fleisher, M; Hamelers, R; Hamlin, P; Horwitz, S; Macgregor-Cortelli, B; Mastrella, J; Moskowitz, CH; Mould, DR; Neylon, E; O'Connor, OA; Patterson, M; Portlock, C; Sarasohn, D; Saunders, M; Seshan, VE; Sirotnak, F; Zelenetz, AD | 1 |
| Marchi, E; O'Connor, OA; Paoluzzi, L; Scotto, L; Seshan, VE; Zain, JM; Zinzani, PL | 1 |
| Bullock, J; Justice, R; Kacuba, A; Lin, SC; Liu, K; Malik, SM; Marathe, A; McGuinn, WD; Ocheltree, T; Pazdur, R; Qiang, X; Sridhara, R; Tang, S; Tornoe, C; Verbois, SL; Vialpando, M; Williams, GM | 1 |
| Foss, FM | 1 |
| Bertino, JR; Bhagavathi, S; Chan, WC; Goodell, L; Johnson-Farley, N; Lubin, M | 1 |
| Barbarotta, L; Foss, F; Parker, T | 1 |
| O'Connor, OA | 1 |
| Dumetrescu, O; Fleischer, M; Hamlin, PA; Horwitz, S; Macgregor-Cortelli, B; Moskowitz, CH; Mould, DR; Neylon, E; Noy, A; O'Connor, OA; Portlock, C; Sarasohn, D; Sirotnak, F; Straus, DJ; Zelenetz, AD | 1 |
| Berthelot, CN; Duvic, M; Jones, D; Leitenberger, JJ; McLaughlin, P; Polder, KD; Pro, B | 1 |
6 review(s) available for 10-propargyl-10-deazaaminopterin and T-Cell Lymphoma
| Article | Year |
|---|---|
Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma.
Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Disease-Free Survival; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Lymphoma, T-Cell | 2013 |
Pralatrexate, a new hope for aggressive T-cell lymphomas?
Topics: Aminopterin; Animals; Antineoplastic Agents; Clinical Trials as Topic; Folic Acid Antagonists; Humans; Lymphoma, T-Cell | 2009 |
Folotyn (pralatrexate injection) for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma: U.S. Food and Drug Administration drug approval summary.
Topics: Aged; Aminopterin; Drug Approval; Female; Folic Acid Antagonists; Humans; Lymphoma, T-Cell; Male; Middle Aged; United States; United States Food and Drug Administration | 2010 |
Evaluation of the pharmacokinetics, preclinical and clinical efficacy of pralatrexate for the treatment of T-cell lymphoma.
Topics: Aminopterin; Antineoplastic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Lymphoma, T-Cell | 2011 |
Pralatrexate: treatment of T-cell non-Hodgkin's lymphoma.
Topics: Aminopterin; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Evaluation, Preclinical; Humans; Lymphoma, T-Cell; Recurrence | 2013 |
Pralatrexate: an emerging new agent with activity in T-cell lymphomas.
Topics: Aminopterin; Animals; Clinical Trials as Topic; Folic Acid Antagonists; Humans; Lymphoma, T-Cell | 2006 |
4 trial(s) available for 10-propargyl-10-deazaaminopterin and T-Cell Lymphoma
| Article | Year |
|---|---|
Pralatrexate pharmacology and clinical development.
Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Deoxycytidine; Depsipeptides; Disease-Free Survival; Drug Approval; Drug Synergism; Gemcitabine; Humans; Lymphoma, T-Cell; Male; Pyrazines; Treatment Outcome; United States; United States Food and Drug Administration | 2013 |
Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies.
Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Constipation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Fatigue; Female; Folic Acid Antagonists; Humans; Lymphoma, T-Cell; Male; Middle Aged; Recurrence; Remission Induction; Stomatitis; Treatment Outcome; Weight Loss; Young Adult | 2009 |
Folotyn (pralatrexate injection) for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma: U.S. Food and Drug Administration drug approval summary.
Topics: Aged; Aminopterin; Drug Approval; Female; Folic Acid Antagonists; Humans; Lymphoma, T-Cell; Male; Middle Aged; United States; United States Food and Drug Administration | 2010 |
Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Folic Acid Antagonists; Humans; Lymphoma, B-Cell; Lymphoma, T-Cell; Male; Membrane Transport Proteins; Middle Aged; Positron-Emission Tomography; Treatment Failure; Treatment Outcome | 2007 |
17 other study(ies) available for 10-propargyl-10-deazaaminopterin and T-Cell Lymphoma
| Article | Year |
|---|---|
[Leucovorin Administration Allows Continued Pralatrexate Treatment in a Patient with Angioimmunoblastic T-Cell Lymphoma].
Topics: Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Folic Acid Antagonists; Humans; Leucovorin; Lymphoma, T-Cell; Male; Neoplasm Recurrence, Local | 2020 |
Generation of pralatrexate resistant T-cell lymphoma lines reveals two patterns of acquired drug resistance that is overcome with epigenetic modifiers.
Topics: Aminopterin; Antineoplastic Agents; Cell Line, Tumor; DNA Methylation; Drug Resistance, Neoplasm; Dual-Specificity Phosphatases; Epigenesis, Genetic; Humans; Inhibitory Concentration 50; Lymphoma, T-Cell; Mitogen-Activated Protein Kinase Phosphatases; STAT5 Transcription Factor | 2020 |
Pralatrexate and angioimmunoblastic T-cell lymphoma: time for a second look?
Topics: Aminopterin; Humans; Immunoblastic Lymphadenopathy; Lymphoma, T-Cell | 2020 |
Pralatrexate-based therapy induced response in an adolescent with refractory hepatosplenic T-cell lymphoma.
Topics: Adolescent; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Liver Neoplasms; Lymphoma, T-Cell; Prednisone; Prognosis; Splenic Neoplasms | 2020 |
Pralatrexate in relapsed/refractory T-cell lymphoma: a retrospective multicenter study.
Topics: Aged; Aminopterin; Australia; Humans; Lymphoma, T-Cell; Neoplasm Recurrence, Local; Retrospective Studies; Treatment Outcome | 2021 |
Peripheral T-cell lymphoma: novel backbone.
Topics: Aminopterin; Depsipeptides; Humans; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral | 2018 |
Successful treatment of monomorphic epitheliotropic intestinal T cell lymphoma with pralatrexate.
Topics: Aged; Aminopterin; Humans; Intestinal Neoplasms; Lymphoma, T-Cell; Male | 2019 |
Pralatrexate for refractory or recurrent subcutaneous panniculitis-like T-cell lymphoma with hemophagocytic syndrome.
Topics: Aged; Aminopterin; Female; Humans; Lymphohistiocytosis, Hemophagocytic; Lymphoma, T-Cell; Male; Middle Aged; Neoplasm Recurrence, Local; Panniculitis; Retrospective Studies; Young Adult | 2020 |
Preclinical pharmacologic evaluation of pralatrexate and romidepsin confirms potent synergy of the combination in a murine model of human T-cell lymphoma.
Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Depsipeptides; Disease Models, Animal; Drug Synergism; Flow Cytometry; Humans; Luminescent Measurements; Lymphoma, T-Cell; Mice; Transfection; Xenograft Model Antitumor Assays | 2015 |
Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma.
Topics: Aminopterin; Animals; Aurora Kinase A; Azepines; Boron Compounds; Cell Cycle; Cell Line, Tumor; Centrosome; Cytokinesis; Depsipeptides; Drug Synergism; Glycine; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Inhibitory Concentration 50; Kaplan-Meier Estimate; Lymphoma, T-Cell; Mice; Mice, SCID; Mitosis; Neoplasm Transplantation; Protein Kinase Inhibitors; Pyrimidines; Spindle Apparatus; Xenograft Model Antitumor Assays | 2015 |
Choosing a systemic treatment for advanced stage cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome.
Topics: Alemtuzumab; Aminopterin; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Clinical Trials as Topic; Deoxycytidine; Depsipeptides; Diphtheria Toxin; Disease Progression; Doxorubicin; Electrons; Gemcitabine; Humans; Hydroxamic Acids; Immunotherapy; Incidence; Interleukin-2; Lenalidomide; Lymphoma, T-Cell; Mycosis Fungoides; Pentostatin; Photopheresis; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Fusion Proteins; Retinoids; Sezary Syndrome; Stem Cell Transplantation; Thalidomide; United States; Vorinostat | 2015 |
The survival outcome of patients with relapsed/refractory peripheral T-cell lymphoma-not otherwise specified and angioimmunoblastic T-cell lymphoma.
Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Depsipeptides; Disease-Free Survival; Female; Humans; Immunoblastic Lymphadenopathy; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Male; Middle Aged; Salvage Therapy; Stem Cell Transplantation; Survival Rate; Young Adult | 2017 |
Importance of early splenectomy in patients with hepatosplenic T-cell lymphoma and severe thrombocytopenia.
Topics: Aminopterin; Fatal Outcome; Hematologic Agents; Humans; Laparoscopy; Liver Neoplasms; Lymphoma, T-Cell; Male; Middle Aged; Splenectomy; Splenic Neoplasms; Thrombocytopenia; Treatment Outcome; Young Adult | 2009 |
T-cell lymphomas.
Topics: Adult; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Combined Modality Therapy; Depsipeptides; Drugs, Investigational; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Lymphoma, T-Cell; Multicenter Studies as Topic; Transplantation, Autologous; Tumor Virus Infections | 2009 |
Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies.
Topics: Aminopterin; Animals; Apoptosis; Boronic Acids; Bortezomib; Caspase 8; Caspase 9; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Humans; Lymphoma, T-Cell; Mice; Mice, SCID; Neoplasm Transplantation; Pyrazines; Xenograft Model Antitumor Assays | 2010 |
Lack of expression of MTAP in uncommon T-cell lymphomas.
Topics: Adenine; Aminopterin; Folic Acid Antagonists; Humans; Lymphoma, T-Cell; Purine-Nucleoside Phosphorylase; Purines; Thioguanine; Tissue Array Analysis | 2012 |
CD4+ CD56+ hematodermic/plasmacytoid dendritic cell tumor with response to pralatrexate.
Topics: Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; CD4 Antigens; CD56 Antigen; Cyclophosphamide; Dendritic Cells; Doxorubicin; Drug Therapy, Combination; Female; Folic Acid; Humans; Killer Cells, Natural; Lymphoma, T-Cell; Neoplasm Recurrence, Local; Positron-Emission Tomography; Prednisone; Skin Neoplasms; Treatment Outcome; Vincristine; Vitamin B 12 | 2008 |