Compounds > 10-propargyl-10-deazaaminopterin
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10-propargyl-10-deazaaminopterin and Carcinoma, Non-Small Cell Lung

10-propargyl-10-deazaaminopterin has been researched along with Carcinoma, Non-Small Cell Lung in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Evande, RE; Grem, JL; Kos, ME; Meza, JL; Schwarz, JK1
Molina, JR1
O'Connor, O; Zain, J1
Azzoli, CG; Dunne, M; Ginsberg, M; Huntington, M; James, L; Kris, MG; Krug, LM; May, J; Miller, V; Patel, JD; Saunders, M; Sirotnak, FM; Subzwari, S; Tyson, L1
Albert, I; Azzoli, CG; Bodkin, D; Iannotti, NO; Jiang, PY; Juhász, E; Kelly, K; Koutsoukos, T; Patel, JD; Pereira, JR; Weems, G; Zatloukal, P1
Azzoli, CG; Baez, V; Ginsberg, MS; Khokhar, NZ; Kris, MG; Krug, LM; Miller, VA; Ng, KK; Pizzo, B; Sirotnak, FM; Tong, W; Tyson, L; Venkatraman, E1
Grant, SC; Heelan, RT; Kelly, J; Kris, MG; Krug, LM; Leon, L; Leung, D; Miller, VA; Ng, KK; Sirotnak, FM; Tong, W1

Reviews

2 review(s) available for 10-propargyl-10-deazaaminopterin and Carcinoma, Non-Small Cell Lung

ArticleYear
Pralatrexate, a dihydrofolate reductase inhibitor for the potential treatment of several malignancies.
    IDrugs : the investigational drugs journal, 2008, Volume: 11, Issue:7

    Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin

2008
Pralatrexate: basic understanding and clinical development.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:10

    Topics: Aminopterin; Animals; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Lung Neoplasms; Lymphoma; Neoplasms

2010

Trials

5 trial(s) available for 10-propargyl-10-deazaaminopterin and Carcinoma, Non-Small Cell Lung

ArticleYear
A phase 1 clinical trial of sequential pralatrexate followed by a 48-hour infusion of 5-fluorouracil given every other week in adult patients with solid tumors.
    Cancer, 2015, Nov-01, Volume: 121, Issue:21

    Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Incidence; Male; Middle Aged; Mucositis; Pancreatic Neoplasms; Polymorphism, Genetic; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Time Factors; Treatment Outcome

2015
Pralatrexate with vitamin supplementation in patients with previously treated, advanced non-small cell lung cancer: safety and efficacy in a phase 1 trial.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2011, Volume: 6, Issue:11

    Topics: Adenocarcinoma; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Prognosis; Tissue Distribution; Vitamin B 12; Vitamin B Complex

2011
Randomized phase 2b study of pralatrexate versus erlotinib in patients with stage IIIB/IV non-small-cell lung cancer (NSCLC) after failure of prior platinum-based therapy.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2012, Volume: 7, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Female; Folic Acid Antagonists; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Platinum; Protein Kinase Inhibitors; Quinazolines; Retrospective Studies; Survival Rate; Treatment Failure; United States

2012
10-propargyl-10-deazaaminopterin: an antifolate with activity in patients with previously treated non-small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:6

    Topics: Adult; Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Female; Folic Acid Antagonists; Homocysteine; Humans; Lung Neoplasms; Male; Membrane Proteins; Membrane Transport Proteins; Middle Aged; RNA, Messenger

2003
Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:9

    Topics: Aminopterin; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Middle Aged

2000