10-propargyl-10-deazaaminopterin and Benign Neoplasms

10-propargyl-10-deazaaminopterin has been researched along with Benign Neoplasms in 9 studies

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	5 (55.56)	24.3611
2020's	1 (11.11)	2.80

Authors

Authors	Studies
Campos, D; Diaz, A; Izbicka, E; Saunders, M; Steffen, R; Streeper, R; Wick, M	1
Chen, XB; Wang, S; Wang, SQ; Yu, B; Yuan, XH; Zhao, W	1
Hou, Z; Matherly, LH; Wilson, MR	1
Goldman, ID; Unal, ES; Visentin, M	1
Marchi, E; Zain, JM	1
O'Connor, O; Zain, J	1
Awada, A; Azim, HA	1
Azzoli, CG; Fury, MG; Kemeny, N; Kris, MG; Krug, LM; Rizvi, NA; Sharma, S; Wu, N	1
Azzoli, CG; Dunne, M; Farmer, A; Ginsberg, MS; Gomez, J; Henry, R; Jones, J; Kris, MG; Krug, LM; Miller, VA; Pizzo, B; Sirotnak, FM; Steffen, R; Tyson, L; Venkatraman, E	1

Reviews

4 review(s) available for 10-propargyl-10-deazaaminopterin and Benign Neoplasms

Article	Year
FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application. European journal of medicinal chemistry, 2021, Mar-15, Volume: 214 Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Humans; Molecular Structure; Neoplasms; Pyrimidines; United States; United States Food and Drug Administration	2021
The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:4 Topics: Aminopterin; Animals; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein	2014
Pralatrexate: basic understanding and clinical development. Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:10 Topics: Aminopterin; Animals; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Lung Neoplasms; Lymphoma; Neoplasms	2010
Clinical development of new formulations of cytotoxics in solid tumors. Current opinion in oncology, 2012, Volume: 24, Issue:3 Topics: Aminopterin; Anthracyclines; Antineoplastic Agents; Camptothecin; Chemistry, Pharmaceutical; Folic Acid Antagonists; Humans; Irinotecan; Neoplasms; Paclitaxel; Topoisomerase I Inhibitors	2012

Trials

2 trial(s) available for 10-propargyl-10-deazaaminopterin and Benign Neoplasms

Article	Year
A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors. Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Probenecid; Treatment Outcome	2006
A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, May-01, Volume: 13, Issue:9 Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Dietary Supplements; Docetaxel; Female; Folic Acid Antagonists; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Neoplasms; Paclitaxel; Taxoids; Vitamins	2007

Article

Year

A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors.

Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:5

Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Probenecid; Treatment Outcome

2006

A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, May-01, Volume: 13, Issue:9

Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Dietary Supplements; Docetaxel; Female; Folic Acid Antagonists; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Neoplasms; Paclitaxel; Taxoids; Vitamins

2007

Other Studies

3 other study(ies) available for 10-propargyl-10-deazaaminopterin and Benign Neoplasms

Article	Year
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers. Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:5 Topics: Aminopterin; Cell Line, Tumor; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Kinetics; Methotrexate; Neoplasms; Pemetrexed; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Xenograft Model Antitumor Assays	2009
The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro. Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:5 Topics: Aminopterin; Carbon-Nitrogen Ligases; Folic Acid Antagonists; HeLa Cells; Humans; Methotrexate; Neoplasms; Tumor Cells, Cultured	2014
Pralatrexate - from bench to bedside. Drugs of today (Barcelona, Spain : 1998), 2010, Volume: 46, Issue:2 Topics: Aminopterin; Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Design; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Neoplasms	2010