10-hydroxynortriptyline has been researched along with Anisocoria* in 1 studies
1 other study(ies) available for 10-hydroxynortriptyline and Anisocoria
Article | Year |
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The pupil response to E-10-hydroxynortriptyline in rabbits with ocular sympathetic paresis.
E-10-hydroxynortriptyline, a metabolite of nortriptyline with half the norepinephrine re-uptake blocking potency of the parent drug, but only 5% of its anticholinergic effect, was as effective as cocaine in demonstrating ocular sympathetic paresis. In five rabbits with unilateral superior cervical ganglionectomies, bilateral 5% cocaine HCl or E-10-hydroxynortriptyline maleate eye drops increased (P less than 0.001) the mean +/- SE anisocoria at 1 h by 1.84 +/- 0.03 mm or 2.16 +/- 0.33 mm, respectively. A single drop of E-10-hydroxynortriptyline did not alter corneal thickness or endothelial cell count. Topics: Animals; Anisocoria; Cocaine; Endothelium, Corneal; Eye; Fluorescein; Fluoresceins; Fluorescent Dyes; Ganglionectomy; Nortriptyline; Osmolar Concentration; Pupil; Rabbits | 1990 |