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10,11-dihydro-10,11-dihydroxy-5h-dibenzazepine-5-carboxamide and Epilepsy

10,11-dihydro-10,11-dihydroxy-5h-dibenzazepine-5-carboxamide has been researched along with Epilepsy in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19906 (31.58)18.7374
1990's12 (63.16)18.2507
2000's1 (5.26)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Divanoglou, D; Gabrieli, C; Kanaze, FI; Kazis, D; Kimiskidis, V; Niopas, I; Spanakis, M1
Bourgeois, BF; Wad, N1
Aucamp, AK; Hundt, HK; Müller, FO; Potgieter, MA1
Delgado, MR; Liu, H2
Delgado, M; Eggers, CM; Forman, LJ; Iannaccone, ST; Liu, H1
Graves, NM; Leppik, IE; Remmel, RP; Wagner, ML1
Eto, S; Noda, A; Noda, H; Tanaka, N1
Pippenger, CE; Svinarov, DA1
Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD1
Boas, J; Dam, M; Flesch, G; Jensen, PK; Jórgensen, L; Mogensen, PH; Vesterager, A1
Hosoda, N; Miura, H; Shirai, H; Sunaoshi, W; Takanashi, S1
Forsythe, WI; Hartley, R; Lucock, MD; McLain, B; Ng, PC1
Bowmer, CJ; Forsythe, WI; Hartley, R; Lucock, MD; McLain, B; Ng, PC1
De Salamanca, RE; Diaz-Obregón, C; Muñoz, JJ; Timoneda, FL1
Paar, WD; von Unruh, GE1
Bittencourt, PR1
Juergens, U; May, T; Rambeck, B1
Friel, PN; van Belle, G1

Trials

7 trial(s) available for 10,11-dihydro-10,11-dihydroxy-5h-dibenzazepine-5-carboxamide and Epilepsy

ArticleYear
Development and validation of a high performance liquid chromatographic method for the determination of oxcarbazepine and its main metabolites in human plasma and cerebrospinal fluid and its application to pharmacokinetic study.
    Journal of pharmaceutical and biomedical analysis, 2007, Jan-17, Volume: 43, Issue:2

    Topics: Acetonitriles; Amines; Anticonvulsants; Biotransformation; Buffers; Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Epilepsy; Guidelines as Topic; Humans; Linear Models; Oxcarbazepine; Phosphates; Potassium Compounds; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solvents; Spectrophotometry, Ultraviolet

2007
Influence of sex, age, weight, and carbamazepine dose on serum concentrations, concentration ratios, and level/dose ratios of carbamazepine and its metabolites.
    Therapeutic drug monitoring, 1994, Volume: 16, Issue:5

    Topics: Aging; Body Weight; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Sex Factors

1994
Effect of felbamate on carbamazepine and its major metabolites.
    Clinical pharmacology and therapeutics, 1993, Volume: 53, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Interactions; Epilepsy; Felbamate; Female; Humans; Male; Middle Aged; Phenylcarbamates; Phenytoin; Propylene Glycols

1993
Relationships between carbamazepine-diol, carbamazepine-epoxide, and carbamazepine total and free steady-state concentrations in epileptic patients: the influence of age, sex, and comedication.
    Therapeutic drug monitoring, 1996, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Phenobarbital; Protein Binding; Sex Factors

1996
The mechanism of the carbamazepine-valproate interaction in humans.
    British journal of clinical pharmacology, 1997, Volume: 44, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid

1997
Gas chromatographic/mass spectrometric assays for oxcarbazepine and its main metabolites, 10-hydroxy-carbazepine and carbazepine-10,11-trans-diol.
    Biomedical & environmental mass spectrometry, 1986, Volume: 13, Issue:12

    Topics: Anticonvulsants; Biological Availability; Carbamazepine; Clinical Trials as Topic; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Oxcarbazepine

1986
Oxcarbazepine and spasticity: further observations.
    Arquivos de neuro-psiquiatria, 1988, Volume: 46, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsy; Female; Humans; Male; Middle Aged; Muscle Spasticity; Oxcarbazepine

1988

Other Studies

12 other study(ies) available for 10,11-dihydro-10,11-dihydroxy-5h-dibenzazepine-5-carboxamide and Epilepsy

ArticleYear
Carbamazepine-10,11-diol steady-state serum levels and renal excretion during carbamazepine therapy in adults and children.
    Therapeutic drug monitoring, 1984, Volume: 6, Issue:3

    Topics: Adult; Biotransformation; Carbamazepine; Child; Epilepsy; Female; Humans; Kinetics; Male

1984
Carbamazepine and its major metabolites in plasma: a summary of eight years of therapeutic drug monitoring.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:4

    Topics: Black People; Carbamazepine; Epilepsy; Humans; White People

1983
The influence of polytherapy on the relationships between serum carbamazepine and its metabolites in epileptic children.
    Epilepsy research, 1994, Volume: 17, Issue:3

    Topics: Aging; Anticonvulsants; Body Weight; Carbamazepine; Child; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Spectrophotometry, Ultraviolet; Valproic Acid

1994
Determination of total and free carbamazepine and the principal metabolites in serum by high-performance liquid chromatography with photodiode-array detection.
    Therapeutic drug monitoring, 1993, Volume: 15, Issue:4

    Topics: Carbamazepine; Child; Chromatography, High Pressure Liquid; Epilepsy; Humans; Spectrophotometry, Ultraviolet; Ultrafiltration

1993
Chiral separation of 10,11-dihydro-10, 11-trans-dihydroxycarbamazepine, a metabolite of carbamazepine with two asymmetric carbons, in human serum.
    Journal of chromatography. B, Biomedical applications, 1996, Mar-03, Volume: 677, Issue:2

    Topics: Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism

1996
Effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites.
    Acta neurologica Scandinavica, 1992, Volume: 85, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Oxcarbazepine; Trigeminal Neuralgia

1992
Influence of concurrent administration of sodium valproate on the plasma concentrations of carbamazepine and its epoxide and diol metabolites.
    The Japanese journal of psychiatry and neurology, 1991, Volume: 45, Issue:2

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Valproic Acid

1991
Daily variations in steady-state plasma concentrations of carbamazepine and its metabolites in epileptic children.
    Clinical pharmacokinetics, 1991, Volume: 20, Issue:3

    Topics: Adolescent; Carbamazepine; Child; Chromatography, High Pressure Liquid; Epilepsy; Female; Humans; Male

1991
Factors influencing plasma level/dose ratios of carbamazepine and its major metabolites in epileptic children.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:5

    Topics: Adolescent; Age Factors; Carbamazepine; Child; Epilepsy; Humans; Regression Analysis; Time Factors

1990
The effect of clobazam on steady state plasma concentrations of carbamazepine and its metabolites.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:6

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Chromatography, High Pressure Liquid; Clobazam; Drug Therapy, Combination; Epilepsy; Humans

1990
Serum concentrations of carbamazepine and its epoxide and diol metabolites in epileptic patients: the influence of dose and comedication.
    Therapeutic drug monitoring, 1987, Volume: 9, Issue:3

    Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Regression Analysis

1987
Problem of spurious correlation in the evaluation of steady-state carbamazepine levels using metabolite data.
    Therapeutic drug monitoring, 1986, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Statistics as Topic

1986