10(9)-hydroxystearic-acid and Carcinoma--Lewis-Lung

10(9)-hydroxystearic-acid has been researched along with Carcinoma--Lewis-Lung* in 1 studies

Other Studies

1 other study(ies) available for 10(9)-hydroxystearic-acid and Carcinoma--Lewis-Lung

Article	Year
Hydroxystearic acid effects on CDC2/histone H1 kinase activity in C108 carcinoma cells. Biochemical and biophysical research communications, 1994, Sep-30, Volume: 203, Issue:3 HSA at appropriate concentrations shows cytostatic and/or cytotoxic effects on murine Lewis carcinoma cell line C108. The cytostatic effect is mediated by an arrest in the cell cycle machinery, with accumulation of cells in G2-M. The combination of enzymatic assays, cell cycle kinetics studies and immunoprecipitation shows that HSA causes to a certainty an accumulation of cells in the M phase, while a similar effect in G2 has still to be demonstrated. It also inhibits histone H1 kinase activity up to 95% of that of mitotic cells, having as a direct or indirect target the cdc2 complex. Topics: Animals; Carcinoma, Lewis Lung; CDC2 Protein Kinase; Cell Cycle; DNA, Neoplasm; Flow Cytometry; Hydroxyurea; Kinetics; Mice; Nocodazole; Protamine Kinase; Stearic Acids; Tumor Cells, Cultured	1994

Article

Year

Hydroxystearic acid effects on CDC2/histone H1 kinase activity in C108 carcinoma cells.

Biochemical and biophysical research communications, 1994, Sep-30, Volume: 203, Issue:3

HSA at appropriate concentrations shows cytostatic and/or cytotoxic effects on murine Lewis carcinoma cell line C108. The cytostatic effect is mediated by an arrest in the cell cycle machinery, with accumulation of cells in G2-M. The combination of enzymatic assays, cell cycle kinetics studies and immunoprecipitation shows that HSA causes to a certainty an accumulation of cells in the M phase, while a similar effect in G2 has still to be demonstrated. It also inhibits histone H1 kinase activity up to 95% of that of mitotic cells, having as a direct or indirect target the cdc2 complex.

Topics: Animals; Carcinoma, Lewis Lung; CDC2 Protein Kinase; Cell Cycle; DNA, Neoplasm; Flow Cytometry; Hydroxyurea; Kinetics; Mice; Nocodazole; Protamine Kinase; Stearic Acids; Tumor Cells, Cultured

1994