Compounds > 1-propanol
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1-propanol and Acute Liver Injury, Drug-Induced

1-propanol has been researched along with Acute Liver Injury, Drug-Induced in 47 studies

1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.
propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
" Therefore, the purpose of this study was to investigate the influence of several hepatotoxic chemicals (allyl alcohol, ethylhexanol, and menadione) and hypoxia on phagocytic activity of Kupffer cells in perfused rat liver."3.68Effect of hepatotoxic chemicals and hypoxia on hepatic nonparenchymal cells: impairment of phagocytosis by Kupffer cells and disruption of the endothelium in rat livers perfused with colloidal carbon. ( Caldwell-Kenkel, JC; Keller, BJ; Lemasters, JJ; te Koppele, JM; Thurman, RG, 1991)
"The effects of allyl alcohol, galactosamine, bromobenzene, and corn oil administration were evaluated in male Fischer 344 rats at 4 to 5, 14 to 15, and 24 to 25 months of age to determine if susceptibility to hepatotoxic injury is modified as a consequence of aging."3.67Influence of aging on the susceptibility of rats to hepatotoxic injury. ( Rikans, LE, 1984)
"Uracil was previously shown by us to be the active principle of Trionyx carapax."1.29Effect of pretreatment of rats with uracil on liver injuries induced by D-galactosamine and allyl alcohol. ( Ariyoshi, T; Kitajima, S; Ogawa, N, 1994)
"Glutathione disulfide was not formed in allyl alcohol-treated cells, and DTT reversal of cytotoxicity occurred without restoring glutathione levels."1.29Dithiothreitol reversal of allyl alcohol cytotoxicity in isolated rat hepatocytes. ( Cai, Y; Rikans, LE, 1994)
" In the initial 3-week dose-response study, as the daily dose of VA increased so did the degree of potentiation of CCl4 hepatotoxicity."1.29Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. ( Earnest, DL; elSisi, AE; Hall, P; Sim, WL; Sipes, IG, 1993)
"The present study was designed to evaluate the effects of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (PMC) in combination with garlic oil against chemical-induced hepatic injury in rats and mice."1.29Enhanced effectiveness of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in combination with garlic oil against experimental hepatic injury in rats and mice. ( Chung, HC; Hong, SY; Jung, KH; Kim, SG; Nam, SY, 1995)
" Bromoacetaldehyde was more toxic (EC(50)60 mu M, 2 hr) and bromoacetic acid was less toxic (EC(50)150 mu M, 2 hr)."1.29The involvement of cytochrome P4502E1 in 2-bromoethanol-induced hepatocyte cytotoxicity. ( Khan, S; O'Brien, PJ; Sood, C, 1996)
"Pretreatment with verapamil reduced the increase of ALT in plasma and the morphological signs of necrosis induced by AA administration."1.29Effect of verapamil on allyl alcohol hepatotoxicity. ( Atzori, L; Congiu, L, 1996)
"Isoflurane was included for comparative purposes."1.28Sevoflurane is biotransformed by guinea pig liver slices but causes minimal cytotoxicity. ( Brendel, K; Fernando, J; Gandolfi, AJ; Ghantous, HN, 1992)
"Pretreatment with acetone or isopropanol (2."1.27Potentiation of the hepatotoxicity of N-nitrosodimethylamine by fasting, diabetes, acetone, and isopropanol. ( Chung, HR; Lorr, NA; Miller, KW; Yang, CS, 1984)
"Mice treated with buthionine sulfoximine [an effective irreversible inhibitor of gamma-glutamylcysteine synthetase (EC 6."1.27Glutathione, a first line of defense against cadmium toxicity. ( Anderson, ME; Meister, A; Singhal, RK, 1987)
" These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency."1.26Quantitative aspects in the assessment of liver injury. ( Plaa, GL, 1976)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199034 (72.34)18.7374
1990's13 (27.66)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Leonard, TB1
Dent, JG1
Plaa, GL4
Hewitt, WR1
du Souich, P1
Caillé, G1
Lock, S1
Tanaka, E1
Nakamura, T1
Misawa, S1
Yoshida, T1
Kuroiwa, Y1
Rikans, LE3
Kosanke, SD1
Poulsen, HE1
Korsholm, B1
Lorr, NA1
Miller, KW1
Chung, HR1
Yang, CS1
Ushakov, VF1
Bidevkina, MV2
Ivanov, NG2
Harris, RN1
Anders, MW1
Fregnan, GB1
Frigerio, L1
Porta, R1
Prada, M1
Ruggieri, F1
Pagella, PG1
Faini, D1
Turba, C1
Laham, S1
Potvin, M1
Schrader, K1
Marino, I1
Willson, RA1
Hart, JR1
Ganey, PE1
Schultze, AE1
Liu, J2
Liu, Y1
Klaassen, CD2
Kitajima, S1
Ogawa, N1
Ariyoshi, T1
Cai, Y1
elSisi, AE1
Hall, P1
Sim, WL1
Earnest, DL1
Sipes, IG4
Kim, SG1
Nam, SY1
Chung, HC1
Hong, SY1
Jung, KH1
Khan, S1
Sood, C1
O'Brien, PJ1
Atzori, L1
Congiu, L1
Tygstrup, N1
Jensen, SA1
Krog, B1
Dalhoff, K1
Butterworth, KR1
Carpanini, FM1
Dunnington, D1
Grasso, P1
Pelling, D1
Silver, EH1
Murphy, SD1
Maling, HM2
Stripp, B1
Highman, B1
Saul, W2
Williams, MA1
Ghantous, HN1
Fernando, J1
Gandolfi, AJ2
Brendel, K2
te Koppele, JM1
Keller, BJ1
Caldwell-Kenkel, JC1
Lemasters, JJ1
Thurman, RG1
Maziasz, TJ1
Madhu, C1
Casini, AF1
Maellaro, E1
Del Bello, B1
Comporti, M2
Glende, EA1
Lee, PY1
Virtanen, P1
Lassila, V1
Njimi, T1
Mengata, DE1
Vengerovskiĭ, AI1
Sedykh, IM1
Saratikov, AS1
Dixon, PA1
Udeagha, AU1
Penttilä, KE1
Mäkinen, J1
Lindros, KO1
Singhal, RK1
Anderson, ME1
Meister, A1
Pompella, A1
Romani, A1
Fulceri, R1
Benedetti, A1
Fisher, RL1
Smith, PF1
Stine, ER1
Deng, JF1
Wang, JD1
Shih, TS1
Lan, FL1
Usakov, VF1
Germanova, AL1
Haddad, P1
Gascon-Barré, M1
Dumont, A1
Hillbom, ME1
Franssila, K1
Forsander, OA1
Glasgow, JF1
Ferris, JA1
Gibel, W1
Lohs, KH1
Wildner, GP1
Schramm, T1
Traiger, GJ2
Eichelbaum, FM1
Brown, EA1
Gillette, JR1

Other Studies

47 other studies available for 1-propanol and Acute Liver Injury, Drug-Induced

ArticleYear
Effects of H2 receptor antagonists on the hepatotoxicity of various chemicals.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 44, Issue:3

    Topics: 1-Propanol; Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug

1984
Isopropanol and acetone potentiation of carbon tetrachloride-induced hepatotoxicity: single versus repetitive pretreatments in rats.
    Journal of toxicology and environmental health, 1982, Volume: 9, Issue:2

    Topics: 1-Propanol; Acetone; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Dru

1982
Effects of allyl alcohol and bromobenzene on trimethadione metabolism in the rat.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 45, Issue:1

    Topics: 1-Propanol; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Dimethadione; Kinetics;

1984
Effect of aging on liver glutathione levels and hepatocellular injury from carbon tetrachloride, allyl alcohol or galactosamine.
    Drug and chemical toxicology, 1984, Volume: 7, Issue:6

    Topics: 1-Propanol; Aging; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug

1984
Influence of aging on the susceptibility of rats to hepatotoxic injury.
    Toxicology and applied pharmacology, 1984, Volume: 73, Issue:2

    Topics: 1-Propanol; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Chemic

1984
Quantitative liver functions after administration of allyl alcohol to rats.
    Acta pharmacologica et toxicologica, 1984, Volume: 54, Issue:2

    Topics: 1-Propanol; Acetaminophen; Acrolein; Animals; Anisoles; Chemical and Drug Induced Liver Injury; Fema

1984
Potentiation of the hepatotoxicity of N-nitrosodimethylamine by fasting, diabetes, acetone, and isopropanol.
    Toxicology and applied pharmacology, 1984, Volume: 73, Issue:3

    Topics: 1-Propanol; Acetone; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytoc

1984
[Effect of hepatotoxic industrial substances on contact interactions of rat hepatocytes].
    Gigiena truda i professional'nye zabolevaniia, 1984, Issue:5

    Topics: 1-Propanol; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Interce

1984
Phosgene: a possible role in the potentiation of carbon tetrachloride hepatotoxicity by 2-propanol.
    Life sciences, 1981, Aug-03, Volume: 29, Issue:5

    Topics: 1-Propanol; Animals; Carbon Dioxide; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical

1981
Therapeutic properties of dihydroxy-dibutylether on sub-acute liver damage induced by several hepatotoxic agents in rats.
    International journal of tissue reactions, 1982, Volume: 4, Issue:4

    Topics: 1-Naphthylisothiocyanate; 1-Propanol; Animals; Aspartate Aminotransferases; Chemical and Drug Induce

1982
Effect of arginine thiazolidinecarboxylate on allyl alcohol hepatotoxicity in the rat.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:9

    Topics: 1-Propanol; Alanine Transaminase; Alkaline Phosphatase; Animals; Arginine; Aspartate Aminotransferas

1981
Studies on inhalation toxicity of 2-propanol.
    Drug and chemical toxicology, 1980, Volume: 3, Issue:4

    Topics: 1-Propanol; Acetone; Animals; Biotransformation; Body Temperature; Chemical and Drug Induced Liver I

1980
In vivo drug metabolism and liver lobule heterogeneity in the rat.
    Gastroenterology, 1981, Volume: 81, Issue:3

    Topics: 1-Propanol; Aminopyrine; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Ethanol; In

1981
Depletion of neutrophils and modulation of Kupffer cell function in allyl alcohol-induced hepatotoxicity.
    Toxicology, 1995, May-05, Volume: 99, Issue:1-2

    Topics: 1-Propanol; Animals; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Drug Interactions; Fe

1995
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.
    Journal of ethnopharmacology, 1994, Volume: 42, Issue:3

    Topics: 1-Propanol; Acetaminophen; Animals; Cadmium; Carbon Tetrachloride; Chemical and Drug Induced Liver I

1994
Effect of pretreatment of rats with uracil on liver injuries induced by D-galactosamine and allyl alcohol.
    Research communications in molecular pathology and pharmacology, 1994, Volume: 85, Issue:1

    Topics: 1-Propanol; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Li

1994
Dithiothreitol reversal of allyl alcohol cytotoxicity in isolated rat hepatocytes.
    Toxicology, 1994, Jan-26, Volume: 86, Issue:1-2

    Topics: 1-Propanol; Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dithiot

1994
Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury.
    Toxicology and applied pharmacology, 1993, Volume: 119, Issue:2

    Topics: 1-Propanol; Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug In

1993
Enhanced effectiveness of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in combination with garlic oil against experimental hepatic injury in rats and mice.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:8

    Topics: 1-Propanol; Administration, Oral; Allyl Compounds; Animals; Antioxidants; Carbon Tetrachloride; Cell

1995
The involvement of cytochrome P4502E1 in 2-bromoethanol-induced hepatocyte cytotoxicity.
    Pharmacology & toxicology, 1996, Volume: 78, Issue:4

    Topics: 1-Propanol; Animals; Antioxidants; Biotransformation; Cell Membrane; Cell Survival; Chemical and Dru

1996
Effect of verapamil on allyl alcohol hepatotoxicity.
    Drug metabolism and drug interactions, 1996, Volume: 13, Issue:2

    Topics: 1-Propanol; Alanine Transaminase; Alcohol Dehydrogenase; Animals; Calcium Channel Blockers; Chemical

1996
Expression of liver functions following sub-lethal and non-lethal doses of allyl alcohol and acetaminophen in the rat.
    Journal of hepatology, 1997, Volume: 27, Issue:1

    Topics: 1-Propanol; Acetaminophen; Acute-Phase Proteins; Animals; Biomarkers; Chemical and Drug Induced Live

1997
The productoin of periportal necrosis by allyl alcohol in the rat [proceedings].
    British journal of pharmacology, 1978, Volume: 63, Issue:2

    Topics: 1-Propanol; Allyl Compounds; Animals; Chemical and Drug Induced Liver Injury; Male; Necrosis; Propan

1978
Effect of carboxylesterase inhibitors on the acute hepatotoxicity of esters of allyl alcohol.
    Toxicology and applied pharmacology, 1978, Volume: 45, Issue:2

    Topics: 1-Propanol; Alanine Transaminase; Allyl Compounds; Animals; Carboxylic Ester Hydrolases; Chemical an

1978
Quantitative aspects in the assessment of liver injury.
    Environmental health perspectives, 1976, Volume: 15

    Topics: 1-Propanol; Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che

1976
Enhanced hepatotoxicity of carbon tetrachloride, thioacetamide, and dimethylnitrosamine by pretreatment of rats with ethanol and some comparisons with potentiation by isopropanol.
    Toxicology and applied pharmacology, 1975, Volume: 33, Issue:2

    Topics: 1-Propanol; Acetaldehyde; Acetamides; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning;

1975
Sevoflurane is biotransformed by guinea pig liver slices but causes minimal cytotoxicity.
    Anesthesia and analgesia, 1992, Volume: 75, Issue:3

    Topics: 1-Propanol; Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Ethers;

1992
Effect of hepatotoxic chemicals and hypoxia on hepatic nonparenchymal cells: impairment of phagocytosis by Kupffer cells and disruption of the endothelium in rat livers perfused with colloidal carbon.
    Toxicology and applied pharmacology, 1991, Volume: 110, Issue:1

    Topics: 1-Propanol; Animals; Carbon; Chemical and Drug Induced Liver Injury; Endothelium; Female; Hypoxia; K

1991
The differential effects of hepatotoxicants on the sulfation pathway in rats.
    Toxicology and applied pharmacology, 1991, Sep-15, Volume: 110, Issue:3

    Topics: 1-Naphthylisothiocyanate; 1-Propanol; Aflatoxin B1; Alanine Transaminase; Animals; Arylsulfotransfer

1991
The role of vitamin E in the hepatotoxicity by glutathione depleting agents.
    Advances in experimental medicine and biology, 1990, Volume: 264

    Topics: 1-Propanol; Animals; Ascorbic Acid; Bromobenzenes; Chemical and Drug Induced Liver Injury; Dehydroas

1990
Isopropanol and chlordecone potentiation of carbon tetrachloride liver injury: retention of potentiating action in hepatocyte suspensions prepared from rats given isopropanol or chlordecone.
    Experimental and molecular pathology, 1985, Volume: 42, Issue:2

    Topics: 1-Propanol; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cells, Cultured; C

1985
Effect of splenectomy on hepasor treatment in allyl-alcohol-traumatized rat liver.
    Acta anatomica, 1989, Volume: 134, Issue:4

    Topics: 1-Propanol; Animals; Berberine Alkaloids; Biopsy; Chemical and Drug Induced Liver Injury; Drug Combi

1989
[Effectiveness of hepatoprotective agents in experimental allyl alcohol poisoning].
    Gigiena truda i professional'nye zabolevaniia, 1989, Issue:5

    Topics: 1-Propanol; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical

1989
The effect of some hepatotoxins on the sulphoxidation of cimetidine in rat.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1986, Volume: 83, Issue:2

    Topics: 1-Propanol; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

1986
Allyl alcohol liver injury: suppression by ethanol and relation to transient glutathione depletion.
    Pharmacology & toxicology, 1987, Volume: 60, Issue:5

    Topics: 1-Propanol; Acrolein; Alanine Transaminase; Aldehyde Oxidoreductases; Animals; Chemical and Drug Ind

1987
Glutathione, a first line of defense against cadmium toxicity.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1987, Volume: 1, Issue:3

    Topics: 1-Propanol; Animals; Buthionine Sulfoximine; Cadmium; Cadmium Chloride; Chemical and Drug Induced Li

1987
4-Hydroxynonenal and other lipid peroxidation products are formed in mouse liver following intoxication with allyl alcohol.
    Biochimica et biophysica acta, 1988, Aug-12, Volume: 961, Issue:3

    Topics: 1-Propanol; Aldehydes; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Thin Layer;

1988
A dynamic liver culture system: a tool for studying chemical biotransformation and toxicity.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1987, Volume: 11

    Topics: 1-Propanol; Adenosine Triphosphate; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Ind

1987
Outbreak of carbon tetrachloride poisoning in a color printing factory related to the use of isopropyl alcohol and an air conditioning system in Taiwan.
    American journal of industrial medicine, 1987, Volume: 12, Issue:1

    Topics: 1-Propanol; Adult; Air Conditioning; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

1987
[Changes in intercellular contact as a parameter of hepatotoxicity of industrial substances].
    Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete, 1986, Volume: 32, Issue:11

    Topics: 1-Propanol; Animals; Carbon Tetrachloride Poisoning; Cell Communication; Chemical and Drug Induced L

1986
Comparative hepatic response to bromobenzene and allyl alcohol in the vitamin D-replete and vitamin D-depleted rat.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:2

    Topics: 1-Propanol; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Chemical and

1985
Effects of chronic ingestion of some lower aliphatic alcohols in rats.
    Research communications in chemical pathology and pharmacology, 1974, Volume: 9, Issue:1

    Topics: 1-Propanol; Alcohol Drinking; Alcoholic Beverages; Animals; Butanols; Chemical and Drug Induced Live

1974
Encephalopathy and visceral fatty infiltration of probable toxic aetiology.
    Lancet (London, England), 1968, Mar-02, Volume: 1, Issue:7540

    Topics: 1-Propanol; Brain Diseases; Chemical and Drug Induced Liver Injury; Child, Preschool; Chromatography

1968
[Experimental studies on the carcinogenic effect of higher alcohols using 3-methyl-1-butanol, 1-propanol and 2-methyl-1-propanol as examples].
    Zeitschrift fur experimentelle Chirurgie, 1974, Volume: 7, Issue:4

    Topics: 1-Propanol; Adenocarcinoma; Alcoholic Beverages; Animals; Bone Marrow Diseases; Butanols; Carcinogen

1974
Effect of aminotriazole on isopropanol- and acetone-induced potentiation of CCl 4 hepatotoxicity.
    Canadian journal of physiology and pharmacology, 1973, Volume: 51, Issue:4

    Topics: 1-Propanol; Acetone; Alanine Transaminase; Amitrole; Aniline Compounds; Animals; Carbon Tetrachlorid

1973
Chlorinated hydrocarbon toxicity. Potentiation by isopropyl alcohol and acetone.
    Archives of environmental health, 1974, Volume: 28, Issue:5

    Topics: 1-Propanol; Acetone; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chlorofo

1974
Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine).
    Biochemical pharmacology, 1974, May-15, Volume: 23, Issue:10

    Topics: 1-Propanol; Animals; Carbon Radioisotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che

1974