1-octanol and Essential Tremor

1-octanol has been researched along with Essential Tremor in 4 studies

1-Octanol: A colorless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticizers. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
octan-1-ol : An octanol carrying the hydroxy group at position 1.

Essential Tremor: A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)

Research

Studies (4)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Blood Plasma Levels of Octanoic Acid After 64 mg/kg 1-Octanol Dose

Octanoic Acid is a metabolite of 1-octanol. Blood plasma levels of octanoic acid were measured at 5, 20, 45, 70, 100, 130, 160, 210, 270 and 360 minutes post-dose. (NCT00102596)
Timeframe: 5, 20, 45, 70, 100, 130, 160, 210, 270 and 360 minutes post-dose

Heart Rate Post 1-Octanol Dose

(NCT00102596)
Timeframe: 0 minutes, 15 minutes, 100 minutes and 24 hours post-dose

Normalized Mean Tremor Amplitude for Both Formulations of 64 mg/kg 1-Octanol in Part B

Spirography mean tremor amplitudes were measured in the right hand of each participant at 0, 15, 30, 60, 90, 120, 150, 180, 240 and 360 minutes post-dose. Then, the scores of each participant were normalized (i.e., divided by) by their baseline tremor severity scores so that all scores are expressed as a proportion of the baseline score. Therefore, 1 is the baseline tremor severity, and lower scores indicate tremor reduction. (NCT00102596)
Timeframe: 0, 15, 30, 60, 90, 120, 150, 180, 240 and 360 minutes post-dose

PR and QTc Intervals Post 1-Octanol Dose

(NCT00102596)
Timeframe: 0 minutes, 15 minutes, 100 minutes and 24 hours post-dose

Auditory-perceptual Tremor Severity Ratings

Three experienced listeners independently rated each participant's voice from paired sample recordings comparing the baseline to post-test samples in randomized order for each condition. Sustained vowel and sentence-level recordings were rated, with decoded samples later analyzed for 1=better for post-test compared to baseline, 0= no difference between post-test and baseline. Maximum score for each participant was 3 (post-test was better for each of three raters). The range of possible scores was the sum of each of three raters' scores (0 to 3), with 0 indicating no difference between baseline and post-test voice tremor severity rating, and 3 indicating better voice (less tremor severity) at post-testing compared to pre-testing. Mean post-test values for task were compared for the octanoic acid and placebo conditions, and all raters were blind to which sample was a baseline versus a post-test recording, and which samples were associated with the [placebo or octanoic acid conditions. (NCT01864525)
Timeframe: Measured at baseline visits (1 & 2) and after 3 weeks of placebo or octanoic acid on post-test visits (1 & 2).

Magnitude of Acoustic Amplitude Tremor and Magnitude of Acoustic Frequency Tremor

Voice recordings were used to measure the degree of tremor in the voice. Mean post-test values for each acoustic measure were compared after the octanoic acid and placebo conditions, with and without consideration of baseline values. Mean values represent the average of two testing days. Degree of amplitude tremor shows the extent of amplitude variation as a percent of the mean signal amplitude, with lower numbers indicating less amplitude tremor. Baseline values for magnitude of amplitude tremor across all participants and conditions ranged from 4.06 to 27.09, and post-test values ranged from 1.94 to 26.02. Degree of frequency tremor shows the extent of fundamental frequency variation as a percent of the mean signal frequency, with lower numbers indicating less frequency tremor. Baseline values for magnitude of frequency tremor across all participants and conditions ranged from 1.21 to 15.31, and post-test values ranged from 0.60 to 13.86. (NCT01864525)
Timeframe: Measured at baseline visits (1 & 2) and after 3 weeks of placebo or octanoic acid on post-test visits (1 & 2)

Trials

3 trials available for 1-octanol and Essential Tremor

Other Studies

1 other study available for 1-octanol and Essential Tremor