Page last updated: 2024-08-21

1-naphthylisothiocyanate and Cholestasis, Intrahepatic

1-naphthylisothiocyanate has been researched along with Cholestasis, Intrahepatic in 75 studies

Research

Studies (75)

TimeframeStudies, this research(%)All Research%
pre-199011 (14.67)18.7374
1990's14 (18.67)18.2507
2000's15 (20.00)29.6817
2010's18 (24.00)24.3611
2020's17 (22.67)2.80

Authors

AuthorsStudies
Gong, H; Gu, H; Guo, L; Hou, Z; Ma, J; Tang, T; Yan, M; Yang, Y; Zhang, B; Zhou, W; Zou, W1
Gao, Q; Guo, S; Li, G; Liu, D; Wang, C; Wang, X; Xu, Y; Zhang, C; Zu, Y1
Hou, LF; Lou, J; Wang, F; Xu, JJ; Yu, XK; Yuan, SQ; Zhang, HZ; Zhao, L; Zhu, YJ1
Han, J; Li, C; Liang, A; Liu, C; Liu, M; Liu, S; Meng, J; Pan, C; Qin, S; Tian, J; Wang, F; Wang, J; Wang, L; Yi, Y; Zhang, Y; Zhao, Y1
Cheng, W; Geng, Q; Miao, Y; She, X; Xu, M; Yang, C; Zhang, Q; Zhang, Z1
Chen, Y; Duan, Y; Guo, F; Hajjar, DP; Han, J; Hu, H; Hu, W; Kong, D; Li, Q; Li, X; Ma, C; Miao, QR; Wang, H; Wei, Z; Yang, X; Yu, M; Zhang, S; Zhang, Y; Zhu, Y1
Huang, T; Lin, C; Liu, C; Yao, Y; Zhang, Q; Zhang, R; Zhu, C1
Amar, MJA; Freeman, LA; Karathanasis, SK; Neufeld, EB; Nishida, T; Pryor, M; Remaley, AT; Sampson, ML; Vaisman, BL1
Barrera-Chimal, J; Bello, O; Bucio-Ortiz, L; Gomez-Quiroz, LE; Gutiérrez-Ruiz, MC; Lazzarini, R; López-Ramirez, J; Miranda-Labra, RU; Razori, MV; Roma, MG; Salas-Silva, S; Simoni-Nieves, A; Souza, V1
Fan, FB; Li, WK; Li, YF; Li, YY; Ma, YM; Shi, R; Wang, GF; Wang, TM; Wu, JS; Zan, B; Zheng, M; Zou, J1
Li, P; Li, X; Sui, J; Sun, F; Wu, J; Xu, C1
Du, R; Gao, Y; Huang, W; Li, J; Ren, H; Xiao, Q; Zhang, S; Zhao, J; Zhu, Y1
Dai, M; Lin, H; Liu, A; Xu, G; Yang, J; Zheng, X1
Chen, M; Dong, Z; Lan, X; Liao, Z; Ma, Y; Wang, G; Wei, X1
Lin, C; Liu, C; Liu, F; Lu, Z; Wang, M; Yao, Y; Zhang, Q; Zhang, R; Zhu, C1
Fan, Y; Li, G; Liu, J; Xu, T; Yu, H; Zhang, C; Zhang, Y; Zhou, L1
Chen, Z; Dun, Z; Fang, J; Gan, C; Luosang, T; Sang, C; Wang, B; Wang, Q; Wu, Y; Xiong, T; Zeren, D1
Chen, M; Liao, Z; Meng, F; Tao, Y; Wang, G; Wei, X; Zong, W1
Cheng, Y; Dai, M; Gonzalez, FJ; Guo, B; Hua, H; Lin, H; Lin, J; Liu, A; Luo, M; Song, D; Xie, M; Xu, G; Yang, J; Zhao, J1
Chen, G; Fan, Y; Hu, Y; Jiang, J; Li, Y; Qiu, F; Su, H; Tan, B; Wang, Q; Zhang, L1
Feng, L; Huo, XK; Liu, J; Ma, XC; Ning, J; Sun, CP; Tian, XG; Wang, C; Wang, YF; Yu, ZL; Zhang, BJ1
Fang, ZZ; Gonzalez, FJ; Tanaka, N; Tang, KL; Wang, BL; Wang, L; Xu, Y; Zhang, CW1
Bi, Y; Fan, G; Gao, X; Han, L; Li, C; Wang, X; Zhang, Y1
Bao, WM; Cheng, Y; Gonzalez, FJ; Hu, DD; Hu, JP; Jiang, T; Li, F; Liu, F; Tang, YM; Xiao, XR; Yang, JH; Zhao, Q1
Chang, MJ; Du, G; Li, XP; Liu, D; Wu, T; Xu, YJ1
Chen, XL; Huo, XK; Liu, KX; Liu, Q; Liu, ZH; Meng, Q; Sun, HJ; Sun, PY; Wang, CY; Yao, JH1
Chen, JW; Li, DY; Ou, QQ; Pei, XN; Qian, XH; Yu, L; Zhang, YX1
Chen, H; Huang, X; Li, W; Liu, C; Mi, S; Min, J; Wang, N; Wang, Q; Yi, L; Zhang, R; Zhao, W; Zhu, C1
Chen, B; Chu, Z; Dai, M; Guo, B; Li, P; Liu, A; Luo, M; Ma, M; Song, D; Tan, Z; Yin, X; Zou, Z1
Huo, X; Jia, Y; Liu, K; Liu, Q; Meng, Q; Peng, J; Sun, H; Sun, P; Wang, C; Xu, Q; Zhang, A1
Chansela, P; Khamphaya, T; Nathanson, MH; Piyachaturawat, P; Suksamrarn, A; Weerachayaphorn, J1
Chen, P; Ding, Y; Jiang, ZX; Li, HR; Qin, H; Xiong, XL; Yan, SQ; Yao, C; Zhang, LL; Zhao, L; Zhou, LS1
Fujita, T; Hasegawa, M; Ide, M; Takenaka, S1
Duke, DS; Mendelson, KG; Schwartz, MZ; Thatch, KA; Yoo, EY1
Alexeenko, TV; Korolenko, TA; Savchenko, NG; Sorochinskaya, NV; Yuz'ko, JV1
Aleksunes, LM; Cui, YJ; Klaassen, CD; Tanaka, Y1
Aleksunes, LM; Cui, YJ; Goedken, MJ; Klaassen, CD; Tanaka, Y1
Alexeenko, TV; Cherkanova, MS; Filjushina, EE; Goncharova, IA; Klishevich, MS; Korolenko, TA; Savchenko, NG; Zhanaeva, SY1
DING, Y; GAO, Y; HUANG, ZH; KANG, SX; MEI, H; PENG, HM; ZHAO, L1
Haber, MM; Katz, MS; Schwartz, MZ; Thatch, KA1
Luyendyk, JP; Sullivan, BP; Tawfik, O; Wang, R1
Xu, H; Zhou, F1
Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R1
Akhmedzhanov, RR; Novozheeva, TP; Saratikov, AS1
da Cunha, MF; Ferreira, FM; Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R1
Cipriano, MA; Ferreira, FM; Martins, MI; Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R1
Chignell, CF; Clark, J; He, YY; Liu, J; Myers, P; Saavedra, JE; Waalkes, MP1
Hardman, RC; Hinton, DE; Howarth, DL; Kullman, SW; Volz, DC1
Ding, Y; Huang, ZH; Mei, H; Peng, HM; Zhao, L1
Mitamura, T1
Hewitt, WR; Plaa, GL1
Höke, H; Krell, H; Pfaff, E1
Ikeda, Y; Kako, M; Oda, T; Oka, H; Toda, G1
Yoshino, K1
DeNicola, DB; Dulik, DM; Goldstein, RS; Kossor, DC; Leonard, TB; Meunier, PC; Ngo, W1
Bergasa, NV; Jones, EA; Swain, MG; Vergalla, J1
Mita, S; Nakata, K; Tanaka, M1
Dulik, DM; Goldstein, RS; Handler, JA; Kossor, DC; Leonard, TB; Meunier, PC1
Chisholm, JW; Dolphin, PJ1
Ahmed-Choudhury, J; Chipman, JK; Coleman, R; Hammond, T; Orsler, DJ1
Alpini, G; Alvaro, D; Baiocchi, L; Francis, H; Glaser, S; Kanno, N; Lesage, G; Phinizy, JL; Ueno, Y1
Ando, M1
Ishiki, Y; Matsumoto, K; Muto, Y; Nakamura, T; Ohnishi, H1
Chamow, SM; Godowski, PJ; Roos, F; Schwall, RH; Terrell, TG1
Dahm, LJ; Roth, RA1
Bailie, MB; Dahm, LJ; Roth, RA1
Bulle, F; Dhumeaux, D; Guellaën, G; Lescs, MC; Mavier, P; Preaux, AM; Siegrist, S; Zafrani, ES1
Fromm, H; Krell, H; Larson, RE1
Almasio, P; Bortolini, M; Coltorti, M; Pagliaro, L1
Hikichi, N; Iizuka, Y; Niwa, H; Sakurai, E1
Alpini, G; Lenzi, R; Liu, MH; Sarkozi, L; Slott, PA; Tavoloni, N; Zhai, WR1
Billington, D; Capstick, A; Morris, AI; Quayle, JA1
Chan, YS; Chang, HM; Cheng, YY; Chuang, KF1
Wu, SM; Xu, CW1
Höke, H; Jaeschke, H; Krell, H; Metz, J; Pfaff, E1

Reviews

2 review(s) available for 1-naphthylisothiocyanate and Cholestasis, Intrahepatic

ArticleYear
Biotransformation products and cholestasis.
    Progress in liver diseases, 1982, Volume: 7

    Topics: 1-Naphthylisothiocyanate; Animals; Antidepressive Agents, Tricyclic; Bile Acids and Salts; Biotransformation; Chlorpromazine; Cholestasis, Intrahepatic; Dantrolene; Liver; Manganese Poisoning; Mixed Function Oxygenases; Rats; Steroids; Thioxanthenes

1982
Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis.
    Drugs, 1990, Volume: 40 Suppl 3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bilirubin; Cholestasis, Intrahepatic; Female; Humans; Pregnancy; Pregnancy Complications; S-Adenosylmethionine

1990

Other Studies

73 other study(ies) available for 1-naphthylisothiocyanate and Cholestasis, Intrahepatic

ArticleYear
Liquiritin alleviates alpha-naphthylisothiocyanate-induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway.
    Journal of applied toxicology : JAT, 2023, Volume: 43, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Liver; Mice; MicroRNAs; NF-E2-Related Factor 2; RNA, Messenger; Sirtuin 1

2023
Ginsenosides Restore Lipid and Redox Homeostasis in Mice with Intrahepatic Cholestasis through SIRT1/AMPK Pathways.
    Nutrients, 2022, Sep-22, Volume: 14, Issue:19

    Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Cholestasis; Cholestasis, Intrahepatic; Fatty Acids; Ginsenosides; Hep G2 Cells; Homeostasis; Humans; Lipids; Liver; Mice; NF-E2-Related Factor 2; Oxidation-Reduction; RNA, Small Interfering; Sirtuin 1

2022
[Study on protective effect of Chaihu Shugan Powder against liver injury in rats with intrahepatic cholestasis by regulating FXR/Nrf2/ARE pathway].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:20

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Liver; NF-E2-Related Factor 2; Oxidative Stress; Powders; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2022
Gardenia extract protects against intrahepatic cholestasis by regulating bile acid enterohepatic circulation.
    Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 1

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Enterohepatic Circulation; Gardenia; Liver; Rats; Rats, Sprague-Dawley; Steroid 12-alpha-Hydroxylase

2024
TianJiu therapy for α-naphthyl isothiocyanate-induced intrahepatic cholestasis in rats treated with fresh Ranunculus sceleratus L.
    Journal of ethnopharmacology, 2020, Feb-10, Volume: 248

    Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Cholestasis, Intrahepatic; Disease Models, Animal; Lipid Peroxidation; Liver; Male; Moxibustion; Oxidative Stress; Ranunculus; Rats, Sprague-Dawley

2020
Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ
    British journal of pharmacology, 2020, Volume: 177, Issue:5

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Humans; Mice; PPAR gamma; Prostaglandin D2; Rosiglitazone

2020
Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics.
    Journal of pharmaceutical and biomedical analysis, 2020, Feb-05, Volume: 179

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Male; Metabolomics; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2020
LCAT protects against Lipoprotein-X formation in a murine model of drug-induced intrahepatic cholestasis.
    Pharmacology research & perspectives, 2020, Volume: 8, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Disease Models, Animal; Gene Knockout Techniques; Humans; Lipoprotein-X; Mice; Mice, Transgenic; Phosphatidylcholine-Sterol O-Acyltransferase

2020
HGF induces protective effects in α-naphthylisothiocyanate-induced intrahepatic cholestasis by counteracting oxidative stress.
    Biochemical pharmacology, 2020, Volume: 174

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Hepatocyte Growth Factor; Male; Mice; Oxidative Stress

2020
Yinchenzhufu decoction protects against alpha-naphthylisothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses.
    Journal of ethnopharmacology, 2020, May-23, Volume: 254

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Homeostasis; Inflammation Mediators; Keratin-19; Male; Metabolomics; Mice

2020
Effect of compound Yindan decoction on alpha-naphthylisothiocyanate-Induced acute intrahepatic cholestasis in rats.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2019, Volume: 39, Issue:3

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis, Intrahepatic; Drugs, Chinese Herbal; gamma-Glutamyltransferase; Liver; Male; Radioimmunoassay; Rats

2019
Ginsenoside Rg1 alleviates ANIT-induced intrahepatic cholestasis in rats via activating farnesoid X receptor and regulating transporters and metabolic enzymes.
    Chemico-biological interactions, 2020, Jun-01, Volume: 324

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Biomarkers; Cholestasis, Intrahepatic; Cytochrome P-450 CYP3A; Cytokines; Ginsenosides; Glucuronosyltransferase; Glutathione Peroxidase; Liver; Male; Malondialdehyde; Membrane Transport Proteins; Protective Agents; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sulfotransferases; Superoxide Dismutase

2020
Cholestatic models induced by lithocholic acid and α‑naphthylisothiocyanate: Different etiological mechanisms for liver injury but shared JNK/STAT3 signaling.
    Molecular medicine reports, 2020, Volume: 22, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Lithocholic Acid; Male; MAP Kinase Signaling System; Metabolome; Mice; Mice, Inbred ICR

2020
Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 80

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile; Bile Acids and Salts; Cholestasis, Intrahepatic; Cucurbitaceae; Hepatocytes; Humans; Isoxazoles; Liver; Male; Molecular Docking Simulation; Phenols; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear

2021
Network pharmacology-based mechanism prediction and pharmacological validation of Xiaoyan Lidan formula on attenuating alpha-naphthylisothiocyanate induced cholestatic hepatic injury in rats.
    Journal of ethnopharmacology, 2021, Apr-24, Volume: 270

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Drugs, Chinese Herbal; Inflammation; Male; Metabolic Networks and Pathways; Molecular Docking Simulation; NF-kappa B; Protective Agents; Protein Interaction Maps; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction

2021
Allopurinol Protects Against Cholestatic Liver Injury in Mice Not Through Depletion of Uric Acid.
    Toxicological sciences : an official journal of the Society of Toxicology, 2021, 05-27, Volume: 181, Issue:2

    Topics: 1-Naphthylisothiocyanate; Allopurinol; Animals; Cholestasis; Cholestasis, Intrahepatic; Liver; Mice; Uric Acid

2021
Intrahepatic cholestasis induced by α-naphthylisothiocyanate can cause gut-liver axis disorders.
    Environmental toxicology and pharmacology, 2021, Volume: 86

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytokines; Feces; Intestinal Diseases; Intestine, Small; Liver; Liver Cirrhosis; Male; Mice, Inbred C57BL

2021
Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 87

    Topics: 1-Naphthylisothiocyanate; Acetates; Alanine Transaminase; Animals; Asteraceae; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Cholestasis, Intrahepatic; Lactones; Male; Molecular Docking Simulation; Plant Extracts; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sesquiterpenes

2021
Inhibition of JNK signalling mediates PPARα-dependent protection against intrahepatic cholestasis by fenofibrate.
    British journal of pharmacology, 2017, Volume: 174, Issue:18

    Topics: 1-Naphthylisothiocyanate; Animals; Anthracenes; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Fenofibrate; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; PPAR alpha; Protein Kinase Inhibitors; Pyrimidines; Signal Transduction; Structure-Activity Relationship

2017
Different effects of ursodeoxycholic acid on intrahepatic cholestasis in acute and recovery stages induced by alpha-naphthylisothiocyanate in mice.
    Toxicology and applied pharmacology, 2018, 03-01, Volume: 342

    Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Cholestasis, Intrahepatic; Mice; Mice, Inbred C57BL; Recovery of Function; Ursodeoxycholic Acid

2018
Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Mar-15, Volume: 42

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alisma; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; China; Cholestasis, Intrahepatic; Drugs, Chinese Herbal; Homeostasis; Liver; Male; Molecular Docking Simulation; Protective Agents; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction

2018
Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis.
    Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:5

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Lipid Metabolism; Mice; Mice, Knockout; Receptors, Aryl Hydrocarbon

2019
Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 03-01, Volume: 168, Issue:1

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cytokines; Emodin; Hep G2 Cells; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction

2019
Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.
    Molecular & cellular proteomics : MCP, 2019, Volume: 18, Issue:3

    Topics: 1-Naphthylisothiocyanate; Adult; Animals; Cholestasis, Intrahepatic; Disease Models, Animal; Female; Gene Expression Profiling; Humans; Male; Metabolomics; Mice; Middle Aged; Pentacyclic Triterpenes; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sirtuin 1; Thioacetamide; Treatment Outcome; Triterpenes

2019
Protective effect of Calculus Bovis Sativus on intrahepatic cholestasis in rats induced by α-naphthylisothiocyanate.
    The American journal of Chinese medicine, 2013, Volume: 41, Issue:6

    Topics: 1-Naphthylisothiocyanate; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile; Bilirubin; Biological Products; Biomarkers; Cholestasis, Intrahepatic; Disease Models, Animal; Drugs, Chinese Herbal; Liver; Male; Malondialdehyde; Phytotherapy; Rats; Rats, Wistar; Superoxide Dismutase

2013
Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis.
    Toxicology and applied pharmacology, 2015, Mar-15, Volume: 283, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cholestenones; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Homeostasis; Humans; Liver; Male; Membrane Transport Proteins; Mice, Inbred C57BL; Protective Agents; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Time Factors; Transfection

2015
Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions.
    Pediatric research, 2016, Volume: 79, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biomarkers; Cholestasis, Intrahepatic; Drugs, Chinese Herbal; Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Rats; RNA, Messenger; Up-Regulation

2016
Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2.
    Journal of ethnopharmacology, 2016, Feb-17, Volume: 179

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Iridoid Glucosides; Male; Protective Agents; Rats; Receptors, Cytoplasmic and Nuclear

2016
Geniposide Inhibits Alpha-Naphthylisothiocyanate-Induced Intrahepatic Cholestasis: The Downregulation of STAT3 and NF[Formula: see text]B Signaling Plays an Important Role.
    The American journal of Chinese medicine, 2016, Volume: 44, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Down-Regulation; Drugs, Chinese Herbal; Humans; Iridoids; Male; Mice; Mice, Inbred ICR; NF-kappa B; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha

2016
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
    Toxicology and applied pharmacology, 2016, 08-15, Volume: 305

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cholestasis, Intrahepatic; Diosgenin; Estrone; Hepatocytes; Liver; Male; Multidrug Resistance-Associated Protein 2; Organic Anion Transporters; Protective Agents; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger

2016
Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.
    European journal of pharmacology, 2016, Oct-15, Volume: 789

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Cell Proliferation; Cholestasis, Intrahepatic; Cyclin D1; Diterpenes; Gene Expression Regulation; Hepatic Stellate Cells; Liver; Male; NF-kappa B; Rats

2016
Preliminary study on Emodin alleviating alpha-naphthylisothiocyanate-induced intrahepatic cholestasis by regulation of liver farnesoid X receptor pathway.
    International journal of immunopathology and pharmacology, 2016, Volume: 29, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cell Line; Cholestasis, Intrahepatic; Emodin; Female; Glucuronosyltransferase; Humans; Liver; Male; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA-Binding Proteins; RNA, Messenger; Signal Transduction

2016
Urinary metabolic fingerprinting for alpha-naphthylisothiocyanate-induced intrahepatic cholestasis in rats using Fourier transform-ion cyclotron resonance mass spectrometry.
    Toxicologic pathology, 2008, Volume: 36, Issue:6

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Cholestasis, Intrahepatic; Cyclotrons; Fourier Analysis; Liver; Male; Mass Spectrometry; Noxae; Principal Component Analysis; Rats

2008
Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease.
    Journal of pediatric surgery, 2008, Volume: 43, Issue:12

    Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Epidermal Growth Factor; Female; Hepatocyte Growth Factor; Infusion Pumps, Implantable; Interleukin-6; Intestinal Absorption; Liver; Liver Regeneration; Parenteral Nutrition, Total; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2008
Activity of lysosomal enzymes in the bile and serum of mice with intrahepatic cholestasis.
    Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:5

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; beta-Galactosidase; beta-N-Acetylhexosaminidases; Bile; Cholestasis, Intrahepatic; Cholesterol; gamma-Glutamyltransferase; Hexosaminidases; Lysosomes; Male; Mice; Mice, Inbred CBA; Polyethylene Glycols

2008
ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 108, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Bilirubin; Blotting, Western; Carrier Proteins; Cholestasis, Intrahepatic; Fluorescent Antibody Technique, Indirect; Indicators and Reagents; Liver; Liver Function Tests; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; RNA; Signal Transduction

2009
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 110, Issue:1

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Branched DNA Signal Amplification Assay; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fluorescent Antibody Technique; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA

2009
In vivo effect of selective macrophage suppression on the development of intrahepatic cholestasis in mice.
    Bulletin of experimental biology and medicine, 2008, Volume: 146, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Cathepsin B; Cathepsin D; Cholestasis, Intrahepatic; Gadolinium; Kupffer Cells; Liver; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission

2008
[Effect and mechanism of emodin on cholestatic hepatitis].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2009, Volume: 17, Issue:5

    Topics: 1-Naphthylisothiocyanate; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Early Growth Response Protein 1; Emodin; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Liver Function Tests; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha

2009
Growth factor modulation of hepatic inflammation: a novel approach to the management of total parenteral nutrition-associated liver disease.
    Journal of pediatric surgery, 2010, Volume: 45, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Female; Hepatocyte Growth Factor; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Liver; Liver Diseases; Liver Failure; Liver Function Tests; Parenteral Nutrition, Total; Rats; Rats, Sprague-Dawley; Short Bowel Syndrome; Tumor Necrosis Factor-alpha

2010
Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 115, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Antibodies, Monoclonal; Biomarkers; Blood Coagulation; Blood Platelets; Cholestasis, Intrahepatic; Clopidogrel; Gene Expression; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Thromboplastin; Ticlopidine

2010
[Effect of emodin on P-gp expression in intrahepatic cholestatic rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010, Volume: 35, Issue:7

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Acids and Salts; Bilirubin; Cholestasis, Intrahepatic; Emodin; Gene Expression Regulation; Liver; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger

2010
Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate.
    Toxicology and applied pharmacology, 2002, Jul-01, Volume: 182, Issue:1

    Topics: 1-Naphthylisothiocyanate; Adenine Nucleotides; Animals; Calcium; Cholestasis, Intrahepatic; Citrate (si)-Synthase; Disease Models, Animal; Energy Metabolism; Female; Hepatocytes; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; NADP; Oxygen Consumption; Random Allocation; Rats; Rats, Wistar

2002
Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis.
    Bulletin of experimental biology and medicine, 2002, Volume: 134, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Barbiturates; Benzhydryl Compounds; Bilirubin; Cholestasis, Intrahepatic; Cytochrome P-450 Enzyme System; Female; Glutathione Transferase; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Urea

2002
Cholestasis induced by chronic treatment with alpha-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics.
    Archives of toxicology, 2003, Volume: 77, Issue:4

    Topics: 1-Naphthylisothiocyanate; Adenine Nucleotides; Animals; Calcium; Cholestasis, Intrahepatic; Disease Models, Animal; Energy Metabolism; Female; Injections, Intraperitoneal; Intracellular Membranes; Kidney; Membrane Potentials; Mitochondria; Mitochondrial Swelling; Phosphorylation; Rats; Rats, Wistar

2003
Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT).
    Toxicology, 2003, Aug-28, Volume: 190, Issue:3

    Topics: 1-Naphthylisothiocyanate; Adenosine Triphosphatases; Animals; Calcium; Cholestasis, Intrahepatic; Energy Metabolism; Female; Ion Channels; Membrane Potentials; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Oxygen Consumption; Random Allocation; Rats; Rats, Wistar

2003
Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice.
    Biochemical pharmacology, 2005, Jul-01, Volume: 70, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Gene Expression Profiling; Liver; Male; Mice; Nitric Oxide Donors; Pyrrolidines

2005
Protective response of the Ah receptor to ANIT-induced biliary epithelial cell toxicity in see-through medaka.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 102, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Bile Ducts, Intrahepatic; Bilirubin; Cell Line, Tumor; Cholestasis, Intrahepatic; Cloning, Molecular; Cytochrome P-450 CYP1A1; Disease Models, Animal; Drug Antagonism; Enzyme Induction; Epithelial Cells; Gallbladder; Gene Expression; Injections, Intraperitoneal; Liver; Male; Mice; Oryzias; Pigmentation; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; RNA, Messenger

2008
[Role of early growth response factor-1 signal pathway in acute intrahepatic cholestatic hepatic injury in rats].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2008, Volume: 16, Issue:3

    Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Chemokine CXCL1; Chemokine CXCL2; Cholestasis, Intrahepatic; Early Growth Response Protein 1; Interleukin-6; Liver; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha

2008
Alterations of high density lipoproteins in experimental intrahepatic cholestasis in the rat induced by administration of alpha-naphthylisothiocyanate.
    Journal of biochemistry, 1984, Volume: 95, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Electrophoresis, Polyacrylamide Gel; Lipids; Lipoproteins, HDL; Male; Rats; Rats, Inbred Strains

1984
Development of intrahepatic cholestasis by alpha-naphthylisothiocyanate in rats.
    Gastroenterology, 1982, Volume: 82, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cell Membrane Permeability; Cholestasis, Intrahepatic; Disease Models, Animal; Liver; Male; Rats; Rats, Inbred Strains; Sulfobromophthalein; Taurocholic Acid; Time Factors

1982
Mechanism of elevation of serum alkaline phosphatase activity in biliary obstruction: an experimental study.
    Clinica chimica acta; international journal of clinical chemistry, 1980, Oct-23, Volume: 107, Issue:1-2

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bile; Cell Membrane; Cholestasis; Cholestasis, Intrahepatic; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Liver; Male; Molecular Weight; Rats

1980
Scanning electron microscopy on the rat liver with alpha-naphthylisothiocyanate- induced cholestasis.
    Gastroenterologia Japonica, 1980, Volume: 15, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Canaliculi; Cholestasis, Intrahepatic; Liver; Male; Microscopy, Electron, Scanning; Rats; Thiocyanates

1980
Biliary epithelial cell proliferation following alpha-naphthylisothiocyanate (ANIT) treatment: relationship to bile duct obstruction.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1995, Volume: 26, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Ducts, Intrahepatic; Bilirubin; Bromodeoxyuridine; Cell Division; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Epithelium; Hyperplasia; Kinetics; Liver; Male; Rats; Rats, Sprague-Dawley

1995
Sympathetic nerves, but not the adrenal gland, contribute to elevated plasma levels of met-enkephalin in rats with acute cholestatic hepatitis.
    Regulatory peptides, 1993, Jul-23, Volume: 46, Issue:3

    Topics: 1-Naphthylisothiocyanate; Adrenal Glands; Adrenalectomy; Aminopeptidases; Animals; Cholestasis, Intrahepatic; Chromatography, High Pressure Liquid; Disease Models, Animal; Enkephalin, Methionine; Hepatitis, Animal; Male; Neprilysin; Portal Vein; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical; Sympathetic Nervous System

1993
The inhibitory effect of SA3443, a novel cyclic disulfide compound, on alpha-naphthyl isothiocyanate-induced intrahepatic cholestasis in rats.
    Clinical and experimental pharmacology & physiology, 1993, Volume: 20, Issue:9

    Topics: 1-Naphthylisothiocyanate; Adjuvants, Immunologic; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Azocines; Bile; Bilirubin; Cholestasis, Intrahepatic; Disulfides; Male; Rats; Rats, Wistar

1993
Cholestatic potentials of alpha-naphthylisothiocyanate (ANIT) and beta-naphthylisothiocyanate (BNIT) in the isolated perfused rat liver.
    Biochemical pharmacology, 1993, Dec-03, Volume: 46, Issue:11

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Isomerism; Liver; Male; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Time Factors

1993
Abnormal lipoproteins in the ANIT-treated rat: a transient and reversible animal model of intrahepatic cholestasis.
    Journal of lipid research, 1996, Volume: 37, Issue:5

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Disease Models, Animal; Fat Emulsions, Intravenous; Female; Humans; Lecithin Cholesterol Acyltransferase Deficiency; Lipolysis; Lipoproteins; Rats; Rats, Sprague-Dawley; Time Factors

1996
ANIT-induced disruption of biliary function in rat hepatocyte couplets.
    Toxicological sciences : an official journal of the Society of Toxicology, 1999, Volume: 47, Issue:2

    Topics: 1-Naphthylisothiocyanate; Actins; Adenosine Triphosphate; Animals; Bile Ducts, Intrahepatic; Cholestasis, Intrahepatic; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Wistar; Toxicity Tests; Vacuoles

1999
Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 281, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Cholestasis, Intrahepatic; Cyclic AMP; Disease Models, Animal; Liver; Male; Organ Size; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2001
[Effects of urso-deoxycholic acid (UDCA) on alpha-naphthyl-isothiocyanate (ANIT) induced intrahepatic cholestasis in rats].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1992, Volume: 89, Issue:10

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Rats; Rats, Wistar; Ursodeoxycholic Acid

1992
Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo.
    Hepatology (Baltimore, Md.), 1992, Volume: 16, Issue:5

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Bilirubin; Carbon Tetrachloride; CHO Cells; Cholestasis, Intrahepatic; Cricetinae; DNA; Hepatectomy; Hepatocyte Growth Factor; Humans; L-Lactate Dehydrogenase; Liver; Liver Regeneration; Male; Mice; Mice, Inbred BALB C; Organ Size; Recombinant Proteins

1992
Reduction of alpha-naphthylisothiocyanate-induced hepatotoxicity by recombinant human hepatocyte growth factor.
    Endocrinology, 1992, Volume: 131, Issue:6

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis, Intrahepatic; Hepatocyte Growth Factor; Liver; Male; Necrosis; Rats; Recombinant Proteins

1992
Protection against alpha-naphthylisothiocyanate-induced liver injury by decreased hepatic non-protein sulfhydryl content.
    Biochemical pharmacology, 1991, Aug-22, Volume: 42, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Bile; Bile Acids and Salts; Bilirubin; Buthionine Sulfoximine; Cholestasis, Intrahepatic; gamma-Glutamyltransferase; Glutathione; Ketones; Liver; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred Strains

1991
Relationship between alpha-naphthylisothiocyanate-induced liver injury and elevations in hepatic non-protein sulfhydryl content.
    Biochemical pharmacology, 1991, Aug-22, Volume: 42, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Bile; Bile Ducts; Bilirubin; Cholestasis, Intrahepatic; gamma-Glutamyltransferase; Glutathione; Liver; Male; Rats; Rats, Inbred Strains

1991
Mechanism of gamma-glutamyl transpeptidase release in serum during intrahepatic and extrahepatic cholestasis in the rat: a histochemical, biochemical and molecular approach.
    Hepatology (Baltimore, Md.), 1990, Volume: 11, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Ducts, Intrahepatic; Bilirubin; Blotting, Northern; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Common Bile Duct; gamma-Glutamyltransferase; Histocytochemistry; Ligation; Liver; Male; Necrosis; Rats; Rats, Inbred Strains; RNA, Messenger

1990
Increased paracellular permeability in intrahepatic cholestasis induced by carmustine (BCNU) in rats.
    Gastroenterology, 1991, Volume: 101, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Biliary Tract; Carbon Radioisotopes; Carmustine; Cell Membrane Permeability; Cholestasis, Intrahepatic; Horseradish Peroxidase; Male; Phosphates; Rats; Rats, Inbred Strains; Sucrose; Taurocholic Acid

1991
[The influences of endogenous bile acids on maltase and alkaline phosphatase activities in intrahepatic cholestasis rats].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1989, Volume: 109, Issue:9

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; alpha-Glucosidases; Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Male; Rats; Rats, Inbred Strains

1989
Bile secretory function of intrahepatic biliary epithelium in the rat.
    The American journal of physiology, 1989, Volume: 257, Issue:1 Pt 1

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Ducts, Intrahepatic; Cholestasis, Intrahepatic; Epithelium; Histocytochemistry; Hyperplasia; Immunohistochemistry; Kinetics; Ligation; Liver; Male; Rats; Rats, Inbred Strains; Secretin

1989
Plasma alkaline phosphodiesterase I in intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.
    Clinical science (London, England : 1979), 1988, Volume: 75, Issue:1

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Cholestasis, Intrahepatic; Chromatography, Gel; Dose-Response Relationship, Drug; Phosphodiesterase I; Phosphoric Diester Hydrolases; Rats

1988
[Active principle in a capillaris compound in the treatment of experimental acute jaundice in rats].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1985, Volume: 5, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Iridoids; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Plant Extracts; Plants, Medicinal; Pyrans; Rats; Rats, Inbred Strains

1985
[Preliminary experimental study of radix Notoginseng in an injectable form on its disicterogenic and cholagogue action].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1985, Volume: 5, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis, Intrahepatic; Female; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Plant Extracts; Plants, Medicinal; Rabbits; Rats

1985
Drug-induced intrahepatic cholestasis: characterization of different pathomechanisms.
    Archives of toxicology, 1987, Volume: 60, Issue:1-3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis, Intrahepatic; Estradiol; Ethinyl Estradiol; In Vitro Techniques; Liver; Microscopy, Electron; Perfusion; Rats; Rats, Inbred Strains

1987