1-naphthylisothiocyanate has been researched along with Chemical and Drug Induced Liver Injury in 107 studies
*Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (16.82) | 18.7374 |
| 1990's | 15 (14.02) | 18.2507 |
| 2000's | 22 (20.56) | 29.6817 |
| 2010's | 40 (37.38) | 24.3611 |
| 2020's | 12 (11.21) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Huang, C; Liu, F; Liu, J; Meng, C; Xia, C | 1 |
| Ahmed A Saad, A; Baldi, S; Refat, M; Wu, X; Zhang, G; Zheng, F | 1 |
| Fujimoto, T; Funakoshi, T; Ikeda, T; Kawaguchi, S; Nakai, K; Okamura, T; Otake, S; Saito, Y; Takahashi, K; Tomonari, Y; Uchida, H; Yamamoto, D | 1 |
| Bai, L; Huang, X; Jiang, Z; Liu, L; Nong, C; Sun, L; Wang, X; Xue, R; Zhang, L; Zou, M | 1 |
| Fan, FB; Li, WK; Li, YF; Li, YY; Ma, YM; Shi, R; Wang, GF; Wang, TM; Wu, JS; Zan, B; Zheng, M; Zou, J | 1 |
| Dai, M; Lin, H; Liu, A; Xu, G; Yang, J; Zheng, X | 1 |
| Guo, Q; Ji, H; Li, L; Li, T; Wang, X; Xu, L; Zheng, R; Zhou, M | 1 |
| Du, Z; Lin, J; Liu, J; Liu, P; Liu, W; Liu, X; Qi, L; Qiu, J; Wang, X; Xie, G; Yan, J | 1 |
| Chai, Y; Heng, C; Huang, X; Jiang, Z; Liu, B; Miao, Y; Sun, L; Wang, X; Wu, Z; Yang, H; Yang, T; Yu, Q; Yuan, Z; Zhang, L; Zhou, Y | 1 |
| Lin, C; Liu, C; Liu, F; Lu, Z; Wang, M; Yao, Y; Zhang, Q; Zhang, R; Zhu, C | 1 |
| Feng, SL; Jin, H; Yuan, Z; Zhang, J; Zhu, WT | 1 |
| Dai, M; Li, S; Liu, A; Lu, Z; Luo, J; Luo, Y; Qiu, J; Yang, J; Zheng, X | 1 |
| Cao, YF; Fang, ZZ; Gonzalez, FJ; Krausz, KW; Meng, R; Tanaka, N; Wang, H | 1 |
| Han, H; Liu, X; Sheng, T; Wang, Z; Xu, L; Zhang, T | 1 |
| Ding, L; Li, J; Wang, Z; Yang, L; Zhang, B | 1 |
| Chen, H; Fang, J; Gong, Z; Huang, T; Li, W; Liu, X; Mi, S; Min, J; Wang, N; Wang, Q; Wu, T; Zhang, Y; Zhao, W; Zhu, C | 1 |
| Han, H; Wang, Z; Xiong, K; Xu, L; Zhang, T | 1 |
| Bi, Y; Fan, G; Gao, X; Han, L; Li, C; Wang, X; Zhang, Y | 1 |
| Chen, M; Jin, YB; Mao, JX; Ning, CT; Wang, GW; Wang, R; Wu, QH; Zhang, XL | 1 |
| Feng, F; Zhu, G | 1 |
| Bi, KS; Li, Q; Lin, S; Liu, R; Wang, Q; Wang, TY; Xu, HR; Zhang, XN | 1 |
| Gu, Y; Li, S; Song, F; Wang, R; Wang, Y; Wu, B; Yuan, Y | 1 |
| Jiang, L; Shan, Q; Tian, C; Wang, L; Zhang, T | 1 |
| Cline-Fedewa, H; Copple, BL; Flick, MJ; Joshi, N; Kopec, AK; Luyendyk, JP; O'Brien, KM; Towery, KL; Williams, KJ | 1 |
| Chen, M; Jiang, ZZ; Li, X; Sun, LX; Wang, T; Xu, ZM; Zhang, LY; Zhao, GL; Zhou, ZX | 1 |
| Chen, XL; Huo, XK; Liu, KX; Liu, Q; Liu, ZH; Meng, Q; Sun, HJ; Sun, PY; Wang, CY; Yao, JH | 1 |
| Jia, L; Li, J; Li, R; Li, Y; Ma, X; Wang, J; Wang, L; Wang, R; Wen, R; Xiao, X; Zhao, Y; Zhu, Y | 1 |
| Imaoka, M; Masubuchi, N; Mizumaki, K; Nishiya, T; Okazaki, O | 1 |
| Church, RJ; Ellinger-Ziegelbauer, H; Hall, L; Harrill, AH; McDuffie, JE; Otieno, M; Singh, B; Sonee, M; Watkins, PB | 1 |
| Chen, H; Huang, X; Li, W; Liu, C; Mi, S; Min, J; Wang, N; Wang, Q; Yi, L; Zhang, R; Zhao, W; Zhu, C | 1 |
| Chen, H; Chen, Z; Li, J; Liu, L; Ma, X; Niu, M; Su, H; Wang, J; Wang, R; Wei, Z; Xiao, X; Zhao, Q; Zhao, Y; Zhu, Y | 1 |
| Cheng, Y; Dai, M; Gonzalez, FJ; Guo, B; Huang, J; Liu, A; Lu, C; Luo, M; Song, D; Tan, Z; Yang, J; Ye, M | 1 |
| Joshi, N; Kopec, AK; Luyendyk, JP; Ray, JL | 2 |
| Gong, J; Han, H; Tang, X; Wang, Z; Yang, F; Yang, L; Yang, Q | 1 |
| Cai, Y; Cao, YF; Du, Z; Fang, ZZ; Fu, ZW; Gao, P; Gonzalez, FJ; Jiang, CT; Krausz, KW; Lu, D; Sun, HZ; Tanaka, N; Yao, Z; Zhang, C; Zhang, WH; Zhu, ZT | 1 |
| Huang, YQ; Li, HT; Li, JY; Li, K; Li, PY; Li, RS; Liu, W; Ma, X; Wang, J; Wang, JB; Wei, SZ; Xiao, XH; Zhao, YL; Zhou, HQ; Zhu, Y | 1 |
| Duke, DS; Mendelson, KG; Schwartz, MZ; Thatch, KA; Yoo, EY | 1 |
| He, Y; Hu, Z; Li, W; Wang, C; Wang, Z; Xiong, A; Yang, L | 1 |
| Cantor, GH; Copple, BL; Kirchhofer, D; Luyendyk, JP; Mackman, N; Wang, R | 1 |
| Shan, LM; Wang, JB; Xiao, XH; Zhao, YL; Zhou, GD | 1 |
| Aleksunes, LM; Cui, YJ; Goedken, MJ; Klaassen, CD; Tanaka, Y | 1 |
| DING, Y; GAO, Y; HUANG, ZH; KANG, SX; MEI, H; PENG, HM; ZHAO, L | 1 |
| Cao, HX; Jiang, XG; Liu, L; Lu, HT; Sun, H; Sun, WJ; Wang, P; Wang, XJ; Wu, ZM; Zhang, GM; Zhou, J | 1 |
| Haber, MM; Katz, MS; Schwartz, MZ; Thatch, KA | 1 |
| Fukami, T; Higuchi, S; Kobayashi, M; Mizuno, K; Nakajima, M; Tsuneyama, K; Yokoi, T | 1 |
| Luyendyk, JP; Mackman, N; Sullivan, BP | 1 |
| Cantor, GH; Flanagan, KC; Jaeschke, H; Luyendyk, JP; Mackman, N; Slusser, JG; Williams, CD | 1 |
| Bejar, J; Hayari, L; Mogilner, JG; Pollak, Y; Razon, H; Sukhotnik, I; Sylvester, KG | 1 |
| Ding, LL; Dou, W; Wang, ZT; Yang, L; Zhan, CS; Zhang, BF | 1 |
| Kim, HY; Lee, SM; Park, J | 1 |
| Cullen, JM; Faiola, B; Jordan, HL; Kimbrough, CL; Melich, DH; Miller, RT; Peterson, RA; Prescott, JS | 1 |
| He, Y; Wan, YJ; Wang, Z; Xiong, A; Xu, Y; Yang, F; Yang, L | 1 |
| Fu, SS; Han, J; Jin, SX; Jin, SY; Li, RS; Lv, JL; Xiao, XH; Yuan, HL | 1 |
| Li, G; Wu, L; Zhu, J | 1 |
| Charuel, C; Clayton, TA; Everett, JR; Hanton, G; Le Net, JL; Lindon, JC; Nicholson, JK; Provost, JP | 1 |
| Beckwith-Hall, BM; Holmes, E; Lindon, JC; Nicholson, JK; Thompson, NA | 1 |
| Lee, G; Maher, JJ; Vierling, JM; Wang, H; Xu, J | 1 |
| Li, X; Li, Z; Pei, F; Wu, H; Wu, Y; Zhang, X | 1 |
| Adler, R; Amacher, DE; Herath, A; Townsend, RR | 1 |
| Choi, J; Jung, HJ; Kim, WB; Lee, JH; Lee, KT; Park, HJ; Park, JK; Park, KK | 1 |
| Azmi, J; Griffin, JL; Holmes, E; Nicholson, JK; Shore, RF | 1 |
| Brown, EJ; Kodali, P; Lahiji, PA; Maher, JJ; Wu, P | 1 |
| Barsky, L; Crooks, GM; Ge, S; Rountree, CB; Senadheera, S; Zhu, J | 1 |
| Ohtani, N | 1 |
| Ikeda, Y; Imai, E; Ito, K; Nose, T; Sato, I; Tajima, S; Takebe, H | 1 |
| Hanzlik, RP; Traiger, GJ; Vyas, KP | 1 |
| Fregnan, GB; Frigerio, L; Porta, R; Prada, M; Ruggieri, F | 1 |
| Kinoshita, H; Kuroiwa, Y; Takabatake, E; Tanaka, E; Yamamoto, T | 1 |
| Fuchshofen, M; Heusler, H; Lutz, B; Mora, E; Richter, E | 1 |
| Jean, PA; Roth, RA | 1 |
| Inoue, T; Kamogawa, A; Ohta, S; Sakurai, N; Sato, N; Shinoda, M | 1 |
| Bailie, MB; Carter, GW; Dahm, LJ; Harris, RR; Peters-Golden, M; Roth, RA | 1 |
| Ohta, S; Sato, N; Shinoda, M; Tu, SH | 1 |
| Lai, TY; Lin, JG; Lin, WC; Wu, YW | 1 |
| Hill, DA; Jean, PA; Roth, RA | 1 |
| Aoki, Y; Itoh, H; Numakami, K; Ogawa, Z | 1 |
| Harada, N; Kongo, M; Ohta, Y; Sasaki, E | 1 |
| Imai, K; Ishizu, T; Kaku, TI; Kato, Y; Liu, KX; Santa, T; Sugiyama, Y; Yagi, A | 1 |
| Braden, TK; Paterson, DA; Reily, MD; Robertson, DG; Sigler, RE; Wells, DF | 1 |
| Chen, JC; Lin, CC; Lin, JG; Lin, KJ; Tsai, CC; Tsauer, W | 1 |
| Antti, H; Azmi, J; Griffin, JL; Holmes, E; Johansson, E; Nicholson, JK; Shore, RF | 1 |
| Chang, YS; Ho, LK; Lin, CC; Lu, KL; Tsai, CC | 1 |
| Hofstetter, GJ; Richter, E; Seifert, H | 1 |
| Breschi, MC; Ducci, M; Giusiani, M; Mazzanti, L; Palagi, U; Poggi, G; Tacca, M | 1 |
| Cooper, P | 1 |
| El-Hawari, AM; Plaa, GL | 1 |
| Plaa, GL; Priestly, BG | 1 |
| Hanasono, GK; Plaa, GL; Witschi, H | 1 |
| Fujita, T; Iwasaki, T; Kumazawa, N; Nakamura, H; Ohta, S; Shinoda, M | 1 |
| Babini, G; Calcamuggi, G; Dughera, L; Emanuelli, G; Lanzio, M | 1 |
| Ishizuka, O; Kamogawa, A; Kumazawa, N; Ohta, S; Shinoda, M | 1 |
| Klaassen, CD; Liu, J; Madhu, C; Maziasz, TJ | 1 |
| Etoh, H; Ishikawa, A; Misawa, S; Nakano, M; Tanaka, E | 1 |
| Kamogawa, A; Kumazawa, N; Ohta, S; Shinoda, M; Tu, SH | 1 |
| Elcombe, C; Nicholson, JK; Sanins, SM; Timbrell, JA | 1 |
| Ito, C; Morishita, S; Saeki, K; Saito, T; Shoji, M; Tanaka, A | 1 |
| Hisano, T; Kohno, M; Shibata, H | 1 |
| Ito, K; Nishimura, N; Tajima, S | 1 |
| Iijima, I; Matsumoto, M; Matsuoka, Y; Saiga, Y | 1 |
| Aoki, Y; Itoh, H; Tanigawa, K | 1 |
| Aburada, M; Harada, M; Maeda, S; Miyamoto, Y; Takeda, S | 1 |
107 other study(ies) available for 1-naphthylisothiocyanate and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Homeostasis; Liver; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Receptors, Cytoplasmic and Nuclear; Tandem Mass Spectrometry | 2022 |
7, 8-Dihydroxy-4-methyl coumarin alleviates cholestasis via activation of the Farnesoid X receptor in vitro and in vivo.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Coumarins; Liver; Liver Diseases; Mice; Molecular Docking Simulation; Receptors, Cytoplasmic and Nuclear | 2023 |
Effects of microsampling on toxicity evaluation of 1-naphthylisothiocyanate (ANIT), a hepatotoxic substance, in a mouse toxicity study.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Necrosis | 2023 |
The role of invariant natural killer T cells in experimental xenobiotic-induced cholestatic hepatotoxicity.
Topics: 1-Naphthylisothiocyanate; Animals; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 Enzyme System; Cytokines; Inflammation; Liver; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Natural Killer T-Cells | 2020 |
Yinchenzhufu decoction protects against alpha-naphthylisothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Homeostasis; Inflammation Mediators; Keratin-19; Male; Metabolomics; Mice | 2020 |
Cholestatic models induced by lithocholic acid and α‑naphthylisothiocyanate: Different etiological mechanisms for liver injury but shared JNK/STAT3 signaling.
Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Lithocholic Acid; Male; MAP Kinase Signaling System; Metabolome; Mice; Mice, Inbred ICR | 2020 |
Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway.
Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis; Cinnamates; Hepatocytes; Iridoid Glucosides; Male; Mice, Inbred C57BL; Protective Agents; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2020 |
Metabolomics analysis delineates the therapeutic effects of Huangqi decoction and astragalosides on α-naphthylisothiocyanate (ANIT) -induced cholestasis in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Male; Metabolomics; Rats; Rats, Wistar; Saponins | 2021 |
SEW2871 attenuates ANIT-induced hepatotoxicity by protecting liver barrier function via sphingosine 1-phosphate receptor-1-mediated AMPK signaling pathway.
Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Liver; Mice; Oxadiazoles; Signal Transduction; Sphingosine-1-Phosphate Receptors; Tandem Mass Spectrometry; Thiophenes | 2021 |
Network pharmacology-based mechanism prediction and pharmacological validation of Xiaoyan Lidan formula on attenuating alpha-naphthylisothiocyanate induced cholestatic hepatic injury in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Drugs, Chinese Herbal; Inflammation; Male; Metabolic Networks and Pathways; Molecular Docking Simulation; NF-kappa B; Protective Agents; Protein Interaction Maps; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2021 |
A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholangitis; Cholestasis; Disease Models, Animal; Hepatitis; Hepatocytes; Hypericum; Kaempferols; Liver; Liver Diseases; Luteolin; Male; Oxidative Stress; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley | 2021 |
Fenofibrate reverses liver fibrosis in cholestatic mice induced by alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Actins; Animals; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Cholestasis; Collagen Type I; Fenofibrate; Inflammation; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Models, Animal; Peptide Fragments; PPAR alpha; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2021 |
Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Gene Expression Regulation; Glycyrrhetinic Acid; Glycyrrhizic Acid; Least-Squares Analysis; Liver; Male; Mass Spectrometry; Metabolomics; Mice | 2017 |
Analyzing the hepatoprotective effect of the Swertia cincta Burkillextract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Chemical and Drug Induced Liver Injury; Cholestasis; Gene Expression Regulation; Liver; Male; Membrane Transport Proteins; Plant Extracts; Rats; Rats, Wistar; RNA, Messenger; Swertia | 2017 |
Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; HEK293 Cells; Hep G2 Cells; Hepatocytes; Humans; Lipopolysaccharides; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Receptors, Cytoplasmic and Nuclear; Resveratrol; Signal Transduction; Stilbenes | 2018 |
Pharmacokinetic and Pharmacodynamic Properties of Rosmarinic Acid in Rat Cholestatic Liver Injury.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Bile; Chemical and Drug Induced Liver Injury; Cholestasis; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Limit of Detection; Liver; Male; Models, Biological; Rats, Sprague-Dawley; Reproducibility of Results; Rosmarinic Acid; Spectrophotometry, Ultraviolet | 2018 |
Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Discriminant Analysis; Gene Expression Regulation; Iridoid Glucosides; Male; Metabolome; Metabolomics; PPAR alpha; Principal Component Analysis; Protective Agents; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptor alpha | 2018 |
Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cytokines; Emodin; Hep G2 Cells; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2019 |
The hepatoprotective effects of Sedum sarmentosum extract and its isolated major constituent through Nrf2 activation and NF-κB inhibition.
Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Humans; Liver; Male; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Plant Extracts; Protective Agents; Rats, Sprague-Dawley; Sedum; Triterpenes | 2019 |
UPLC-MS-based metabonomic analysis of intervention effects of Da-Huang-Xiao-Shi decoction on ANIT-induced cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Liver; Male; Mass Spectrometry; Rats, Sprague-Dawley | 2019 |
A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Liver; Male; Metabolome; Metabolomics; Mice, Inbred C57BL; Tandem Mass Spectrometry | 2019 |
Salvianolic acid B protects against ANIT-induced cholestatic liver injury through regulating bile acid transporters and enzymes, and NF-κB/IκB and MAPK pathways.
Topics: 1-Naphthylisothiocyanate; Animals; Benzofurans; Carrier Proteins; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cholestasis; Cytokines; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Male; Membrane Glycoproteins; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Protective Agents; Rats, Sprague-Dawley; Signal Transduction | 2019 |
The hepatoprotective effect and chemical constituents of total iridoids and xanthones extracted from Swertia mussotii Franch.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Chemical and Drug Induced Liver Injury; Iridoids; Liver; Phytotherapy; Protective Agents; Rats, Wistar; Swertia; Xanthones | 2014 |
Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Antithrombin III; Bile Acids and Salts; Blood Coagulation; Blood Platelets; Chemical and Drug Induced Liver Injury; Cholestasis; Fibrinogens, Abnormal; Genotype; Liver; Liver Cirrhosis, Experimental; Male; Mice, Inbred C57BL; Mice, Knockout; Mutation; Necrosis; Peptide Hydrolases; Phenotype; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Serotonin; Signal Transduction | 2015 |
Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms.
Topics: 1-Naphthylisothiocyanate; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Bile; Biomarkers; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis; Cytoprotection; Disease Models, Animal; DNA, Mitochondrial; Inflammation Mediators; Liver; Male; Membrane Transport Proteins; Neutrophil Infiltration; Oxidative Stress; Rats, Sprague-Dawley; Resveratrol; Stilbenes | 2014 |
Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cholestenones; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Homeostasis; Humans; Liver; Male; Membrane Transport Proteins; Mice, Inbred C57BL; Protective Agents; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Time Factors; Transfection | 2015 |
Large dose means significant effect--dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; gamma-Glutamyltransferase; Hepatitis; Liver; Male; Paeonia; Phytotherapy; Pueraria; Rats; Salvia miltiorrhiza | 2015 |
Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Gene Expression Regulation; Liver; Male; Metabolome; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley | 2016 |
Beyond miR-122: Identification of MicroRNA Alterations in Blood During a Time Course of Hepatobiliary Injury and Biliary Hyperplasia in Rats.
Topics: 1-Naphthylisothiocyanate; Animals; Biliary Tract; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hyperplasia; Liver; Male; MicroRNAs; Rats, Sprague-Dawley | 2016 |
Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Iridoid Glucosides; Male; Protective Agents; Rats; Receptors, Cytoplasmic and Nuclear | 2016 |
Serum Metabolomic Profiling in a Rat Model Reveals Protective Function of Paeoniflorin Against ANIT Induced Cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Glucosides; Male; Metabolome; Monoterpenes; Rats; Rats, Sprague-Dawley | 2016 |
Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Cholestasis; Cytokines; Liver; Male; Mice; NF-kappa B; Phytotherapy; Plant Extracts; Polyphenols; Signal Transduction; STAT3 Transcription Factor | 2016 |
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Clopidogrel; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Activation; Purinergic P2Y Receptor Antagonists; Receptors, Proteinase-Activated; Serotonin; Ticlopidine; Xenobiotics | 2016 |
Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Homeostasis; Iridoid Glucosides; Liver; Mice; Mice, Inbred C57BL | 2016 |
Dose-dependent effects of alpha-naphthylisothiocyanate disconnect biliary fibrosis from hepatocellular necrosis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Liver; Liver Cirrhosis, Biliary; Male; Mice; Necrosis | 2017 |
Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Interleukin-6; Lipid Metabolism; Male; Mice, Inbred C57BL; Mice, Mutant Strains; NF-kappa B; PPAR alpha; Pyrimidines; STAT3 Transcription Factor | 2017 |
Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Cytokines; Genes, bcl-2; Glucosides; Liver; Mitochondria; Monoterpenes; Neutrophil Infiltration; Rats; Rats, Wistar; Signal Transduction | 2017 |
Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Epidermal Growth Factor; Female; Hepatocyte Growth Factor; Infusion Pumps, Implantable; Interleukin-6; Intestinal Absorption; Liver; Liver Regeneration; Parenteral Nutrition, Total; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2008 |
Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Discriminant Analysis; Disease Models, Animal; Liver; Liver Failure; Male; Metabolomics; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2008 |
Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Cholestasis; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Thromboplastin | 2009 |
Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Anthraquinones; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; gamma-Glutamyltransferase; Liver; Lyases; Male; Plant Roots; Rats; Rats, Sprague-Dawley; Rheum; Rhizome; Transaminases | 2009 |
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Branched DNA Signal Amplification Assay; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fluorescent Antibody Technique; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA | 2009 |
[Effect and mechanism of emodin on cholestatic hepatitis].
Topics: 1-Naphthylisothiocyanate; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Early Growth Response Protein 1; Emodin; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Liver Function Tests; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2009 |
Comparative study on the protective effects of Yinchenhao Decoction against liver injury induced by alpha-naphthylisothiocyanate and carbon tetrachloride.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Annonaceae; Aspartate Aminotransferases; Bilirubin; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Glutathione; Hepatocytes; Jaundice; Liver; Liver Diseases; Male; Malondialdehyde; Organ Size; Rats; Rats, Wistar; Superoxide Dismutase | 2009 |
Growth factor modulation of hepatic inflammation: a novel approach to the management of total parenteral nutrition-associated liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Female; Hepatocyte Growth Factor; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Liver; Liver Diseases; Liver Failure; Liver Function Tests; Parenteral Nutrition, Total; Rats; Rats, Sprague-Dawley; Short Bowel Syndrome; Tumor Necrosis Factor-alpha | 2010 |
Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Female; Interleukin-17; Mice; Mice, Inbred BALB C; Recombinant Proteins | 2010 |
Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Cholestasis; Disease Models, Animal; Female; Fibrinogen; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Receptor, PAR-1; Receptors, Proteinase-Activated; Xenobiotics | 2011 |
Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.
Topics: 1-Naphthylisothiocyanate; Animals; Blood Coagulation; CD11b Antigen; Chemical and Drug Induced Liver Injury; Chemokines; Cholestasis; Intercellular Adhesion Molecule-1; Liver; Male; Mice; Myeloid Cells; Neutrophil Activation; Neutrophils; Peroxidase; Thromboplastin; Xenobiotics | 2011 |
Effect of alpha-naphthylisothiocyanate-induced liver injury on intestinal adaptation in a rat model of short bowel syndrome.
Topics: 1-Naphthylisothiocyanate; Adaptation, Physiological; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Proliferation; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA; Enterocytes; Gene Expression Regulation; Intestine, Small; Male; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Short Bowel Syndrome | 2012 |
Protective effect of Danning tablet on acute livery injury with cholestasis induced by α-naphthylisothiocyanate in rats.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Anthraquinones; Antioxidants; Bile; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Liver; Magnoliopsida; Male; Neutrophil Infiltration; Phytotherapy; Rats, Wistar; Stilbenes; Transaminases | 2012 |
Protective effects of Moutan Cortex Radicis against acute hepatotoxicity.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drugs, Chinese Herbal; Injections, Intraperitoneal; Liver; Male; Mice; Paeonia; Protective Agents; Rats; Rats, Sprague-Dawley; Transaminases | 2011 |
Effects of Kupffer cell depletion on acute alpha-naphthylisothiocyanate-induced liver toxicity in male mice.
Topics: 1-Naphthylisothiocyanate; Analysis of Variance; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cholangitis; Clodronic Acid; Gallbladder; Hyperplasia; Immunohistochemistry; Ki-67 Antigen; Kupffer Cells; Liposomes; Liver; Male; Mice; Mice, Inbred C57BL | 2013 |
Evaluation of the protective effect of Rhei Radix et Rhizoma against α-naphthylisothiocyanate induced liver injury based on metabolic profile of bile acids.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Male; Plant Extracts; Plant Roots; Protective Agents; Rats; Rats, Wistar; Rheum; Rhizome | 2012 |
Changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate-induced experimental hepatic injury after Yinchenhao Decoction () treatment.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Liver; Models, Biological; Rats; Rats, Sprague-Dawley; Validation Studies as Topic | 2012 |
[Study on hepatic-protective effect of "yinzhihuang" granula].
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Galactosamine; Liver; Mice; Protective Agents; Rats | 2001 |
An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Creatinine; Cysteine; Disease Models, Animal; Ethionine; Formic Acid Esters; Injections, Intraperitoneal; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Taurine | 2003 |
A metabonomic investigation of hepatotoxicity using diffusion-edited 1H NMR spectroscopy of blood serum.
Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Lipoproteins; Liver Diseases; Magnetic Resonance Spectroscopy; Male; Principal Component Analysis; Rats; Rats, Sprague-Dawley | 2003 |
Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Biomarkers; Chemical and Drug Induced Liver Injury; Chemokines, CXC; Cholestasis; Enzyme-Linked Immunosorbent Assay; Hydroxyproline; Leukocyte Count; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils | 2004 |
Comparison of metabolic profiles from serum from hepatotoxin-treated rats by nuclear-magnetic-resonance-spectroscopy-based metabonomic analysis.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hydrazines; Liver Diseases; Magnetic Resonance Spectroscopy; Male; Pattern Recognition, Automated; Principal Component Analysis; Rats; Rats, Wistar; Toxins, Biological; Xenobiotics | 2005 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertrophy; Liver Diseases; Male; Methylcellulose; Organ Size; Phenobarbital; Proteomics; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 2005 |
In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Ethionine; Fatty Liver; Galactosamine; gamma-Glutamyltransferase; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Lipids; Liver; Liver Diseases; Male; Plant Leaves; Rats; Rats, Sprague-Dawley | 2005 |
Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products.
Topics: 1-Naphthylamine; 1-Naphthylisothiocyanate; Animals; Blood Chemical Analysis; Body Fluids; Chemical and Drug Induced Liver Injury; Isocyanates; Liver; Liver Diseases; Magnetic Resonance Spectroscopy; Organ Specificity; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Urine | 2005 |
ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18.
Topics: 1-Naphthylisothiocyanate; Animals; CD18 Antigens; Cells, Cultured; Chemical and Drug Induced Liver Injury; Hepatocytes; Male; Mice; Mice, Inbred C57BL; Neutrophil Activation; Neutrophils | 2006 |
A CD133-expressing murine liver oval cell population with bilineage potential.
Topics: 1-Naphthylisothiocyanate; AC133 Antigen; Animals; Antigens, CD; Biomarkers; Bone Marrow Transplantation; Carbon Tetrachloride Poisoning; Cell Division; Cell Lineage; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dicarbethoxydihydrocollidine; Gene Expression Profiling; Glycoproteins; Immunophenotyping; Liver; Liver Regeneration; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Peptides; Radiation Chimera | 2007 |
[Experimental and clinical studies on enzymes of mitochondria in various liver diseases; with special reference to alcoholic liver disease (author's transl)].
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Humans; Liver Diseases, Alcoholic; Male; Mitochondria, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Ornithine Carbamoyltransferase; Rats; Sodium-Potassium-Exchanging ATPase; Succinate Cytochrome c Oxidoreductase | 1980 |
[Effects of cianidanol (KB-53) on experimental liver injury in mice--histopathological, histochemical and enzyme-histochemical studies].
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Benzopyrans; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver Injury; Flavonoids; Glucose-6-Phosphatase; Histocytochemistry; Liver; Liver Diseases; Male; Mice; Mice, Inbred ICR | 1983 |
Effect of thiocarbonyl compounds on alpha-naphthylisothiocyanate-induced hepatotoxicity and the urinary excretion of [35S]alpha-naphthylisothiocyanate in the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Disulfiram; Ditiocarb; Ethionamide; Male; Rats; Rats, Inbred Strains; Sulfates; Thiocarbamates; Thiocyanates | 1984 |
Therapeutic properties of dihydroxy-dibutylether on sub-acute liver damage induced by several hepatotoxic agents in rats.
Topics: 1-Naphthylisothiocyanate; 1-Propanol; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Ethers; Ethionine; Female; Liver Diseases; Male; Propanols; Rats; Rats, Inbred Strains | 1982 |
Pharmacokinetic studies of trimethadione and its metabolite in rats with chemical-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dimethadione; Galactosamine; Injections, Intravenous; Kinetics; Male; Oxazoles; Rats; Time Factors; Trimethadione | 1981 |
[Lidocain clearance after oral and intravenous application in rats with low grade ANIT-cholestasis and galactosamine-induced hepatitis (author's transl)].
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biological Availability; Chemical and Drug Induced Liver Injury; Cholestasis; Galactosamine; Hepatitis; Injections, Intravenous; Lidocaine; Liver; Male; Rats | 1980 |
Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Glutathione; Isomerism; Liver; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley | 1995 |
[Protective effects of the stem of Berchemia racemosa Sieb. et Zucc. on experimental liver injuries].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Liver Diseases; Male; Plant Stems; Rats; Rats, Wistar | 1995 |
Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Hydroxyurea; Indoles; Inflammation; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Liver; Liver Diseases; Male; Phenyl Ethers; Rats; Rats, Sprague-Dawley | 1995 |
[Protective effects of Taiwan crude drugs on experimental liver injuries].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Liver Diseases; Male; Methanol; Rats; Rats, Wistar; Water | 1993 |
Effect of pretreatment of rats with an urinary preparation on liver injuries induced by carbon tetrachloride and alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholangitis; Glutathione; Humans; Hyperbilirubinemia; Lipid Peroxidation; Liver; Liver Diseases; Male; Rats; Rats, Wistar; Urine | 1998 |
Bile duct epithelial cells exposed to alpha-naphthylisothiocyanate produce a factor that causes neutrophil-dependent hepatocellular injury in vitro.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Cathepsin G; Cathepsins; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemotaxis, Leukocyte; Culture Media, Conditioned; Epithelial Cells; Male; Neutrophils; Pancreatic Elastase; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Serine Endopeptidases | 1999 |
A kinetic model of mitochondrial aspartate aminotransferase transmigration in hepatobiliary disorders.
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholestasis; Computer Simulation; Indocyanine Green; Isoenzymes; Kinetics; Liver Diseases; Male; Mitochondria; Models, Biological; Rats; Rats, Wistar; Time Factors | 1999 |
Change in hepatic antioxidant defense system with liver injury development in rats with a single alpha-naphthylisothiocyanate intoxication.
Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Ascorbic Acid; Bile Acids and Salts; Bilirubin; Cattle; Chemical and Drug Induced Liver Injury; Cholangitis; Drug Administration Schedule; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Selenium | 1999 |
Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Radioisotopes; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytosol; Dipeptides; Gastric Mucosa; Glycyrrhizic Acid; Intestinal Absorption; Intestinal Mucosa; Intestines; Liver; Male; Microvilli; Peptides, Cyclic; Rabbits; Rats; Rats, Wistar | 2000 |
Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants.
Topics: 1-Naphthylisothiocyanate; Aminophenols; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethylamines; Furosemide; Kidney; Kidney Diseases; Liver; Magnetic Resonance Spectroscopy; Male; Pattern Recognition, Automated; Quantitative Structure-Activity Relationship; Rats; Rats, Wistar; Toxicity Tests; Toxicity Tests, Acute | 2000 |
Prophylactic effect of four prescriptions of traditional Chinese medicine on alpha-naphthylisothiocyanate and carbon tetrachloride induced toxicity in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholangitis; Disease Models, Animal; Drugs, Chinese Herbal; Hyperbilirubinemia; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar | 2001 |
Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Data Interpretation, Statistical; Liver Diseases; Magnetic Resonance Spectroscopy; Male; Multivariate Analysis; Rats; Rats, Sprague-Dawley; Xenobiotics | 2002 |
Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on alpha-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Liver; Liver Function Tests; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Silymarin; Taiwan | 2002 |
[Intravenous and oral galactose loading of rats suffering from galactosamine hepatitis and ANIT-cholestasis; comparison of the kinetics in vivo and the galactose metabolism in the liver in vitro (author's transl)].
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Enzyme Activation; Galactokinase; Galactosamine; Galactose; In Vitro Techniques; Injections, Intravenous; Kinetics; Liver; Male; Rats; Thiocyanates; Time Factors | 1979 |
Distribution and fate of alpha-naphthl-isothiocyanate (ANIT) in the organs and body fluids of the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Thin Layer; Male; Rats; Spectrophotometry, Ultraviolet; Thiocyanates | 1977 |
Hepatotoxic ANIT.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Female; Gallbladder Diseases; Male; Mice; Rats; Thiocyanates | 1977 |
alpha-Naphthylisothiocyanate (ANIT) hepatotoxicity and irreversible binding to rat liver microsomes.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glutathione; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Protein Binding; Rats; Thiocyanates | 1977 |
Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Hydrocarbons, Chlorinated; Lethal Dose 50; Liver; Male; Mice; Nicotine | 1976 |
Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Bilirubin; Blood Glucose; Chemical and Drug Induced Liver Injury; Chloroform; Diabetes Mellitus, Experimental; Ethane; Galactosamine; Hydrocarbons, Chlorinated; Insulin; Isocitrate Dehydrogenase; Liver; Male; Rats; Trichloroethylene; Triglycerides | 1975 |
[Protective effects of the fractions extracted from the callus of Acer nikoense Maxim. on alpha-naphthylisothiocyanate induced liver injury].
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis; Liver Diseases; Male; Plant Extracts; Rats; Rats, Inbred Strains; Trees | 1992 |
Endotoxin tolerance and polymyxin B modify liver damage and cholestasis induced by a single dose of alpha-naphthylisothiocyanate in the rat.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Endotoxins; Lead Poisoning; Liver; Male; Polymyxin B; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1992 |
[Effects of various methanol extracts of crude drugs on experimental subacute and chronic hepatic injury].
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chronic Disease; Drugs, Chinese Herbal; Ethanol; Male; Rats; Rats, Inbred Strains | 1992 |
The differential effects of hepatotoxicants on the sulfation pathway in rats.
Topics: 1-Naphthylisothiocyanate; 1-Propanol; Aflatoxin B1; Alanine Transaminase; Animals; Arylsulfotransferase; Bromobenzenes; Cadmium; Cadmium Chloride; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytosol; Dichloroethylenes; L-Iditol 2-Dehydrogenase; Liver; Liver Diseases; Male; Phosphoadenosine Phosphosulfate; Propanols; Rats; Rats, Inbred Strains; Sulfates; Thioacetamide | 1991 |
Influence of liver damage on antipyrine metabolite formation in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Antipyrine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Male; Rats; Rats, Inbred Strains | 1991 |
[Protective effects of various methanol extracts of crude drugs on experimental hepatic injury induced by alpha-naphthylisothiocyanate in rats].
Topics: 1-Naphthylisothiocyanate; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Depression, Chemical; Drugs, Chinese Herbal; Liver; Male; Methanol; Rats; Rats, Inbred Strains | 1991 |
Hepatotoxin-induced hypertaurinuria: a proton NMR study.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hydrazines; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Taurine; Thioacetamide | 1990 |
[Pharmacological effects of reiousan on experimental hepatic injuries and hepatic functions].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Ethanol; Galactosamine; Guinea Pigs; Liver Circulation; Male; Rats; Rats, Inbred Strains; Superoxides | 1989 |
Relation between blood clearance and hepatic uptake of 99mTc-phytate in rats with hepatic injury.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Ethionine; Galactosamine; Male; Organotechnetium Compounds; Phytic Acid; Radionuclide Imaging; Rats; Rats, Inbred Strains | 1989 |
Suppression of delayed-type hypersensitivity mediated by macrophage-like cells in mice with experimental liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver Injury; Dinoprostone; Drug Hypersensitivity; Hypersensitivity, Delayed; Indomethacin; Liver Diseases; Macrophages; Male; Mice; Mice, Inbred BALB C; Picryl Chloride; Prostaglandins E; Spleen; Superoxides; T-Lymphocytes, Regulatory | 1985 |
Effects of methyl (+)(3S)-1,2,3,4-tetrahydro-3-hydroxy-methyl-beta-carboline-2- carbodithioate (THC), a new hepatoprotective agent, on acute liver injuries induced by various hepatotoxic substances in mice and rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Carbolines; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; In Vitro Techniques; Lipid Peroxides; Male; Mice; Rats; Rats, Inbred Strains; Species Specificity; Triglycerides | 1987 |
Transmigration of mitochondrial GOT in cholestatic liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholestasis; Indicators and Reagents; Isoenzymes; Kinetics; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains | 1986 |
Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Galactosamine; Indocyanine Green; Lignans; Liver; Liver Function Tests; Male; Orotic Acid; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1985 |