Page last updated: 2024-08-21

1-naphthylisothiocyanate and Bile Duct Obstruction

1-naphthylisothiocyanate has been researched along with Bile Duct Obstruction in 140 studies

Research

Studies (140)

TimeframeStudies, this research(%)All Research%
pre-199027 (19.29)18.7374
1990's17 (12.14)18.2507
2000's17 (12.14)29.6817
2010's49 (35.00)24.3611
2020's30 (21.43)2.80

Authors

AuthorsStudies
Cai, J; Fang, S; Li, Y; Liu, S; Ma, Y; Shi, R; Wang, T; Wang, Z; Wu, J; Yang, L; Zou, J1
Barrera-Chimal, J; Bucio-Ortiz, L; Gomez-Quiroz, LE; Gutiérrez-Ruiz, MC; Lazzarini-Lechuga, R; López-Ramirez, J; Masso, F; Miranda-Labra, RU; Roma, MG; Salas-Silva, S; Simoni-Nieves, A; Souza, V1
Han, H; Shi, M; Tang, J; Zhang, T1
Huang, C; Liu, F; Liu, J; Meng, C; Xia, C1
Li, K; Ran, X; Wang, W; Wei, X; Wu, W; Xu, X; Zhang, T; Zhang, Y1
Jiang, T; Li, J; Liu, J; Liu, S; Luo, S; Lv, Z; Qian, B; Shi, J; Yang, Z; Zhao, Z; Zhou, L; Zhou, Y1
Gong, H; Gu, H; Guo, L; Hou, Z; Ma, J; Tang, T; Yan, M; Yang, Y; Zhang, B; Zhou, W; Zou, W1
Gao, Q; Guo, S; Li, G; Liu, D; Wang, C; Wang, X; Xu, Y; Zhang, C; Zu, Y1
Jiang, S; Liang, Y; Tang, L; Wang, W; Xu, C; Zhao, Y; Zhu, G1
Attar, R; Khalil, A; Malkani, N; Mumtaz, S; Sohail, I; Tahir, N1
Cai, J; Li, Y; Ma, Y; Peng, X; Shi, R; Tian, T; Wang, T; Wu, J; Zhang, L; Zou, J1
Ahmed A Saad, A; Baldi, S; Refat, M; Wu, X; Zhang, G; Zheng, F1
Jin, J; Li, Y; Liu, C; Qiu, FR; Song, G; Sun, X; Weng, F; Yan, D; Zhao, J; Zou, B1
Cao, P; Cheng, B; Gan, J; Hu, Y; Huang, J; Li, F; Li, X; Si, L; Wu, S; Xia, B; Yu, H; Zeng, H1
Han, J; Li, C; Liang, A; Liu, C; Liu, M; Liu, S; Meng, J; Pan, C; Qin, S; Tian, J; Wang, F; Wang, J; Wang, L; Yi, Y; Zhang, Y; Zhao, Y1
Cheng, X; Gao, Q; He, W; Li, G; Liu, D; Shang, T; Wang, C; Xiang, D; Xu, Y; Zhang, C; Zu, Y1
Heng, C; Huang, X; Jiang, Z; Li, L; Pang, J; Wang, X; Wei, C; Xia, Z; Yang, T; Zhang, L1
Bai, L; Huang, X; Jiang, Z; Liu, L; Nong, C; Sun, L; Wang, X; Xue, R; Zhang, L; Zou, M1
Hu, Q; Ji, H; Li, L; Li, T; Wang, X; Xu, L; Zheng, R1
Dai, M; Liu, A; Luo, Y; Xu, G; Xu, L; Yang, J; Zhang, H1
Huang, F; Shi, H; Tao, Y; Wu, H; Wu, X; Zhou, J; Zhu, H1
Chai, Y; Huang, X; Jiang, Z; Miao, Y; Sun, L; Wang, H; Wang, X; Wu, Z; Yang, T; Yu, Q; Yuan, Z; Zhang, L1
Guo, Q; Ji, H; Li, L; Li, T; Wang, X; Xu, L; Zheng, R; Zhou, M1
Chen, F; Hua, W; Lu, Q; Sun, Y; Tan, S; Tang, L; Zhang, S1
Chang, L; Dai, M; Liu, A; Xu, G; Yang, J; Zheng, X1
Du, Z; Lin, J; Liu, J; Liu, P; Liu, W; Liu, X; Qi, L; Qiu, J; Wang, X; Xie, G; Yan, J1
Feng, SL; Jin, H; Yuan, Z; Zhang, J; Zhu, WT1
Dai, M; Li, S; Liu, A; Lu, Z; Luo, J; Luo, Y; Qiu, J; Yang, J; Zheng, X1
Fan, Y; Li, G; Liu, J; Xu, T; Yu, H; Zhang, C; Zhang, Y; Zhou, L1
Dai, P; Lin, C; Liu, F; Ma, H; Ma, Y; Wang, M; Wang, Q; Xie, Y; Yao, Y; Zhang, K; Zhu, C1
Hu, P; Hu, Y; Huang, F; Jia, W; Liang, C; Liu, P; Wang, X; Xie, G; Yan, J; Zhao, A1
Han, H; Liu, X; Sheng, T; Wang, Z; Xu, L; Zhang, T1
Ding, J; Hassan, HM; Huang, X; Jiang, Z; Liu, J; Mei, H; Shu, T; Sun, L; Wang, X; Xu, D; Yang, T; Zhang, L; Zhou, W; Zhu, X1
Ding, L; Li, J; Wang, Z; Yang, L; Zhang, B1
Bothe, MK; Harleman, J; Meyer, C; Mueller, U; Queudot, JC; Roger, V; Westphal, M1
Dai, M; Gonzalez, FJ; Hu, X; Hua, H; Li, F; Lin, H; Liu, A; Xu, G; Yang, J1
Cui, SC; Gong, LK; Lu, HL; Ren, J; Wang, L; Wu, SY; Xing, GZ; Yan, XX; Zhang, YT1
Chen, H; Fang, J; Gong, Z; Huang, T; Li, W; Liu, X; Mi, S; Min, J; Wang, N; Wang, Q; Wu, T; Zhang, Y; Zhao, W; Zhu, C1
Han, H; Wang, Z; Xiong, K; Xu, L; Zhang, T1
Gao, SJ; He, X; Li, PY; Ma, X; Wei, SZ; Wen, JX; Xiao, XH; Yang, YX; Zhao, YL1
Inoue, A; Kishi, K; Koh, M; Miyazaki, H; Takitani, K; Tamai, H; Tamaki, H1
Deng, H; Deng, X; Li, Y; Shi, S; Shi, X; Wang, D; Wang, Y; Xu, Z; Yu, H; Zeng, B; Zhong, X1
Bao, HD; Cao, F; Dong, X; Gong, P; Liu, P; Liu, WH; Shang, YR; Wang, L; Wang, ZY; Zhu, LL1
Chen, Y; Fan, G; Feng, K; Li, Q; Liu, L; Ma, C; Mao, J; Qu, J; Wei, L; Xia, R; Xu, S; Yang, S; Yu, M; Zhang, W1
Feng, F; Zhu, G1
Groen, AK; Hoekstra, M; van der Geest, R; van der Sluis, RJ; Van Eck, M1
Gu, Y; Li, S; Song, F; Wang, R; Wang, Y; Wu, B; Yuan, Y1
Jia, L; Li, R; Liu, B; Liu, S; Shan, L; Song, X; Wang, J; Xiao, X; Zhang, P; Zhao, Y; Zhou, G1
Boyer, JL; Cai, SY; Mennone, A; Soroka, CJ1
Ding, L; Wang, Z; Yang, L; Zhan, C; Zhang, B1
Cline-Fedewa, H; Copple, BL; Flick, MJ; Joshi, N; Kopec, AK; Luyendyk, JP; O'Brien, KM; Towery, KL; Williams, KJ1
Chen, M; Jiang, ZZ; Li, X; Sun, LX; Wang, T; Xu, ZM; Zhang, LY; Zhao, GL; Zhou, ZX1
Jia, L; Li, J; Li, R; Li, Y; Ma, X; Wang, J; Wang, L; Wang, R; Wen, R; Xiao, X; Zhao, Y; Zhu, Y1
Ai, G; Huang, ZM; Xu, HJ; Yan, JY; Zhang, XJ1
Bi, KS; Chen, KL; Han, F; Mao, XJ; Yin, R; Zhang, XS; Zhu, HY1
Chen, C; Chen, Z; Jiao, W; Li, J; Li, R; Liu, H; Ma, X; Shen, H; Wang, J; Wang, L; Wang, R; Wei, S; Xiao, X; Zhang, Y; Zhao, Y; Zhu, Y1
Imaoka, M; Masubuchi, N; Mizumaki, K; Nishiya, T; Okazaki, O1
Chen, C; Chen, Z; Li, JY; Li, RY; Li, YG; Liu, B; Ma, X; Wang, JB; Wang, LF; Wang, RL; Wei, SZ; Xiao, XH; Zhao, YL; Zhu, Y1
Dong, LC; Dong, X; Fan, YX; Li, HJ; Li, P; Ma, J; Yu, Q1
Chen, H; Chen, Z; Li, J; Liu, L; Ma, X; Niu, M; Su, H; Wang, J; Wang, R; Wei, Z; Xiao, X; Zhao, Q; Zhao, Y; Zhu, Y1
Groothuis, GMM; Olinga, P; Pennings, JLA; Vatakuti, S1
Cheng, Y; Dai, M; Gonzalez, FJ; Guo, B; Huang, J; Liu, A; Lu, C; Luo, M; Song, D; Tan, Z; Yang, J; Ye, M1
Groen, AK; Hoekstra, M; Ouweneel, AB; van der Geest, R; van der Sluis, RJ; Van Eck, M1
Joshi, N; Kopec, AK; Luyendyk, JP; Ray, JL1
Gong, JT; Tang, XW; Wang, GY; Wang, ZT; Yang, F; Yang, L; Yang, QL1
Gong, J; Han, H; Tang, X; Wang, Z; Yang, F; Yang, L; Yang, Q1
Ding, L; Gong, J; Tang, X; Wang, G; Wang, Z; Yang, F; Yang, L; Yang, Q; Zhou, Y1
Jiang, Z; Li, X; Liu, R; Sun, R; Yang, H; Yu, L; Yuan, Z; Zhang, L1
Jiang, N; Lin, Y; Wang, L; Wu, F; Wu, G1
Cao, WR; Chen, M; Dong, ZY; Fan, ML; Fan, XD; Ge, JQ; Lan, XZ; Liao, ZH; Wang, H; Xie, X1
He, X; Li, H; Li, K; Li, P; Li, R; Liu, H; Ma, X; Wang, J; Wei, S; Wen, J; Xiao, X; Zhao, Y; Zhou, X; Zhu, Y1
Huang, YQ; Li, HT; Li, JY; Li, K; Li, PY; Li, RS; Liu, W; Ma, X; Wang, J; Wang, JB; Wei, SZ; Xiao, XH; Zhao, YL; Zhou, HQ; Zhu, Y1
Ding, Y; Duan, YY; Huang, ZH; Mei, H; Ye, P; Zhang, SL; Zhao, L1
Cantor, GH; Copple, BL; Kirchhofer, D; Luyendyk, JP; Mackman, N; Wang, R1
Shan, LM; Wang, JB; Xiao, XH; Zhao, YL; Zhou, GD1
Aoki, T; Asai, N; Inomata, A; Ishihara, K; Katsutani, N; Sawada, K; Suganuma, A; Uemura, Y; Yokoi, T1
Kamio, Y; Mori, N; Murakami, T; Yokooji, T1
Luyendyk, JP; Mackman, N; Sullivan, BP1
Cantor, GH; Flanagan, KC; Jaeschke, H; Luyendyk, JP; Mackman, N; Slusser, JG; Williams, CD1
Allen, K; Cantor, GH; Copple, BL; Guo, GL; Kassel, KM; Li, G; Luyendyk, JP1
Copple, BL; Cui, W; Luyendyk, JP; Sullivan, BP1
Ding, LL; Dou, W; Wang, ZT; Yang, L; Zhan, CS; Zhang, BF1
He, Y; Wan, YJ; Wang, Z; Xiong, A; Xu, Y; Yang, F; Yang, L1
Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R4
Kishikawa, T; Kongo, M; Ohta, Y1
Lee, G; Maher, JJ; Vierling, JM; Wang, H; Xu, J1
Jung, YS; Kim, SK; Kim, YC1
Kurihara, H; Sano, N; Takikawa, H1
Fukushima, K; Gershwin, ME; Kanno, N; Moritoki, Y; Shimosegawa, T; Ueno, Y; Yamagiwa, Y1
Imai, Y; Kitagawa, A; Kongo-Nishimura, M; Ohta, Y1
Dehpour, AR; Doratotaj, B; Gholipour, T; Honar, H; Jannati, A; Nik, HH; Noorian, AR; Riazi, K; Shariftabrizi, A1
Fears, R; Ferres, H; Rush, WR; Walker, P1
Hart, FE; Hew, JT; Willson, RA1
Jaeschke, H; Krell, H; Pfaff, E1
Lavigne, J; Lock, S; Plaa, GL1
Maile, PA; Woodman, DD1
De Lamirande, E; Plaa, GL1
Ikeda, Y; Kako, M; Oda, T; Oka, H; Toda, G1
Fuchshofen, M; Heusler, H; Lutz, B; Mora, E; Richter, E1
Inoue, T; Kamogawa, A; Ohta, S; Sakurai, N; Sato, N; Shinoda, M1
Delabar, U; Enderle, GJ; Krell, H1
Araki, T; Ishizaki, K; Kinbara, S; Miyazawa, N; Takeuchi, Y1
Ohta, S; Sato, N; Shinoda, M; Tu, SH1
Goldstein, RS; Handler, JA; Kossor, DC; Meunier, PC; Sozio, RS1
Bergasa, NV; Carson, R; Jones, EA; Swain, MG; Wahler, JB1
Neghab, M; Stacey, NH1
Contis, J; Kaminski, DL; Li, AP; Solomon, H1
Ambu, R; Desmet, VJ; Faa, G; Miyazaki, H; Roskams, T; Serreli, S; Van Eyken, P1
Dulik, DM; Goldstein, RS; Kossor, DC; Leonard, TB; Meunier, PC1
Harada, N; Ishiguro, I; Kongo, M; Nishida, K; Ohta, Y; Sasaki, E1
Agellon, LB; Chisholm, JW; Dolphin, PJ; Nation, P1
Aoki, Y; Itoh, H; Numakami, K; Ogawa, Z1
Harada, N; Ishiguro, I; Kongo, M; Ohta, Y; Sasaki, E1
Chisholm, JW; Dolphin, PJ; Paterniti, JR1
Plaa, GL; Priestly, BG1
Hinton, RH; Mullock, BM; Woolley, J1
Hofstetter, GJ; Richter, E; Seifert, H1
Buschmann, J; Joeres, R; Richter, E; Zilly, W1
Fukumoto, Y; Hayakawa, M; Nawata, J; Nishimura, H; Odawara, M1
Brachtel, D; Gallenkamp, H; Richter, E; Zilly, W1
Brachtel, D; Gallenkamp, H; Richter, E1
Gallenkamp, H1
Ditschuneit, H; Ditschuneit, HH; Felgenhauer, K; Hotz, J; Klör, HU1
Drew, R; Priestly, BG1
Fujita, T; Iwasaki, T; Kumazawa, N; Nakamura, H; Ohta, S; Shinoda, M1
Duane, WC; Eckfeldt, JH; Furne, J; Hillstrom, J; Levitt, MD1
Babini, G; Calcamuggi, G; Dughera, L; Emanuelli, G; Lanzio, M1
Bay, MK; Johnson, RF; Leighton, JA; Maldonado, AL; Schenker, S; Speeg, KV1
Kast, A; Yabe, T1
Chan, YS; Chang, HM; Cheng, YY; Chiang, TC; Tai, KF1
Aoki, Y; Itoh, H; Suzuki, H1
Aoki, Y; Itoh, H; Tanigawa, K1
Fujisaki, K1
Platt, D; Vömel, T1
Bhathal, PS; Gall, JA1
Di Padova, C; Di Padova, F; Stramentinoli, G; Tritapepe, R1
Plaa, GL; Roberts, RJ1

Reviews

1 review(s) available for 1-naphthylisothiocyanate and Bile Duct Obstruction

ArticleYear
Intrahepatic cholestasis induced by drugs and chemicals.
    Pharmacological reviews, 1976, Volume: 28, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Bile; Bile Acids and Salts; Bile Ducts; Cholestasis; Endoplasmic Reticulum; Erythromycin; Gonadal Steroid Hormones; Humans; Ligation; Liver; Manganese; Membranes; Mitochondria; Phenothiazines; Progestins; Time Factors

1976

Other Studies

139 other study(ies) available for 1-naphthylisothiocyanate and Bile Duct Obstruction

ArticleYear
Cultured bear bile powder ameliorates acute liver injury in cholestatic mice via inhibition of hepatic inflammation and apoptosis.
    Journal of ethnopharmacology, 2022, Feb-10, Volume: 284

    Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Bile; Chickens; Cholestasis; Inflammation; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Mice; Mice, Inbred C57BL; Powders; Random Allocation; Ursidae

2022
Hepatocyte growth factor reverses cholemic nephropathy associated with α-naphthylisothiocyanate-induced cholestasis in mice.
    Life sciences, 2022, Apr-15, Volume: 295

    Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Bile Acids and Salts; Bile Ducts; Cholestasis; Disease Models, Animal; Hepatocyte Growth Factor; Kidney; Kidney Diseases; Liver; Male; Mice; Oxidative Stress; Reactive Oxygen Species

2022
Swertiamarin, an active iridoid glycoside from Swertia pseudochinensis H. Hara, protects against alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway.
    Journal of ethnopharmacology, 2022, Jun-12, Volume: 291

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Iridoid Glucosides; Iridoid Glycosides; Iridoids; Liver; Pyrones; Rats; Swertia

2022
Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Jul-20, Volume: 102

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Homeostasis; Liver; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Receptors, Cytoplasmic and Nuclear; Tandem Mass Spectrometry

2022
Combination of resveratrol and luteolin ameliorates α-naphthylisothiocyanate-induced cholestasis by regulating the bile acid homeostasis and suppressing oxidative stress.
    Food & function, 2022, Jul-04, Volume: 13, Issue:13

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Homeostasis; Liver; Luteolin; Oxidative Stress; Rats; Resveratrol; Taurine

2022
IL-25 ameliorates acute cholestatic liver injury via promoting hepatic bile acid secretion.
    Cytokine, 2022, Volume: 158

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Interleukin-17; Liver; Liver Diseases; Mice; Mice, Inbred C57BL

2022
Liquiritin alleviates alpha-naphthylisothiocyanate-induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway.
    Journal of applied toxicology : JAT, 2023, Volume: 43, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Liver; Mice; MicroRNAs; NF-E2-Related Factor 2; RNA, Messenger; Sirtuin 1

2023
Ginsenosides Restore Lipid and Redox Homeostasis in Mice with Intrahepatic Cholestasis through SIRT1/AMPK Pathways.
    Nutrients, 2022, Sep-22, Volume: 14, Issue:19

    Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Cholestasis; Cholestasis, Intrahepatic; Fatty Acids; Ginsenosides; Hep G2 Cells; Homeostasis; Humans; Lipids; Liver; Mice; NF-E2-Related Factor 2; Oxidation-Reduction; RNA, Small Interfering; Sirtuin 1

2022
Transcriptome and Gut Microbiota Profiling Analysis of ANIT-Induced Cholestasis and the Effects of Da-Huang-Xiao-Shi Decoction Intervention.
    Microbiology spectrum, 2022, 12-21, Volume: 10, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Gastrointestinal Microbiome; Liver; Rats; RNA, Ribosomal, 16S; Transcriptome; United States

2022
Silymarin protects the liver from α-naphthylisothiocyanate-induced cholestasis by modulating the expression of genes involved in bile acid homeostasis.
    Cellular and molecular biology (Noisy-le-Grand, France), 2022, Jul-31, Volume: 68, Issue:7

    Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Cholestasis; Liver; Mice; RNA, Messenger; Silymarin

2022
Identification of Yinchenwuling fang's active components and hepatoprotective effects against cholestatic liver damage induced by alpha-naphthyl isothiocyanate in mice.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2023, Jan-15, Volume: 1215

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Isothiocyanates; Liver; Liver Diseases; Mice

2023
7, 8-Dihydroxy-4-methyl coumarin alleviates cholestasis via activation of the Farnesoid X receptor in vitro and in vivo.
    Chemico-biological interactions, 2023, Jan-25, Volume: 370

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Coumarins; Liver; Liver Diseases; Mice; Molecular Docking Simulation; Receptors, Cytoplasmic and Nuclear

2023
The choleretic role of tauroursodeoxycholic acid exacerbates alpha-naphthylisothiocyanate induced cholestatic liver injury through the FXR/BSEP pathway.
    Journal of applied toxicology : JAT, 2023, Volume: 43, Issue:7

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis; Liver; Mice; Receptors, Cytoplasmic and Nuclear

2023
Molecular mechanisms of hepatoprotective effect of tectorigenin against ANIT-induced cholestatic liver injury: Role of FXR and Nrf2 pathways.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 178

    Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Bile Acids and Salts; Bilirubin; Cholestasis; Isoflavones; Liver; Mice; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases

2023
Gardenia extract protects against intrahepatic cholestasis by regulating bile acid enterohepatic circulation.
    Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 1

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Enterohepatic Circulation; Gardenia; Liver; Rats; Rats, Sprague-Dawley; Steroid 12-alpha-Hydroxylase

2024
Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation.
    Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Diabetes Mellitus, Type 2; Ginsenosides; Inflammation; Liver; Mice; Molecular Docking Simulation; Oxidative Stress; Panax; Saponins; Sirtuin 1

2024
Modulating intestinal barrier function by sphingosine-1-phosphate receptor 1 specific agonist SEW2871 attenuated ANIT-induced cholestatic hepatitis via the gut-liver axis.
    International immunopharmacology, 2023, Volume: 125, Issue:Pt A

    Topics: 1-Naphthylisothiocyanate; Animals; Caco-2 Cells; Cholestasis; Chromatography, Liquid; Hepatitis; Humans; Liver; Mice; Sphingosine-1-Phosphate Receptors; Tandem Mass Spectrometry

2023
The role of invariant natural killer T cells in experimental xenobiotic-induced cholestatic hepatotoxicity.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 122

    Topics: 1-Naphthylisothiocyanate; Animals; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 Enzyme System; Cytokines; Inflammation; Liver; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Natural Killer T-Cells

2020
Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2020, Volume: 68

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Cholestasis; Cinnamates; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Iridoid Glucosides; Liver; Liver Diseases; Male; Mice, Inbred C57BL; Protective Agents; Receptors, Cytoplasmic and Nuclear

2020
Therapeutic action against chronic cholestatic liver injury by low-dose fenofibrate involves anti-chemotaxis via JNK-AP1-CCL2/CXCL2 signaling.
    Pharmacological reports : PR, 2020, Volume: 72, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Chemokine CCL2; Chemokine CXCL2; Chemotaxis; Cholestasis; End Stage Liver Disease; Fenofibrate; Hypolipidemic Agents; MAP Kinase Signaling System; Mice; Mice, 129 Strain; Mice, Knockout

2020
Alpha-naphthylisothiocyanate-induced cholestatic mice display anxiety-like behavior closely related with enhanced serotoninergic signaling transduction in central nervous system.
    Neuroreport, 2020, 05-07, Volume: 31, Issue:7

    Topics: 1-Naphthylisothiocyanate; Animals; Anxiety; Behavior, Animal; Cholestasis; Liver; Male; Mice, Inbred C57BL; Serotonin; Signal Transduction

2020
Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver.
    Toxicology letters, 2020, Oct-01, Volume: 331

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Down-Regulation; Hepatocytes; Homeostasis; Liver; Male; Mice, Inbred C57BL; Oxadiazoles; Sphingosine-1-Phosphate Receptors; Thiophenes; Tight Junctions

2020
Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway.
    Toxicology and applied pharmacology, 2020, 12-01, Volume: 408

    Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis; Cinnamates; Hepatocytes; Iridoid Glucosides; Male; Mice, Inbred C57BL; Protective Agents; Receptors, Cytoplasmic and Nuclear; Signal Transduction

2020
Protective effects of n-Butanol extract and iridoid glycosides of Veronica ciliata Fisch. Against ANIT-induced cholestatic liver injury in mice.
    Journal of ethnopharmacology, 2021, Feb-10, Volume: 266

    Topics: 1-Butanol; 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biological Transport; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Iridoid Glycosides; Liver; Male; Medicine, Tibetan Traditional; Mice; Oxidative Stress; Plant Extracts; Veronica

2021
Inhibition of inflammation by SP600125 in cholestatic liver injury is dependent on the administration‑based exposure profile.
    International journal of molecular medicine, 2020, Volume: 46, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Anthracenes; Bile Acids and Salts; Biological Transport; Biomarkers; Cholestasis; Gene Expression Regulation; Inflammation; Liver; MAP Kinase Signaling System; Mice; RNA, Messenger

2020
Metabolomics analysis delineates the therapeutic effects of Huangqi decoction and astragalosides on α-naphthylisothiocyanate (ANIT) -induced cholestasis in rats.
    Journal of ethnopharmacology, 2021, Mar-25, Volume: 268

    Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Male; Metabolomics; Rats; Rats, Wistar; Saponins

2021
A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model.
    Medical science monitor : international medical journal of experimental and clinical research, 2021, Mar-03, Volume: 27

    Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholangitis; Cholestasis; Disease Models, Animal; Hepatitis; Hepatocytes; Hypericum; Kaempferols; Liver; Liver Diseases; Luteolin; Male; Oxidative Stress; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley

2021
Fenofibrate reverses liver fibrosis in cholestatic mice induced by alpha-naphthylisothiocyanate.
    Die Pharmazie, 2021, 02-25, Volume: 76, Issue:2

    Topics: 1-Naphthylisothiocyanate; Actins; Animals; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Cholestasis; Collagen Type I; Fenofibrate; Inflammation; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Models, Animal; Peptide Fragments; PPAR alpha; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1

2021
Allopurinol Protects Against Cholestatic Liver Injury in Mice Not Through Depletion of Uric Acid.
    Toxicological sciences : an official journal of the Society of Toxicology, 2021, 05-27, Volume: 181, Issue:2

    Topics: 1-Naphthylisothiocyanate; Allopurinol; Animals; Cholestasis; Cholestasis, Intrahepatic; Liver; Mice; Uric Acid

2021
A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 91

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Isodon; Liver; Metabolomics; Rats; Tandem Mass Spectrometry

2021
Herbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats.
    Scientific reports, 2017, 06-23, Volume: 7, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bilirubin; Cholestasis; Cytokines; Drugs, Chinese Herbal; Gene Expression Regulation; Inflammation Mediators; Liver; Male; Protective Agents; Rats, Wistar; RNA, Messenger

2017
Analyzing the hepatoprotective effect of the Swertia cincta Burkillextract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes.
    Journal of ethnopharmacology, 2017, Sep-14, Volume: 209

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Chemical and Drug Induced Liver Injury; Cholestasis; Gene Expression Regulation; Liver; Male; Membrane Transport Proteins; Plant Extracts; Rats; Rats, Wistar; RNA, Messenger; Swertia

2017
Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017, Volume: 110

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cell Polarity; Cholestasis; Hepatocytes; Homeostasis; Humans; Liver; Male; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors

2017
Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway.
    Molecular medicine reports, 2018, Volume: 17, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; HEK293 Cells; Hep G2 Cells; Hepatocytes; Humans; Lipopolysaccharides; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Receptors, Cytoplasmic and Nuclear; Resveratrol; Signal Transduction; Stilbenes

2018
Characterization of a rat model of moderate liver dysfunction based on alpha-naphthylisothiocyanate-induced cholestasis.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:6

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Amino Acids, Branched-Chain; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis; Disease Models, Animal; Humans; Liver Diseases; Rats, Wistar; Serum Albumin; Severity of Illness Index; Time Factors

2017
Targeted Metabolomics Reveals a Protective Role for Basal PPARα in Cholestasis Induced by α-Naphthylisothiocyanate.
    Journal of proteome research, 2018, 04-06, Volume: 17, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Metabolomics; Mice, Inbred Strains; Mice, Knockout; NF-kappa B; PPAR alpha; Protective Agents; Signal Transduction; STAT3 Transcription Factor

2018
18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.
    Acta pharmacologica Sinica, 2018, Volume: 39, Issue:12

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Glycyrrhetinic Acid; Male; NF-E2-Related Factor 2; Protective Agents; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sirtuin 1

2018
Pharmacokinetic and Pharmacodynamic Properties of Rosmarinic Acid in Rat Cholestatic Liver Injury.
    Molecules (Basel, Switzerland), 2018, Sep-07, Volume: 23, Issue:9

    Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Bile; Chemical and Drug Induced Liver Injury; Cholestasis; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Limit of Detection; Liver; Male; Models, Biological; Rats, Sprague-Dawley; Reproducibility of Results; Rosmarinic Acid; Spectrophotometry, Ultraviolet

2018
Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 49, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Discriminant Analysis; Gene Expression Regulation; Iridoid Glucosides; Male; Metabolome; Metabolomics; PPAR alpha; Principal Component Analysis; Protective Agents; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptor alpha

2018
Paeonia lactiflora Pall. regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis in rats.
    The Journal of pharmacy and pharmacology, 2018, Volume: 70, Issue:12

    Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; Humans; Inflammasomes; Inflammation Mediators; Liver; Liver Function Tests; Medicine, Chinese Traditional; NF-kappa B; Paeonia; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger

2018
Altered Expression of Retinol Metabolism-Related Genes in an ANIT-Induced Cholestasis Rat Model.
    International journal of molecular sciences, 2018, Oct-26, Volume: 19, Issue:11

    Topics: 1-Naphthylisothiocyanate; Acyltransferases; Aldehyde Dehydrogenase; Animals; beta-Carotene 15,15'-Monooxygenase; Cholestasis; Disease Models, Animal; Gene Expression Regulation; Male; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase; Vitamin A

2018
Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats.
    Molecular medicine reports, 2019, Volume: 19, Issue:2

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Cholestasis; Glutamate-Cysteine Ligase; Glutathione; Liver; Male; Melatonin; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction

2019
Andrographolide impairs alpha-naphthylisothiocyanate-induced cholestatic liver injury in vivo.
    Journal of natural medicines, 2019, Volume: 73, Issue:2

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis; Diterpenes; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Inflammation; Liver; Male; NF-E2-Related Factor 2; Oxidative Stress; Phytotherapy; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Sirtuin 1

2019
Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα.
    Biochemical and biophysical research communications, 2019, 05-14, Volume: 512, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biological Transport; Cholestasis; Disease Models, Animal; Hep G2 Cells; Hepatocytes; Humans; Isoflavones; Liver; Male; Mice, Inbred C57BL; PPAR alpha; Sirtuin 1

2019
UPLC-MS-based metabonomic analysis of intervention effects of Da-Huang-Xiao-Shi decoction on ANIT-induced cholestasis.
    Journal of ethnopharmacology, 2019, Jun-28, Volume: 238

    Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Liver; Male; Mass Spectrometry; Rats, Sprague-Dawley

2019
Cholestasis-associated glucocorticoid overexposure does not increase atherogenesis.
    The Journal of endocrinology, 2019, Volume: 242, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Apolipoproteins E; Atherosclerosis; Cholestasis; Cholesterol; Corticosterone; Disease Models, Animal; Glucocorticoids; Humans; Hypercholesterolemia; Mice, Inbred C57BL; Mice, Knockout; Risk Factors; Species Specificity

2019
Salvianolic acid B protects against ANIT-induced cholestatic liver injury through regulating bile acid transporters and enzymes, and NF-κB/IκB and MAPK pathways.
    Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:9

    Topics: 1-Naphthylisothiocyanate; Animals; Benzofurans; Carrier Proteins; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cholestasis; Cytokines; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Male; Membrane Glycoproteins; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Protective Agents; Rats, Sprague-Dawley; Signal Transduction

2019
Paeoniflorin protects against ANIT-induced cholestasis by ameliorating oxidative stress in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 58

    Topics: 1-Naphthylisothiocyanate; Animals; Benzoates; Bridged-Ring Compounds; Cholestasis; Glucosides; Monoterpenes; Oxidative Stress; Rats

2013
All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 349, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Bile Acids and Salts; Cell Proliferation; Cholagogues and Choleretics; Cholestasis; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; Liver; Male; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Tretinoin; Ursodeoxycholic Acid

2014
Danning tablets attenuates α-naphthylisothiocyanate-induced cholestasis by modulating the expression of transporters and metabolic enzymes.
    BMC complementary and alternative medicine, 2014, Jul-17, Volume: 14

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Biological Transport; Cholestasis; Drugs, Chinese Herbal; Liver; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Random Allocation; Rats; Rats, Wistar

2014
Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.
    Journal of thrombosis and haemostasis : JTH, 2015, Volume: 13, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Antithrombin III; Bile Acids and Salts; Blood Coagulation; Blood Platelets; Chemical and Drug Induced Liver Injury; Cholestasis; Fibrinogens, Abnormal; Genotype; Liver; Liver Cirrhosis, Experimental; Male; Mice, Inbred C57BL; Mice, Knockout; Mutation; Necrosis; Peptide Hydrolases; Phenotype; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Serotonin; Signal Transduction

2015
Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms.
    Acta pharmacologica Sinica, 2014, Volume: 35, Issue:12

    Topics: 1-Naphthylisothiocyanate; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Bile; Biomarkers; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis; Cytoprotection; Disease Models, Animal; DNA, Mitochondrial; Inflammation Mediators; Liver; Male; Membrane Transport Proteins; Neutrophil Infiltration; Oxidative Stress; Rats, Sprague-Dawley; Resveratrol; Stilbenes

2014
Large dose means significant effect--dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats.
    BMC complementary and alternative medicine, 2015, Apr-02, Volume: 15

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; gamma-Glutamyltransferase; Hepatitis; Liver; Male; Paeonia; Phytotherapy; Pueraria; Rats; Salvia miltiorrhiza

2015
Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against α-naphthylisothiocyanate-induced cholestatic liver injury in rats.
    Journal of ethnopharmacology, 2015, Aug-22, Volume: 172

    Topics: 1-Naphthylisothiocyanate; Abelmoschus; Administration, Oral; Animals; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Flowers; Liver; Male; Rats; Rats, Wistar

2015
Evaluation of the protective effect of Zhi-Zi-da-Huang decoction on acute liver injury with cholestasis induced by α-naphthylisothiocyanate in rats.
    Journal of ethnopharmacology, 2015, Aug-22, Volume: 172

    Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Antioxidants; Cholestasis; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Liver Diseases; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley

2015
Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:11

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Benzoates; Bile Acids and Salts; Bilirubin; Bridged-Ring Compounds; China; Cholestasis; gamma-Glutamyltransferase; Glucosides; Glutamate-Cysteine Ligase; Glutathione; Liver; Liver Function Tests; Male; Monoterpenes; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Rats

2015
Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development.
    Chemico-biological interactions, 2016, Aug-05, Volume: 255

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Gene Expression Regulation; Liver; Male; Metabolome; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley

2016
Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Biomarkers; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Liver; Male; NF-E2-Related Factor 2; Oxidative Stress; Paeonia; Phosphatidylinositol 3-Kinase; Phytotherapy; Plant Extracts; Plant Roots; Plants, Medicinal; Protein Interaction Maps; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction

2015
Synergistic effects of rhubarb-gardenia herb pair in cholestatic rats at pharmacodynamic and pharmacokinetic levels.
    Journal of ethnopharmacology, 2015, Dec-04, Volume: 175

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Anthraquinones; Aspartate Aminotransferases; Bilirubin; Cholestasis; Drug Synergism; Emodin; Fruit; Gardenia; Iridoids; Liver; Male; Plant Extracts; Protective Agents; Rats, Sprague-Dawley; Rheum; Rhizome

2015
Serum Metabolomic Profiling in a Rat Model Reveals Protective Function of Paeoniflorin Against ANIT Induced Cholestasis.
    Phytotherapy research : PTR, 2016, Volume: 30, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Glucosides; Male; Metabolome; Monoterpenes; Rats; Rats, Sprague-Dawley

2016
Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.
    Archives of toxicology, 2017, Volume: 91, Issue:3

    Topics: 1-Naphthylisothiocyanate; Aged; Chlorpromazine; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Gene Expression Profiling; Humans; Liver; Male; Methyltestosterone; Middle Aged; Signal Transduction; Transcriptome; Young Adult

2017
Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation.
    The Journal of pharmacy and pharmacology, 2016, Volume: 68, Issue:9

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Cholestasis; Cytokines; Liver; Male; Mice; NF-kappa B; Phytotherapy; Plant Extracts; Polyphenols; Signal Transduction; STAT3 Transcription Factor

2016
Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice.
    Toxicology and applied pharmacology, 2016, 09-01, Volume: 306

    Topics: 1-Naphthylisothiocyanate; Adrenalectomy; Animals; Bile Acids and Salts; Cholestasis; Cholesterol; Corticosterone; Hypercholesterolemia; Liver; Liver Diseases; Mice, Inbred C57BL; Mifepristone; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid

2016
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.
    Toxicology, 2016, 07-15, Volume: 365

    Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Clopidogrel; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Activation; Purinergic P2Y Receptor Antagonists; Receptors, Proteinase-Activated; Serotonin; Ticlopidine; Xenobiotics

2016
Sweroside ameliorates α-naphthylisothiocyanate-induced cholestatic liver injury in mice by regulating bile acids and suppressing pro-inflammatory responses.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:9

    Topics: 1-Naphthylisothiocyanate; Animals; Anti-Inflammatory Agents; Bile Acids and Salts; Biomarkers; Cell Survival; Cholestasis; Disease Models, Animal; Gene Expression; Hepatocytes; Immunologic Factors; Iridoid Glucosides; Liver; Male; Mice; Mice, Inbred C57BL; Primary Cell Culture

2016
Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice.
    Journal of ethnopharmacology, 2016, Dec-24, Volume: 194

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Homeostasis; Iridoid Glucosides; Liver; Mice; Mice, Inbred C57BL

2016
Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation.
    Scientific reports, 2016, 09-14, Volume: 6

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Curcumin; Disease Models, Animal; HEK293 Cells; Humans; Inflammation; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear

2016
Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes.
    Toxicology, 2016, Aug-31, Volume: 370

    Topics: 1-Naphthylisothiocyanate; Adenosine A1 Receptor Antagonists; AMP-Activated Protein Kinases; Animals; Bile Acids and Salts; Bile Ducts; Cell Survival; Cholestasis; Epithelial Cells; Hepatocytes; Homeostasis; Liver; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Xanthines

2016
Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats.
    Journal of ethnopharmacology, 2017, Jan-20, Volume: 196

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis; Cytochrome P-450 Enzyme System; Down-Regulation; Glucuronosyltransferase; Homeostasis; Iridoids; Liver; Organic Anion Transporters; Pregnane X Receptor; Protective Agents; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Sulfotransferases

2017
Protective effects of petroleum ether extracts of Herpetospermum caudigerum against α-naphthylisothiocyanate-induced acute cholestasis of rats.
    Journal of ethnopharmacology, 2017, Feb-23, Volume: 198

    Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Cholestasis; Cucurbitaceae; Dose-Response Relationship, Drug; Liver; Male; Medicine, Tibetan Traditional; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley

2017
Paeoniflorin ameliorates cholestasis via regulating hepatic transporters and suppressing inflammation in ANIT-fed rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Biomarkers; Carrier Proteins; Cholestasis; Edema; Glucosides; Inflammation; Liver; Liver Function Tests; Male; Monoterpenes; Necrosis; Neutrophil Infiltration; NF-kappa B; Rats; Rats, Sprague-Dawley

2017
Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89

    Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Cytokines; Genes, bcl-2; Glucosides; Liver; Mitochondria; Monoterpenes; Neutrophil Infiltration; Rats; Rats, Wistar; Signal Transduction

2017
Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: 1-Naphthylisothiocyanate; Animals; Anti-Inflammatory Agents; Cholestasis; Early Growth Response Protein 1; Emodin; Hepatitis; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2008
Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 296, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Cholestasis; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Thromboplastin

2009
Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 104, Issue:6

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Anthraquinones; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; gamma-Glutamyltransferase; Liver; Lyases; Male; Plant Roots; Rats; Rats, Sprague-Dawley; Rheum; Rhizome; Transaminases

2009
Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:3

    Topics: 1-Naphthylisothiocyanate; Aniline Compounds; Animals; Biomarkers; Cholestasis; Cyclosporine; Disease Models, Animal; Kidney; Magnetic Resonance Spectroscopy; Male; Metabolomics; Rats; Rats, Sprague-Dawley

2009
Increased intestinal absorption of mizoribine, an immunosuppressive agent, in cholestatic rats.
    Die Pharmazie, 2010, Volume: 65, Issue:7

    Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Cholestasis; Food-Drug Interactions; Immunosuppressive Agents; Intestinal Absorption; Male; Rats; Rats, Sprague-Dawley; Ribonucleosides

2010
Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 119, Issue:1

    Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Cholestasis; Disease Models, Animal; Female; Fibrinogen; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Receptor, PAR-1; Receptors, Proteinase-Activated; Xenobiotics

2011
Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.
    Toxicology and applied pharmacology, 2011, Feb-01, Volume: 250, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Blood Coagulation; CD11b Antigen; Chemical and Drug Induced Liver Injury; Chemokines; Cholestasis; Intercellular Adhesion Molecule-1; Liver; Male; Mice; Myeloid Cells; Neutrophil Activation; Neutrophils; Peroxidase; Thromboplastin; Xenobiotics

2011
Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis.
    The American journal of pathology, 2011, Volume: 178, Issue:3

    Topics: 1-Naphthylisothiocyanate; Afibrinogenemia; Aged; Animals; Bile Ducts; Cholestasis; Chronic Disease; Collagen; Diet; Disease Models, Animal; Early Growth Response Protein 1; Feeding Behavior; Female; Fibrin; Fibrinogen; Gene Expression Regulation; Humans; Hyperplasia; Inflammation; Liver; Liver Cirrhosis; Male; Mice; Middle Aged; Neutrophils; Xenobiotics

2011
Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 126, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Biliary Tract; Cholestasis; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Early Growth Response Protein 1; Female; Fibrosis; Gene Expression Regulation; Integrin beta Chains; Liver; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1

2012
Protective effect of Danning tablet on acute livery injury with cholestasis induced by α-naphthylisothiocyanate in rats.
    Journal of ethnopharmacology, 2012, Mar-27, Volume: 140, Issue:2

    Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Anthraquinones; Antioxidants; Bile; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Liver; Magnoliopsida; Male; Neutrophil Infiltration; Phytotherapy; Rats, Wistar; Stilbenes; Transaminases

2012
Evaluation of the protective effect of Rhei Radix et Rhizoma against α-naphthylisothiocyanate induced liver injury based on metabolic profile of bile acids.
    Journal of ethnopharmacology, 2012, Dec-18, Volume: 144, Issue:3

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Male; Plant Extracts; Plant Roots; Protective Agents; Rats; Rats, Wistar; Rheum; Rhizome

2012
Reduction in cardiac mitochondrial calcium loading capacity is observable during alpha-naphthylisothiocyanate-induced acute cholestasis: a clue for hepatic-derived cardiomyopathies?
    Biochimica et biophysica acta, 2003, Jan-20, Volume: 1637, Issue:1

    Topics: 1-Naphthylisothiocyanate; Acute Disease; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cardiomyopathies; Cholestasis; Energy Metabolism; Female; Ion Channels; Membrane Potentials; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Rats; Rats, Wistar

2003
Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats.
    Journal of pineal research, 2003, Volume: 34, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Catalase; Cholestasis; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Melatonin; Neutrophil Infiltration; Peroxidase; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2003
Cardiac mitochondrial calcium loading capacity is severely affected after chronic cholestasis in Wistar rats.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2003, Volume: 51, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts, Intrahepatic; Blood Chemical Analysis; Calcium; Cholestasis; Chronic Disease; Disease Models, Animal; Energy Metabolism; Female; Ion Channels; Liver; Membrane Potentials; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Wistar

2003
Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 2003, Volume: 22, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Calcium; Cardiovascular Diseases; Cholestasis; Chronic Disease; Cyclosporine; Disease Models, Animal; Female; Fibrosis; Liver Diseases; Mitochondria, Heart; Oxidative Stress; Rats; Rats, Wistar

2003
Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Biomarkers; Chemical and Drug Induced Liver Injury; Chemokines, CXC; Cholestasis; Enzyme-Linked Immunosorbent Assay; Hydroxyproline; Leukocyte Count; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils

2004
Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by alpha-naphthylisothiocyanate.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2005, Volume: 43, Issue:5

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Amino Acids, Sulfur; Analysis of Variance; Animals; Aspartate Aminotransferases; Betaine; Bilirubin; Cholestasis; Cysteine; Dietary Supplements; Glutathione; Kinetics; Liver; Male; Mice; Mice, Inbred ICR; S-Adenosylhomocysteine; S-Adenosylmethionine

2005
Biliary excretion of taurocholate, organic anions and vinblastine in rats with alpha-naphthylisothiocyanate-induced cholestasis.
    Journal of gastroenterology and hepatology, 2005, Volume: 20, Issue:7

    Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Anions; Antineoplastic Agents, Phytogenic; Bile; Bile Acids and Salts; Biological Transport; Cholagogues and Choleretics; Cholestasis; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Taurocholic Acid; Vinblastine

2005
Lack of evidence that bone marrow cells contribute to cholangiocyte repopulation during experimental cholestatic ductal hyperplasia.
    Liver international : official journal of the International Association for the Study of the Liver, 2006, Volume: 26, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Basic Helix-Loop-Helix Transcription Factors; Bile Ducts; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Proliferation; Cholestasis; Disease Models, Animal; Female; Gene Expression Regulation; Green Fluorescent Proteins; Homeodomain Proteins; Hyperplasia; Keratin-7; Keratins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Protein-Tyrosine Kinases; Receptors, Notch; Regeneration; Transcription Factor HES-1

2006
Melatonin attenuates disruption of serum cholesterol status in rats with a single alpha-naphthylisothiocyanate treatment.
    Journal of pineal research, 2007, Volume: 42, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cholesterol; Male; Melatonin; Rats; Rats, Wistar

2007
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
    European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Cholestasis; Corn Oil; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Infusions, Intravenous; Intubation, Gastrointestinal; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Receptors, Opioid; Seizures; Time Factors

2008
Hyperalphalipoproteinaemic activity of BRL 26314--I. Enhanced cholesterol turnover in rats.
    Biochemical pharmacology, 1984, Jan-15, Volume: 33, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biological Transport; Cholestasis; Cholesterol; Feces; Hyperlipoproteinemias; Lipoproteins, HDL; Male; Phenobarbital; Phenylalanine; Rats; Rats, Inbred Strains

1984
Experimental hepatobiliary injury. Comparison of in vivo drug elimination with in vitro drug-metabolizing enzyme capacity in the rat.
    Digestive diseases and sciences, 1981, Volume: 26, Issue:1

    Topics: 1-Naphthylisothiocyanate; Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Cholestasis; Cytochrome P-450 Enzyme System; Ethinyl Estradiol; Hepatic Duct, Common; In Vitro Techniques; Liver; Metabolic Clearance Rate; Rats

1981
No increase of biliary permeability in ethinylestradiol-treated rats.
    Gastroenterology, 1983, Volume: 85, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Biliary Tract; Cholestasis; Ethinyl Estradiol; Inulin; Male; Permeability; Rats; Rats, Inbred Strains; Sucrose

1983
The effect of alpha-naphthylisothiocyanate on bile secretion prior to and during the onset of cholestasis in the rat.
    Toxicology letters, 1982, Volume: 10, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Cholestasis; Male; Rats; Rats, Inbred Strains; Thiocyanates; Time Factors

1982
Bile acid assays as an index of cholestasis.
    Clinical chemistry, 1981, Volume: 27, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Cholestasis; Cholic Acids; Clinical Laboratory Techniques; Glycocholic Acid; Male; Rats

1981
1,3-Butanediol pretreatment on the cholestasis induced in rats by manganese--bilirubin combination, taurolithocholic acid, or alpha-naphthylisothiocyanate.
    Toxicology and applied pharmacology, 1981, Volume: 59, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bilirubin; Butylene Glycols; Cholestasis; Drug Synergism; Male; Manganese Poisoning; Rats; Taurolithocholic Acid; Time Factors

1981
Mechanism of elevation of serum alkaline phosphatase activity in biliary obstruction: an experimental study.
    Clinica chimica acta; international journal of clinical chemistry, 1980, Oct-23, Volume: 107, Issue:1-2

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bile; Cell Membrane; Cholestasis; Cholestasis, Intrahepatic; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Liver; Male; Molecular Weight; Rats

1980
[Lidocain clearance after oral and intravenous application in rats with low grade ANIT-cholestasis and galactosamine-induced hepatitis (author's transl)].
    Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:8

    Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biological Availability; Chemical and Drug Induced Liver Injury; Cholestasis; Galactosamine; Hepatitis; Injections, Intravenous; Lidocaine; Liver; Male; Rats

1980
[Protective effects of the stem of Berchemia racemosa Sieb. et Zucc. on experimental liver injuries].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1995, Volume: 115, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Liver Diseases; Male; Plant Stems; Rats; Rats, Wistar

1995
Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers.
    Biochemical pharmacology, 1995, Jan-31, Volume: 49, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis; Estradiol; Ethionine; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Leukotriene C4; Liver; Male; Perfusion; Rats; Rats, Wistar; Taurocholic Acid

1995
Protection against alpha-naphthylisothiocyanate-induced acute cholestasis in mice by a novel taurine conjugate of ursodeoxycholate (UR-906).
    Japanese journal of pharmacology, 1993, Volume: 63, Issue:1

    Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Bile Acids and Salts; Bilirubin; Biomarkers; Cholestasis; L-Lactate Dehydrogenase; Liver; Male; Mice; Taurine; Ursodeoxycholic Acid

1993
[Protective effects of Taiwan crude drugs on experimental liver injuries].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1993, Volume: 113, Issue:12

    Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Liver Diseases; Male; Methanol; Rats; Rats, Wistar; Water

1993
Temporal relationship of changes in hepatobiliary function and morphology in rats following alpha-naphthylisothiocyanate (ANIT) administration.
    Toxicology and applied pharmacology, 1993, Volume: 119, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Biliary Tract; Cholestasis; Dose-Response Relationship, Drug; Erythritol; Liver; Male; Necrosis; Perfusion; Rats; Rats, Sprague-Dawley

1993
Blood-brain barrier permeability is markedly decreased in cholestasis in the rat.
    Hepatology (Baltimore, Md.), 1993, Volume: 17, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Blood-Brain Barrier; Capillary Permeability; Cholestasis; Cholesterol; Dexamethasone; Male; Rats; Rats, Sprague-Dawley

1993
Alpha-naphthylisothiocyanate-induced elevation of serum bile acids: lack of causative effect on bile acid transport.
    Chemico-biological interactions, 1996, Jan-05, Volume: 99, Issue:1-3

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Bile Acids and Salts; Biological Transport; Cell Survival; Cholestasis; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Sprague-Dawley; Taurocholic Acid

1996
The effect of prostanoids on hepatic bile flow in dogs with normal liver and bile duct cell hyperplasia.
    Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 54, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Bile Duct Diseases; Cholestasis; Common Bile Duct; Dinoprostone; Dogs; Epoprostenol; Glucagon; Hyperplasia; Secretin

1996
Expression of cytokeratin 20 in developing rat liver and in experimental models of ductular and oval cell proliferation.
    Journal of hepatology, 1998, Volume: 29, Issue:4

    Topics: 1-Naphthylisothiocyanate; Age Factors; Animals; Bile Ducts, Intrahepatic; Cell Division; Cholestasis; Choline Deficiency; Female; Intermediate Filament Proteins; Keratin-20; Keratins; Liver; Male; Pregnancy; Rats; Rats, Inbred F344

1998
Bile duct obstruction is not a prerequisite for type I biliary epithelial cell hyperplasia.
    Toxicology and applied pharmacology, 1998, Volume: 152, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bile Ducts; Cholestasis; Epithelial Cells; Glucose; Humans; Hyperplasia; Male; Rats; Rats, Sprague-Dawley

1998
An association between lipid peroxidation and alpha-naphthylisothiocyanate-induced liver injury in rats.
    Toxicology letters, 1999, Mar-29, Volume: 105, Issue:2

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Bile Acids and Salts; Bilirubin; Body Weight; Cholestasis; gamma-Glutamyltransferase; Injections, Intraperitoneal; Lipid Peroxidation; Lipid Peroxides; Liver; Male; Organ Size; Peroxidase; Rats; Rats, Wistar; Statistics as Topic

1999
High plasma cholesterol in drug-induced cholestasis is associated with enhanced hepatic cholesterol synthesis.
    The American journal of physiology, 1999, Volume: 276, Issue:5

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Bilirubin; Cholestasis; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Female; Gallbladder; Hydroxymethylglutaryl CoA Reductases; Lipids; Lipoproteins; Liver; Mice; Mice, Inbred C57BL; Phospholipids

1999
A kinetic model of mitochondrial aspartate aminotransferase transmigration in hepatobiliary disorders.
    Annals of clinical biochemistry, 1999, Volume: 36 ( Pt 2)

    Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholestasis; Computer Simulation; Indocyanine Green; Isoenzymes; Kinetics; Liver Diseases; Male; Mitochondria; Models, Biological; Rats; Rats, Wistar; Time Factors

1999
Protective effect of melatonin against alpha-naphthylisothiocyanate-induced liver injury in rats.
    Journal of pineal research, 2000, Volume: 29, Issue:1

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Cholestasis; L-Lactate Dehydrogenase; Lipid Peroxides; Liver; Male; Melatonin; Neutrophils; Peroxidase; Rats; Rats, Wistar

2000
Accumulation of cholestatic lipoproteins in ANIT-treated human apolipoprotein A-I transgenic rats is diminished through dose-dependent apolipoprotein A-I activation of LCAT.
    Biochimica et biophysica acta, 2000, Sep-27, Volume: 1487, Issue:2-3

    Topics: 1-Naphthylisothiocyanate; Animals; Animals, Genetically Modified; Apolipoprotein A-I; Cholestasis; Cholesterol; Cholesterol Esters; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Fatty Acids; Humans; Lipoproteins, LDL; Phospholipids; Rats

2000
Disruption of mitochondrial calcium homeostasis after chronic alpha-naphthylisothiocyanate administration: relevance for cholestasis.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2002, Volume: 50, Issue:3

    Topics: 1-Naphthylisothiocyanate; Adenine Nucleotides; Alanine Transaminase; Animals; Calcium; Cell Membrane Permeability; Chenodeoxycholic Acid; Cholestasis; Energy Metabolism; Female; Hepatocytes; Homeostasis; Injections, Intraperitoneal; Intracellular Membranes; Membrane Potentials; Mitochondria, Liver; Rats; Rats, Wistar

2002
Reflux of billiary components into blood in experimental intrahepatic cholestasis induced in rats by treatment with alpha-naphthylisothiocyanate.
    Clinica chimica acta; international journal of clinical chemistry, 1979, Mar-15, Volume: 92, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Bilirubin; Cholestasis; Gallbladder; Immunoglobulin A; Isoenzymes; Male; Nucleotidases; Rats

1979
[Intravenous and oral galactose loading of rats suffering from galactosamine hepatitis and ANIT-cholestasis; comparison of the kinetics in vivo and the galactose metabolism in the liver in vitro (author's transl)].
    Zeitschrift fur Gastroenterologie, 1979, Volume: 17, Issue:10

    Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Enzyme Activation; Galactokinase; Galactosamine; Galactose; In Vitro Techniques; Injections, Intravenous; Kinetics; Liver; Male; Rats; Thiocyanates; Time Factors

1979
Alternative transport pathways of cholephilic 14C-hexobarbital metabolites in rats with experimental hepatitis and cholestasis.
    Acta hepato-gastroenterologica, 1979, Volume: 26, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis; Chromatography, Thin Layer; Galactosamine; Hepatitis, Animal; Hexobarbital; Liver Function Tests; Male; Phenobarbital; Rats

1979
[Alkaline phosphatase (ALP) in alpha-naphthylisothiocyanate-administered rats; with special reference to hepatic and intestinal ALP].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1977, Volume: 74, Issue:2

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Cholestasis; Disease Models, Animal; Intestine, Small; Isoenzymes; Liver; Male; Rats; Thiocyanates

1977
[Symposion B: Experimental cholestasis--in vitro metabolism and in vivo metabolic clearance of hexobarbital in rats with ANIT-cholestasis].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cytochrome P-450 Enzyme System; Hexobarbital; Male; Metabolic Clearance Rate; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Rats

1976
[Hexobarbital-oxidation in vivo and in vitro in rats with bile duct ligation or ANIT-cholestasis (author's transl)].
    Zeitschrift fur Gastroenterologie, 1977, Volume: 15, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Biotransformation; Cholestasis; Common Bile Duct; Disease Models, Animal; Hexobarbital; In Vitro Techniques; Ligation; Male; Microsomes, Liver; Rats; Thiocyanates

1977
Phospholipids in endoplasmic reticulum - their relationship to drug metabolism in experimental liver disease.
    Acta hepato-gastroenterologica, 1977, Volume: 24, Issue:5

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Choline Deficiency; Endoplasmic Reticulum; Galactosamine; Hepatitis; Liver Diseases; Phospholipids; Rats

1977
[Lipid metabolism in experimental rat liver lesions].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Common Bile Duct; Ligation; Lipids; Male; Rats

1976
Microsomal drug metabolism during alpha-naphthylisothiocyanate-induced cholestasis.
    Toxicology and applied pharmacology, 1976, Volume: 35, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmaceutical Preparations; Rats; Sleep; Thiocyanates; Time Factors

1976
[Protective effects of the fractions extracted from the callus of Acer nikoense Maxim. on alpha-naphthylisothiocyanate induced liver injury].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1992, Volume: 112, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis; Liver Diseases; Male; Plant Extracts; Rats; Rats, Inbred Strains; Trees

1992
Lack of benefit of ursodeoxycholic acid in drug-induced cholestasis in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 200, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cyclosporine; Ethinyl Estradiol; Male; Rats; Rats, Inbred Strains; Ursodeoxycholic Acid

1992
Endotoxin tolerance and polymyxin B modify liver damage and cholestasis induced by a single dose of alpha-naphthylisothiocyanate in the rat.
    Archives of toxicology, 1992, Volume: 66, Issue:2

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Endotoxins; Lead Poisoning; Liver; Male; Polymyxin B; Rats; Rats, Inbred Strains; Salmonella typhimurium

1992
The effect of liver dysfunction on colchicine pharmacokinetics in the rat.
    Hepatology (Baltimore, Md.), 1990, Volume: 11, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cimetidine; Colchicine; Cytochrome P-450 Enzyme Inhibitors; Galactosamine; Liver Diseases; Rats; Rats, Inbred Strains

1990
The optimum pH of serum alkaline phosphatase after induced cholestasis in the male rat, mouse and rabbit.
    The Journal of toxicological sciences, 1988, Volume: 13, Issue:4

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Cholestasis; Cystine; Electrophoresis, Cellulose Acetate; Fasting; Homoarginine; Hydrogen-Ion Concentration; Intestines; Isoenzymes; Liver; Male; Mice; Phenylalanine; Rabbits; Rats

1988
[Choleretic effects of acetophenone derivatives and analogues on rats].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:5

    Topics: 1-Naphthylisothiocyanate; Acetophenones; Animals; Bile; Cholagogues and Choleretics; Cholestasis; Male; Rats; Rats, Inbred Strains; Secretory Rate

1986
Changes in polyamine metabolism in rat liver after oral administration of alpha-naphthylisothiocyanate.
    The Journal of toxicological sciences, 1986, Volume: 11, Issue:2

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile; Cholestasis; Liver; Liver Regeneration; Male; Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred Strains; Thiocyanates; Urea

1986
Transmigration of mitochondrial GOT in cholestatic liver injury.
    The Journal of toxicological sciences, 1986, Volume: 11, Issue:3

    Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholestasis; Indicators and Reagents; Isoenzymes; Kinetics; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains

1986
[Changes and induction of drug-metabolizing enzymes in rats with hepatic injuries].
    Fukuoka igaku zasshi = Hukuoka acta medica, 1986, Volume: 77, Issue:9

    Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Cholestasis; Enzyme Induction; In Vitro Techniques; Liver; Microsomes, Liver; Rats; Rats, Inbred Strains

1986
Age-dependent phagocytosis of erythrocytes by the isolated perfused rat liver after galactosamine hepatitis and alpha-naphthylisothiocyanate cholestasis.
    Archives of gerontology and geriatrics, 1986, Volume: 5, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Cell Survival; Cholestasis; Erythrocytes; Galactosamine; Hepatitis, Animal; Liver; Male; Phagocytosis; Rats; Rats, Inbred Strains

1986
Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus.
    Liver, 1985, Volume: 5, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Cell Division; Cell Survival; Cholestasis; Common Bile Duct; Disease Models, Animal; Epithelium; Hyperplasia; Jejunum; Liver; Liver Cirrhosis, Biliary; Male; Rats; Rats, Inbred Strains

1985
S-adenosyl-L-methionine protection against alpha-naphthylisothiocyanate-induced cholestasis in the rat.
    Toxicology letters, 1985, Volume: 29, Issue:2-3

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Body Weight; Cholestasis; Lipids; Male; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thiocyanates

1985
The effect of bile duct ligation, bile duct cannulation, and hypothermia on alpha-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis in rats.
    Gastroenterology, 1966, Volume: 50, Issue:6

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Catheterization; Cholestasis; Hyperbilirubinemia; Hypothermia, Induced; Ligation; Rats; Thiocyanates

1966