1-naphthylisothiocyanate has been researched along with Bile Duct Obstruction in 140 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (19.29) | 18.7374 |
| 1990's | 17 (12.14) | 18.2507 |
| 2000's | 17 (12.14) | 29.6817 |
| 2010's | 49 (35.00) | 24.3611 |
| 2020's | 30 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, J; Fang, S; Li, Y; Liu, S; Ma, Y; Shi, R; Wang, T; Wang, Z; Wu, J; Yang, L; Zou, J | 1 |
| Barrera-Chimal, J; Bucio-Ortiz, L; Gomez-Quiroz, LE; Gutiérrez-Ruiz, MC; Lazzarini-Lechuga, R; López-Ramirez, J; Masso, F; Miranda-Labra, RU; Roma, MG; Salas-Silva, S; Simoni-Nieves, A; Souza, V | 1 |
| Han, H; Shi, M; Tang, J; Zhang, T | 1 |
| Huang, C; Liu, F; Liu, J; Meng, C; Xia, C | 1 |
| Li, K; Ran, X; Wang, W; Wei, X; Wu, W; Xu, X; Zhang, T; Zhang, Y | 1 |
| Jiang, T; Li, J; Liu, J; Liu, S; Luo, S; Lv, Z; Qian, B; Shi, J; Yang, Z; Zhao, Z; Zhou, L; Zhou, Y | 1 |
| Gong, H; Gu, H; Guo, L; Hou, Z; Ma, J; Tang, T; Yan, M; Yang, Y; Zhang, B; Zhou, W; Zou, W | 1 |
| Gao, Q; Guo, S; Li, G; Liu, D; Wang, C; Wang, X; Xu, Y; Zhang, C; Zu, Y | 1 |
| Jiang, S; Liang, Y; Tang, L; Wang, W; Xu, C; Zhao, Y; Zhu, G | 1 |
| Attar, R; Khalil, A; Malkani, N; Mumtaz, S; Sohail, I; Tahir, N | 1 |
| Cai, J; Li, Y; Ma, Y; Peng, X; Shi, R; Tian, T; Wang, T; Wu, J; Zhang, L; Zou, J | 1 |
| Ahmed A Saad, A; Baldi, S; Refat, M; Wu, X; Zhang, G; Zheng, F | 1 |
| Jin, J; Li, Y; Liu, C; Qiu, FR; Song, G; Sun, X; Weng, F; Yan, D; Zhao, J; Zou, B | 1 |
| Cao, P; Cheng, B; Gan, J; Hu, Y; Huang, J; Li, F; Li, X; Si, L; Wu, S; Xia, B; Yu, H; Zeng, H | 1 |
| Han, J; Li, C; Liang, A; Liu, C; Liu, M; Liu, S; Meng, J; Pan, C; Qin, S; Tian, J; Wang, F; Wang, J; Wang, L; Yi, Y; Zhang, Y; Zhao, Y | 1 |
| Cheng, X; Gao, Q; He, W; Li, G; Liu, D; Shang, T; Wang, C; Xiang, D; Xu, Y; Zhang, C; Zu, Y | 1 |
| Heng, C; Huang, X; Jiang, Z; Li, L; Pang, J; Wang, X; Wei, C; Xia, Z; Yang, T; Zhang, L | 1 |
| Bai, L; Huang, X; Jiang, Z; Liu, L; Nong, C; Sun, L; Wang, X; Xue, R; Zhang, L; Zou, M | 1 |
| Hu, Q; Ji, H; Li, L; Li, T; Wang, X; Xu, L; Zheng, R | 1 |
| Dai, M; Liu, A; Luo, Y; Xu, G; Xu, L; Yang, J; Zhang, H | 1 |
| Huang, F; Shi, H; Tao, Y; Wu, H; Wu, X; Zhou, J; Zhu, H | 1 |
| Chai, Y; Huang, X; Jiang, Z; Miao, Y; Sun, L; Wang, H; Wang, X; Wu, Z; Yang, T; Yu, Q; Yuan, Z; Zhang, L | 1 |
| Guo, Q; Ji, H; Li, L; Li, T; Wang, X; Xu, L; Zheng, R; Zhou, M | 1 |
| Chen, F; Hua, W; Lu, Q; Sun, Y; Tan, S; Tang, L; Zhang, S | 1 |
| Chang, L; Dai, M; Liu, A; Xu, G; Yang, J; Zheng, X | 1 |
| Du, Z; Lin, J; Liu, J; Liu, P; Liu, W; Liu, X; Qi, L; Qiu, J; Wang, X; Xie, G; Yan, J | 1 |
| Feng, SL; Jin, H; Yuan, Z; Zhang, J; Zhu, WT | 1 |
| Dai, M; Li, S; Liu, A; Lu, Z; Luo, J; Luo, Y; Qiu, J; Yang, J; Zheng, X | 1 |
| Fan, Y; Li, G; Liu, J; Xu, T; Yu, H; Zhang, C; Zhang, Y; Zhou, L | 1 |
| Dai, P; Lin, C; Liu, F; Ma, H; Ma, Y; Wang, M; Wang, Q; Xie, Y; Yao, Y; Zhang, K; Zhu, C | 1 |
| Hu, P; Hu, Y; Huang, F; Jia, W; Liang, C; Liu, P; Wang, X; Xie, G; Yan, J; Zhao, A | 1 |
| Han, H; Liu, X; Sheng, T; Wang, Z; Xu, L; Zhang, T | 1 |
| Ding, J; Hassan, HM; Huang, X; Jiang, Z; Liu, J; Mei, H; Shu, T; Sun, L; Wang, X; Xu, D; Yang, T; Zhang, L; Zhou, W; Zhu, X | 1 |
| Ding, L; Li, J; Wang, Z; Yang, L; Zhang, B | 1 |
| Bothe, MK; Harleman, J; Meyer, C; Mueller, U; Queudot, JC; Roger, V; Westphal, M | 1 |
| Dai, M; Gonzalez, FJ; Hu, X; Hua, H; Li, F; Lin, H; Liu, A; Xu, G; Yang, J | 1 |
| Cui, SC; Gong, LK; Lu, HL; Ren, J; Wang, L; Wu, SY; Xing, GZ; Yan, XX; Zhang, YT | 1 |
| Chen, H; Fang, J; Gong, Z; Huang, T; Li, W; Liu, X; Mi, S; Min, J; Wang, N; Wang, Q; Wu, T; Zhang, Y; Zhao, W; Zhu, C | 1 |
| Han, H; Wang, Z; Xiong, K; Xu, L; Zhang, T | 1 |
| Gao, SJ; He, X; Li, PY; Ma, X; Wei, SZ; Wen, JX; Xiao, XH; Yang, YX; Zhao, YL | 1 |
| Inoue, A; Kishi, K; Koh, M; Miyazaki, H; Takitani, K; Tamai, H; Tamaki, H | 1 |
| Deng, H; Deng, X; Li, Y; Shi, S; Shi, X; Wang, D; Wang, Y; Xu, Z; Yu, H; Zeng, B; Zhong, X | 1 |
| Bao, HD; Cao, F; Dong, X; Gong, P; Liu, P; Liu, WH; Shang, YR; Wang, L; Wang, ZY; Zhu, LL | 1 |
| Chen, Y; Fan, G; Feng, K; Li, Q; Liu, L; Ma, C; Mao, J; Qu, J; Wei, L; Xia, R; Xu, S; Yang, S; Yu, M; Zhang, W | 1 |
| Feng, F; Zhu, G | 1 |
| Groen, AK; Hoekstra, M; van der Geest, R; van der Sluis, RJ; Van Eck, M | 1 |
| Gu, Y; Li, S; Song, F; Wang, R; Wang, Y; Wu, B; Yuan, Y | 1 |
| Jia, L; Li, R; Liu, B; Liu, S; Shan, L; Song, X; Wang, J; Xiao, X; Zhang, P; Zhao, Y; Zhou, G | 1 |
| Boyer, JL; Cai, SY; Mennone, A; Soroka, CJ | 1 |
| Ding, L; Wang, Z; Yang, L; Zhan, C; Zhang, B | 1 |
| Cline-Fedewa, H; Copple, BL; Flick, MJ; Joshi, N; Kopec, AK; Luyendyk, JP; O'Brien, KM; Towery, KL; Williams, KJ | 1 |
| Chen, M; Jiang, ZZ; Li, X; Sun, LX; Wang, T; Xu, ZM; Zhang, LY; Zhao, GL; Zhou, ZX | 1 |
| Jia, L; Li, J; Li, R; Li, Y; Ma, X; Wang, J; Wang, L; Wang, R; Wen, R; Xiao, X; Zhao, Y; Zhu, Y | 1 |
| Ai, G; Huang, ZM; Xu, HJ; Yan, JY; Zhang, XJ | 1 |
| Bi, KS; Chen, KL; Han, F; Mao, XJ; Yin, R; Zhang, XS; Zhu, HY | 1 |
| Chen, C; Chen, Z; Jiao, W; Li, J; Li, R; Liu, H; Ma, X; Shen, H; Wang, J; Wang, L; Wang, R; Wei, S; Xiao, X; Zhang, Y; Zhao, Y; Zhu, Y | 1 |
| Imaoka, M; Masubuchi, N; Mizumaki, K; Nishiya, T; Okazaki, O | 1 |
| Chen, C; Chen, Z; Li, JY; Li, RY; Li, YG; Liu, B; Ma, X; Wang, JB; Wang, LF; Wang, RL; Wei, SZ; Xiao, XH; Zhao, YL; Zhu, Y | 1 |
| Dong, LC; Dong, X; Fan, YX; Li, HJ; Li, P; Ma, J; Yu, Q | 1 |
| Chen, H; Chen, Z; Li, J; Liu, L; Ma, X; Niu, M; Su, H; Wang, J; Wang, R; Wei, Z; Xiao, X; Zhao, Q; Zhao, Y; Zhu, Y | 1 |
| Groothuis, GMM; Olinga, P; Pennings, JLA; Vatakuti, S | 1 |
| Cheng, Y; Dai, M; Gonzalez, FJ; Guo, B; Huang, J; Liu, A; Lu, C; Luo, M; Song, D; Tan, Z; Yang, J; Ye, M | 1 |
| Groen, AK; Hoekstra, M; Ouweneel, AB; van der Geest, R; van der Sluis, RJ; Van Eck, M | 1 |
| Joshi, N; Kopec, AK; Luyendyk, JP; Ray, JL | 1 |
| Gong, JT; Tang, XW; Wang, GY; Wang, ZT; Yang, F; Yang, L; Yang, QL | 1 |
| Gong, J; Han, H; Tang, X; Wang, Z; Yang, F; Yang, L; Yang, Q | 1 |
| Ding, L; Gong, J; Tang, X; Wang, G; Wang, Z; Yang, F; Yang, L; Yang, Q; Zhou, Y | 1 |
| Jiang, Z; Li, X; Liu, R; Sun, R; Yang, H; Yu, L; Yuan, Z; Zhang, L | 1 |
| Jiang, N; Lin, Y; Wang, L; Wu, F; Wu, G | 1 |
| Cao, WR; Chen, M; Dong, ZY; Fan, ML; Fan, XD; Ge, JQ; Lan, XZ; Liao, ZH; Wang, H; Xie, X | 1 |
| He, X; Li, H; Li, K; Li, P; Li, R; Liu, H; Ma, X; Wang, J; Wei, S; Wen, J; Xiao, X; Zhao, Y; Zhou, X; Zhu, Y | 1 |
| Huang, YQ; Li, HT; Li, JY; Li, K; Li, PY; Li, RS; Liu, W; Ma, X; Wang, J; Wang, JB; Wei, SZ; Xiao, XH; Zhao, YL; Zhou, HQ; Zhu, Y | 1 |
| Ding, Y; Duan, YY; Huang, ZH; Mei, H; Ye, P; Zhang, SL; Zhao, L | 1 |
| Cantor, GH; Copple, BL; Kirchhofer, D; Luyendyk, JP; Mackman, N; Wang, R | 1 |
| Shan, LM; Wang, JB; Xiao, XH; Zhao, YL; Zhou, GD | 1 |
| Aoki, T; Asai, N; Inomata, A; Ishihara, K; Katsutani, N; Sawada, K; Suganuma, A; Uemura, Y; Yokoi, T | 1 |
| Kamio, Y; Mori, N; Murakami, T; Yokooji, T | 1 |
| Luyendyk, JP; Mackman, N; Sullivan, BP | 1 |
| Cantor, GH; Flanagan, KC; Jaeschke, H; Luyendyk, JP; Mackman, N; Slusser, JG; Williams, CD | 1 |
| Allen, K; Cantor, GH; Copple, BL; Guo, GL; Kassel, KM; Li, G; Luyendyk, JP | 1 |
| Copple, BL; Cui, W; Luyendyk, JP; Sullivan, BP | 1 |
| Ding, LL; Dou, W; Wang, ZT; Yang, L; Zhan, CS; Zhang, BF | 1 |
| He, Y; Wan, YJ; Wang, Z; Xiong, A; Xu, Y; Yang, F; Yang, L | 1 |
| Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R | 4 |
| Kishikawa, T; Kongo, M; Ohta, Y | 1 |
| Lee, G; Maher, JJ; Vierling, JM; Wang, H; Xu, J | 1 |
| Jung, YS; Kim, SK; Kim, YC | 1 |
| Kurihara, H; Sano, N; Takikawa, H | 1 |
| Fukushima, K; Gershwin, ME; Kanno, N; Moritoki, Y; Shimosegawa, T; Ueno, Y; Yamagiwa, Y | 1 |
| Imai, Y; Kitagawa, A; Kongo-Nishimura, M; Ohta, Y | 1 |
| Dehpour, AR; Doratotaj, B; Gholipour, T; Honar, H; Jannati, A; Nik, HH; Noorian, AR; Riazi, K; Shariftabrizi, A | 1 |
| Fears, R; Ferres, H; Rush, WR; Walker, P | 1 |
| Hart, FE; Hew, JT; Willson, RA | 1 |
| Jaeschke, H; Krell, H; Pfaff, E | 1 |
| Lavigne, J; Lock, S; Plaa, GL | 1 |
| Maile, PA; Woodman, DD | 1 |
| De Lamirande, E; Plaa, GL | 1 |
| Ikeda, Y; Kako, M; Oda, T; Oka, H; Toda, G | 1 |
| Fuchshofen, M; Heusler, H; Lutz, B; Mora, E; Richter, E | 1 |
| Inoue, T; Kamogawa, A; Ohta, S; Sakurai, N; Sato, N; Shinoda, M | 1 |
| Delabar, U; Enderle, GJ; Krell, H | 1 |
| Araki, T; Ishizaki, K; Kinbara, S; Miyazawa, N; Takeuchi, Y | 1 |
| Ohta, S; Sato, N; Shinoda, M; Tu, SH | 1 |
| Goldstein, RS; Handler, JA; Kossor, DC; Meunier, PC; Sozio, RS | 1 |
| Bergasa, NV; Carson, R; Jones, EA; Swain, MG; Wahler, JB | 1 |
| Neghab, M; Stacey, NH | 1 |
| Contis, J; Kaminski, DL; Li, AP; Solomon, H | 1 |
| Ambu, R; Desmet, VJ; Faa, G; Miyazaki, H; Roskams, T; Serreli, S; Van Eyken, P | 1 |
| Dulik, DM; Goldstein, RS; Kossor, DC; Leonard, TB; Meunier, PC | 1 |
| Harada, N; Ishiguro, I; Kongo, M; Nishida, K; Ohta, Y; Sasaki, E | 1 |
| Agellon, LB; Chisholm, JW; Dolphin, PJ; Nation, P | 1 |
| Aoki, Y; Itoh, H; Numakami, K; Ogawa, Z | 1 |
| Harada, N; Ishiguro, I; Kongo, M; Ohta, Y; Sasaki, E | 1 |
| Chisholm, JW; Dolphin, PJ; Paterniti, JR | 1 |
| Plaa, GL; Priestly, BG | 1 |
| Hinton, RH; Mullock, BM; Woolley, J | 1 |
| Hofstetter, GJ; Richter, E; Seifert, H | 1 |
| Buschmann, J; Joeres, R; Richter, E; Zilly, W | 1 |
| Fukumoto, Y; Hayakawa, M; Nawata, J; Nishimura, H; Odawara, M | 1 |
| Brachtel, D; Gallenkamp, H; Richter, E; Zilly, W | 1 |
| Brachtel, D; Gallenkamp, H; Richter, E | 1 |
| Gallenkamp, H | 1 |
| Ditschuneit, H; Ditschuneit, HH; Felgenhauer, K; Hotz, J; Klör, HU | 1 |
| Drew, R; Priestly, BG | 1 |
| Fujita, T; Iwasaki, T; Kumazawa, N; Nakamura, H; Ohta, S; Shinoda, M | 1 |
| Duane, WC; Eckfeldt, JH; Furne, J; Hillstrom, J; Levitt, MD | 1 |
| Babini, G; Calcamuggi, G; Dughera, L; Emanuelli, G; Lanzio, M | 1 |
| Bay, MK; Johnson, RF; Leighton, JA; Maldonado, AL; Schenker, S; Speeg, KV | 1 |
| Kast, A; Yabe, T | 1 |
| Chan, YS; Chang, HM; Cheng, YY; Chiang, TC; Tai, KF | 1 |
| Aoki, Y; Itoh, H; Suzuki, H | 1 |
| Aoki, Y; Itoh, H; Tanigawa, K | 1 |
| Fujisaki, K | 1 |
| Platt, D; Vömel, T | 1 |
| Bhathal, PS; Gall, JA | 1 |
| Di Padova, C; Di Padova, F; Stramentinoli, G; Tritapepe, R | 1 |
| Plaa, GL; Roberts, RJ | 1 |
1 review(s) available for 1-naphthylisothiocyanate and Bile Duct Obstruction
| Article | Year |
|---|---|
Intrahepatic cholestasis induced by drugs and chemicals.
Topics: 1-Naphthylisothiocyanate; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Bile; Bile Acids and Salts; Bile Ducts; Cholestasis; Endoplasmic Reticulum; Erythromycin; Gonadal Steroid Hormones; Humans; Ligation; Liver; Manganese; Membranes; Mitochondria; Phenothiazines; Progestins; Time Factors | 1976 |
139 other study(ies) available for 1-naphthylisothiocyanate and Bile Duct Obstruction
| Article | Year |
|---|---|
Cultured bear bile powder ameliorates acute liver injury in cholestatic mice via inhibition of hepatic inflammation and apoptosis.
Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Bile; Chickens; Cholestasis; Inflammation; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Mice; Mice, Inbred C57BL; Powders; Random Allocation; Ursidae | 2022 |
Hepatocyte growth factor reverses cholemic nephropathy associated with α-naphthylisothiocyanate-induced cholestasis in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Bile Acids and Salts; Bile Ducts; Cholestasis; Disease Models, Animal; Hepatocyte Growth Factor; Kidney; Kidney Diseases; Liver; Male; Mice; Oxidative Stress; Reactive Oxygen Species | 2022 |
Swertiamarin, an active iridoid glycoside from Swertia pseudochinensis H. Hara, protects against alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Iridoid Glucosides; Iridoid Glycosides; Iridoids; Liver; Pyrones; Rats; Swertia | 2022 |
Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Homeostasis; Liver; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Receptors, Cytoplasmic and Nuclear; Tandem Mass Spectrometry | 2022 |
Combination of resveratrol and luteolin ameliorates α-naphthylisothiocyanate-induced cholestasis by regulating the bile acid homeostasis and suppressing oxidative stress.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Homeostasis; Liver; Luteolin; Oxidative Stress; Rats; Resveratrol; Taurine | 2022 |
IL-25 ameliorates acute cholestatic liver injury via promoting hepatic bile acid secretion.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Interleukin-17; Liver; Liver Diseases; Mice; Mice, Inbred C57BL | 2022 |
Liquiritin alleviates alpha-naphthylisothiocyanate-induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Liver; Mice; MicroRNAs; NF-E2-Related Factor 2; RNA, Messenger; Sirtuin 1 | 2023 |
Ginsenosides Restore Lipid and Redox Homeostasis in Mice with Intrahepatic Cholestasis through SIRT1/AMPK Pathways.
Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Cholestasis; Cholestasis, Intrahepatic; Fatty Acids; Ginsenosides; Hep G2 Cells; Homeostasis; Humans; Lipids; Liver; Mice; NF-E2-Related Factor 2; Oxidation-Reduction; RNA, Small Interfering; Sirtuin 1 | 2022 |
Transcriptome and Gut Microbiota Profiling Analysis of ANIT-Induced Cholestasis and the Effects of Da-Huang-Xiao-Shi Decoction Intervention.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Gastrointestinal Microbiome; Liver; Rats; RNA, Ribosomal, 16S; Transcriptome; United States | 2022 |
Silymarin protects the liver from α-naphthylisothiocyanate-induced cholestasis by modulating the expression of genes involved in bile acid homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Cholestasis; Liver; Mice; RNA, Messenger; Silymarin | 2022 |
Identification of Yinchenwuling fang's active components and hepatoprotective effects against cholestatic liver damage induced by alpha-naphthyl isothiocyanate in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Isothiocyanates; Liver; Liver Diseases; Mice | 2023 |
7, 8-Dihydroxy-4-methyl coumarin alleviates cholestasis via activation of the Farnesoid X receptor in vitro and in vivo.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Coumarins; Liver; Liver Diseases; Mice; Molecular Docking Simulation; Receptors, Cytoplasmic and Nuclear | 2023 |
The choleretic role of tauroursodeoxycholic acid exacerbates alpha-naphthylisothiocyanate induced cholestatic liver injury through the FXR/BSEP pathway.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis; Liver; Mice; Receptors, Cytoplasmic and Nuclear | 2023 |
Molecular mechanisms of hepatoprotective effect of tectorigenin against ANIT-induced cholestatic liver injury: Role of FXR and Nrf2 pathways.
Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Bile Acids and Salts; Bilirubin; Cholestasis; Isoflavones; Liver; Mice; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases | 2023 |
Gardenia extract protects against intrahepatic cholestasis by regulating bile acid enterohepatic circulation.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Enterohepatic Circulation; Gardenia; Liver; Rats; Rats, Sprague-Dawley; Steroid 12-alpha-Hydroxylase | 2024 |
Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Diabetes Mellitus, Type 2; Ginsenosides; Inflammation; Liver; Mice; Molecular Docking Simulation; Oxidative Stress; Panax; Saponins; Sirtuin 1 | 2024 |
Modulating intestinal barrier function by sphingosine-1-phosphate receptor 1 specific agonist SEW2871 attenuated ANIT-induced cholestatic hepatitis via the gut-liver axis.
Topics: 1-Naphthylisothiocyanate; Animals; Caco-2 Cells; Cholestasis; Chromatography, Liquid; Hepatitis; Humans; Liver; Mice; Sphingosine-1-Phosphate Receptors; Tandem Mass Spectrometry | 2023 |
The role of invariant natural killer T cells in experimental xenobiotic-induced cholestatic hepatotoxicity.
Topics: 1-Naphthylisothiocyanate; Animals; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 Enzyme System; Cytokines; Inflammation; Liver; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Natural Killer T-Cells | 2020 |
Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Cholestasis; Cinnamates; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Iridoid Glucosides; Liver; Liver Diseases; Male; Mice, Inbred C57BL; Protective Agents; Receptors, Cytoplasmic and Nuclear | 2020 |
Therapeutic action against chronic cholestatic liver injury by low-dose fenofibrate involves anti-chemotaxis via JNK-AP1-CCL2/CXCL2 signaling.
Topics: 1-Naphthylisothiocyanate; Animals; Chemokine CCL2; Chemokine CXCL2; Chemotaxis; Cholestasis; End Stage Liver Disease; Fenofibrate; Hypolipidemic Agents; MAP Kinase Signaling System; Mice; Mice, 129 Strain; Mice, Knockout | 2020 |
Alpha-naphthylisothiocyanate-induced cholestatic mice display anxiety-like behavior closely related with enhanced serotoninergic signaling transduction in central nervous system.
Topics: 1-Naphthylisothiocyanate; Animals; Anxiety; Behavior, Animal; Cholestasis; Liver; Male; Mice, Inbred C57BL; Serotonin; Signal Transduction | 2020 |
Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Down-Regulation; Hepatocytes; Homeostasis; Liver; Male; Mice, Inbred C57BL; Oxadiazoles; Sphingosine-1-Phosphate Receptors; Thiophenes; Tight Junctions | 2020 |
Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway.
Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis; Cinnamates; Hepatocytes; Iridoid Glucosides; Male; Mice, Inbred C57BL; Protective Agents; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2020 |
Protective effects of n-Butanol extract and iridoid glycosides of Veronica ciliata Fisch. Against ANIT-induced cholestatic liver injury in mice.
Topics: 1-Butanol; 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biological Transport; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Iridoid Glycosides; Liver; Male; Medicine, Tibetan Traditional; Mice; Oxidative Stress; Plant Extracts; Veronica | 2021 |
Inhibition of inflammation by SP600125 in cholestatic liver injury is dependent on the administration‑based exposure profile.
Topics: 1-Naphthylisothiocyanate; Animals; Anthracenes; Bile Acids and Salts; Biological Transport; Biomarkers; Cholestasis; Gene Expression Regulation; Inflammation; Liver; MAP Kinase Signaling System; Mice; RNA, Messenger | 2020 |
Metabolomics analysis delineates the therapeutic effects of Huangqi decoction and astragalosides on α-naphthylisothiocyanate (ANIT) -induced cholestasis in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Male; Metabolomics; Rats; Rats, Wistar; Saponins | 2021 |
A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholangitis; Cholestasis; Disease Models, Animal; Hepatitis; Hepatocytes; Hypericum; Kaempferols; Liver; Liver Diseases; Luteolin; Male; Oxidative Stress; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley | 2021 |
Fenofibrate reverses liver fibrosis in cholestatic mice induced by alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Actins; Animals; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Cholestasis; Collagen Type I; Fenofibrate; Inflammation; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Models, Animal; Peptide Fragments; PPAR alpha; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2021 |
Allopurinol Protects Against Cholestatic Liver Injury in Mice Not Through Depletion of Uric Acid.
Topics: 1-Naphthylisothiocyanate; Allopurinol; Animals; Cholestasis; Cholestasis, Intrahepatic; Liver; Mice; Uric Acid | 2021 |
A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Isodon; Liver; Metabolomics; Rats; Tandem Mass Spectrometry | 2021 |
Herbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bilirubin; Cholestasis; Cytokines; Drugs, Chinese Herbal; Gene Expression Regulation; Inflammation Mediators; Liver; Male; Protective Agents; Rats, Wistar; RNA, Messenger | 2017 |
Analyzing the hepatoprotective effect of the Swertia cincta Burkillextract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Chemical and Drug Induced Liver Injury; Cholestasis; Gene Expression Regulation; Liver; Male; Membrane Transport Proteins; Plant Extracts; Rats; Rats, Wistar; RNA, Messenger; Swertia | 2017 |
Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cell Polarity; Cholestasis; Hepatocytes; Homeostasis; Humans; Liver; Male; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors | 2017 |
Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; HEK293 Cells; Hep G2 Cells; Hepatocytes; Humans; Lipopolysaccharides; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Receptors, Cytoplasmic and Nuclear; Resveratrol; Signal Transduction; Stilbenes | 2018 |
Characterization of a rat model of moderate liver dysfunction based on alpha-naphthylisothiocyanate-induced cholestasis.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Amino Acids, Branched-Chain; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis; Disease Models, Animal; Humans; Liver Diseases; Rats, Wistar; Serum Albumin; Severity of Illness Index; Time Factors | 2017 |
Targeted Metabolomics Reveals a Protective Role for Basal PPARα in Cholestasis Induced by α-Naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Metabolomics; Mice, Inbred Strains; Mice, Knockout; NF-kappa B; PPAR alpha; Protective Agents; Signal Transduction; STAT3 Transcription Factor | 2018 |
18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Glycyrrhetinic Acid; Male; NF-E2-Related Factor 2; Protective Agents; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sirtuin 1 | 2018 |
Pharmacokinetic and Pharmacodynamic Properties of Rosmarinic Acid in Rat Cholestatic Liver Injury.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Bile; Chemical and Drug Induced Liver Injury; Cholestasis; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Limit of Detection; Liver; Male; Models, Biological; Rats, Sprague-Dawley; Reproducibility of Results; Rosmarinic Acid; Spectrophotometry, Ultraviolet | 2018 |
Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Discriminant Analysis; Gene Expression Regulation; Iridoid Glucosides; Male; Metabolome; Metabolomics; PPAR alpha; Principal Component Analysis; Protective Agents; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptor alpha | 2018 |
Paeonia lactiflora Pall. regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; Humans; Inflammasomes; Inflammation Mediators; Liver; Liver Function Tests; Medicine, Chinese Traditional; NF-kappa B; Paeonia; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2018 |
Altered Expression of Retinol Metabolism-Related Genes in an ANIT-Induced Cholestasis Rat Model.
Topics: 1-Naphthylisothiocyanate; Acyltransferases; Aldehyde Dehydrogenase; Animals; beta-Carotene 15,15'-Monooxygenase; Cholestasis; Disease Models, Animal; Gene Expression Regulation; Male; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase; Vitamin A | 2018 |
Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Cholestasis; Glutamate-Cysteine Ligase; Glutathione; Liver; Male; Melatonin; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 2019 |
Andrographolide impairs alpha-naphthylisothiocyanate-induced cholestatic liver injury in vivo.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis; Diterpenes; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Inflammation; Liver; Male; NF-E2-Related Factor 2; Oxidative Stress; Phytotherapy; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Sirtuin 1 | 2019 |
Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biological Transport; Cholestasis; Disease Models, Animal; Hep G2 Cells; Hepatocytes; Humans; Isoflavones; Liver; Male; Mice, Inbred C57BL; PPAR alpha; Sirtuin 1 | 2019 |
UPLC-MS-based metabonomic analysis of intervention effects of Da-Huang-Xiao-Shi decoction on ANIT-induced cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Liver; Male; Mass Spectrometry; Rats, Sprague-Dawley | 2019 |
Cholestasis-associated glucocorticoid overexposure does not increase atherogenesis.
Topics: 1-Naphthylisothiocyanate; Animals; Apolipoproteins E; Atherosclerosis; Cholestasis; Cholesterol; Corticosterone; Disease Models, Animal; Glucocorticoids; Humans; Hypercholesterolemia; Mice, Inbred C57BL; Mice, Knockout; Risk Factors; Species Specificity | 2019 |
Salvianolic acid B protects against ANIT-induced cholestatic liver injury through regulating bile acid transporters and enzymes, and NF-κB/IκB and MAPK pathways.
Topics: 1-Naphthylisothiocyanate; Animals; Benzofurans; Carrier Proteins; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cholestasis; Cytokines; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Male; Membrane Glycoproteins; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Protective Agents; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Paeoniflorin protects against ANIT-induced cholestasis by ameliorating oxidative stress in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Benzoates; Bridged-Ring Compounds; Cholestasis; Glucosides; Monoterpenes; Oxidative Stress; Rats | 2013 |
All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Bile Acids and Salts; Cell Proliferation; Cholagogues and Choleretics; Cholestasis; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; Liver; Male; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Tretinoin; Ursodeoxycholic Acid | 2014 |
Danning tablets attenuates α-naphthylisothiocyanate-induced cholestasis by modulating the expression of transporters and metabolic enzymes.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Biological Transport; Cholestasis; Drugs, Chinese Herbal; Liver; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Random Allocation; Rats; Rats, Wistar | 2014 |
Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Antithrombin III; Bile Acids and Salts; Blood Coagulation; Blood Platelets; Chemical and Drug Induced Liver Injury; Cholestasis; Fibrinogens, Abnormal; Genotype; Liver; Liver Cirrhosis, Experimental; Male; Mice, Inbred C57BL; Mice, Knockout; Mutation; Necrosis; Peptide Hydrolases; Phenotype; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Serotonin; Signal Transduction | 2015 |
Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms.
Topics: 1-Naphthylisothiocyanate; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Bile; Biomarkers; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis; Cytoprotection; Disease Models, Animal; DNA, Mitochondrial; Inflammation Mediators; Liver; Male; Membrane Transport Proteins; Neutrophil Infiltration; Oxidative Stress; Rats, Sprague-Dawley; Resveratrol; Stilbenes | 2014 |
Large dose means significant effect--dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; gamma-Glutamyltransferase; Hepatitis; Liver; Male; Paeonia; Phytotherapy; Pueraria; Rats; Salvia miltiorrhiza | 2015 |
Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against α-naphthylisothiocyanate-induced cholestatic liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Abelmoschus; Administration, Oral; Animals; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Flowers; Liver; Male; Rats; Rats, Wistar | 2015 |
Evaluation of the protective effect of Zhi-Zi-da-Huang decoction on acute liver injury with cholestasis induced by α-naphthylisothiocyanate in rats.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Antioxidants; Cholestasis; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Liver Diseases; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley | 2015 |
Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Benzoates; Bile Acids and Salts; Bilirubin; Bridged-Ring Compounds; China; Cholestasis; gamma-Glutamyltransferase; Glucosides; Glutamate-Cysteine Ligase; Glutathione; Liver; Liver Function Tests; Male; Monoterpenes; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Rats | 2015 |
Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Gene Expression Regulation; Liver; Male; Metabolome; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley | 2016 |
Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Biomarkers; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Liver; Male; NF-E2-Related Factor 2; Oxidative Stress; Paeonia; Phosphatidylinositol 3-Kinase; Phytotherapy; Plant Extracts; Plant Roots; Plants, Medicinal; Protein Interaction Maps; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction | 2015 |
Synergistic effects of rhubarb-gardenia herb pair in cholestatic rats at pharmacodynamic and pharmacokinetic levels.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Anthraquinones; Aspartate Aminotransferases; Bilirubin; Cholestasis; Drug Synergism; Emodin; Fruit; Gardenia; Iridoids; Liver; Male; Plant Extracts; Protective Agents; Rats, Sprague-Dawley; Rheum; Rhizome | 2015 |
Serum Metabolomic Profiling in a Rat Model Reveals Protective Function of Paeoniflorin Against ANIT Induced Cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Glucosides; Male; Metabolome; Monoterpenes; Rats; Rats, Sprague-Dawley | 2016 |
Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.
Topics: 1-Naphthylisothiocyanate; Aged; Chlorpromazine; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Gene Expression Profiling; Humans; Liver; Male; Methyltestosterone; Middle Aged; Signal Transduction; Transcriptome; Young Adult | 2017 |
Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Cholestasis; Cytokines; Liver; Male; Mice; NF-kappa B; Phytotherapy; Plant Extracts; Polyphenols; Signal Transduction; STAT3 Transcription Factor | 2016 |
Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice.
Topics: 1-Naphthylisothiocyanate; Adrenalectomy; Animals; Bile Acids and Salts; Cholestasis; Cholesterol; Corticosterone; Hypercholesterolemia; Liver; Liver Diseases; Mice, Inbred C57BL; Mifepristone; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid | 2016 |
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Clopidogrel; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Activation; Purinergic P2Y Receptor Antagonists; Receptors, Proteinase-Activated; Serotonin; Ticlopidine; Xenobiotics | 2016 |
Sweroside ameliorates α-naphthylisothiocyanate-induced cholestatic liver injury in mice by regulating bile acids and suppressing pro-inflammatory responses.
Topics: 1-Naphthylisothiocyanate; Animals; Anti-Inflammatory Agents; Bile Acids and Salts; Biomarkers; Cell Survival; Cholestasis; Disease Models, Animal; Gene Expression; Hepatocytes; Immunologic Factors; Iridoid Glucosides; Liver; Male; Mice; Mice, Inbred C57BL; Primary Cell Culture | 2016 |
Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Homeostasis; Iridoid Glucosides; Liver; Mice; Mice, Inbred C57BL | 2016 |
Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Curcumin; Disease Models, Animal; HEK293 Cells; Humans; Inflammation; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear | 2016 |
Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes.
Topics: 1-Naphthylisothiocyanate; Adenosine A1 Receptor Antagonists; AMP-Activated Protein Kinases; Animals; Bile Acids and Salts; Bile Ducts; Cell Survival; Cholestasis; Epithelial Cells; Hepatocytes; Homeostasis; Liver; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Xanthines | 2016 |
Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis; Cytochrome P-450 Enzyme System; Down-Regulation; Glucuronosyltransferase; Homeostasis; Iridoids; Liver; Organic Anion Transporters; Pregnane X Receptor; Protective Agents; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Sulfotransferases | 2017 |
Protective effects of petroleum ether extracts of Herpetospermum caudigerum against α-naphthylisothiocyanate-induced acute cholestasis of rats.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Cholestasis; Cucurbitaceae; Dose-Response Relationship, Drug; Liver; Male; Medicine, Tibetan Traditional; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley | 2017 |
Paeoniflorin ameliorates cholestasis via regulating hepatic transporters and suppressing inflammation in ANIT-fed rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Biomarkers; Carrier Proteins; Cholestasis; Edema; Glucosides; Inflammation; Liver; Liver Function Tests; Male; Monoterpenes; Necrosis; Neutrophil Infiltration; NF-kappa B; Rats; Rats, Sprague-Dawley | 2017 |
Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Cytokines; Genes, bcl-2; Glucosides; Liver; Mitochondria; Monoterpenes; Neutrophil Infiltration; Rats; Rats, Wistar; Signal Transduction | 2017 |
Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Anti-Inflammatory Agents; Cholestasis; Early Growth Response Protein 1; Emodin; Hepatitis; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2008 |
Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Cholestasis; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Thromboplastin | 2009 |
Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Anthraquinones; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; gamma-Glutamyltransferase; Liver; Lyases; Male; Plant Roots; Rats; Rats, Sprague-Dawley; Rheum; Rhizome; Transaminases | 2009 |
Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis.
Topics: 1-Naphthylisothiocyanate; Aniline Compounds; Animals; Biomarkers; Cholestasis; Cyclosporine; Disease Models, Animal; Kidney; Magnetic Resonance Spectroscopy; Male; Metabolomics; Rats; Rats, Sprague-Dawley | 2009 |
Increased intestinal absorption of mizoribine, an immunosuppressive agent, in cholestatic rats.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Cholestasis; Food-Drug Interactions; Immunosuppressive Agents; Intestinal Absorption; Male; Rats; Rats, Sprague-Dawley; Ribonucleosides | 2010 |
Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Cholestasis; Disease Models, Animal; Female; Fibrinogen; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Receptor, PAR-1; Receptors, Proteinase-Activated; Xenobiotics | 2011 |
Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.
Topics: 1-Naphthylisothiocyanate; Animals; Blood Coagulation; CD11b Antigen; Chemical and Drug Induced Liver Injury; Chemokines; Cholestasis; Intercellular Adhesion Molecule-1; Liver; Male; Mice; Myeloid Cells; Neutrophil Activation; Neutrophils; Peroxidase; Thromboplastin; Xenobiotics | 2011 |
Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis.
Topics: 1-Naphthylisothiocyanate; Afibrinogenemia; Aged; Animals; Bile Ducts; Cholestasis; Chronic Disease; Collagen; Diet; Disease Models, Animal; Early Growth Response Protein 1; Feeding Behavior; Female; Fibrin; Fibrinogen; Gene Expression Regulation; Humans; Hyperplasia; Inflammation; Liver; Liver Cirrhosis; Male; Mice; Middle Aged; Neutrophils; Xenobiotics | 2011 |
Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Biliary Tract; Cholestasis; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Early Growth Response Protein 1; Female; Fibrosis; Gene Expression Regulation; Integrin beta Chains; Liver; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2012 |
Protective effect of Danning tablet on acute livery injury with cholestasis induced by α-naphthylisothiocyanate in rats.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Anthraquinones; Antioxidants; Bile; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Liver; Magnoliopsida; Male; Neutrophil Infiltration; Phytotherapy; Rats, Wistar; Stilbenes; Transaminases | 2012 |
Evaluation of the protective effect of Rhei Radix et Rhizoma against α-naphthylisothiocyanate induced liver injury based on metabolic profile of bile acids.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Male; Plant Extracts; Plant Roots; Protective Agents; Rats; Rats, Wistar; Rheum; Rhizome | 2012 |
Reduction in cardiac mitochondrial calcium loading capacity is observable during alpha-naphthylisothiocyanate-induced acute cholestasis: a clue for hepatic-derived cardiomyopathies?
Topics: 1-Naphthylisothiocyanate; Acute Disease; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cardiomyopathies; Cholestasis; Energy Metabolism; Female; Ion Channels; Membrane Potentials; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Rats; Rats, Wistar | 2003 |
Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Catalase; Cholestasis; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Melatonin; Neutrophil Infiltration; Peroxidase; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2003 |
Cardiac mitochondrial calcium loading capacity is severely affected after chronic cholestasis in Wistar rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts, Intrahepatic; Blood Chemical Analysis; Calcium; Cholestasis; Chronic Disease; Disease Models, Animal; Energy Metabolism; Female; Ion Channels; Liver; Membrane Potentials; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Wistar | 2003 |
Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?
Topics: 1-Naphthylisothiocyanate; Animals; Calcium; Cardiovascular Diseases; Cholestasis; Chronic Disease; Cyclosporine; Disease Models, Animal; Female; Fibrosis; Liver Diseases; Mitochondria, Heart; Oxidative Stress; Rats; Rats, Wistar | 2003 |
Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Biomarkers; Chemical and Drug Induced Liver Injury; Chemokines, CXC; Cholestasis; Enzyme-Linked Immunosorbent Assay; Hydroxyproline; Leukocyte Count; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils | 2004 |
Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Amino Acids, Sulfur; Analysis of Variance; Animals; Aspartate Aminotransferases; Betaine; Bilirubin; Cholestasis; Cysteine; Dietary Supplements; Glutathione; Kinetics; Liver; Male; Mice; Mice, Inbred ICR; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
Biliary excretion of taurocholate, organic anions and vinblastine in rats with alpha-naphthylisothiocyanate-induced cholestasis.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Anions; Antineoplastic Agents, Phytogenic; Bile; Bile Acids and Salts; Biological Transport; Cholagogues and Choleretics; Cholestasis; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Taurocholic Acid; Vinblastine | 2005 |
Lack of evidence that bone marrow cells contribute to cholangiocyte repopulation during experimental cholestatic ductal hyperplasia.
Topics: 1-Naphthylisothiocyanate; Animals; Basic Helix-Loop-Helix Transcription Factors; Bile Ducts; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Proliferation; Cholestasis; Disease Models, Animal; Female; Gene Expression Regulation; Green Fluorescent Proteins; Homeodomain Proteins; Hyperplasia; Keratin-7; Keratins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Protein-Tyrosine Kinases; Receptors, Notch; Regeneration; Transcription Factor HES-1 | 2006 |
Melatonin attenuates disruption of serum cholesterol status in rats with a single alpha-naphthylisothiocyanate treatment.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cholesterol; Male; Melatonin; Rats; Rats, Wistar | 2007 |
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Cholestasis; Corn Oil; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Infusions, Intravenous; Intubation, Gastrointestinal; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Receptors, Opioid; Seizures; Time Factors | 2008 |
Hyperalphalipoproteinaemic activity of BRL 26314--I. Enhanced cholesterol turnover in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biological Transport; Cholestasis; Cholesterol; Feces; Hyperlipoproteinemias; Lipoproteins, HDL; Male; Phenobarbital; Phenylalanine; Rats; Rats, Inbred Strains | 1984 |
Experimental hepatobiliary injury. Comparison of in vivo drug elimination with in vitro drug-metabolizing enzyme capacity in the rat.
Topics: 1-Naphthylisothiocyanate; Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Cholestasis; Cytochrome P-450 Enzyme System; Ethinyl Estradiol; Hepatic Duct, Common; In Vitro Techniques; Liver; Metabolic Clearance Rate; Rats | 1981 |
No increase of biliary permeability in ethinylestradiol-treated rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Biliary Tract; Cholestasis; Ethinyl Estradiol; Inulin; Male; Permeability; Rats; Rats, Inbred Strains; Sucrose | 1983 |
The effect of alpha-naphthylisothiocyanate on bile secretion prior to and during the onset of cholestasis in the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Cholestasis; Male; Rats; Rats, Inbred Strains; Thiocyanates; Time Factors | 1982 |
Bile acid assays as an index of cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Cholestasis; Cholic Acids; Clinical Laboratory Techniques; Glycocholic Acid; Male; Rats | 1981 |
1,3-Butanediol pretreatment on the cholestasis induced in rats by manganese--bilirubin combination, taurolithocholic acid, or alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bilirubin; Butylene Glycols; Cholestasis; Drug Synergism; Male; Manganese Poisoning; Rats; Taurolithocholic Acid; Time Factors | 1981 |
Mechanism of elevation of serum alkaline phosphatase activity in biliary obstruction: an experimental study.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bile; Cell Membrane; Cholestasis; Cholestasis, Intrahepatic; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Liver; Male; Molecular Weight; Rats | 1980 |
[Lidocain clearance after oral and intravenous application in rats with low grade ANIT-cholestasis and galactosamine-induced hepatitis (author's transl)].
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biological Availability; Chemical and Drug Induced Liver Injury; Cholestasis; Galactosamine; Hepatitis; Injections, Intravenous; Lidocaine; Liver; Male; Rats | 1980 |
[Protective effects of the stem of Berchemia racemosa Sieb. et Zucc. on experimental liver injuries].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Liver Diseases; Male; Plant Stems; Rats; Rats, Wistar | 1995 |
Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis; Estradiol; Ethionine; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Leukotriene C4; Liver; Male; Perfusion; Rats; Rats, Wistar; Taurocholic Acid | 1995 |
Protection against alpha-naphthylisothiocyanate-induced acute cholestasis in mice by a novel taurine conjugate of ursodeoxycholate (UR-906).
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Bile Acids and Salts; Bilirubin; Biomarkers; Cholestasis; L-Lactate Dehydrogenase; Liver; Male; Mice; Taurine; Ursodeoxycholic Acid | 1993 |
[Protective effects of Taiwan crude drugs on experimental liver injuries].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholestasis; Drugs, Chinese Herbal; Liver Diseases; Male; Methanol; Rats; Rats, Wistar; Water | 1993 |
Temporal relationship of changes in hepatobiliary function and morphology in rats following alpha-naphthylisothiocyanate (ANIT) administration.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Biliary Tract; Cholestasis; Dose-Response Relationship, Drug; Erythritol; Liver; Male; Necrosis; Perfusion; Rats; Rats, Sprague-Dawley | 1993 |
Blood-brain barrier permeability is markedly decreased in cholestasis in the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Blood-Brain Barrier; Capillary Permeability; Cholestasis; Cholesterol; Dexamethasone; Male; Rats; Rats, Sprague-Dawley | 1993 |
Alpha-naphthylisothiocyanate-induced elevation of serum bile acids: lack of causative effect on bile acid transport.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Bile Acids and Salts; Biological Transport; Cell Survival; Cholestasis; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Sprague-Dawley; Taurocholic Acid | 1996 |
The effect of prostanoids on hepatic bile flow in dogs with normal liver and bile duct cell hyperplasia.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Bile Duct Diseases; Cholestasis; Common Bile Duct; Dinoprostone; Dogs; Epoprostenol; Glucagon; Hyperplasia; Secretin | 1996 |
Expression of cytokeratin 20 in developing rat liver and in experimental models of ductular and oval cell proliferation.
Topics: 1-Naphthylisothiocyanate; Age Factors; Animals; Bile Ducts, Intrahepatic; Cell Division; Cholestasis; Choline Deficiency; Female; Intermediate Filament Proteins; Keratin-20; Keratins; Liver; Male; Pregnancy; Rats; Rats, Inbred F344 | 1998 |
Bile duct obstruction is not a prerequisite for type I biliary epithelial cell hyperplasia.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bile Ducts; Cholestasis; Epithelial Cells; Glucose; Humans; Hyperplasia; Male; Rats; Rats, Sprague-Dawley | 1998 |
An association between lipid peroxidation and alpha-naphthylisothiocyanate-induced liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Bile Acids and Salts; Bilirubin; Body Weight; Cholestasis; gamma-Glutamyltransferase; Injections, Intraperitoneal; Lipid Peroxidation; Lipid Peroxides; Liver; Male; Organ Size; Peroxidase; Rats; Rats, Wistar; Statistics as Topic | 1999 |
High plasma cholesterol in drug-induced cholestasis is associated with enhanced hepatic cholesterol synthesis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Bilirubin; Cholestasis; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Female; Gallbladder; Hydroxymethylglutaryl CoA Reductases; Lipids; Lipoproteins; Liver; Mice; Mice, Inbred C57BL; Phospholipids | 1999 |
A kinetic model of mitochondrial aspartate aminotransferase transmigration in hepatobiliary disorders.
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholestasis; Computer Simulation; Indocyanine Green; Isoenzymes; Kinetics; Liver Diseases; Male; Mitochondria; Models, Biological; Rats; Rats, Wistar; Time Factors | 1999 |
Protective effect of melatonin against alpha-naphthylisothiocyanate-induced liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Cholestasis; L-Lactate Dehydrogenase; Lipid Peroxides; Liver; Male; Melatonin; Neutrophils; Peroxidase; Rats; Rats, Wistar | 2000 |
Accumulation of cholestatic lipoproteins in ANIT-treated human apolipoprotein A-I transgenic rats is diminished through dose-dependent apolipoprotein A-I activation of LCAT.
Topics: 1-Naphthylisothiocyanate; Animals; Animals, Genetically Modified; Apolipoprotein A-I; Cholestasis; Cholesterol; Cholesterol Esters; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Fatty Acids; Humans; Lipoproteins, LDL; Phospholipids; Rats | 2000 |
Disruption of mitochondrial calcium homeostasis after chronic alpha-naphthylisothiocyanate administration: relevance for cholestasis.
Topics: 1-Naphthylisothiocyanate; Adenine Nucleotides; Alanine Transaminase; Animals; Calcium; Cell Membrane Permeability; Chenodeoxycholic Acid; Cholestasis; Energy Metabolism; Female; Hepatocytes; Homeostasis; Injections, Intraperitoneal; Intracellular Membranes; Membrane Potentials; Mitochondria, Liver; Rats; Rats, Wistar | 2002 |
Reflux of billiary components into blood in experimental intrahepatic cholestasis induced in rats by treatment with alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Animals; Bilirubin; Cholestasis; Gallbladder; Immunoglobulin A; Isoenzymes; Male; Nucleotidases; Rats | 1979 |
[Intravenous and oral galactose loading of rats suffering from galactosamine hepatitis and ANIT-cholestasis; comparison of the kinetics in vivo and the galactose metabolism in the liver in vitro (author's transl)].
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Enzyme Activation; Galactokinase; Galactosamine; Galactose; In Vitro Techniques; Injections, Intravenous; Kinetics; Liver; Male; Rats; Thiocyanates; Time Factors | 1979 |
Alternative transport pathways of cholephilic 14C-hexobarbital metabolites in rats with experimental hepatitis and cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis; Chromatography, Thin Layer; Galactosamine; Hepatitis, Animal; Hexobarbital; Liver Function Tests; Male; Phenobarbital; Rats | 1979 |
[Alkaline phosphatase (ALP) in alpha-naphthylisothiocyanate-administered rats; with special reference to hepatic and intestinal ALP].
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Cholestasis; Disease Models, Animal; Intestine, Small; Isoenzymes; Liver; Male; Rats; Thiocyanates | 1977 |
[Symposion B: Experimental cholestasis--in vitro metabolism and in vivo metabolic clearance of hexobarbital in rats with ANIT-cholestasis].
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cytochrome P-450 Enzyme System; Hexobarbital; Male; Metabolic Clearance Rate; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Rats | 1976 |
[Hexobarbital-oxidation in vivo and in vitro in rats with bile duct ligation or ANIT-cholestasis (author's transl)].
Topics: 1-Naphthylisothiocyanate; Animals; Biotransformation; Cholestasis; Common Bile Duct; Disease Models, Animal; Hexobarbital; In Vitro Techniques; Ligation; Male; Microsomes, Liver; Rats; Thiocyanates | 1977 |
Phospholipids in endoplasmic reticulum - their relationship to drug metabolism in experimental liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Choline Deficiency; Endoplasmic Reticulum; Galactosamine; Hepatitis; Liver Diseases; Phospholipids; Rats | 1977 |
[Lipid metabolism in experimental rat liver lesions].
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Common Bile Duct; Ligation; Lipids; Male; Rats | 1976 |
Microsomal drug metabolism during alpha-naphthylisothiocyanate-induced cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmaceutical Preparations; Rats; Sleep; Thiocyanates; Time Factors | 1976 |
[Protective effects of the fractions extracted from the callus of Acer nikoense Maxim. on alpha-naphthylisothiocyanate induced liver injury].
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis; Liver Diseases; Male; Plant Extracts; Rats; Rats, Inbred Strains; Trees | 1992 |
Lack of benefit of ursodeoxycholic acid in drug-induced cholestasis in the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cyclosporine; Ethinyl Estradiol; Male; Rats; Rats, Inbred Strains; Ursodeoxycholic Acid | 1992 |
Endotoxin tolerance and polymyxin B modify liver damage and cholestasis induced by a single dose of alpha-naphthylisothiocyanate in the rat.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Endotoxins; Lead Poisoning; Liver; Male; Polymyxin B; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1992 |
The effect of liver dysfunction on colchicine pharmacokinetics in the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cimetidine; Colchicine; Cytochrome P-450 Enzyme Inhibitors; Galactosamine; Liver Diseases; Rats; Rats, Inbred Strains | 1990 |
The optimum pH of serum alkaline phosphatase after induced cholestasis in the male rat, mouse and rabbit.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Cholestasis; Cystine; Electrophoresis, Cellulose Acetate; Fasting; Homoarginine; Hydrogen-Ion Concentration; Intestines; Isoenzymes; Liver; Male; Mice; Phenylalanine; Rabbits; Rats | 1988 |
[Choleretic effects of acetophenone derivatives and analogues on rats].
Topics: 1-Naphthylisothiocyanate; Acetophenones; Animals; Bile; Cholagogues and Choleretics; Cholestasis; Male; Rats; Rats, Inbred Strains; Secretory Rate | 1986 |
Changes in polyamine metabolism in rat liver after oral administration of alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile; Cholestasis; Liver; Liver Regeneration; Male; Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred Strains; Thiocyanates; Urea | 1986 |
Transmigration of mitochondrial GOT in cholestatic liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholestasis; Indicators and Reagents; Isoenzymes; Kinetics; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains | 1986 |
[Changes and induction of drug-metabolizing enzymes in rats with hepatic injuries].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Cholestasis; Enzyme Induction; In Vitro Techniques; Liver; Microsomes, Liver; Rats; Rats, Inbred Strains | 1986 |
Age-dependent phagocytosis of erythrocytes by the isolated perfused rat liver after galactosamine hepatitis and alpha-naphthylisothiocyanate cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Cell Survival; Cholestasis; Erythrocytes; Galactosamine; Hepatitis, Animal; Liver; Male; Phagocytosis; Rats; Rats, Inbred Strains | 1986 |
Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Cell Division; Cell Survival; Cholestasis; Common Bile Duct; Disease Models, Animal; Epithelium; Hyperplasia; Jejunum; Liver; Liver Cirrhosis, Biliary; Male; Rats; Rats, Inbred Strains | 1985 |
S-adenosyl-L-methionine protection against alpha-naphthylisothiocyanate-induced cholestasis in the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Body Weight; Cholestasis; Lipids; Male; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thiocyanates | 1985 |
The effect of bile duct ligation, bile duct cannulation, and hypothermia on alpha-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Catheterization; Cholestasis; Hyperbilirubinemia; Hypothermia, Induced; Ligation; Rats; Thiocyanates | 1966 |