1-naphthylisothiocyanate has been researched along with Bile Duct Obstruction, Intrahepatic in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (14.67) | 18.7374 |
| 1990's | 14 (18.67) | 18.2507 |
| 2000's | 15 (20.00) | 29.6817 |
| 2010's | 18 (24.00) | 24.3611 |
| 2020's | 17 (22.67) | 2.80 |
| Authors | Studies |
|---|---|
| Gong, H; Gu, H; Guo, L; Hou, Z; Ma, J; Tang, T; Yan, M; Yang, Y; Zhang, B; Zhou, W; Zou, W | 1 |
| Gao, Q; Guo, S; Li, G; Liu, D; Wang, C; Wang, X; Xu, Y; Zhang, C; Zu, Y | 1 |
| Hou, LF; Lou, J; Wang, F; Xu, JJ; Yu, XK; Yuan, SQ; Zhang, HZ; Zhao, L; Zhu, YJ | 1 |
| Han, J; Li, C; Liang, A; Liu, C; Liu, M; Liu, S; Meng, J; Pan, C; Qin, S; Tian, J; Wang, F; Wang, J; Wang, L; Yi, Y; Zhang, Y; Zhao, Y | 1 |
| Cheng, W; Geng, Q; Miao, Y; She, X; Xu, M; Yang, C; Zhang, Q; Zhang, Z | 1 |
| Chen, Y; Duan, Y; Guo, F; Hajjar, DP; Han, J; Hu, H; Hu, W; Kong, D; Li, Q; Li, X; Ma, C; Miao, QR; Wang, H; Wei, Z; Yang, X; Yu, M; Zhang, S; Zhang, Y; Zhu, Y | 1 |
| Huang, T; Lin, C; Liu, C; Yao, Y; Zhang, Q; Zhang, R; Zhu, C | 1 |
| Amar, MJA; Freeman, LA; Karathanasis, SK; Neufeld, EB; Nishida, T; Pryor, M; Remaley, AT; Sampson, ML; Vaisman, BL | 1 |
| Barrera-Chimal, J; Bello, O; Bucio-Ortiz, L; Gomez-Quiroz, LE; Gutiérrez-Ruiz, MC; Lazzarini, R; López-Ramirez, J; Miranda-Labra, RU; Razori, MV; Roma, MG; Salas-Silva, S; Simoni-Nieves, A; Souza, V | 1 |
| Fan, FB; Li, WK; Li, YF; Li, YY; Ma, YM; Shi, R; Wang, GF; Wang, TM; Wu, JS; Zan, B; Zheng, M; Zou, J | 1 |
| Li, P; Li, X; Sui, J; Sun, F; Wu, J; Xu, C | 1 |
| Du, R; Gao, Y; Huang, W; Li, J; Ren, H; Xiao, Q; Zhang, S; Zhao, J; Zhu, Y | 1 |
| Dai, M; Lin, H; Liu, A; Xu, G; Yang, J; Zheng, X | 1 |
| Chen, M; Dong, Z; Lan, X; Liao, Z; Ma, Y; Wang, G; Wei, X | 1 |
| Lin, C; Liu, C; Liu, F; Lu, Z; Wang, M; Yao, Y; Zhang, Q; Zhang, R; Zhu, C | 1 |
| Fan, Y; Li, G; Liu, J; Xu, T; Yu, H; Zhang, C; Zhang, Y; Zhou, L | 1 |
| Chen, Z; Dun, Z; Fang, J; Gan, C; Luosang, T; Sang, C; Wang, B; Wang, Q; Wu, Y; Xiong, T; Zeren, D | 1 |
| Chen, M; Liao, Z; Meng, F; Tao, Y; Wang, G; Wei, X; Zong, W | 1 |
| Cheng, Y; Dai, M; Gonzalez, FJ; Guo, B; Hua, H; Lin, H; Lin, J; Liu, A; Luo, M; Song, D; Xie, M; Xu, G; Yang, J; Zhao, J | 1 |
| Chen, G; Fan, Y; Hu, Y; Jiang, J; Li, Y; Qiu, F; Su, H; Tan, B; Wang, Q; Zhang, L | 1 |
| Feng, L; Huo, XK; Liu, J; Ma, XC; Ning, J; Sun, CP; Tian, XG; Wang, C; Wang, YF; Yu, ZL; Zhang, BJ | 1 |
| Fang, ZZ; Gonzalez, FJ; Tanaka, N; Tang, KL; Wang, BL; Wang, L; Xu, Y; Zhang, CW | 1 |
| Bi, Y; Fan, G; Gao, X; Han, L; Li, C; Wang, X; Zhang, Y | 1 |
| Bao, WM; Cheng, Y; Gonzalez, FJ; Hu, DD; Hu, JP; Jiang, T; Li, F; Liu, F; Tang, YM; Xiao, XR; Yang, JH; Zhao, Q | 1 |
| Chang, MJ; Du, G; Li, XP; Liu, D; Wu, T; Xu, YJ | 1 |
| Chen, XL; Huo, XK; Liu, KX; Liu, Q; Liu, ZH; Meng, Q; Sun, HJ; Sun, PY; Wang, CY; Yao, JH | 1 |
| Chen, JW; Li, DY; Ou, QQ; Pei, XN; Qian, XH; Yu, L; Zhang, YX | 1 |
| Chen, H; Huang, X; Li, W; Liu, C; Mi, S; Min, J; Wang, N; Wang, Q; Yi, L; Zhang, R; Zhao, W; Zhu, C | 1 |
| Chen, B; Chu, Z; Dai, M; Guo, B; Li, P; Liu, A; Luo, M; Ma, M; Song, D; Tan, Z; Yin, X; Zou, Z | 1 |
| Huo, X; Jia, Y; Liu, K; Liu, Q; Meng, Q; Peng, J; Sun, H; Sun, P; Wang, C; Xu, Q; Zhang, A | 1 |
| Chansela, P; Khamphaya, T; Nathanson, MH; Piyachaturawat, P; Suksamrarn, A; Weerachayaphorn, J | 1 |
| Chen, P; Ding, Y; Jiang, ZX; Li, HR; Qin, H; Xiong, XL; Yan, SQ; Yao, C; Zhang, LL; Zhao, L; Zhou, LS | 1 |
| Fujita, T; Hasegawa, M; Ide, M; Takenaka, S | 1 |
| Duke, DS; Mendelson, KG; Schwartz, MZ; Thatch, KA; Yoo, EY | 1 |
| Alexeenko, TV; Korolenko, TA; Savchenko, NG; Sorochinskaya, NV; Yuz'ko, JV | 1 |
| Aleksunes, LM; Cui, YJ; Klaassen, CD; Tanaka, Y | 1 |
| Aleksunes, LM; Cui, YJ; Goedken, MJ; Klaassen, CD; Tanaka, Y | 1 |
| Alexeenko, TV; Cherkanova, MS; Filjushina, EE; Goncharova, IA; Klishevich, MS; Korolenko, TA; Savchenko, NG; Zhanaeva, SY | 1 |
| DING, Y; GAO, Y; HUANG, ZH; KANG, SX; MEI, H; PENG, HM; ZHAO, L | 1 |
| Haber, MM; Katz, MS; Schwartz, MZ; Thatch, KA | 1 |
| Luyendyk, JP; Sullivan, BP; Tawfik, O; Wang, R | 1 |
| Xu, H; Zhou, F | 1 |
| Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R | 1 |
| Akhmedzhanov, RR; Novozheeva, TP; Saratikov, AS | 1 |
| da Cunha, MF; Ferreira, FM; Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R | 1 |
| Cipriano, MA; Ferreira, FM; Martins, MI; Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R | 1 |
| Chignell, CF; Clark, J; He, YY; Liu, J; Myers, P; Saavedra, JE; Waalkes, MP | 1 |
| Hardman, RC; Hinton, DE; Howarth, DL; Kullman, SW; Volz, DC | 1 |
| Ding, Y; Huang, ZH; Mei, H; Peng, HM; Zhao, L | 1 |
| Mitamura, T | 1 |
| Hewitt, WR; Plaa, GL | 1 |
| Höke, H; Krell, H; Pfaff, E | 1 |
| Ikeda, Y; Kako, M; Oda, T; Oka, H; Toda, G | 1 |
| Yoshino, K | 1 |
| DeNicola, DB; Dulik, DM; Goldstein, RS; Kossor, DC; Leonard, TB; Meunier, PC; Ngo, W | 1 |
| Bergasa, NV; Jones, EA; Swain, MG; Vergalla, J | 1 |
| Mita, S; Nakata, K; Tanaka, M | 1 |
| Dulik, DM; Goldstein, RS; Handler, JA; Kossor, DC; Leonard, TB; Meunier, PC | 1 |
| Chisholm, JW; Dolphin, PJ | 1 |
| Ahmed-Choudhury, J; Chipman, JK; Coleman, R; Hammond, T; Orsler, DJ | 1 |
| Alpini, G; Alvaro, D; Baiocchi, L; Francis, H; Glaser, S; Kanno, N; Lesage, G; Phinizy, JL; Ueno, Y | 1 |
| Ando, M | 1 |
| Ishiki, Y; Matsumoto, K; Muto, Y; Nakamura, T; Ohnishi, H | 1 |
| Chamow, SM; Godowski, PJ; Roos, F; Schwall, RH; Terrell, TG | 1 |
| Dahm, LJ; Roth, RA | 1 |
| Bailie, MB; Dahm, LJ; Roth, RA | 1 |
| Bulle, F; Dhumeaux, D; Guellaën, G; Lescs, MC; Mavier, P; Preaux, AM; Siegrist, S; Zafrani, ES | 1 |
| Fromm, H; Krell, H; Larson, RE | 1 |
| Almasio, P; Bortolini, M; Coltorti, M; Pagliaro, L | 1 |
| Hikichi, N; Iizuka, Y; Niwa, H; Sakurai, E | 1 |
| Alpini, G; Lenzi, R; Liu, MH; Sarkozi, L; Slott, PA; Tavoloni, N; Zhai, WR | 1 |
| Billington, D; Capstick, A; Morris, AI; Quayle, JA | 1 |
| Chan, YS; Chang, HM; Cheng, YY; Chuang, KF | 1 |
| Wu, SM; Xu, CW | 1 |
| Höke, H; Jaeschke, H; Krell, H; Metz, J; Pfaff, E | 1 |
2 review(s) available for 1-naphthylisothiocyanate and Bile Duct Obstruction, Intrahepatic
| Article | Year |
|---|---|
Biotransformation products and cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Antidepressive Agents, Tricyclic; Bile Acids and Salts; Biotransformation; Chlorpromazine; Cholestasis, Intrahepatic; Dantrolene; Liver; Manganese Poisoning; Mixed Function Oxygenases; Rats; Steroids; Thioxanthenes | 1982 |
Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Bilirubin; Cholestasis, Intrahepatic; Female; Humans; Pregnancy; Pregnancy Complications; S-Adenosylmethionine | 1990 |
73 other study(ies) available for 1-naphthylisothiocyanate and Bile Duct Obstruction, Intrahepatic
| Article | Year |
|---|---|
Liquiritin alleviates alpha-naphthylisothiocyanate-induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Liver; Mice; MicroRNAs; NF-E2-Related Factor 2; RNA, Messenger; Sirtuin 1 | 2023 |
Ginsenosides Restore Lipid and Redox Homeostasis in Mice with Intrahepatic Cholestasis through SIRT1/AMPK Pathways.
Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Cholestasis; Cholestasis, Intrahepatic; Fatty Acids; Ginsenosides; Hep G2 Cells; Homeostasis; Humans; Lipids; Liver; Mice; NF-E2-Related Factor 2; Oxidation-Reduction; RNA, Small Interfering; Sirtuin 1 | 2022 |
[Study on protective effect of Chaihu Shugan Powder against liver injury in rats with intrahepatic cholestasis by regulating FXR/Nrf2/ARE pathway].
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Liver; NF-E2-Related Factor 2; Oxidative Stress; Powders; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2022 |
Gardenia extract protects against intrahepatic cholestasis by regulating bile acid enterohepatic circulation.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Enterohepatic Circulation; Gardenia; Liver; Rats; Rats, Sprague-Dawley; Steroid 12-alpha-Hydroxylase | 2024 |
TianJiu therapy for α-naphthyl isothiocyanate-induced intrahepatic cholestasis in rats treated with fresh Ranunculus sceleratus L.
Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Cholestasis, Intrahepatic; Disease Models, Animal; Lipid Peroxidation; Liver; Male; Moxibustion; Oxidative Stress; Ranunculus; Rats, Sprague-Dawley | 2020 |
Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Humans; Mice; PPAR gamma; Prostaglandin D2; Rosiglitazone | 2020 |
Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Male; Metabolomics; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2020 |
LCAT protects against Lipoprotein-X formation in a murine model of drug-induced intrahepatic cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Disease Models, Animal; Gene Knockout Techniques; Humans; Lipoprotein-X; Mice; Mice, Transgenic; Phosphatidylcholine-Sterol O-Acyltransferase | 2020 |
HGF induces protective effects in α-naphthylisothiocyanate-induced intrahepatic cholestasis by counteracting oxidative stress.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Hepatocyte Growth Factor; Male; Mice; Oxidative Stress | 2020 |
Yinchenzhufu decoction protects against alpha-naphthylisothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Homeostasis; Inflammation Mediators; Keratin-19; Male; Metabolomics; Mice | 2020 |
Effect of compound Yindan decoction on alpha-naphthylisothiocyanate-Induced acute intrahepatic cholestasis in rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis, Intrahepatic; Drugs, Chinese Herbal; gamma-Glutamyltransferase; Liver; Male; Radioimmunoassay; Rats | 2019 |
Ginsenoside Rg1 alleviates ANIT-induced intrahepatic cholestasis in rats via activating farnesoid X receptor and regulating transporters and metabolic enzymes.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Biomarkers; Cholestasis, Intrahepatic; Cytochrome P-450 CYP3A; Cytokines; Ginsenosides; Glucuronosyltransferase; Glutathione Peroxidase; Liver; Male; Malondialdehyde; Membrane Transport Proteins; Protective Agents; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sulfotransferases; Superoxide Dismutase | 2020 |
Cholestatic models induced by lithocholic acid and α‑naphthylisothiocyanate: Different etiological mechanisms for liver injury but shared JNK/STAT3 signaling.
Topics: 1-Naphthylisothiocyanate; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Lithocholic Acid; Male; MAP Kinase Signaling System; Metabolome; Mice; Mice, Inbred ICR | 2020 |
Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile; Bile Acids and Salts; Cholestasis, Intrahepatic; Cucurbitaceae; Hepatocytes; Humans; Isoxazoles; Liver; Male; Molecular Docking Simulation; Phenols; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2021 |
Network pharmacology-based mechanism prediction and pharmacological validation of Xiaoyan Lidan formula on attenuating alpha-naphthylisothiocyanate induced cholestatic hepatic injury in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Drugs, Chinese Herbal; Inflammation; Male; Metabolic Networks and Pathways; Molecular Docking Simulation; NF-kappa B; Protective Agents; Protein Interaction Maps; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2021 |
Allopurinol Protects Against Cholestatic Liver Injury in Mice Not Through Depletion of Uric Acid.
Topics: 1-Naphthylisothiocyanate; Allopurinol; Animals; Cholestasis; Cholestasis, Intrahepatic; Liver; Mice; Uric Acid | 2021 |
Intrahepatic cholestasis induced by α-naphthylisothiocyanate can cause gut-liver axis disorders.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytokines; Feces; Intestinal Diseases; Intestine, Small; Liver; Liver Cirrhosis; Male; Mice, Inbred C57BL | 2021 |
Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism.
Topics: 1-Naphthylisothiocyanate; Acetates; Alanine Transaminase; Animals; Asteraceae; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Cholestasis, Intrahepatic; Lactones; Male; Molecular Docking Simulation; Plant Extracts; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sesquiterpenes | 2021 |
Inhibition of JNK signalling mediates PPARα-dependent protection against intrahepatic cholestasis by fenofibrate.
Topics: 1-Naphthylisothiocyanate; Animals; Anthracenes; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Fenofibrate; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; PPAR alpha; Protein Kinase Inhibitors; Pyrimidines; Signal Transduction; Structure-Activity Relationship | 2017 |
Different effects of ursodeoxycholic acid on intrahepatic cholestasis in acute and recovery stages induced by alpha-naphthylisothiocyanate in mice.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Cholestasis, Intrahepatic; Mice; Mice, Inbred C57BL; Recovery of Function; Ursodeoxycholic Acid | 2018 |
Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alisma; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; China; Cholestasis, Intrahepatic; Drugs, Chinese Herbal; Homeostasis; Liver; Male; Molecular Docking Simulation; Protective Agents; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2018 |
Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Lipid Metabolism; Mice; Mice, Knockout; Receptors, Aryl Hydrocarbon | 2019 |
Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cytokines; Emodin; Hep G2 Cells; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2019 |
Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.
Topics: 1-Naphthylisothiocyanate; Adult; Animals; Cholestasis, Intrahepatic; Disease Models, Animal; Female; Gene Expression Profiling; Humans; Male; Metabolomics; Mice; Middle Aged; Pentacyclic Triterpenes; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sirtuin 1; Thioacetamide; Treatment Outcome; Triterpenes | 2019 |
Protective effect of Calculus Bovis Sativus on intrahepatic cholestasis in rats induced by α-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile; Bilirubin; Biological Products; Biomarkers; Cholestasis, Intrahepatic; Disease Models, Animal; Drugs, Chinese Herbal; Liver; Male; Malondialdehyde; Phytotherapy; Rats; Rats, Wistar; Superoxide Dismutase | 2013 |
Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cholestenones; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Homeostasis; Humans; Liver; Male; Membrane Transport Proteins; Mice, Inbred C57BL; Protective Agents; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Time Factors; Transfection | 2015 |
Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biomarkers; Cholestasis, Intrahepatic; Drugs, Chinese Herbal; Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Rats; RNA, Messenger; Up-Regulation | 2016 |
Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Iridoid Glucosides; Male; Protective Agents; Rats; Receptors, Cytoplasmic and Nuclear | 2016 |
Geniposide Inhibits Alpha-Naphthylisothiocyanate-Induced Intrahepatic Cholestasis: The Downregulation of STAT3 and NF[Formula: see text]B Signaling Plays an Important Role.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Down-Regulation; Drugs, Chinese Herbal; Humans; Iridoids; Male; Mice; Mice, Inbred ICR; NF-kappa B; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2016 |
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cholestasis, Intrahepatic; Diosgenin; Estrone; Hepatocytes; Liver; Male; Multidrug Resistance-Associated Protein 2; Organic Anion Transporters; Protective Agents; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger | 2016 |
Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Cell Proliferation; Cholestasis, Intrahepatic; Cyclin D1; Diterpenes; Gene Expression Regulation; Hepatic Stellate Cells; Liver; Male; NF-kappa B; Rats | 2016 |
Preliminary study on Emodin alleviating alpha-naphthylisothiocyanate-induced intrahepatic cholestasis by regulation of liver farnesoid X receptor pathway.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cell Line; Cholestasis, Intrahepatic; Emodin; Female; Glucuronosyltransferase; Humans; Liver; Male; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA-Binding Proteins; RNA, Messenger; Signal Transduction | 2016 |
Urinary metabolic fingerprinting for alpha-naphthylisothiocyanate-induced intrahepatic cholestasis in rats using Fourier transform-ion cyclotron resonance mass spectrometry.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Cholestasis, Intrahepatic; Cyclotrons; Fourier Analysis; Liver; Male; Mass Spectrometry; Noxae; Principal Component Analysis; Rats | 2008 |
Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Epidermal Growth Factor; Female; Hepatocyte Growth Factor; Infusion Pumps, Implantable; Interleukin-6; Intestinal Absorption; Liver; Liver Regeneration; Parenteral Nutrition, Total; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2008 |
Activity of lysosomal enzymes in the bile and serum of mice with intrahepatic cholestasis.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; beta-Galactosidase; beta-N-Acetylhexosaminidases; Bile; Cholestasis, Intrahepatic; Cholesterol; gamma-Glutamyltransferase; Hexosaminidases; Lysosomes; Male; Mice; Mice, Inbred CBA; Polyethylene Glycols | 2008 |
ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Bilirubin; Blotting, Western; Carrier Proteins; Cholestasis, Intrahepatic; Fluorescent Antibody Technique, Indirect; Indicators and Reagents; Liver; Liver Function Tests; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; RNA; Signal Transduction | 2009 |
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Branched DNA Signal Amplification Assay; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fluorescent Antibody Technique; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA | 2009 |
In vivo effect of selective macrophage suppression on the development of intrahepatic cholestasis in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Cathepsin B; Cathepsin D; Cholestasis, Intrahepatic; Gadolinium; Kupffer Cells; Liver; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission | 2008 |
[Effect and mechanism of emodin on cholestatic hepatitis].
Topics: 1-Naphthylisothiocyanate; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Early Growth Response Protein 1; Emodin; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Liver Function Tests; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2009 |
Growth factor modulation of hepatic inflammation: a novel approach to the management of total parenteral nutrition-associated liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Disease Models, Animal; Female; Hepatocyte Growth Factor; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Liver; Liver Diseases; Liver Failure; Liver Function Tests; Parenteral Nutrition, Total; Rats; Rats, Sprague-Dawley; Short Bowel Syndrome; Tumor Necrosis Factor-alpha | 2010 |
Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.
Topics: 1-Naphthylisothiocyanate; Animals; Antibodies, Monoclonal; Biomarkers; Blood Coagulation; Blood Platelets; Cholestasis, Intrahepatic; Clopidogrel; Gene Expression; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Thromboplastin; Ticlopidine | 2010 |
[Effect of emodin on P-gp expression in intrahepatic cholestatic rats].
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Acids and Salts; Bilirubin; Cholestasis, Intrahepatic; Emodin; Gene Expression Regulation; Liver; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2010 |
Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Adenine Nucleotides; Animals; Calcium; Cholestasis, Intrahepatic; Citrate (si)-Synthase; Disease Models, Animal; Energy Metabolism; Female; Hepatocytes; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; NADP; Oxygen Consumption; Random Allocation; Rats; Rats, Wistar | 2002 |
Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Barbiturates; Benzhydryl Compounds; Bilirubin; Cholestasis, Intrahepatic; Cytochrome P-450 Enzyme System; Female; Glutathione Transferase; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Urea | 2002 |
Cholestasis induced by chronic treatment with alpha-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics.
Topics: 1-Naphthylisothiocyanate; Adenine Nucleotides; Animals; Calcium; Cholestasis, Intrahepatic; Disease Models, Animal; Energy Metabolism; Female; Injections, Intraperitoneal; Intracellular Membranes; Kidney; Membrane Potentials; Mitochondria; Mitochondrial Swelling; Phosphorylation; Rats; Rats, Wistar | 2003 |
Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT).
Topics: 1-Naphthylisothiocyanate; Adenosine Triphosphatases; Animals; Calcium; Cholestasis, Intrahepatic; Energy Metabolism; Female; Ion Channels; Membrane Potentials; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Oxygen Consumption; Random Allocation; Rats; Rats, Wistar | 2003 |
Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Gene Expression Profiling; Liver; Male; Mice; Nitric Oxide Donors; Pyrrolidines | 2005 |
Protective response of the Ah receptor to ANIT-induced biliary epithelial cell toxicity in see-through medaka.
Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Bile Ducts, Intrahepatic; Bilirubin; Cell Line, Tumor; Cholestasis, Intrahepatic; Cloning, Molecular; Cytochrome P-450 CYP1A1; Disease Models, Animal; Drug Antagonism; Enzyme Induction; Epithelial Cells; Gallbladder; Gene Expression; Injections, Intraperitoneal; Liver; Male; Mice; Oryzias; Pigmentation; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; RNA, Messenger | 2008 |
[Role of early growth response factor-1 signal pathway in acute intrahepatic cholestatic hepatic injury in rats].
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Chemokine CXCL1; Chemokine CXCL2; Cholestasis, Intrahepatic; Early Growth Response Protein 1; Interleukin-6; Liver; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2008 |
Alterations of high density lipoproteins in experimental intrahepatic cholestasis in the rat induced by administration of alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Electrophoresis, Polyacrylamide Gel; Lipids; Lipoproteins, HDL; Male; Rats; Rats, Inbred Strains | 1984 |
Development of intrahepatic cholestasis by alpha-naphthylisothiocyanate in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cell Membrane Permeability; Cholestasis, Intrahepatic; Disease Models, Animal; Liver; Male; Rats; Rats, Inbred Strains; Sulfobromophthalein; Taurocholic Acid; Time Factors | 1982 |
Mechanism of elevation of serum alkaline phosphatase activity in biliary obstruction: an experimental study.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bile; Cell Membrane; Cholestasis; Cholestasis, Intrahepatic; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Liver; Male; Molecular Weight; Rats | 1980 |
Scanning electron microscopy on the rat liver with alpha-naphthylisothiocyanate- induced cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Canaliculi; Cholestasis, Intrahepatic; Liver; Male; Microscopy, Electron, Scanning; Rats; Thiocyanates | 1980 |
Biliary epithelial cell proliferation following alpha-naphthylisothiocyanate (ANIT) treatment: relationship to bile duct obstruction.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Ducts, Intrahepatic; Bilirubin; Bromodeoxyuridine; Cell Division; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Epithelium; Hyperplasia; Kinetics; Liver; Male; Rats; Rats, Sprague-Dawley | 1995 |
Sympathetic nerves, but not the adrenal gland, contribute to elevated plasma levels of met-enkephalin in rats with acute cholestatic hepatitis.
Topics: 1-Naphthylisothiocyanate; Adrenal Glands; Adrenalectomy; Aminopeptidases; Animals; Cholestasis, Intrahepatic; Chromatography, High Pressure Liquid; Disease Models, Animal; Enkephalin, Methionine; Hepatitis, Animal; Male; Neprilysin; Portal Vein; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical; Sympathetic Nervous System | 1993 |
The inhibitory effect of SA3443, a novel cyclic disulfide compound, on alpha-naphthyl isothiocyanate-induced intrahepatic cholestasis in rats.
Topics: 1-Naphthylisothiocyanate; Adjuvants, Immunologic; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Azocines; Bile; Bilirubin; Cholestasis, Intrahepatic; Disulfides; Male; Rats; Rats, Wistar | 1993 |
Cholestatic potentials of alpha-naphthylisothiocyanate (ANIT) and beta-naphthylisothiocyanate (BNIT) in the isolated perfused rat liver.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Isomerism; Liver; Male; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Abnormal lipoproteins in the ANIT-treated rat: a transient and reversible animal model of intrahepatic cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Disease Models, Animal; Fat Emulsions, Intravenous; Female; Humans; Lecithin Cholesterol Acyltransferase Deficiency; Lipolysis; Lipoproteins; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
ANIT-induced disruption of biliary function in rat hepatocyte couplets.
Topics: 1-Naphthylisothiocyanate; Actins; Adenosine Triphosphate; Animals; Bile Ducts, Intrahepatic; Cholestasis, Intrahepatic; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Wistar; Toxicity Tests; Vacuoles | 1999 |
Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis.
Topics: 1-Naphthylisothiocyanate; Animals; Apoptosis; Cholestasis, Intrahepatic; Cyclic AMP; Disease Models, Animal; Liver; Male; Organ Size; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2001 |
[Effects of urso-deoxycholic acid (UDCA) on alpha-naphthyl-isothiocyanate (ANIT) induced intrahepatic cholestasis in rats].
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Rats; Rats, Wistar; Ursodeoxycholic Acid | 1992 |
Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Bilirubin; Carbon Tetrachloride; CHO Cells; Cholestasis, Intrahepatic; Cricetinae; DNA; Hepatectomy; Hepatocyte Growth Factor; Humans; L-Lactate Dehydrogenase; Liver; Liver Regeneration; Male; Mice; Mice, Inbred BALB C; Organ Size; Recombinant Proteins | 1992 |
Reduction of alpha-naphthylisothiocyanate-induced hepatotoxicity by recombinant human hepatocyte growth factor.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis, Intrahepatic; Hepatocyte Growth Factor; Liver; Male; Necrosis; Rats; Recombinant Proteins | 1992 |
Protection against alpha-naphthylisothiocyanate-induced liver injury by decreased hepatic non-protein sulfhydryl content.
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Bile; Bile Acids and Salts; Bilirubin; Buthionine Sulfoximine; Cholestasis, Intrahepatic; gamma-Glutamyltransferase; Glutathione; Ketones; Liver; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1991 |
Relationship between alpha-naphthylisothiocyanate-induced liver injury and elevations in hepatic non-protein sulfhydryl content.
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Bile; Bile Ducts; Bilirubin; Cholestasis, Intrahepatic; gamma-Glutamyltransferase; Glutathione; Liver; Male; Rats; Rats, Inbred Strains | 1991 |
Mechanism of gamma-glutamyl transpeptidase release in serum during intrahepatic and extrahepatic cholestasis in the rat: a histochemical, biochemical and molecular approach.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Ducts, Intrahepatic; Bilirubin; Blotting, Northern; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Common Bile Duct; gamma-Glutamyltransferase; Histocytochemistry; Ligation; Liver; Male; Necrosis; Rats; Rats, Inbred Strains; RNA, Messenger | 1990 |
Increased paracellular permeability in intrahepatic cholestasis induced by carmustine (BCNU) in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Biliary Tract; Carbon Radioisotopes; Carmustine; Cell Membrane Permeability; Cholestasis, Intrahepatic; Horseradish Peroxidase; Male; Phosphates; Rats; Rats, Inbred Strains; Sucrose; Taurocholic Acid | 1991 |
[The influences of endogenous bile acids on maltase and alkaline phosphatase activities in intrahepatic cholestasis rats].
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; alpha-Glucosidases; Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Male; Rats; Rats, Inbred Strains | 1989 |
Bile secretory function of intrahepatic biliary epithelium in the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Ducts, Intrahepatic; Cholestasis, Intrahepatic; Epithelium; Histocytochemistry; Hyperplasia; Immunohistochemistry; Kinetics; Ligation; Liver; Male; Rats; Rats, Inbred Strains; Secretin | 1989 |
Plasma alkaline phosphodiesterase I in intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Cholestasis, Intrahepatic; Chromatography, Gel; Dose-Response Relationship, Drug; Phosphodiesterase I; Phosphoric Diester Hydrolases; Rats | 1988 |
[Active principle in a capillaris compound in the treatment of experimental acute jaundice in rats].
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis, Intrahepatic; Iridoids; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Plant Extracts; Plants, Medicinal; Pyrans; Rats; Rats, Inbred Strains | 1985 |
[Preliminary experimental study of radix Notoginseng in an injectable form on its disicterogenic and cholagogue action].
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis, Intrahepatic; Female; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Plant Extracts; Plants, Medicinal; Rabbits; Rats | 1985 |
Drug-induced intrahepatic cholestasis: characterization of different pathomechanisms.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis, Intrahepatic; Estradiol; Ethinyl Estradiol; In Vitro Techniques; Liver; Microscopy, Electron; Perfusion; Rats; Rats, Inbred Strains | 1987 |