1-monooleoyl-rac-glycerol has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 1 studies
1 other study(ies) available for 1-monooleoyl-rac-glycerol and Chemical-and-Drug-Induced-Liver-Injury
| Article | Year |
|---|---|
Improved Oral Bioavailability, Therapeutic Efficacy, and Reduced Toxicity of Tamoxifen-Loaded Liquid Crystalline Nanoparticles.
Present investigation deals with formulation and evaluation of tamoxifen (TMX)-loaded liquid crystalline nanoparticles (TMX-LCNPs) for improving oral bioavailability and safety of the existing treatment. Hexagonal Glyceryl monooleate-based TMX-LCNPs (GLCNPs) and Phytantriol-based TMX-LCNPs (PLCNPs) were prepared by dilution-through-hydrotrope method for oral administration. Oleic acid was incorporated in the lipid matrix to enhance the drug loading in the LCNPs. Optimized LCNPs displayed small particle size with a narrow distribution, sustained drug release and high gastrointestinal stability. TMX-LCNPs were found to be considerably higher cytotoxic to MCF-7 cells as compared to free TMX. Substantial fold enhancement in oral bioavailability (~7- and ~5-folds with TMX-GLCNPs and TMX-PLCNPs, respectively) was evident followed by significant reduction in tumor burden with lesser hepatotoxicity. Out of the two LCNP formulations, PLCNPs were found to be better in convalescing the disease. Topics: Animals; Antineoplastic Agents, Hormonal; Biological Availability; Caco-2 Cells; Cell Proliferation; Chemical and Drug Induced Liver Injury; Delayed-Action Preparations; Drug Compounding; Fatty Alcohols; Female; Glycerides; Humans; Liquid Crystals; MCF-7 Cells; Nanoparticles; Oleic Acid; Particle Size; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Tamoxifen | 2018 |