1-methylpropyl-2-imidazolyl-disulfide and Stomach-Neoplasms

Thioredoxin-1 (Trx-1) is a small redox protein, which plays an important role in many biological processes. Although increased expression of Trx-1 in various solid tumors has been reported, the prognostic significance and function of Trx-1 in human gastric cancer (GC) are still unclear. Here, we investigated the clinical and prognostic significance of Trx-1 expression and the function and mechanism of Trx-1 in human GC.. We analyzed Trx-1 mRNA expression from the GEO database and Trx-1 protein expression in 144 GC tissues using immunohistochemistry. Effects of Trx-1 on GC cell were assessed. Increased Trx-1 expression was found in GC tissues and associated with poor prognosis and aggressive clinicopathological characteristics in patients with GC. High Trx-1 expression predicted poor prognosis, and its expression was an independent prognostic factor for overall survival of GC patients. Knockdown of Trx-1 expression inhibited GC cell growth, migration, and invasion. Our results indicate that Trx-1 may be a promising prognostic indicator and therapeutic target for GC patients.

Topics: Aged; Animals; Apoptosis; Cell Movement; Cell Proliferation; Disease Progression; Disulfides; Female; Humans; Imidazoles; Lentivirus; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Stomach Neoplasms; Thioredoxins; Up-Regulation