Compounds > 1-methyl-beta-carboline-3-carboxylic-acid

1-methyl-beta-carboline-3-carboxylic-acid and Muscle-Spasticity

1-methyl-beta-carboline-3-carboxylic-acid has been researched along with Muscle-Spasticity* in 1 studies

Other Studies

1 other study(ies) available for 1-methyl-beta-carboline-3-carboxylic-acid and Muscle-Spasticity

Article	Year
CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats. Life sciences, 1984, Oct-01, Volume: 35, Issue:14 Diazepam (0.4-4 mg/kg i.p.) reduced the spontaneous tonic activity in the electromyogram (EMG) recorded from the gastrocnemius-soleus muscle of spastic mutant Han-Wistar rats in a dose-dependent manner. The muscle relaxant effect of diazepam was antagonized by the benzodiazepine antagonists Ro 15-1788 (5 mg/kg i.p.), beta-CCM (2 mg/kg i.p.) and CGS 8216 (5 mg/kg i.p.), but not by EMD 41717 (50 mg/kg i.p.). These results add further support to the hypothesis that Ro 15-1788, CGS 8216 and beta-CCM do antagonize all pharmacological effects of benzodiazepines while EMD 41717 displays more selectivity in antagonizing the different actions of benzodiazepines. Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Electromyography; Female; Flumazenil; Imidazoles; Kinetics; Male; Muscle Contraction; Muscle Relaxation; Muscle Spasticity; Pyrazoles; Rats; Rats, Mutant Strains	1984

Article

Year

CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats.

Life sciences, 1984, Oct-01, Volume: 35, Issue:14

Diazepam (0.4-4 mg/kg i.p.) reduced the spontaneous tonic activity in the electromyogram (EMG) recorded from the gastrocnemius-soleus muscle of spastic mutant Han-Wistar rats in a dose-dependent manner. The muscle relaxant effect of diazepam was antagonized by the benzodiazepine antagonists Ro 15-1788 (5 mg/kg i.p.), beta-CCM (2 mg/kg i.p.) and CGS 8216 (5 mg/kg i.p.), but not by EMD 41717 (50 mg/kg i.p.). These results add further support to the hypothesis that Ro 15-1788, CGS 8216 and beta-CCM do antagonize all pharmacological effects of benzodiazepines while EMD 41717 displays more selectivity in antagonizing the different actions of benzodiazepines.

Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Electromyography; Female; Flumazenil; Imidazoles; Kinetics; Male; Muscle Contraction; Muscle Relaxation; Muscle Spasticity; Pyrazoles; Rats; Rats, Mutant Strains

1984