Page last updated: 2024-08-23

1-methyl-4-phenylpyridinium and Parkinson Disease

1-methyl-4-phenylpyridinium has been researched along with Parkinson Disease in 318 studies

Research

Studies (318)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (1.89)	18.7374
1990's	31 (9.75)	18.2507
2000's	68 (21.38)	29.6817
2010's	148 (46.54)	24.3611
2020's	65 (20.44)	2.80

Authors

Authors	Studies
Seo, MH; Yeo, S	2
Ouyang, X; Wang, S; Wen, Q; Xiong, B; Yu, X; Zhang, L	1
Kang, Y; Liu, S; Wang, L; Wang, Y; Xu, X; Zhang, Y	1
Li, J; Wang, C; Zhang, H	1
Brito, C; Carecho, R; de Oliveira Sequeira, C; Figueira, I; Godinho-Pereira, J; Leist, M; Milenkovic, D; Nunes Dos Santos, C; Pereira, SA; Terrasso, AP	1
Bao, HH; Han, YP; Liu, ZJ; Su, LL; Wang, Q	1
Li, JY; Li, QY; Liu, HB; Shi, Y; Zhang, XD	1
Sun, X; Tao, H; Wu, X; Yao, S; Zhang, C	1
Liu, Y; Wang, Q	1
Huo, X; Jin, X; Shao, J; Wang, L; Ying, X; Zhao, J; Zhou, C	1
Lim, HS; Park, G	1
Azam, S; Cho, DY; Choi, DK; Haque, ME; Jakaria, M; Kim, IS; Kim, JS	1
Agarwal, S; Chiang, CY; Day, CH; Hsieh, DJ; Huang, CY; Kung, YL; Kuo, CH; Lin, PY; Lin, SZ; Wu, LK	1
Choi, H; Jung, YJ; Oh, E	1
Chen, J; Chen, Y; Yu, H; Zhao, J; Zheng, Y; Zhu, J	1
Cha, DS; Han, YT; Lee, TY; Yang, W	1
Fu, S; Gao, X; He, D; He, Y; Li, J; Li, Z; Liu, D; Liu, Y; Wang, H; Ye, B	1
Huang, YH; Lin, TK; Yang, YL	1
Dang, T; Qiao, C; Wang, M; Zhao, R; Zhou, Y; Zhou, YZ	1
Elson, JL; Fouché, B; García-Beltrán, O; Gorham, R; Gutbier, S; Pienaar, IS; Stephenson, EJ; Turner, S; Van Der Westhuizen, FH	1
Li, J; Song, L; Sun, Z	1
Jiang, M; Jin, W; Lai, X; Ma, H; Shen, M; Sun, D; Wu, J; Yan, J; Yin, S; Zhang, Y	1
Gao, Y; Gao, Z; Han, G; Jiang, Z; Li, F; Wang, M; Wang, Y; Wang, Z; Yin, X	1
Beliakov, SV; Blokhin, V; Surkov, SA; Ugrumov, MV	1
Ashok Kumar, K; Chang, YM; Chiu, PL; Ho, TJ; Hsieh, DJ; Huang, CY; Ju, DT; Kuo, WW; Lee, TK; Liao, PH; Liao, SC	1
Ceafalan, LC; Ioghen, OC; Popescu, BO	1
Arslan, ME; Yılmaz, A	1
Chang, KH; Chen, CM; Chen, YC; Chiu, YJ; Lee-Chen, GJ; Lin, CH; Lin, CY; Lo, YS; Wu, YR; Yang, PN; Yao, CF	1
Gao, J; Gao, X; He, C; Liu, R; Qi, C; Sun, ZN; Wang, J; Xu, SY; Ye, ZY; You, WY; Zhang, JQ	1
Guo, X; Guo, Y; Li, C; Liu, M; Peng, J; Xing, H; Xing, Y; Zuo, S	1
Del Bel, E; do Amaral, L; Dos Santos, AC; Dos Santos, NAG; Sisti, FM	1
Chandramohan, V; Chithra, Y; Dey, G; Ghose, V; Gowthami, N; Srinivas Bharath, MM; Vasudev, V	1
Alimujiang, A; Huang, D; Jiang, Y; Xie, G; Xie, H; Yang, W; Yin, F	1
Gao, Y; Guo, S; Zhao, Y	1
Çelik, Ö; Öz, A	1
Chen, J; Gong, R; Huang, K; Jia, C; Li, X; Liang, W; Liu, W; Wei, W; Zhang, F; Zhang, J	1
Gupta, P; Laha, JK; Roy, I; Sharma, SS; Vaidya, B	1
León, CTG; Monroy, A; Montes, S; Morales-Montor, J; Ríos, C; Rubio, C; Rubio-Osornio, M	1
Cui, M; Fu, S; Gao, X; He, D; Huang, B; Li, Z; Liu, D; Wang, H; Yang, S; Ye, B	1
Han, YS; Lee, JH; Lee, SH	1
Gu, RZ; Lan, R; Lang, XY; Li, XX; Liu, QS; Qin, XY; Yu, Y	1
Avila-Acevedo, JG; Garcia-Jimenez, S; Monroy-Noyola, A; Montes, S; Perez-Barron, GA; Rios, LC; Rubio-Osornio, M	1
Gu, C; Guo, R; Li, J; Liu, J; Lv, R; Ma, C; Ouyang, F; Shi, R; Wang, G; Wu, E; Yu, T; Zaczek, A	1
Bousset, L; Fukunaga, K; Kawahata, I; Melki, R	1
Chen, Y; Geng, L; Wu, C; Zhao, J	1
Cheung, KH; Chun-Kit Tong, B; Gopalkrishnashetty Sreenivasmurthy, S; Iyaswamy, A; Li, M; Liu, J; Lu, J; Malampati, S; Song, J; Su, C; Wang, Z; Yang, C; Zhu, Z	1
Jiao, Y; Song, CJ; Zheng, Y	1
Gong, D; Zhu, M	1
Chen, X; Fan, F; Li, S; Wen, Z; Ye, Q	1
Chiaino, E; Davey, GP; Fernandez-Abascal, J; Frosini, M; Valoti, M	1
Liu, L; Wang, H; Wang, J	1
Chen, J; Gu, Y; Jiang, Z; Liu, N; Wang, T; Wang, Y; Zhou, Z	1
Chen, P; Hong, C; Ke, L; Lin, J; Lu, W; Wu, X; Zheng, D	1
Bhatia, G; Nehru, B; Singh, J	1
Amiry-Moghaddam, M; Ottersen, OP; Prydz, A; Skare, Ø; Skauli, N; Stahl, K; Zahl, S	1
Dong, L; He, Z; Liu, N; Luo, X; Zheng, Y	1
Cui, CC; Cui, GY; Dong, LG; Jin, GL; Lu, FF; Shen, T; Xiao, QH; Xu, CY; Xu, R; Yang, XX; Zhang, W; Zhou, S; Zhu, JN; Zu, J	1
Aparicio-Puerta, E; Backes, C; Danz, K; Diener, C; Fehlmann, T; Hart, M; Kahraman, M; Kehl, T; Keller, A; Kern, F; Krammes, L; Küchler, O; Lenhof, HP; Ludwig, N; Meese, E; Rheinheimer, S; von Briesen, H; Wagner, S	1
Dong, X; Li, Z; Liu, J; Yu, M; Zheng, Y; Zhuang, J	1
Murphy, D; Patel, H; Wimalasena, K	1
Binlateh, T; Chanvorachote, P; Chonpathompikunlert, P; Hutamekalin, P; Nonpanya, N; Prommeenate, P; Reudhabibadh, R	1
Chen, B; Lian, H; Lu, Q; Wang, B; Yang, H	1
Tian, J; Wang, H; Xu, F; Xu, H	1
Choi, SY; Choi, YJ; Eum, WS; Han, KH; Kim, DS; Kim, DW; Lee, KW; Lee, LR; Park, J; Park, JK; Shin, MJ; Song, Y; Yeo, EJ; Yeo, HJ	1
Hu, D; Liu, Z; Qi, X	1
Li, C; Liu, R; Mai, Y; Zhang, Y	1
Andersen, JK; Ghosh, A; Hernandez-Quijada, K; Kim, YH; Ko, HS; Ma, SX; Seo, BA; Verma, DK	1
Ávila-Gámiz, F; Boraldi, F; Garcia-Fernandez, M; Garrido-Gil, P; Labandeira-Garcia, JL; Ladrón de Guevara-Miranda, D; Lara, E; Martín-Montañez, E; Millon, C; Pavia, J; Pérez-Cano, AM; Romero-Zerbo, YS; Santin, LJ; Valverde, N	1
Chen, Y; Fan, Y; Hao, S; Hu, J; Liu, Y; Qin, X; Yang, B	1
Chen, L; Chen, Z; Gao, X; Xu, J; Yang, C	1
Cavallaro, S; D'Agata, V; D'Amico, AG; Federico, C; La Cognata, V; Maugeri, G; Saccone, S	1
Cao, LJ; Chen, B; Wei, M; Xiao, F; Xu, CS; Xue, LJ; Zheng, JL	1
Aguirre-Vidal, Y; Anaya-Ramos, L; Arteaga-Silva, M; Díaz-Zaragoza, M; Mendez-Armenta, M; Monroy-Noyola, A; Montes, S; Morales-Montor, J; Ostoa-Saloma, P; Ríos, C	1
Chen, S; Liu, A; Tang, L; Wan, J; Xiong, Y; Zhang, S; Zheng, N	1
Chakraborty, S; Chiou, A; Karmenyan, A; Tsai, JW	1
Balakrishnan, R; Elangovan, N; Essa, MM; Guizani, N; Hemalatha, T; Justin-Thenmozhi, A; Manivasagam, T; Singh, V; Velusamy, T	1
Ahuja, M; Andersen, JK; Chinta, SJ; Rajagopalan, S; Rane, A; Thomas, B	1
Chen, J; Li, W; Ren, Y; Wang, G; Wang, H; Zhao, M; Zou, F	1
Chen, Y; Geng, L; Liu, W; Zhang, T	1
Chen, X; Liu, Y; Song, Y	1
Baghi, M; Ghaedi, K; Kiani-Esfahani, A; Nasr-Esfahani, MH; Rostamian Delavar, M; Safaeinejad, Z	1
Alberio, T; Fasano, M; Finzi, G; Lualdi, M; Sessa, F; Zilocchi, M	1
Cai, J; Iacovitti, L; Kostuk, EW	1
Bai, J; Chen, Y; Fan, Y; Huang, M; Li, Y; Wang, S; Zhang, S	1
Chen, J; Jiang, J; Sun, J; Zhou, J	1
Liang, Y; Wang, S; Xu, X; Zhu, J	1
Liu, X; Qi, L; Sang, Q; Sun, W; Sun, Y; Wang, L; Wang, W; Zhang, H	1
Chen, S; Chu, X; Ding, J; Dou, F; Liang, L; Lu, G; Zhang, B	1
Li, J; Liu, Z; Lu, G; Wang, Q; Wang, Y; Zhao, Y	1
Wang, YH; Wu, Q; Xi, DZ	1
Boonying, W; Callaghan, SM; Chung, YH; Figeys, D; Gonzalez, YR; Huang, E; Iyirhiaro, GO; Joselin, A; Park, DS; Qu, D; Safarpour, F; Slack, RS	1
Kalivendi, SV; Rao, SP; Sharma, N	1
Lickteig, B; Wimalasena, K; Wimalasena, VK	1
Callizot, N; Combes, M; Henriques, A; Poindron, P	1
Bao, B; Chai, JY; Chen, ZY; Wu, XB; Xia, ZB; Yin, XP; Zhang, MQ	1
Ansah, T; Channon, KM; Charlton, C; Gangula, PR; Hale, A; Kalpana, R; Sampath, C; Srinivasan, S	1
Duan, SJ; Li, J; Xie, SP; Zhou, F	1
Cao, BB; Chen, JN; Gu, TT; Huang, Y; Liu, Z; Peng, YP; Qiu, AW; Qiu, YH; Yang, Y	1
Qu, M	1
Bi, F; Huang, C; Li, F; Zhou, H	1
Chen, X; Huang, B; Ye, Q; Zhang, X; Zhu, Y	1
Cheng, SY; Lin, Y; Maynard, A; Williams, CA	1
Anantharam, V; Ghosh, A; Harischandra, DS; Jin, H; Kanthasamy, A; Kanthasamy, AG; Qian, Z; Rana, A; Saminathan, H; Sondarva, G	1
Dewapriya, P; Himaya, SW; Kim, SK; Li, YX	1
Alvarez-Fischer, D; Fuchs, J; Grünewald, A; Guerreiro, S; Hartmann, A; Hirsch, EC; Lombès, A; Lu, L; Michel, PP; Noelker, C; Oertel, WH; Vulinović, F	1
Li, S; Zhan, C; Zhong, Q; Zhou, D	1
Hirsch, EC; Michel, PP; Rousseau, E	1
Channon, KM; Crabtree, MJ; Hale, AB; Lourenço-Venda, LL; Ryan, BJ; Wade-Martins, R	1
Du, J; Duan, H; Guo, B; Lee, SM; Wang, Y; Xu, D; Zhang, Z	1
Chen, W; Fei, Z; Li, X; Liu, WB; Zhang, L	1
Pyszko, J; Strosznajder, JB	1
Dou, D; Jia, D; Kang, T; Li, D; Liu, Q; Wang, X	1
Cowley, SA; Hartfield, EM; James, WS; Ribeiro Fernandes, HJ; Vowles, J; Wade-Martins, R; Yamasaki-Mann, M	1
Kim, HN; Lee, PH; Oh, SH; Park, HJ; Shin, JY	1
Choi, MS; Jeon, MT; Jung, UJ; Kim, SR	1
Alberio, T; Alloggio, I; Bondi, H; Colombo, F; Fasano, M; Pieroni, L; Urbani, A	1
Chen, L; Chen, S; Guo, M; Huang, S; Liu, C; Liu, L; Ren, Q; Xu, C; Xu, Y; Ye, Y; Zhang, H; Zhou, Q	1
Choi, MS; Jeon, MT; Jin, BK; Jung, UJ; Kim, SR; Leem, E; Nam, JH; Park, SJ; Shin, WH; Won, SY	1
Deng, Q; Yang, X	1
Yin, M; Zhang, MH; Zhang, XM	1
He, JJ; Li, ZY; Liu, Q; Ma, YH; Qu, XD; Zhou, J	1
Aiastui, A; Bravo-San Pedro, JM; Climent, V; Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; López de Munain, A; Pizarro-Estrella, E; Rodríguez-Arribas, M; Yakhine-Diop, SM	1
Chen, CM; Chen, IC; Chen, YC; Chen, YL; Huang, YC; Juan, HF; Lai, YJ; Lee, CM; Lee, LC; Lee-Chen, GJ; Lin, CH; Wu, YR	1
Chen, W; Dong, YH; Li, DW; Li, GR; Sun, BQ; Tang, MN; Yao, M	1
Cao, X; Hu, D; Mao, L; Wang, H; Wang, T; Xiong, J; Xiong, N; Zhang, G; Zhang, Z	1
Do, JH	1
Choi, IY; Choi, MS; Chu, JW; Jang, MC; Jeon, MT; Jeong, KH; Jung, UJ; Kim, HD; Kim, SR; Yang, SJ	1
Anantharam, V; Harischandra, DS; Jin, H; Kanthasamy, A; Rana, A	1
Lee, D; Wiemerslage, L	1
Bae, N; Cha, JW; Chung, S; Gu, MY; Kim, HJ; Oh, H; Oh, MS; Yang, HO	1
Lu, BX; Luo, YF; Man, RY; Wang, XF; Zeng, QG; Zeng, Y	1
Barbier-Chassefière, V; Garrigue-Antar, L; Hénault, E; Lehri-Boufala, S; Morin, C; Ouidja, MO; Papy-Garcia, D; Raisman-Vozari, R	1
Chang, HH; Hu, HI; Sun, DS	1
Chong, CM; Guo, BJ; Hoi, PM; Lee, SM; Li, S; Sa, F; Zhang, LQ; Zhang, ZJ; Zheng, Y	1
Chaudhuri, AD; Choi, DC; Junn, E; Kabaria, S; Mouradian, MM	1
Geng, ZM; Hu, ZW; Wang, H; Wang, SY; Zhao, B	1
Lavalley, N; McFerrin, M; Slone, SR; Wang, B; Yacoubian, TA	1
Cintra, AC; Martins, NM; Sampaio, SV; Santos, AC; Santos, NA; Sartim, MA	1
Chang, YZ; Duan, XL; Fan, YM; Fu, XR; Gao, GF; Shi, ZH; Wang, MY; Wang, YQ; Zhao, BL	1
Guo, H; Hu, L; Li, M; Liu, Q; Shi, F; Yu, B	1
Deng, X; Hu, X; Hu, Y; Huang, B; Huang, T; Le, W; Lei, X; Li, H; Li, J; Li, L; Liu, L; Lü, L; Rizak, J; Wang, Z; Wu, J; Xu, L; Yao, Y; Zhang, B	1
Jia, Y; Lu, H; Lu, J; Peng, T; Teng, J; Wang, J	1
Zhang, GF; Zhang, Y; Zhao, G	1
Benassi, B; Consales, C; Filomeni, G; Lopresto, V; Marino, C; Merla, C; Montagna, C; Pinto, R	1
Du, Z; Fan, L; Jiang, L	1
Hotta, K; Oka, K; Shindo, Y; Suzuki, K; Yamanaka, R	1
Bourque, MJ; Giguère, N; Lévesque, M; Pacelli, C; Slack, RS; Trudeau, LÉ	1
Brunner, T; Cirri, E; Ferger, B; Friemel, A; Hiller, K; Karreman, C; Leist, M; Marx, A; Meiser, J; Möller, HM; Odermatt, M; Pape, R; Pasquarelli, N; Ringwald, M; Schildknecht, S; Strittmatter, T	1
Chen, Q; Chen, XP; Li, XZ; Sui, CY; Zhang, H; Zhou, XP	1
Hanaki, T; Horikoshi, Y; Kitagawa, Y; Koike, T; Matsura, T; Nakaso, K; Nakasone, M; Takahashi, T	1
Fernandes, LS; Ferreira, RS; Martins, NM; Queiroz, RH; Santos, AC; Santos, NA; Sisti, FM	1
Fattal, R; Kempuraj, D; Pattani, S; Santillan, DA; Santillan, MK; Thangavel, R; Yang, E; Zaheer, A; Zaheer, S	1
Feng, JJ; Li, DW; Li, GR; Zhang, BL; Zhao, H	1
Calcagno, M; Collins, LM; Dal Bo, G; Gutierrez, H; Monzón-Sandoval, J; Morari, M; O'Keeffe, GW; Sullivan, AM	1
Breckenridge, JM; Macarthur, H; Touchette, JC; Wilken, GH	1
Bezard, E; Blanchard-Desce, M; Bourdenx, M; Daniel, J; Dehay, B; Genin, E; Soria, FN	1
Cui, XX; Dong, SY; Feng, Y; Guo, YJ; Kuo, SH; Liu, T; Wu, YC	1
Chen, Z; Liao, J; Liu, X; Wang, Q; Wang, R; Wang, Y; Weng, R; Xia, Y; Zhou, P; Zou, J	1
Jiao, F; Ming, J; Shu, Y; Tian, B; Wang, Q; Zhang, P	1
Hou, B; Niu, M; Wang, J; Xie, A; Xu, R	1
Chang, YZ; Duan, XL; Li, Z; Shi, ZH; You, LH; Zhao, BL	1
Courtney, MJ; Goldsteins, G; Jaronen, M; Keksa-Goldsteine, V; Koistinaho, J; Lakso, M; Lehtonen, Š; Rudgalvyte, M; Vehviläinen, P; Wong, G	1
Cao, W; Guo, Z; Han, B; Han, Z; Zhao, S	1
Chung, KC; Darnell, RB; Hwang, IY; Hwang, JY; Kang, HW; Kim, K; Kim, S; Lee, J; Oh, CK; Oh, YJ; Park, HC; Park, WY; Shin, JH; Um, HD; Um, JW	1
Bingzhen, C; Honglei, Y; Hongwei, W; Jinfeng, L; Peng, X; Qingshan, L; Shanshan, W; Xia, C; Xiaopeng, Y; Xinshan, L; Yunliang, W; Yutong, W; Zhixiu, X	1
Carroll, CB; Eastwood, J; Hanemann, CO; McCorry, K; Zajicek, JP; Zeissler, ML	1
Ismael, S; Lee, D; Wiemerslage, L	1
Agim, ZS; Bai, Q; Berman, SB; Bonkowsky, JL; Burton, EA; Cannon, JR; Croix, CM; David, CN; Dukes, AA; Ilin, V; Van Laar, VS; Watkins, SC; Zhou, Y	1
Shao, N; Wang, R; Xia, Y; Xu, Y; Yang, Y; Zhi, F	1
Guevara-Lora, I; Kozik, A; Niewiarowska-Sendo, A	1
Chao, CY; Chen, CM; Chen, IC; Chen, TS; Chen, WL; Chen, YL; Chien, HC; Lee, CM; Lee, CY; Lee-Chen, GJ; Lin, TH; Lu, YT; Wu, YR	1
Brundin, P; Colca, JR; Escobar Galvis, ML; George, S; Ghosh, A; Hildebrandt, EN; Kordower, JH; Machiela, E; Madaj, Z; McDonald, WG; Schulz, E; Steiner, JA; Tyson, T; Van Raamsdonk, JM	1
Li, XX; Weng, LH; Wu, JY; Xu, Y; Yu, LJ; Zhang, Y	1
Ascenzi, P; Beltrami, AP; Bertuzzi, M; Cesselli, D; Codrich, M; Espinoza, S; Francescatto, M; Giacca, M; Gustincich, S; Leanza, G; Persichetti, F; Russo, R; Zentilin, L; Zucchelli, S	1
Du, XX; Jiang, H; Li, Y; Shen, XL; Song, N; Xie, JX	1
He, X; Meng, X; Qu, S; Tong, H; Wu, X; Zhang, X; Zhang, Y	1
German, DC; Sonsalla, PK; Zeevalk, GD	1
Chen, RZ; Lin, YC; Ruan, HL; Wang, XL; Yu, ZY; Zhu, XN	1
Cai, X; Feng, Z; Hou, B; Jia, H; Li, W; Liu, J; Liu, Z; Luo, C	1
Chetsawang, B; Ebadi, M; Govitrapong, P; Kooncumchoo, P	1
Eells, JT; Liang, HL; Whelan, HT; Wong-Riley, MT; Ying, R	1
Cheng, WD; Guo, CJ; Guo, XL; Li, J; Li, XL; Meng, XH; Sun, SG; Wang, LX	1
Ahn, KH; Huh, Y; Jeong, JW; Kim, SY; Kim, YS; Park, C	1
Chen, ZW; Cheng, H; Cheng, YF; Fang, N; Li, QL; Wang, M; Wang, N; Wang, XC; Xiao, XQ; Zhou, A; Zhu, GQ	1
Montes, S; Rojas, P; Rojas-Castañeda, J; Serrano-García, N	1
Cano, J; Hernández-Romero, MC; Machado, A; Santiago, M	1
Gai, Y; Guo, LH; Jiang, ZH; Qin, GW; Zhao, G; Zheng, XW	1
Bae, ON; Chung, JH; Chung, SM; Kim, HH; Kim, HY; Kim, KY; Kim, SH; Lim, KM; Noh, JY; Shin, S	1
Liu, L; Wang, X; Wang, Y	1
Kim, HS; Kim, SY; Park, JS; Woo, MS	1
Liu, HM; Sun, FY; Yang, SZ	1
Chung, KC; Jeon, I; Lee, G; Lee, PH; Park, HJ; Song, J; Um, JW	1
Fan, LL; He, JQ; Hu, B; Li, YJ; Shen, XT; Tang, XQ; Xu, JH; Zhuan, YY	1
Guo, JF; Shi, ZH; Tang, BS; Xiao, ZQ; Yan, XX; Yuan, XL; Zhao, BL	1
Cho, KH; Doo, AR; Eun-Kyung, K; Hong, J; Jung, JH; Jung, WS; Kim, SN; Lee, H; Moon, SK; Park, HJ; Park, JY	1
Huang, X; Li, XQ; Liang, QH; Lin, Y; Luo, JK; Tang, T; Wu, HJ; Yang, QD; You, WH; Zeng, G	1
An, L; Dong, W; Dong, Y; Liu, S; Tang, B	1
Feng, ZW; Wang, L; Xia, YY; Yang, HJ	1
Du, T; Jiang, H; Li, L; Song, N; Xie, J	1
Bharath, MM; Dubey, SK; Harish, G; Misra, K; Mythri, RB	1
Caldwell, GA; Caldwell, KA; Hamamichi, S; Harrington, AJ; Schieltz, JM; Slone, SR; Standaert, DG; Yacoubian, TA	1
Ahn, T; Bae, N; Chung, S; Ko, H; Oh, H; Oh, MS; Park, G; Yang, HO	1
Choi, DK; Kim, BW; Kim, IS; Ko, HM; Koppula, S	1
Han, R; Han, Y; Hu, S; Mak, S	1
Choi, WS; Palmiter, RD; Xia, Z	1
Akashi, S; Arai, T; Kimura, T; Kobayashi, S; Kuramochi, K; Sugawara, F; Takeuchi, T; Watanabe, N	1
Cao, YB; Hu, LF; Li, J; Liu, CF; Sun, X; Wang, F; Yang, YP	1
Castellani, RJ; Gao, Y; He, X; Liu, W; Perry, G; Smith, MA; Su, B; Wang, X; Zhu, X	1
Jia, J; Liang, X; Pan, Y; Wang, H; Wang, X; Xue, B; Zhao, F	1
Hsieh, YC; Mounsey, RB; Teismann, P	1
Cui, W; Han, R; Han, Y; Hu, S; Li, W; Mak, S; Rong, J; Zhang, H	1
Chen, RZ; Ruan, HL; Wang, XL; Yang, Y; Zhu, XN	1
Kocak, M; Korff, A; Pfeiffer, B; Pfeiffer, RF; Smeyne, M; Smeyne, RJ	1
Braun, JE; Faraji, J; Metz, GA; Proft, J; Robbins, JC; Zhao, X; Zucchi, FC	1
Boisvert, M; Carange, J; Daoust, B; Ismaili, J; Le Gall, C; Longpré, F; Martinoli, MG	1
Carroll, CB; Hanemann, CO; Zajicek, JP; Zeissler, ML	1
Gao, GD; Li, LH; Qin, HZ; Wang, JL; Wu, L; Xia, Y; Yang, JD; Yao, LB; Zhang, J; Zhang, ZG	1
Antenor-Dorsey, JA; O'Malley, KL	1
Grau, CM; Greene, LA	1
Chen, X; Huang, B; Xu, X; Ye, L; Ye, Q; Zhang, X; Zhu, Y	1
Kim, H; Kim, K; Park, JH	1
Britt, J; De Jesús-Cortés, H; Drawbridge, J; Estill, SJ; Huntington, P; McKnight, SL; Melito, LM; Morlock, L; Naidoo, J; Pieper, AA; Ready, JM; Tesla, R; Tran, S; Wang, G; Williams, NS; Xu, P	1
Dun, Y; Feng, M; Li, G; Ma, R; Wang, M; Xiang, J; Xiong, Z; Yang, Y; Zhang, Y	1
Aguilera, P; Floriano-Sánchez, E; Guevara, J; Heras-Romero, Y; Monroy-Noyola, A; Montes, S; Ríos, C; Rivera-Mancia, S; Rubio, C; Rubio-Osornio, M	1
Cao, Y; Dong, XZ; Hu, Y; Liu, P; Zhao, HX; Zhou, XJ	1
Cory-Slechta, DA; Di Monte, DA; Langston, JW; Manning-Bog, AB; McCormack, AL; Thiffault, C; Thiruchelvam, M	1
Burke, R; Dauer, W; Goodchild, R; Hen, R; Hersch, S; Jackson-Lewis, V; Kholodilov, N; Larsen, KE; Przedborski, S; Rocha, M; Schmitz, Y; Staal, R; Sulzer, D; Tieu, K; Trillat, AC; Vila, M; Yuan, CA	1
Lei, L; Li, C; Pu, X; Sheng, G; Tu, P	1
Angelastro, JM; Greene, LA; Harding, HP; Ron, D; Ryu, EJ; Vitolo, OV	1
Cunningham, S; Hillard, CJ; Kalivendi, SV; Kalyanaraman, B; Kotamraju, S; Shang, T	1
Mazzio, E; Soliman, KF	1
Hillard, CJ; Kalivendi, SV; Kalyanaraman, B; Kotamraju, S; Shang, T	1
Coates, PW; Everse, J	1
Brooks, A; Chung, CY; Isacson, O; Lin, L; Seo, H; Sonntag, KC	1
Kress, GJ; Reynolds, IJ	1
Ding, JH; Hu, G; Hu, LF; Liu, SY; Shi, XR; Sun, YH; Wang, S; Yao, HH	1
Chew, KC; Dawson, TM; Dawson, VL; Ho, MW; Ko, HS; Lim, KL; Lim, TM; Pletnikova, O; Soong, TW; Tay, SP; Thomas, B; Troncoso, J; Tsang, F; Wang, C	1
Barkats, M; Colin, P; Faucon-Biguet, N; Horellou, P; Mallet, J; Millecamps, S	1
Alves da Costa, C; Brau, F; Cappai, R; Checler, F; Dunys, J; Wilk, S	1
Chen, J; Chen, PX; Cui, Y; Feng, JQ; Sun, SN; Tang, EH; Tang, XQ; Yu, HM; Zhi, JL	1
Block, M; Hong, JS; Miller, DS; Pei, Z; Reece, JM; Wang, T; Wilson, B; Zhang, W	1
Chen, SD; Fan, GH; Yang, H; Zhou, HY	1
Beck, KE; Billett, EE; De Girolamo, LA; Griffin, M	1
Lazarovici, P; Lipman, T; Tabakman, R	1
Anantharam, V; Jin, H; Kanthasamy, A; Kanthasamy, AG; Kaul, S; Latchoumycandane, C; Zhang, D	1
Kim, MY; Kim, SY; Mo, JS; Park, HS; Park, JW	1
Benigno, A; Crescimanno, G; Di Giovanni, G; Di Matteo, V; Esposito, E; Giuliano, DA; Pierucci, M	1
Brady, ST; Llinás, RR; Moreira, JE; Morfini, G; Opalach, K; Pigino, G; Serulle, Y; Sugimori, M	1
Brady, ST; Llinás, RR; Moreira, JE; Morfini, G; Pigino, G; Serulle, Y; Sugimori, M	1
Alvarez-Fischer, D; Boutillier, AL; Breunig, JJ; Degregori, J; Depboylu, C; Hirsch, EC; Höglinger, GU; Hunot, S; Michel, PP; Oertel, WH; Rakic, P; Rouaux, C	1
Amazzal, L; Bagrel, D; Lapôtre, A; Quignon, F	1
Altmann, S; Amore, A; Grammatopoulos, TN; Hyman, BT; Kazantsev, AG; Outeiro, TF; Standaert, DG	1
Cai, DF; Li, WW; Wang, H; Yang, R	1
Caidahl, K; Gramsbergen, JB; Larsen, TR; Roepstorff, P; Söderling, AS	1
Ambrosio, S; Francisco, R; Giménez-Xavier, P; Gómez-Santos, C	1
Li, Q; Li, YY; Lu, JH; Pu, XP; Zhao, YY	1
Jiang, H; Song, N; Wang, J; Xie, J; Zhang, S	1
Kanthasamy, AG; Reddy, MB; Xu, Q	1
Chang, NS; Chen, ST; Chuang, JI; Hsu, LJ; Hsu, SY; Li, MY; Lin, SR; Lo, CP; Tsai, MS	1
Cardoso, SM; Domingues, AF; Esteves, AR; Ferreira, IL; Januário, C; Oliveira, CR; Swerdlow, RH	1
Aurelian, L; Chen, L; Laing, JM; Wales, SQ	1
Akaneya, Y; Hatanaka, H; Takahashi, M	1
Altomare, C; Carotti, A; Carrupt, PA; Cellamare, S; Jenner, P; Marsden, CD; McNaught, KS; Testa, B; Thull, U	1
Ambrosio, S; Bartrons, R; Calopa, M; Espino, A; Llorens, J; Rodriguez-Farré, E	1
Chiueh, CC; Mohanakumar, KP; Murphy, DL; Wu, RM	1
Atadzhanov, MA; Basharova, LA; Golubev, KM; Karaban', IN; Kryzhanovskiĭ, GN; Magaeva, SV; Man'kovskiĭ, NB; Trekova, NA; Vetrilé, LA	1
Armanini, M; Berkemeier, L; Hynes, MA; Phillips, H; Poulsen, K; Rosenthal, A	1
Cooper, JM; Hartley, A; Heron, C; Schapira, AH; Stone, JM	1
Lange, KW; Riederer, P	1
Cobuzzi, RJ; Collins, MA; Neafsey, EJ	1
Griffiths, HR; Lunec, J; Willets, JM; Williams, AC	1
Singer, TP; Tipton, KF	1
Fang, J; Yu, PH; Zuo, D	1
Akaike, A; Kawamura, T; Kimura, J; Sawada, H; Shimohama, S; Tamura, Y	1
Hatta, M; Iwamoto, K; Kimura, K; Kobayashi, S; Kobayashi, Y; Koide, H; Matsubara, K; Tanaka, O; Yamashita, K	1
Bennett, JP; Davis, RE; Miller, SW; Parker, WD; Parks, JK; Sheehan, JP; Swerdlow, RH; Trimmer, PA; Tuttle, JB	1
Akaike, A; Kawamura, T; Kimura, J; Kitamura, Y; Sawada, H; Shimohama, S; Taniguchi, T	1
Olanow, CW	1
Davis, RE; Miller, SW; Parker, WD; Sheehan, JP; Swerdlow, RH; Tuttle, JB	1
Mizuno, Y; Mochizuki, H; Mori, H	1
Cooper, JM; Schapira, AH; Seaton, TA	2
Blandini, F; Greenamyre, JT; Nappi, G	1
Baik, HH; Baik, HW; Cho, YH; Gwag, MR; Jeong, MY; Jin, BK; Joo, WS; Kim, YS; Shin, DY; Yoon, KS	1
Cheng, FC; Dryhurst, G; Han, J; Yang, Z	1
Bémeur, C; Lambert, J; Montgomery, J; Ste-Marie, L; Vachon, L	1
Jenner, P; McNaught, KS	1
Abramova, NN; Bennett, JP; Cassarino, DS; Halvorsen, EM; Parker, WD; Sturgill, TW; Swerdlow, RH	1
Brenneman, DE; Fridkin, M; Gozes, I; Melamed, E; Offen, D; Sherki, Y	1
Clarke, K; Kashiwaya, Y; Mori, N; Nakashima, K; Takeshima, T; Veech, RL	1
Eisenhofer, G; Harvey-White, J; Kirk, K; Kopin, IJ; Lamensdorf, I; Nechustan, A	1
Bennett, JP; Dennis, J; Fall, CP; Keeney, PM; Parker, WD; Swerdlow, RH; Veech, GA	1
Helmuth, L	1
Ambrosio, S; Ferrer, I; Gil, J; Gómez, C; Piqué, M; Reiriz, J	1
Agid, Y; Faucheux, BA; Hartmann, A; Hirsch, EC; Michel, PP; Mouatt-Prigent, A; Ruberg, M; Troadec, JD	1
Awaya, T; Chiba, K; Hayase, N; Kimura, K; Matsubara, K; Ogawa, S; Senda, T; Shimizu, K; Uezono, T	1
Liu, J; O'Brien, JS; Wang, CY	1
Obata, T; Yamanaka, Y	1
Kubota, S; Obata, T; Yamanaka, Y	1
Conn, KJ; Eisenhauer, PB; Fine, RE; Ullman, MD; Wells, JM	1
Fukuhara, Y; Ishitani, R; Kashiwaya, Y; Nakashima, K; Shimoda, K; Takeshima, T	1
Jeyarasasingam, G; Quik, M; Tompkins, L	1
Abramova, NA; Bennett, JP; Cassarino, DS; Khan, SM; Painter, TW	1
Bilsland, J; Grimm, E; Han, Y; Harper, SJ; Hefti, F; Nicholson, DW; Roy, S; Xanthoudakis, S	1
Wang, X; Yang, Y; Zhang, W	1
Ambrosio, S; Barrachina, M; Ferrer, I; Gómez-Santos, C; Reiriz, J; Viñals, F	1
Kondo, T; Mizuno, Y; Nakagawa-Hattori, Y; Yoshino, H	1
Ikeda, H; Markey, CJ; Markey, SP	1
Marsden, CD	1
Beck, KD; Denton, TL; Hefti, F; Michel, PP	1
Nagatsu, T	1
Brücke, T; Riederer, P	1
Agid, YA; Graybiel, AM; Hirsch, E	1
D'Amato, RJ; Lipman, ZP; Snyder, SH	1
Castagnoli, NE; McKeown, K; Ramsay, RR; Singer, TP; Trevor, A	1
Dadgar, J; Ramsay, RR; Salach, JI; Singer, TP	1
Lewin, R	1

Reviews

8 review(s) available for 1-methyl-4-phenylpyridinium and Parkinson Disease

Article	Year
SH-SY5Y Cell Line Journal of integrative neuroscience, 2023, Jan-16, Volume: 22, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Cell Line; Humans; Neuroblastoma; Parkinson Disease	2023
Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson's disease. Parkinsonism & related disorders, 2008, Volume: 14 Suppl 2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Drug Administration Schedule; Herbicides; Humans; Injections, Intraventricular; Parkinson Disease	2008
Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (selegiline). Annals of the New York Academy of Sciences, 1994, Nov-17, Volume: 738 Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Animals; Antioxidants; Corpus Striatum; Free Radicals; Humans; Hydroxyl Radical; Lipid Peroxidation; Monoamine Oxidase; Neurons; Parkinson Disease; Rats; Selegiline; Substantia Nigra	1994
Glutamatergic drugs in Parkinson's disease. Life sciences, 1994, Volume: 55, Issue:25-26 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Excitatory Amino Acid Antagonists; Humans; Parkinson Disease; Parkinson Disease, Secondary; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate	1994
Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. Journal of neurochemistry, 1993, Volume: 61, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aging; Animals; Biological Transport; Humans; Mitochondria; Nervous System; Oxidation-Reduction; Parkinson Disease; Selegiline; Species Specificity	1993
Deprenyl in the treatment of Parkinson's disease: clinical effects and speculations on mechanism of action. Journal of neural transmission. Supplementum, 1996, Volume: 48 Topics: 1-Methyl-4-phenylpyridinium; Antioxidants; Apoptosis; Clinical Trials as Topic; Dopamine; Double-Blind Method; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase Inhibitors; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Parkinson Disease; Parkinson Disease, Secondary; Prospective Studies; Randomized Controlled Trials as Topic; Selegiline	1996
Parkinson's disease. Lancet (London, England), 1990, Apr-21, Volume: 335, Issue:8695 Topics: 1-Methyl-4-phenylpyridinium; Adrenal Glands; Adult; Antiparkinson Agents; Brain Chemistry; Child; Child, Preschool; Cytoplasmic Granules; Dyskinesia, Drug-Induced; Environmental Pollutants; Fetus; Humans; Levodopa; Middle Aged; Palliative Care; Parkinson Disease; Prevalence; Research; Selegiline; Substantia Nigra; Time Factors	1990
Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP+), the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicology, 1988, Volume: 49, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Mitochondria; Monoamine Oxidase; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Parkinson Disease; Pyridines; Pyridinium Compounds	1988

Trials

1 trial(s) available for 1-methyl-4-phenylpyridinium and Parkinson Disease

Article	Year
Clinical trial for Parkinson's disease? Science (New York, N.Y.), 1985, Nov-01, Volume: 230, Issue:4725 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Levodopa; Models, Neurological; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Prospective Studies; Pyridines; Pyridinium Compounds; Selegiline	1985

Article

Year

Clinical trial for Parkinson's disease?

Science (New York, N.Y.), 1985, Nov-01, Volume: 230, Issue:4725

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Levodopa; Models, Neurological; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Prospective Studies; Pyridines; Pyridinium Compounds; Selegiline

1985

Other Studies

309 other study(ies) available for 1-methyl-4-phenylpyridinium and Parkinson Disease

Article	Year
International journal of molecular sciences, 2021, Aug-29, Volume: 22, Issue:17 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Cell Line; Disease Models, Animal; Male; Mice, Inbred C57BL; MPTP Poisoning; Muscle, Skeletal; Parkinson Disease; Protein Serine-Threonine Kinases	2021
Long Noncoding RNA NEAT1 Knockdown Ameliorates 1-Methyl-4-Phenylpyridine-Induced Cell Injury Through MicroRNA-519a-3p/SP1 Axis in Parkinson Disease. World neurosurgery, 2021, Volume: 156 Topics: 1-Methyl-4-phenylpyridinium; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Gene Knockdown Techniques; Herbicides; Humans; MicroRNAs; Parkinson Disease; RNA, Long Noncoding; Sp1 Transcription Factor	2021
LncRNA MIAT Inhibits MPP Neurochemical research, 2021, Volume: 46, Issue:12 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Proliferation; Gene Expression Regulation; Herbicides; MicroRNAs; Neurodegenerative Diseases; Parkinson Disease; PC12 Cells; Protective Agents; Rats; RNA, Long Noncoding; Sirtuin 1	2021
LncRNA JHDM1D-AS1 Suppresses MPP + -Induced Neuronal Injury in Parkinson's Disease via miR-134-5p/PIK3R3 Axis. Neurotoxicity research, 2021, Volume: 39, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Blotting, Western; Cell Line, Tumor; Flow Cytometry; Humans; Jumonji Domain-Containing Histone Demethylases; MicroRNAs; Neurons; Parkinson Disease; Phosphatidylinositol 3-Kinases; Real-Time Polymerase Chain Reaction; RNA, Long Noncoding	2021
Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease. Molecular nutrition & food research, 2022, Volume: 66, Issue:21 Topics: 1-Methyl-4-phenylpyridinium; Dopaminergic Neurons; Humans; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Phenol; Sulfates	2022
miR-126-5p Targets SP1 to Inhibit the Progression of Parkinson's Disease. European neurology, 2022, Volume: 85, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Humans; MicroRNAs; Parkinson Disease; Sp1 Transcription Factor	2022
The neuroprotective effects of Galectin-1 on Parkinson's Disease via regulation of Nrf2 expression. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Galectin 1; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Zebrafish	2022
LINC00943 acts as miR-338-3p sponge to promote MPP Brain research, 2022, 05-01, Volume: 1782 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; Inflammation; Mice; MicroRNAs; Parkinson Disease; RNA, Long Noncoding; Sp1 Transcription Factor	2022
Cryptotanshinone ameliorates MPP Metabolic brain disease, 2022, Volume: 37, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Mice; Neuroblastoma; Oxidative Stress; Parkinson Disease; Phenanthrenes; STAT3 Transcription Factor	2022
LINC00667 regulates MPP Annals of clinical and translational neurology, 2022, Volume: 9, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Humans; MicroRNAs; Parkinson Disease; RNA, Long Noncoding	2022
Resilin, an insect-derived elastomeric protein, protects dopaminergic neurons in Parkinson disease models. Neuroscience letters, 2022, 06-11, Volume: 781 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Insect Proteins; Mice; Mice, Inbred C57BL; Neuroblastoma; Neuroprotective Agents; Parkinson Disease; Substantia Nigra	2022
Dioscin-Mediated Autophagy Alleviates MPP Molecules (Basel, Switzerland), 2022, Apr-29, Volume: 27, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Diosgenin; Parkinson Disease	2022
Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 104 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Artemisia; Autophagy; beta Catenin; Dopaminergic Neurons; Humans; Mice; Mice, Inbred C57BL; Mitophagy; Neuroblastoma; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Transient Receptor Potential Channels	2022
Melatonin attenuates MPP Biochemical and biophysical research communications, 2022, 09-17, Volume: 621 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Dopaminergic Neurons; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Melatonin; Neuroblastoma; Parkinson Disease	2022
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model. Molecules (Basel, Switzerland), 2022, Aug-06, Volume: 27, Issue:15 Topics: 1-Methyl-4-phenylpyridinium; Animals; Biflavonoids; Catechin; Oxidative Stress; Parkinson Disease; Proanthocyanidins; Rats; Selegiline; Zebrafish	2022
Synthesis of a natural quinoline alkaloid isolated from the deep-sea-derived fungus and its potential as a therapeutic for Parkinson's disease. Journal of Asian natural products research, 2023, Volume: 25, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Alkaloids; alpha-Synuclein; Animals; Caenorhabditis elegans; Disease Models, Animal; Fungi; Neuroprotective Agents; Parkinson Disease; Quinolines	2023
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease. Cells, 2022, 09-19, Volume: 11, Issue:18 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Inflammation; Inflammation Mediators; Iodides; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; NF-E2-Related Factor 2; NF-kappa B; Parkinson Disease; Proto-Oncogene Proteins c-akt; Pyrrolidines; Sesquiterpenes	2022
MiR-29a inhibits MPP + - Induced cell death and inflammation in Parkinson's disease model in vitro by potential targeting of MAVS. European journal of pharmacology, 2022, Nov-05, Volume: 934 Topics: 1-Methyl-4-phenylpyridinium; 3' Untranslated Regions; Antiviral Agents; Apoptosis; Caspase 3; Cell Death; Cell Line, Tumor; Humans; Inflammation; Interleukin-6; MicroRNAs; Neuroblastoma; Parkinson Disease; Poly(ADP-ribose) Polymerase Inhibitors; Reactive Oxygen Species; Superoxide Dismutase	2022
Targeting microglial NLRP3 in the SNc region as a promising disease-modifying therapy for Parkinson's disease. Brain and behavior, 2022, Volume: 12, Issue:11 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Pars Compacta	2022
A Novel Mitochondria-Targeting Iron Chelator Neuroprotects Multimodally via HIF-1 Modulation Against a Mitochondrial Toxin in a Dopaminergic Cell Model of Parkinson's Disease. Molecular neurobiology, 2023, Volume: 60, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Antioxidants; Cell Line, Tumor; Dopaminergic Neurons; Humans; Hypoxia-Inducible Factor 1; Iron; Iron Chelating Agents; Mitochondria; Neuroprotective Agents; Parkinson Disease; Reactive Oxygen Species	2023
Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model. Molecular neurobiology, 2023, Volume: 60, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Disease Models, Animal; Dopaminergic Neurons; Humans; Mice; Mice, Inbred C57BL; Neuroblastoma; Parkinson Disease; Protein Serine-Threonine Kinases; RNA, Small Interfering; Substantia Nigra	2023
LncRNA SNHG15 mediates 1-methyl-4-phenylpyridinium (MPP Neurological research, 2023, Volume: 45, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; MicroRNAs; Neurodegenerative Diseases; Parkinson Disease; RNA, Long Noncoding	2023
Nonreceptor Tyrosine Kinase c-Abl-Mediated PHB2 Phosphorylation Aggravates Mitophagy Disorder in Parkinson's Disease Model. Oxidative medicine and cellular longevity, 2022, Volume: 2022 Topics: 1-Methyl-4-phenylpyridinium; Animals; Humans; Mice; Mitophagy; Neuroblastoma; Parkinson Disease; Phosphorylation; Prohibitins; TYK2 Kinase; Tyrosine	2022
β-Hydroxybutyrate alleviates pyroptosis in MPP International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3-Hydroxybutyric Acid; Animals; Cytokines; Ketone Bodies; Mice; Neurodegenerative Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Pyroptosis	2022
LUHMES Cells: Phenotype Refinement and Development of an MPP International journal of molecular sciences, 2023, Jan-01, Volume: 24, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Antiparkinson Agents; Dopamine; Dopaminergic Neurons; Humans; Parkinson Disease; Phenotype	2023
Garcinol protects SH-SY5Y cells against MPP+-induced cell death by activating DJ-1/SIRT1 and PGC-1α mediated antioxidant pathway in sequential stimulation of p-AMPK mediated autophagy. Environmental toxicology, 2023, Volume: 38, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; AMP-Activated Protein Kinases; Antioxidants; Apoptosis; Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Neuroblastoma; Neurodegenerative Diseases; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Sirtuin 1	2023
Neuroprotective effects of Geranium Robertianum L. Aqueous extract on the cellular Parkinson's disease model. European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Acetylcholinesterase; Antioxidants; Apoptosis; Geranium; Neuroprotective Agents; Parkinson Disease; Plant Extracts	2023
Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson's Disease. International journal of molecular sciences, 2023, Jan-30, Volume: 24, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Humans; Inflammation; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Neuroinflammatory Diseases; Neurotoxins; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Parkinson Disease; Tumor Necrosis Factor-alpha	2023
The deficiency of Maged1 attenuates Parkinson's disease progression in mice. Molecular brain, 2023, 02-11, Volume: 16, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Disease Progression; Dopaminergic Neurons; Humans; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Parkinson Disease; Signal Transduction	2023
The Study of Overexpression of Peroxiredoxin-2 Reduces MPP Neurochemical research, 2023, Volume: 48, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Survival; Dopaminergic Neurons; Humans; Neuroblastoma; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sirtuin 1	2023
Doxycycline inhibits dopaminergic neurodegeneration through upregulation of axonal and synaptic proteins. Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; Animals; Doxycycline; Humans; Nerve Growth Factor; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Proteins; Rats; Tubulin; Up-Regulation	2023
Mitochondrial Complex I Inhibition in Dopaminergic Neurons Causes Altered Protein Profile and Protein Oxidation: Implications for Parkinson's disease. Neurochemical research, 2023, Volume: 48, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; Cell Death; Dopaminergic Neurons; Electron Transport Complex I; Humans; Paraquat; Parkinson Disease; Proteomics; Rotenone	2023
Protective Effects of Querectin against MPP Frontiers in bioscience (Landmark edition), 2023, 03-02, Volume: 28, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Cell Line, Tumor; Dopaminergic Neurons; Humans; Neuroblastoma; NF-E2-Related Factor 2; Parkinson Disease; Quercetin; Signal Transduction	2023
Neuroprotective microRNA-381 Binds to Repressed Early Growth Response 1 (EGR1) and Alleviates Oxidative Stress Injury in Parkinson's Disease. ACS chemical neuroscience, 2023, 06-07, Volume: 14, Issue:11 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopaminergic Neurons; Early Growth Response Protein 1; Mice; Mice, Inbred C57BL; MicroRNAs; Oxidative Stress; Parkinson Disease; Tumor Suppressor Protein p53	2023
Downregulation of TRPM7, TRPM8, and TRPV1 channels modulate apoptotic parameters and neurodegenerative markers: Focus on neuronal differentiation and Parkinson's disease model. Cell biology international, 2023, Volume: 47, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Down-Regulation; Humans; Membrane Proteins; Neuroblastoma; Parkinson Disease; Protein Serine-Threonine Kinases; Transient Receptor Potential Channels; TRPM Cation Channels; TRPV Cation Channels	2023
Integrated insight into the molecular mechanisms of selenium-modulated, MPP Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2023, Volume: 79 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Humans; Neurodegenerative Diseases; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Selenium	2023
Amelioration of Parkinson's disease by pharmacological inhibition and knockdown of redox sensitive TRPC5 channels: Focus on mitochondrial health. Life sciences, 2023, Sep-01, Volume: 328 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Calcium; Dopaminergic Neurons; Humans; Neuroblastoma; Oxidation-Reduction; Parkinson Disease; Rats; Rats, Sprague-Dawley; Transient Receptor Potential Channels; TRPC Cation Channels	2023
Repurposing Simvastatin in Parkinson's Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the International journal of molecular sciences, 2023, Jun-21, Volume: 24, Issue:13 Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Parkinson Disease; Proteomics; Rats; Simvastatin; Substantia Nigra	2023
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease. Chemico-biological interactions, 2023, Oct-01, Volume: 384 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Administration, Oral; Animals; Disease Models, Animal; Dopaminergic Neurons; Mammals; Mice; Mice, Inbred C57BL; Microglia; Neuroinflammatory Diseases; Neuroprotective Agents; NF-kappa B; Parkinson Disease	2023
Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC-1α Expression. Marine drugs, 2019, Sep-02, Volume: 17, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Adenylate Kinase; Cell Death; Cell Line, Tumor; Dopaminergic Neurons; Humans; Mitochondria; Mitochondrial Diseases; Neurons; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Polysaccharides	2019
2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis. Food & function, 2019, Sep-01, Volume: 10, Issue:9 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Survival; Dopaminergic Neurons; Drugs, Chinese Herbal; Fallopia multiflora; Fibroblast Growth Factor 2; Glucosides; Humans; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Stilbenes	2019
Hydroxytyrosol inhibits MAO isoforms and prevents neurotoxicity inducible by MPP+ invivo. Frontiers in bioscience (Scholar edition), 2020, 01-01, Volume: 12, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Catecholamines; Corpus Striatum; Dopamine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenylethyl Alcohol; Protein Isoforms; Rats; Rats, Wistar	2020
Sensitive detection of caspase-3 enzymatic activities and inhibitor screening by mass spectrometry with dual maleimide labelling quantitation. The Analyst, 2019, Nov-04, Volume: 144, Issue:22 Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Sequence; Animals; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Enzyme Assays; Humans; Limit of Detection; Maleimides; Mice; Oligopeptides; Parkinson Disease; Pentanoic Acids; Peptides; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2019
Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP International journal of molecular sciences, 2019, Oct-28, Volume: 20, Issue:21 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Biological Transport; Cells, Cultured; Dopamine; Dopaminergic Neurons; Fatty Acid Binding Protein 3; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Parkinson Disease; Reactive Oxygen Species; Tyrosine 3-Monooxygenase	2019
SNHG1 promotes MPP Biological research, 2020, Jan-06, Volume: 53, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Blotting, Western; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Parkinson Disease; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Real-Time Polymerase Chain Reaction; RNA, Long Noncoding; Signal Transduction; TOR Serine-Threonine Kinases; Transfection	2020
A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity International journal of molecular sciences, 2020, Feb-22, Volume: 21, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Active Transport, Cell Nucleus; alpha-Synuclein; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line, Tumor; Cell Survival; Curcumin; HeLa Cells; Humans; Lysosomes; Neurodegenerative Diseases; Neurons; Parkinson Disease; PC12 Cells; Rats; RNA Interference; Signal Transduction	2020
[Protective effect of edaravone on balance of mitochondrial fusion and fission in MPP Sheng li xue bao : [Acta physiologica Sinica], 2020, Apr-25, Volume: 72, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Dynamins; Edaravone; GTP Phosphohydrolases; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Parkinson Disease; PC12 Cells; Rats; Up-Regulation	2020
A Mouse Model of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Parkinson Disease Shows that 2-Aminoquinoline Targets JNK Phosphorylation. Medical science monitor : international medical journal of experimental and clinical research, 2020, Apr-25, Volume: 26 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aminoquinolines; Animals; Apoptosis; Astrocytes; Disease Models, Animal; Dopaminergic Neurons; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Parkinson Disease; Phosphorylation; Pyrrolidines	2020
Regulation of PGC-1α mediated by acetylation and phosphorylation in MPP+ induced cell model of Parkinson's disease. Aging, 2020, 05-26, Volume: 12, Issue:10 Topics: 1-Methyl-4-phenylpyridinium; Acetylation; AMP-Activated Protein Kinase Kinases; Blotting, Western; Cell Line; Cell Survival; Flow Cytometry; Humans; MAP Kinase Signaling System; Oxidative Stress; p300-CBP Transcription Factors; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Kinases; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction	2020
β-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration. International journal of molecular sciences, 2020, May-31, Volume: 21, Issue:11 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; beta-Naphthoflavone; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Ethanol; Humans; Kinetics; Membrane Potential, Mitochondrial; Mitochondria; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Protein Isoforms; Reactive Oxygen Species; Xenobiotics	2020
Hydrogen sulfide alleviates oxidative stress injury and reduces apoptosis induced by MPP Molecular and cellular biochemistry, 2020, Volume: 472, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Caspase 3; Cell Survival; Gasotransmitters; Herbicides; Humans; Hydrogen Sulfide; Malondialdehyde; Neuroblastoma; Nitric Oxide Synthase Type II; Oxidative Stress; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Tumor Cells, Cultured	2020
The Chinese Herb Journal of integrative neuroscience, 2020, Jun-30, Volume: 19, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Cell Line, Tumor; Codonopsis; Drugs, Chinese Herbal; Neurotoxins; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Stilbenes	2020
Overexpression of MicroRNA-133a Inhibits Apoptosis and Autophagy in a Cell Model of Parkinson's Disease by Downregulating Ras-Related C3 Botulinum Toxin Substrate 1 (RAC1). Medical science monitor : international medical journal of experimental and clinical research, 2020, Jul-27, Volume: 26 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Autophagy; Cell Proliferation; MicroRNAs; Parkinson Disease; PC12 Cells; rac1 GTP-Binding Protein; Rats; Receptor, IGF Type 1	2020
Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson's disease. Environmental science and pollution research international, 2021, Volume: 28, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; Eclipta; Male; Neuroprotective Agents; Parkinson Disease; Plant Extracts; Rats; Rats, Wistar	2021
Pro-Inflammatory Role of AQP4 in Mice Subjected to Intrastriatal Injections of the Parkinsonogenic Toxin MPP. Cells, 2020, 11-05, Volume: 9, Issue:11 Topics: 1-Methyl-4-phenylpyridinium; Animals; Aquaporin 4; Astrocytes; Dopaminergic Neurons; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Inflammation; Injections; Male; Mesencephalon; Mice, Inbred C57BL; Neuroglia; Parkinson Disease; RNA, Messenger; Substantia Nigra	2020
Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease. BioMed research international, 2020, Volume: 2020 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Differentiation; Cytokines; Disease Models, Animal; Membrane Potential, Mitochondrial; MicroRNAs; Nerve Growth Factor; Neurites; Neurotoxicity Syndromes; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Reactive Oxygen Species; Sirtuin 1	2020
MiR-133b inhibits MPP+-induced apoptosis in Parkinson's disease model by inhibiting the ERK1/2 signaling pathway. European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:21 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Parkinson Disease; PC12 Cells; Rats; Signal Transduction	2020
Validation of human microRNA target pathways enables evaluation of target prediction tools. Nucleic acids research, 2021, 01-11, Volume: 49, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; 3' Untranslated Regions; Cell Line; Cell Line, Tumor; Gene Expression Regulation; Genes, Reporter; High-Throughput Screening Assays; Humans; Mesencephalon; MicroRNAs; Neuroblastoma; Neurons; Parkinson Disease; Predictive Value of Tests; Sensitivity and Specificity; Signal Transduction; Transcriptome; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha	2021
Silencing of UCA1 Protects Against MPP Neurochemical research, 2021, Volume: 46, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; MicroRNAs; Parkinson Disease; RNA, Long Noncoding; RNA, Small Interfering	2021
Chemical research in toxicology, 2021, 05-17, Volume: 34, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Animals; Caenorhabditis elegans; Disease Models, Animal; Dopaminergic Neurons; Molecular Structure; Oxidative Stress; Parkinson Disease	2021
Suppressing Cdk5 Activity by Luteolin Inhibits MPP Molecules (Basel, Switzerland), 2021, Feb-28, Volume: 26, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cyclin-Dependent Kinase 5; Dopaminergic Neurons; Dynamins; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Glycogen Synthase Kinase 3 beta; Humans; Luteolin; Mitochondrial Membranes; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction	2021
LINC00943 knockdown exerts neuroprotective effects in Parkinson's disease through regulates CXCL12 expression by sponging miR-7-5p. Genes & genomics, 2021, Volume: 43, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Cell Survival; Chemokine CXCL12; Gene Knockdown Techniques; Humans; MicroRNAs; Neuroprotection; Parkinson Disease; RNA, Long Noncoding; Up-Regulation	2021
Down-Regulation of ID2-AS1 Alleviates the Neuronal Injury Induced by 1-Methy1-4-Phenylpyridinium in Human Neuroblastoma Cell Line SH-SY5Y Cells Through Regulating miR-199a-5p/IFNAR1/JAK2/STAT1 Axis. Neurochemical research, 2021, Volume: 46, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Gene Knockdown Techniques; Humans; Inflammation; Janus Kinase 2; MicroRNAs; Oxidative Stress; Parkinson Disease; Receptor, Interferon alpha-beta; RNA, Long Noncoding; Signal Transduction; STAT1 Transcription Factor; Up-Regulation	2021
PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson's Disease. Molecules (Basel, Switzerland), 2021, Jun-01, Volume: 26, Issue:11 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line; Cysteamine; Disease Models, Animal; Dopaminergic Neurons; Gene Expression Regulation; Glutaredoxins; Humans; Male; MAP Kinase Signaling System; Mice; Parkinson Disease; Peptides; Substantia Nigra	2021
UPR Biochemical and biophysical research communications, 2021, 09-10, Volume: 569 Topics: 1-Methyl-4-phenylpyridinium; Activating Transcription Factors; Cell Line, Tumor; Cell Survival; Chaperonin 60; Endopeptidase Clp; Gene Expression; Humans; Mitochondria; Mitochondrial Proteins; Models, Biological; Parkinson Disease; Protective Agents; Reactive Oxygen Species; Ubiquitins; Unfolded Protein Response	2021
Ramelteon ameliorated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway. Bioengineered, 2021, Volume: 12, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Humans; Indenes; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease	2021
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models. Cells, 2021, 07-05, Volume: 10, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Astrocytes; Biomarkers; Brain; Cell Line; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Dopaminergic Neurons; Female; Glial Fibrillary Acidic Protein; HMGB1 Protein; Homeodomain Proteins; Humans; Lamin Type B; Male; Mice, Inbred C57BL; Microglia; Parkinson Disease; Postmortem Changes; Rats	2021
Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease. Redox biology, 2021, Volume: 46 Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopaminergic Neurons; Insulin-Like Growth Factor II; Mice; Oxidative Stress; Parkinson Disease	2021
Wnt/β-catenin signaling plays an essential role in α7 nicotinic receptor-mediated neuroprotection of dopaminergic neurons in a mouse Parkinson's disease model. Biochemical pharmacology, 2017, 09-15, Volume: 140 Topics: 1-Methyl-4-phenylpyridinium; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Line; Dopaminergic Neurons; Herbicides; Humans; Immunohistochemistry; Male; Mice, Inbred C57BL; Mice, Knockout; MPTP Poisoning; Nerve Tissue Proteins; Neuroprotection; Parkinson Disease; Random Allocation; RNA Interference; Substantia Nigra; Wnt Signaling Pathway	2017
Resolvin D1 Attenuates Mpp+-Induced Parkinson Disease via Inhibiting Inflammation in PC12 Cells. Medical science monitor : international medical journal of experimental and clinical research, 2017, Jun-02, Volume: 23 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Disease Models, Animal; Docosahexaenoic Acids; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Inflammation; Interleukin-6; MAP Kinase Kinase 4; MAP Kinase Signaling System; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; PC12 Cells; Phosphorylation; Rats; Tumor Necrosis Factor-alpha; Up-Regulation	2017
Differential expression of PARK2 splice isoforms in an in vitro model of dopaminergic-like neurons exposed to toxic insults mimicking Parkinson's disease. Journal of cellular biochemistry, 2018, Volume: 119, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Alternative Splicing; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Differentiation; Cell Line; Cell Survival; Down-Regulation; Humans; In Vitro Techniques; Leupeptins; Models, Biological; Neurotoxins; Oxidopamine; Parkinson Disease; Protein Isoforms; Signal Transduction; Tretinoin; Ubiquitin-Protein Ligases	2018
MicroRNA-181c functions as a protective factor in a 1-methyl-4-phenylpyridinium iodide-induced cellular Parkinson's disease model via BCL2L11. European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:14 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Bcl-2-Like Protein 11; Cell Survival; MicroRNAs; Parkinson Disease; PC12 Cells; Protective Factors; Rats; Reactive Oxygen Species	2017
β-Estradiol-3-benzoate confers neuroprotection in Parkinson MPP Steroids, 2017, Volume: 126 Topics: 1-Methyl-4-phenylpyridinium; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Estradiol; Lipid Peroxidation; Male; Neostriatum; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Wistar	2017
Inhibition of BDNF production by MPP Neuroscience letters, 2018, 05-14, Volume: 675 Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Dopaminergic Neurons; Down-Regulation; Humans; Mice, Inbred C57BL; MicroRNAs; Parkinson Disease; Parkinsonian Disorders; Up-Regulation	2018
Inhibitory effects of curcumin and cyclocurcumin in 1-methyl-4-phenylpyridinium (MPP Scientific reports, 2017, 12-05, Volume: 7, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Differentiation; Cell Survival; Curcumin; Microscopy, Fluorescence; NAD; Nerve Growth Factor; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease; PC12 Cells; Rats; Reactive Oxygen Species	2017
Protective effect of Frontiers in bioscience (Scholar edition), 2018, 03-01, Volume: 10, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Antioxidants; Apoptosis; Caspase 3; Cell Line, Tumor; Fruit; Humans; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Phytotherapy; Plant Extracts; Reactive Oxygen Species; Ziziphus	2018
Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease. Neurotoxicology, 2018, Volume: 65 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Dopaminergic Neurons; Gene Knockdown Techniques; HSP90 Heat-Shock Proteins; Hypoxia-Inducible Factor-Proline Dioxygenases; Limonins; Mitochondria; Molecular Chaperones; Neuroprotective Agents; Parkinson Disease; Procollagen-Proline Dioxygenase; Rats	2018
Mitochondrial calcium uniporter-mediated inhibition of 1-methyl-4-phenylpyridinium ions neurotoxicity in PC12 cells. Neuroreport, 2018, 05-02, Volume: 29, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Calcium; Calcium Channels; Membrane Potential, Mitochondrial; Mitochondria; Parkinson Disease; PC12 Cells; Rats; Reactive Oxygen Species	2018
miR-494-3p modulates the progression of in vitro and in vivo Parkinson's disease models by targeting SIRT3. Neuroscience letters, 2018, 05-14, Volume: 675 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Gene Expression Regulation; Humans; Male; Mice, Inbred C57BL; MicroRNAs; Motor Activity; Parkinson Disease; Parkinsonian Disorders; Sirtuin 3	2018
MiR-212 Attenuates MPP⁺-Induced Neuronal Damage by Targeting KLF4 in SH-SY5Y Cells. Yonsei medical journal, 2018, Volume: 59, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Humans; Interleukin-1beta; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; MicroRNAs; Neurons; Parkinson Disease; Protective Agents; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2018
Differential expression of miR-34a, miR-141, and miR-9 in MPP+-treated differentiated PC12 cells as a model of Parkinson's disease. Gene, 2018, Jul-01, Volume: 662 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Differentiation; Cell Survival; Computer Simulation; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Down-Regulation; MicroRNAs; Parkinson Disease; Parkinsonian Disorders; PC12 Cells; Rats; Reactive Oxygen Species; RNA, Messenger; Sirtuin 1; Substantia Nigra; Transcriptome; Up-Regulation	2018
Mitochondrial alterations in Parkinson's disease human samples and cellular models. Neurochemistry international, 2018, Volume: 118 Topics: 1-Methyl-4-phenylpyridinium; Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Dopamine; Female; Humans; Male; Middle Aged; Mitochondria; Parkinson Disease; Substantia Nigra	2018
Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson's disease. Journal of neuroinflammation, 2018, May-11, Volume: 15, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Coculture Techniques; Dopaminergic Neurons; Female; Mesencephalon; Microglia; Nerve Degeneration; Parkinson Disease; Pregnancy; Rats; Rats, Transgenic; Transcription, Genetic	2018
Morphine reverses the effects of 1-methyl-4-phenylpyridinium in PC12 cells through activating PI3K/Akt. The International journal of neuroscience, 2019, Volume: 129, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Morphine; Parkinson Disease; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Tyrosine 3-Monooxygenase	2019
Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells from 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity. Pharmacology, 2018, Volume: 102, Issue:3-4 Topics: 1-Methyl-4-phenylpyridinium; Anthocyanins; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Survival; Dopaminergic Neurons; Drug Interactions; Humans; Mitochondria; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Phenanthridines; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species	2018
Inhibition of microRNA-505 suppressed MPP+ -induced cytotoxicity of SHSY5Y cells in an in vitro Parkinson's disease model. European journal of pharmacology, 2018, Sep-15, Volume: 835 Topics: 1-Methyl-4-phenylpyridinium; Base Sequence; Cell Line, Tumor; Down-Regulation; Gene Knockdown Techniques; Humans; MicroRNAs; Nerve Tissue Proteins; Parkinson Disease	2018
Curcumin Protects an SH-SY5Y Cell Model of Parkinson's Disease Against Toxic Injury by Regulating HSP90. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 51, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Curcumin; Dopamine; Dopamine Plasma Membrane Transport Proteins; Gene Regulatory Networks; HSP90 Heat-Shock Proteins; Humans; Models, Biological; Parkinson Disease; RNA Interference; RNA, Small Interfering	2018
EriB targeted inhibition of microglia activity attenuates MPP Molecular brain, 2018, 12-18, Volume: 11, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Nucleus; Cytokines; Disease Models, Animal; Diterpenes; Dopaminergic Neurons; Inflammation Mediators; Mice, Inbred C57BL; Microglia; Motor Activity; NF-kappa B; Parkinson Disease; Phenotype; Phosphorylation; Protein Transport; Signal Transduction; Transcription Factor RelA	2018
Glutamine protects against oxidative stress injury through inhibiting the activation of PI3K/Akt signaling pathway in parkinsonian cell model. Environmental health and preventive medicine, 2019, Jan-05, Volume: 24, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Cell Culture Techniques; Disease Models, Animal; Glutamine; Oxidative Stress; Parkinson Disease; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats	2019
MicroRNA-599 regulates the development of Parkinson's disease through mediating LRRK2 expression. European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Brain; Cell Line, Tumor; Disease Models, Animal; Down-Regulation; Gene Knockdown Techniques; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lipopolysaccharides; MicroRNAs; MPTP Poisoning; Neurons; Parkinson Disease; Up-Regulation	2019
Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP Journal of neurochemistry, 2019, Volume: 150, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; HEK293 Cells; Humans; Mice; Mice, Knockout; Neurons; Neurotoxins; Parkinson Disease; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Tacrolimus Binding Proteins	2019
The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease. Free radical biology & medicine, 2019, 05-01, Volume: 135 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Cell Line; Dopaminergic Neurons; Gene Expression Regulation, Enzymologic; Glycation End Products, Advanced; Humans; Hydrogen Peroxide; Mice; Oxidative Stress; Parkinson Disease; Pars Compacta; Protein Aggregates; Protein Deglycase DJ-1; Pyruvaldehyde; Substrate Specificity	2019
N-Methyl-4-phenylpyridinium Scaffold-Containing Lipophilic Compounds Are Potent Complex I Inhibitors and Selective Dopaminergic Toxins. ACS chemical neuroscience, 2019, 06-19, Volume: 10, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopaminergic Neurons; Electron Transport Complex I; Hep G2 Cells; Humans; Mice; Parkinson Disease; Reactive Oxygen Species	2019
Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins. PloS one, 2019, Volume: 14, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Apoptosis; Cells, Cultured; Dopaminergic Neurons; Embryo, Mammalian; Energy Metabolism; Female; Humans; Mesencephalon; Mitochondria; Necroptosis; Necrosis; Neurotoxins; Oxidative Stress; Oxidopamine; Parkinson Disease; Primary Cell Culture; Protein Aggregation, Pathological; Rats; Rotenone	2019
Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway. Molecular medicine reports, 2019, Volume: 19, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidant Response Elements; Antioxidants; Antiparkinson Agents; Apoptosis; Cell Survival; Heme Oxygenase-1; Isothiocyanates; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; PC12 Cells; Protective Agents; Rats; Reactive Oxygen Species; Signal Transduction; Sulfoxides; Survival Rate; Time Factors	2019
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease. Digestive diseases and sciences, 2019, Volume: 64, Issue:12 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Biopterins; Blotting, Western; Colon; Constipation; Disease Models, Animal; Enzyme Inhibitors; Gastric Emptying; Gastrointestinal Motility; Gene Expression Regulation; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; MPTP Poisoning; NF-E2-Related Factor 2; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Parkinson Disease; Parkinsonian Disorders; Tyrosine 3-Monooxygenase	2019
NEAT1 regulates MPP Neuroscience letters, 2019, 08-24, Volume: 708 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Cell Survival; Gene Knockdown Techniques; Humans; MicroRNAs; Neuroblastoma; Neurons; Parkinson Disease; RNA, Long Noncoding	2019
IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson's disease. Brain, behavior, and immunity, 2019, Volume: 81 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Interleukin-17; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurodegenerative Diseases; Neuroimmunomodulation; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Th17 Cells; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase	2019
The Neuroprotective Effect of Steroid Receptor Coactivator-Interacting Protein (SIP) in Astrocyte Model of 1-Methyl-4-Phenylpyridinium (MPP⁺)-Induced Parkinson's Disease. Medical science monitor : international medical journal of experimental and clinical research, 2019, Aug-03, Volume: 25 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Astrocytes; Cell Line, Tumor; Cell Survival; Intracellular Signaling Peptides and Proteins; Models, Biological; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Reactive Oxygen Species; Receptors, Steroid; Tumor Necrosis Factor-alpha	2019
Pathogenic mutation in VPS35 impairs its protection against MPP(+) cytotoxicity. International journal of biological sciences, 2013, Volume: 9, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Cloning, Molecular; Dopaminergic Neurons; Fluorescent Antibody Technique; Gene Expression Regulation; Genetic Vectors; Humans; Immunoblotting; Microscopy, Fluorescence; Mutagenesis; Mutation, Missense; Open Reading Frames; Parkinson Disease; Vesicular Transport Proteins	2013
Astaxanthin suppresses MPP(+)-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway. Marine drugs, 2013, Mar-28, Volume: 11, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Animals; Blotting, Western; Fluorescent Antibody Technique; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; PC12 Cells; Plicamycin; Rats; Real-Time Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Sp1 Transcription Factor; Xanthophylls	2013
Involvement of NF kappa B in potentiated effect of Mn-containing dithiocarbamates on MPP(+) induced cell death. Cellular and molecular neurobiology, 2013, Volume: 33, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Cell Survival; Ditiocarb; Luciferases; Maneb; Manganese; NF-kappa B; Parkinson Disease; PC12 Cells; Peptides; Rats; Response Elements; Signal Transduction; Zineb	2013
The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. The Journal of biological chemistry, 2013, Jul-26, Volume: 288, Issue:30 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Brain; Cells, Cultured; Dopaminergic Neurons; Gene Expression; Humans; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Motor Activity; Naphthoquinones; Neurotoxins; NIMA-Interacting Peptidylprolyl Isomerase; Parkinson Disease; Parkinson Disease, Secondary; Peptidylprolyl Isomerase; RNA Interference; RNA-Directed DNA Polymerase; Substantia Nigra; Up-Regulation	2013
Tyrosol exerts a protective effect against dopaminergic neuronal cell death in in vitro model of Parkinson's disease. Food chemistry, 2013, Nov-15, Volume: 141, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Death; Cell Line; Dopamine; Dopaminergic Neurons; Humans; Membrane Potential, Mitochondrial; Mice; Neuroprotective Agents; Parkinson Disease; Phenylethyl Alcohol; Reactive Oxygen Species; Tyrosine 3-Monooxygenase	2013
Probenecid potentiates MPTP/MPP+ toxicity by interference with cellular energy metabolism. Journal of neurochemistry, 2013, Volume: 127, Issue:6 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dopaminergic Neurons; Drug Synergism; Electron Transport Complex I; Energy Metabolism; Mice; Neurotoxins; Parkinson Disease; Probenecid; Rotenone; Uricosuric Agents	2013
Upregulation of sestrin-2 expression via P53 protects against 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity. Journal of molecular neuroscience : MN, 2013, Volume: 51, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Aged; Aged, 80 and over; Apoptosis; Cell Line, Tumor; Female; Humans; Male; Membrane Potential, Mitochondrial; Mesencephalon; Neurons; Nuclear Proteins; Oxidative Stress; Parkinson Disease; Tumor Suppressor Protein p53; Up-Regulation	2013
The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis. Molecular pharmacology, 2013, Volume: 84, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Binding Sites; Calcium; Cell Death; Cells, Cultured; Dopamine; Focal Adhesion Kinase 1; Glial Cell Line-Derived Neurotrophic Factor; Homeostasis; Humans; Lactoferrin; Mesencephalon; Mitochondria; Nerve Degeneration; Neuroglia; Neurons; Parkinson Disease; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Recombinant Proteins	2013
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease. Free radical biology & medicine, 2014, Volume: 67 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; alpha-Synuclein; Biopterins; Cell Line, Tumor; Dopaminergic Neurons; Gene Expression Regulation; GTP Cyclohydrolase; Guanosine Triphosphate; Humans; Mitochondria; Models, Biological; Oxidative Phosphorylation; Parkinson Disease; RNA, Small Interfering	2014
Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo. Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Ligusticum; Male; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxidopamine; Parkinson Disease; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Substantia Nigra; Zebrafish	2014
Inhibition of store-operated calcium entry attenuates MPP(+)-induced oxidative stress via preservation of mitochondrial function in PC12 cells: involvement of Homer1a. PloS one, 2013, Volume: 8, Issue:12 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Calcium; Calcium Signaling; Carrier Proteins; Homer Scaffolding Proteins; Lipid Peroxidation; Mitochondria; Neurons; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Reactive Oxygen Species; RNA, Small Interfering	2013
Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. Molecular neurobiology, 2014, Volume: 50, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Cell Line, Tumor; Ceramides; Dopaminergic Neurons; Humans; Lysophospholipids; Oxidative Stress; Parkinson Disease; Phosphotransferases (Alcohol Group Acceptor); Reactive Oxygen Species; Signal Transduction; Sphingosine	2014
Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity. Planta medica, 2014, Volume: 80, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Brain; Cell Line, Tumor; Cell Survival; Dopamine; Furans; gamma-Aminobutyric Acid; Humans; Lignans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease	2014
Physiological characterisation of human iPS-derived dopaminergic neurons. PloS one, 2014, Volume: 9, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Blotting, Western; Calcium; Cell Differentiation; Cells, Cultured; Chromatography, High Pressure Liquid; Dopaminergic Neurons; Embryoid Bodies; Endoplasmic Reticulum; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Immunohistochemistry; Induced Pluripotent Stem Cells; Membrane Potential, Mitochondrial; Mesencephalon; Parkinson Disease; Patch-Clamp Techniques; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine 3-Monooxygenase	2014
Neuroprotective effects of mesenchymal stem cells through autophagy modulation in a parkinsonian model. Neurobiology of aging, 2014, Volume: 35, Issue:8 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Autophagy; Cell Survival; Cells, Cultured; Disease Models, Animal; Dopaminergic Neurons; Humans; Male; Mesenchymal Stem Cells; Mice, Inbred C57BL; Neurotoxins; Parkinson Disease; Protein Aggregates; Protein Aggregation, Pathological	2014
Silibinin attenuates MPP⁺-induced neurotoxicity in the substantia nigra in vivo. Journal of medicinal food, 2014, Volume: 17, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Female; Inflammation; Interleukin-1beta; Microglia; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide Synthase Type II; Parkinson Disease; Rats; Rats, Sprague-Dawley; Silybin; Silymarin; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase	2014
Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Molecular bioSystems, 2014, Volume: 10, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Cell Line, Tumor; Dopamine; Gene Expression Regulation, Neoplastic; Homeostasis; Humans; Mitochondrial Proteins; Models, Neurological; Neurotoxins; Parkinson Disease; Proteomics; Reactive Oxygen Species	2014
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease. Cellular signalling, 2014, Volume: 26, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; AMP-Activated Protein Kinases; Animals; Apoptosis; Carrier Proteins; Caspase 3; Cell Survival; Cells, Cultured; Intracellular Signaling Peptides and Proteins; Models, Biological; Neurons; Oxidopamine; Parkinson Disease; PC12 Cells; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; Rotenone; Signal Transduction; TOR Serine-Threonine Kinases	2014
Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson's disease. The Journal of nutritional biochemistry, 2014, Volume: 25, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopamine; Female; Flavanones; Glial Cell Line-Derived Neurotrophic Factor; Neuroprotective Agents; Parkinson Disease; Rats, Sprague-Dawley; Substantia Nigra	2014
Protective effects of Gynostemma pentaphyllum polysaccharides on PC12 cells impaired by MPP(+). International journal of biological macromolecules, 2014, Volume: 69 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Cytochromes c; Gene Expression Regulation; Gynostemma; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Poly(ADP-ribose) Polymerases; Polysaccharides; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Rats	2014
Cell-based assays for Parkinson's disease using differentiated human LUHMES cells. Acta pharmacologica Sinica, 2014, Volume: 35, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Cell Death; Cell Differentiation; Cell Line; Cyclin-Dependent Kinase 2; Drug Evaluation, Preclinical; Glycogen Synthase Kinase 3; Humans; Indoles; Maleimides; Mesencephalon; Neurons; Neuroprotective Agents; Parkinson Disease; Parkinson Disease, Secondary	2014
Salvianolic acid B attenuates toxin-induced neuronal damage via Nrf2-dependent glial cells-mediated protective activity in Parkinson's disease models. PloS one, 2014, Volume: 9, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Benzofurans; Cells, Cultured; Cytokines; Dopaminergic Neurons; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Models, Biological; NF-E2-Related Factor 2; Parkinson Disease	2014
G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy. Toxicology, 2014, Oct-03, Volume: 324 Topics: 1-Methyl-4-phenylpyridinium; Adenine; Autophagy; Case-Control Studies; Caspases; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lysosomes; Macrolides; Mutation; Parkinson Disease; Phenotype; Protein Serine-Threonine Kinases; Risk Factors; TOR Serine-Threonine Kinases; Transfection	2014
FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease. PloS one, 2014, Volume: 9, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Adult; Amino Acid Sequence; Animals; Case-Control Studies; Cell Line, Tumor; Cell Survival; F-Box Proteins; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Models, Molecular; Molecular Sequence Data; Mutation; Parkinson Disease; Polymorphism, Single Nucleotide; Protective Factors; Protein Stability; Protein Structure, Secondary; Sequence Homology, Amino Acid; TNF Receptor-Associated Factor 2; Ubiquitination; Young Adult	2014
Guanosine exerts neuroprotective effects by reversing mitochondrial dysfunction in a cellular model of Parkinson's disease. International journal of molecular medicine, 2014, Volume: 34, Issue:5 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Dopaminergic Neurons; Gene Expression Regulation; Guanosine; Membrane Potential, Mitochondrial; Mitochondria; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Reactive Oxygen Species	2014
Proliferating cell nuclear antigen binds DNA polymerase-β and mediates 1-methyl-4-phenylpyridinium-induced neuronal death. PloS one, 2014, Volume: 9, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Cell Division; DNA Polymerase beta; DNA Replication; Dopaminergic Neurons; HEK293 Cells; Humans; Mice; Mice, Knockout; Parkinson Disease; Proliferating Cell Nuclear Antigen; Protein Binding; Substantia Nigra	2014
Neurotoxin-induced pathway perturbation in human neuroblastoma SH-EP cells. Molecules and cells, 2014, Volume: 37, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Gene Expression Profiling; Humans; MAP Kinase Signaling System; Neuroblastoma; Neurons; Neurotoxins; Oxidative Stress; Parkinson Disease; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Transcription Factor CHOP; Tumor Cells, Cultured	2014
Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson's disease. Journal of medicinal food, 2015, Volume: 18, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopaminergic Neurons; Female; Flavones; Glial Cell Line-Derived Neurotrophic Factor; Humans; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra	2015
Targeted toxicants to dopaminergic neuronal cell death. Methods in molecular biology (Clifton, N.J.), 2015, Volume: 1254 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Mice; Nerve Degeneration; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase	2015
Role of Drosophila calcium channel cacophony in dopaminergic neurodegeneration and neuroprotection. Neuroscience letters, 2015, Jan-01, Volume: 584 Topics: 1-Methyl-4-phenylpyridinium; Animals; Calcium Channels; Calcium Chelating Agents; Dopaminergic Neurons; Drosophila; Drosophila Proteins; Edetic Acid; Embryo, Nonmammalian; Mutation; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Primary Cell Culture; Quinpirole; Receptors, Dopamine D2	2015
Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson's disease. Journal of ethnopharmacology, 2015, Jan-15, Volume: 159 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Autophagy; Medicine, Korean Traditional; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Plant Extracts; Rats; Rotenone	2015
Induction of GADD45α protects M17 neuroblastoma cells against MPP. IUBMB life, 2014, Volume: 66, Issue:11* Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Anthracenes; Blotting, Western; Caspase 3; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Imidazoles; In Situ Nick-End Labeling; Nuclear Proteins; Parkinson Disease; Pyridines; Real-Time Polymerase Chain Reaction; RNA Interference; Tetrazolium Salts; Thiazoles	2014
New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease. PloS one, 2015, Volume: 10, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Amino Acid Sequence; Apoptosis; Cathepsin D; Cell Line, Tumor; Glycosaminoglycans; Humans; Intracellular Space; Parkinson Disease; Protein Aggregates; Protein Transport; Proteolysis	2015
Differential regulation of caspase-2 in MPP⁺-induced apoptosis in primary cortical neurons. Experimental cell research, 2015, Mar-01, Volume: 332, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase 2; Cell Survival; Cells, Cultured; Cerebral Cortex; Female; Humans; Male; Mice, Inbred ICR; Neurons; Parkinson Disease; Primary Cell Culture; Protein Transport	2015
Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo. Neuroscience letters, 2015, Apr-23, Volume: 593 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Brain; Cell Line, Tumor; Cell Survival; Cyclic AMP Response Element-Binding Protein; Cyclooctanes; Dioxoles; Dopaminergic Neurons; Humans; Lignans; Male; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction	2015
MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death. The Journal of biological chemistry, 2015, May-08, Volume: 290, Issue:19 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Survival; Deoxyglucose; Glucose; Glucose Transporter Type 3; Glycolysis; HEK293 Cells; Humans; Lactic Acid; Mice; Mice, Inbred C57BL; MicroRNAs; Mitochondria; Neurons; Oxidative Phosphorylation; Oxygen; Parkinson Disease; Phosphorylation; Transcription Factor RelA	2015
[Neuroprotective effects of paeonol in a cell model of Parkinson disease]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2015, Volume: 44, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Acetophenones; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Down-Regulation; Fluoresceins; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species	2015
Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins. Neurobiology of disease, 2015, Volume: 79 Topics: 1-Methyl-4-phenylpyridinium; 14-3-3 Proteins; alpha-Synuclein; Animals; bcl-2-Associated X Protein; Casein Kinases; Cell Line, Tumor; Green Fluorescent Proteins; HEK293 Cells; Hippocampus; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice, Inbred C57BL; Mice, Transgenic; Parkinson Disease; Parkinsonian Disorders; Phosphorylation; Protein Serine-Threonine Kinases; Rotenone; Temporal Lobe	2015
A tripeptide isolated from Bothrops atrox venom has neuroprotective and neurotrophic effects on a cellular model of Parkinson's disease. Chemico-biological interactions, 2015, Jun-25, Volume: 235 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Bothrops; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dopamine; Dopaminergic Neurons; Glutamic Acid; Mitochondria; Models, Biological; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Peptides; Rats; Tryptophan; Valine; Venoms	2015
Neuroprotective effects of ginkgetin against neuroinjury in Parkinson's disease model induced by MPTP via chelating iron. Free radical research, 2015, Volume: 49, Issue:9 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antigens, CD; Apoferritins; Apoptosis; Biflavonoids; Caspase 3; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Ginkgo biloba; Homeostasis; Humans; Iron; Iron Chelating Agents; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Receptors, Transferrin; Superoxide Dismutase; Tyrosine 3-Monooxygenase	2015
Neuroprotective effects of Eucommia ulmoides Oliv. and its bioactive constituent work via ameliorating the ubiquitin-proteasome system. BMC complementary and alternative medicine, 2015, May-21, Volume: 15 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Dopamine; Eucommiaceae; Male; Mice; Mice, Inbred C57BL; Motor Disorders; MPTP Poisoning; Neuroprotective Agents; Neurotransmitter Agents; Parkinson Disease; Parkinsonian Disorders; Phytotherapy; Plant Extracts; Proteasome Endopeptidase Complex; Ubiquitin	2015
1-Methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque. PloS one, 2015, Volume: 10, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Animals; Behavior, Animal; Body Weight; Cell Count; Corpus Striatum; Dopaminergic Neurons; Hematologic Tests; Macaca mulatta; Male; Neural Pathways; Parkinson Disease; Respiration; Rotation; Stereotaxic Techniques; Substantia Nigra; Tyrosine 3-Monooxygenase	2015
Neuroprotective effects of α-melanocyte-stimulating hormone against the neurotoxicity of 1-methyl-4-phenylpyridinium. IUBMB life, 2017, Volume: 69, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; alpha-MSH; Cell Line, Tumor; Cell Survival; Cytochromes c; Humans; Membrane Potential, Mitochondrial; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease; Reactive Oxygen Species	2017
Crocin protects PC12 cells against MPP(+)-induced injury through inhibition of mitochondrial dysfunction and ER stress. Neurochemistry international, 2015, Volume: 89 Topics: 1-Methyl-4-phenylpyridinium; Animals; Carotenoids; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Membrane Potential, Mitochondrial; Mitochondria; Parkinson Disease; PC12 Cells; Rats	2015
Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson's Disease Toxin MPP(.). Molecular neurobiology, 2016, Volume: 53, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Homeostasis; Humans; Magnetic Fields; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Carbonylation; Sulfhydryl Compounds	2016
Myeloid cell leukemia 1 (Mcl(-1)) protects against 1-methyl-4-phenylpyridinium ion (MPP+) induced apoptosis in Parkinson's disease. Metabolic brain disease, 2015, Volume: 30, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Parkinson Disease	2015
Intracellular magnesium level determines cell viability in the MPP(+) model of Parkinson's disease. Biochimica et biophysica acta, 2015, Volume: 1853, Issue:12 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Magnesium; Parkinson Disease; PC12 Cells; Rats	2015
Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons. Current biology : CB, 2015, Sep-21, Volume: 25, Issue:18 Topics: 1-Methyl-4-phenylpyridinium; Animals; Axons; Dopaminergic Neurons; Energy Metabolism; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Neuronal Plasticity; Neurotoxins; Oxidative Phosphorylation; Parkinson Disease; Pars Compacta; Rotenone; Ventral Tegmental Area	2015
Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+. Antioxidants & redox signaling, 2015, Nov-01, Volume: 23, Issue:13 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Astrocytes; Biological Transport; Catecholamines; Cell Line; Cell Membrane; Diffusion; Dopaminergic Neurons; Extracellular Fluid; Humans; Monoamine Oxidase; Oxidation-Reduction; Parkinson Disease; Pyridinium Compounds	2015
Upregulation of cell surface estrogen receptor alpha is associated with the mitogen-activated protein kinase/extracellular signal-regulated kinase activity and promotes autophagy maturation. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; Animals; Autophagy; Blotting, Western; Cell Line; Disease Models, Animal; Estrogen Receptor alpha; Extracellular Signal-Regulated MAP Kinases; Fluorescent Antibody Technique; MAP Kinase Signaling System; Membrane Proteins; Mice; Microscopy, Electron, Transmission; Neurons; Parkinson Disease; Up-Regulation	2015
Estrogen receptor-mediated effect of δ-tocotrienol prevents neurotoxicity and motor deficit in the MPTP mouse model of Parkinson's disease. Neuroscience letters, 2016, Jan-01, Volume: 610 Topics: 1-Methyl-4-phenylpyridinium; Animals; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Male; Mice, Inbred C57BL; Motor Skills; Neuroprotective Agents; Parkinson Disease; Vitamin E	2016
The neuroprotection of cannabidiol against MPP⁺-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Dec-25, Volume: 30, Issue:1 Pt B Topics: 1-Methyl-4-phenylpyridinium; Animals; Axons; Cannabidiol; Humans; Nerve Growth Factor; Nerve Tissue Proteins; Neurites; Neuroblastoma; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Rats; Receptor, trkA; Synapses; Up-Regulation	2015
Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP(+)). Neurochemical research, 2016, Volume: 41, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Cells, Cultured; Chemokine CCL2; Coculture Techniques; Fetal Blood; Glia Maturation Factor; Humans; Mast Cells; Mice; Mice, Knockout; Mitochondrial Uncoupling Proteins; Parkinson Disease	2016
Damage to dopaminergic neurons is mediated by proliferating cell nuclear antigen through the p53 pathway under conditions of oxidative stress in a cell model of Parkinson's disease. International journal of molecular medicine, 2016, Volume: 37, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; DNA Damage; Dopaminergic Neurons; Gene Expression Regulation; Humans; Mice; Oxidative Stress; Parkinson Disease; PC12 Cells; Proliferating Cell Nuclear Antigen; Rats; Tumor Suppressor Protein p53	2016
Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism. Molecular neurobiology, 2016, Volume: 53, Issue:10 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Axons; Cell Line, Tumor; Cell Survival; Dopaminergic Neurons; Humans; Mesencephalon; Neurotoxins; Nociceptin; Opioid Peptides; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Rats, Sprague-Dawley; RNA, Messenger	2016
Direct intranigral injection of dopaminochrome causes degeneration of dopamine neurons. Neuroscience letters, 2016, Jan-26, Volume: 612 Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopaminergic Neurons; Indolequinones; Male; Nerve Degeneration; Parkinson Disease; Pars Compacta; Rats, Sprague-Dawley	2016
Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases. Autophagy, 2016, Volume: 12, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Acids; Alkalies; Animals; Cell Death; Dopaminergic Neurons; Humans; Hydrogen-Ion Concentration; Injections, Intraventricular; Lactic Acid; Lysosomal Storage Diseases; Lysosomes; Mice; Models, Biological; Models, Genetic; Nanoparticles; Neostriatum; Nerve Degeneration; Parkinson Disease; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2016
The epigenetic regulation of HIF-1α by SIRT1 in MPP(+) treated SH-SY5Y cells. Biochemical and biophysical research communications, 2016, Feb-05, Volume: 470, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neurons; Parkinson Disease; Sirtuin 1	2016
TLR4 Signaling in MPP⁺-Induced Activation of BV-2 Cells. Neural plasticity, 2016, Volume: 2016 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Line; Cell Survival; In Vitro Techniques; Inflammation; Interleukin-1beta; Mice; Microglia; NF-kappa B; Nitric Oxide Synthase Type II; Parkinson Disease; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha	2016
Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity. PloS one, 2016, Volume: 11, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Sequence; Animals; Cells, Cultured; Cyclin-Dependent Kinase 5; HEK293 Cells; Herbicides; Humans; Immunoblotting; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; Mutation, Missense; Neurons; Parkinson Disease; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Serine; Up-Regulation	2016
MiR-133b ameliorates axon degeneration induced by MPP(+) via targeting RhoA. Neuroscience, 2016, 06-14, Volume: 325 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Axons; Cells, Cultured; Dopaminergic Neurons; MicroRNAs; Neurites; Parkinson Disease; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Signal Transduction	2016
Mitochondrial ferritin suppresses MPTP-induced cell damage by regulating iron metabolism and attenuating oxidative stress. Brain research, 2016, 07-01, Volume: 1642 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoferritins; Apoptosis; Brain; Cation Transport Proteins; Cell Survival; Corpus Striatum; Disease Models, Animal; Ferritins; Hippocampus; Iron; Mice; Mice, Knockout; Mitochondria; MPTP Poisoning; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Receptors, Transferrin; Substantia Nigra; Tyrosine 3-Monooxygenase	2016
Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models. Antioxidants & redox signaling, 2016, 09-10, Volume: 25, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Autophagy; Bacitracin; Caenorhabditis elegans; Calcium; Cell Line; Cell Survival; Dopaminergic Neurons; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Gene Knockdown Techniques; Herbicides; Humans; Oxidation-Reduction; Oxidoreductases; Parkinson Disease; Protein Folding; Unfolded Protein Response	2016
Protection against 1-methyl-4-phenyl pyridinium-induced neurotoxicity in human neuroblastoma SH-SY5Y cells by Soyasaponin I by the activation of the phosphoinositide 3-kinase/AKT/GSK3β pathway. Neuroreport, 2016, 07-06, Volume: 27, Issue:10 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Humans; Neuroprotective Agents; Oleanolic Acid; Parkinson Disease; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Saponins; Signal Transduction	2016
Proteolytic degradation and potential role of onconeural protein cdr2 in neurodegeneration. Cell death & disease, 2016, 06-02, Volume: 7, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Aging; Animals; Calpain; Cell Death; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Mesencephalon; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotection; Parkinson Disease; Postmortem Changes; Proteolysis; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Ubiquitin	2016
Therapeutic Effects of CUR-Activated Human Umbilical Cord Mesenchymal Stem Cells on 1-Methyl-4-phenylpyridine-Induced Parkinson's Disease Cell Model. BioMed research international, 2016, Volume: 2016 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspases; Cell Differentiation; Cell Proliferation; Cell Separation; Curcumin; Cytokines; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Models, Biological; Neurons; Nitric Oxide; Nitric Oxide Synthase Type II; Parkinson Disease; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Tyrosine 3-Monooxygenase; Umbilical Cord	2016
Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis. Oncotarget, 2016, Jul-19, Volume: 7, Issue:29 Topics: 1-Methyl-4-phenylpyridinium; Cell Line, Tumor; Dronabinol; Humans; Mitochondria; Mitochondrial Diseases; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pioglitazone; PPAR gamma; Thiazolidinediones	2016
Early alterations of mitochondrial morphology in dopaminergic neurons from Parkinson's disease-like pathology and time-dependent neuroprotection with D2 receptor activation. Mitochondrion, 2016, Volume: 30 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Disease Models, Animal; Dopaminergic Neurons; Drosophila melanogaster; Mitochondria; Neuroprotection; Parkinson Disease; Quinpirole; Receptors, Dopamine D2	2016
Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure. Neurobiology of disease, 2016, Volume: 95 Topics: 1-Methyl-4-phenylpyridinium; Animals; Axonal Transport; Axons; Cell Death; Central Nervous System; Dopamine; Dopaminergic Neurons; Mitochondria; Mitochondrial Dynamics; MPTP Poisoning; Neuroimaging; Parkinson Disease; Zebrafish	2016
Cytoprotection against Hypoxic and/or MPP⁺ Injury: Effect of δ-Opioid Receptor Activation on Caspase 3. International journal of molecular sciences, 2016, Aug-09, Volume: 17, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; Animals; Caspase 3; Cell Hypoxia; Cell Survival; Parkinson Disease; PC12 Cells; Protein Kinases; Rats; Receptors, Opioid, delta	2016
Kinin Peptides Enhance Inflammatory and Oxidative Responses Promoting Apoptosis in a Parkinson's Disease Cellular Model. Mediators of inflammation, 2016, Volume: 2016 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Bradykinin; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cytokines; Humans; Kallidin; Kinins; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species	2016
Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Nov-15, Volume: 23, Issue:12 Topics: 1-Methyl-4-phenylpyridinium; Cell Survival; F-Box Proteins; GATA2 Transcription Factor; Gene Expression; Gene Expression Regulation; HEK293 Cells; Herbicides; Humans; Magnoliopsida; Membrane Potential, Mitochondrial; Mutation; Neuroprotective Agents; Oenanthe; Parkinson Disease; Phytotherapy; Plant Extracts; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Sorghum; TNF Receptor-Associated Factor 2	2016
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease. Science translational medicine, 2016, 12-07, Volume: 8, Issue:368 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Autophagy; Behavior, Animal; Brain; Caenorhabditis elegans; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Heterozygote; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurodegenerative Diseases; Neurons; Oxygen Consumption; Parkinson Disease; Pyridines; Pyruvic Acid; Signal Transduction; Substantia Nigra; Thiazolidinediones	2016
Valproic acid protects against MPP Neuroscience letters, 2017, 01-18, Volume: 638 Topics: 1-Methyl-4-phenylpyridinium; Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Macrolides; Mitochondria; Neuroprotective Agents; Parkinson Disease; Reactive Oxygen Species; Valproic Acid	2017
Neuronal hemoglobin affects dopaminergic cells' response to stress. Cell death & disease, 2017, 01-05, Volume: 8, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Autophagy; Brain; Dopaminergic Neurons; Epigenesis, Genetic; Gene Expression; Hemoglobins; Humans; Mice; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Substantia Nigra	2017
Nesfatin-1 protects dopaminergic neurons against MPP Scientific reports, 2017, 01-20, Volume: 7 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Calcium-Binding Proteins; Caspase 3; Cells, Cultured; Cytochromes c; Disease Models, Animal; DNA-Binding Proteins; Dopaminergic Neurons; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Nucleobindins; Parkinson Disease; Proto-Oncogene Proteins c-raf	2017
Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson's disease model. Cell death & disease, 2017, 02-02, Volume: 8, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amino Acid Transport System X-AG; Animals; Astrocytes; Cells, Cultured; Corpus Striatum; Cytoplasm; Disease Models, Animal; Endosomal Sorting Complexes Required for Transport; Glutamic Acid; Male; Membranes; Mesencephalon; Mice; Mice, Inbred C57BL; Nedd4 Ubiquitin Protein Ligases; Parkinson Disease; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases; Ubiquitination	2017
[Isolation and identification of Suavissimoside R1 from roots of Rubus parvifollus used for protecting dopaminergic neurons against MPP+ toxicity]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2008, Volume: 31, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Dopamine; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Parkinson Disease; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Rosaceae; Saponins	2008
Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease. Journal of neuroscience research, 2008, Volume: 86, Issue:16 Topics: 1-Methyl-4-phenylpyridinium; Cell Death; Cell Line, Tumor; Cell Survival; DNA Damage; Electron Transport Chain Complex Proteins; Free Radical Scavengers; Fullerenes; Herbicides; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; Models, Biological; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species	2008
1-Methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline. Neurochemistry international, 2008, Volume: 53, Issue:6-8 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis Regulatory Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Herbicides; Humans; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Phosphorylation; Proteins; Proto-Oncogene Proteins c-jun; Reactive Oxygen Species; Selegiline; Serine; Signal Transduction	2008
Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity. Brain research, 2008, Dec-03, Volume: 1243 Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Cytoprotection; Electron Transport Complex I; Energy Metabolism; Hazardous Substances; Herbicides; Light; Neurons; Neurotoxins; Parkinson Disease; Phototherapy; Rats; Rats, Sprague-Dawley; Rotenone; Telencephalon; Treatment Outcome; Uncoupling Agents	2008
Protective effect of estrogen on apoptosis in a cell culture model of Parkinson's disease. Clinical and investigative medicine. Medecine clinique et experimentale, 2008, Oct-01, Volume: 31, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; bcl-X Protein; Caspase 1; Cell Survival; Estrogens; Herbicides; Models, Biological; Parkinson Disease; PC12 Cells; Rats; Tyrosine 3-Monooxygenase	2008
Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis. Neuroscience letters, 2009, Jan-09, Volume: 449, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Cytoprotection; Enzyme Inhibitors; Herbicides; Humans; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Okadaic Acid; Oxidative Stress; Parkinson Disease; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction	2009
Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP(+)-elicited apoptosis. Neuroscience research, 2009, Volume: 63, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Cell Line, Tumor; Herbicides; Humans; Isoflavones; Mitochondria; Molecular Structure; Neurons; Neuroprotective Agents; Parkinson Disease; Proteasome Endopeptidase Complex; Ubiquitin; Ubiquitination; Vasodilator Agents	2009
Effect of EGb761 supplementation on the content of copper in mouse brain in an animal model of Parkinson's disease. Nutrition (Burbank, Los Angeles County, Calif.), 2009, Volume: 25, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Copper; Disease Models, Animal; Ginkgo biloba; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Phytotherapy; Plant Extracts	2009
Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not. European journal of pharmacology, 2009, May-01, Volume: 609, Issue:1-3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Lipopolysaccharides; Male; Microdialysis; Nerve Endings; Neuroprotective Agents; Parkinson Disease; Perfusion; Rats; Rats, Wistar; Simvastatin	2009
In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta 3,2-hydroxybakuchiol isolated from Psoralea corylifolia (L.). Cellular and molecular life sciences : CMLS, 2009, Volume: 66, Issue:9 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Cell Line; CHO Cells; Cocaine; Cricetinae; Cricetulus; Dopamine; Dopamine Agents; Humans; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Norepinephrine; Parkinson Disease; Phenols; Psoralea; Rats; Rats, Sprague-Dawley; Synaptosomes; Tyrosine 3-Monooxygenase	2009
Inhibition of platelet aggregation by 1-methyl-4-phenyl pyridinium ion (MPP+) through ATP depletion: Evidence for the reduced platelet activities in Parkinson's disease. Platelets, 2009, Volume: 20, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Blood Platelets; Calcium; Cell Survival; Collagen; Deoxyglucose; Glutathione; In Vitro Techniques; Parkinson Disease; Platelet Aggregation; Rats; Rats, Sprague-Dawley	2009
HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells. Neuroscience letters, 2009, Dec-31, Volume: 467, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Apoptosis; Cell Line; Cell Survival; Dopamine; Drug Evaluation, Preclinical; Genetic Predisposition to Disease; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mice; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Rotenone; Substantia Nigra	2009
Regulation of matrix metalloproteinase-9 gene expression in MPP+- or 6-OHDA-treated human neuroblastoma SK-N-BE(2)C cells. Neurochemistry international, 2010, Volume: 56, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Line; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Matrix Metalloproteinase 9; Mice; Neurons; Neurotoxins; NF-kappa B; Oxidative Stress; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Reactive Oxygen Species; Signal Transduction; Substantia Nigra; Transcription Factor AP-1; Transcriptional Activation; Tumor Cells, Cultured	2010
1-Methyl-4-phenyl-pyridinium time-dependently alters expressions of oxoguanine glycosylase 1 and xeroderma pigmentosum group F protein in PC12 cells. Neuroscience bulletin, 2010, Volume: 26, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; 8-Hydroxy-2'-Deoxyguanosine; Animals; Blotting, Western; Cell Nucleus; Cell Survival; Cytoplasm; Deoxyguanosine; DNA Damage; DNA Glycosylases; DNA-Binding Proteins; Immunohistochemistry; Oxidants; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Time Factors	2010
Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease. Biochemical and biophysical research communications, 2010, Mar-19, Volume: 393, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Cell Line; Disease Models, Animal; Humans; Leupeptins; Lewy Bodies; Mice; Oxidopamine; Parkinson Disease; Protein Kinases; Rats; Solubility; Ubiquitin-Protein Ligases	2010
Inhibition of hydrogen sulfide generation contributes to 1-methy-4-phenylpyridinium ion-induced neurotoxicity. Neurotoxicity research, 2011, Volume: 19, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Humans; Hydrogen Sulfide; Neurons; Parkinson Disease; PC12 Cells; Rats; Reactive Oxygen Species	2011
R492X mutation in PTEN-induced putative kinase 1 induced cellular mitochondrial dysfunction and oxidative stress. Brain research, 2010, Sep-10, Volume: 1351 Topics: 1-Methyl-4-phenylpyridinium; Cell Line, Tumor; Cell Membrane; Fetus; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mutation; Oxidative Stress; Parkinson Disease; Protein Kinases; Reactive Oxygen Species	2010
Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo. Journal of ethnopharmacology, 2010, Sep-15, Volume: 131, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Caspase 3; Cell Line, Tumor; Chromones; Cytotoxins; Disease Models, Animal; Dopamine; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Magnoliopsida; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Neuroblastoma; Neurons; Neuroprotective Agents; Parkinson Disease; Phosphorylation; Phytotherapy; Proto-Oncogene Proteins c-akt	2010
Salvianolic acid B protects SH-SY5Y neuroblastoma cells from 1-methyl-4-phenylpyridinium-induced apoptosis. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; Antiparkinson Agents; Apoptosis; bcl-2-Associated X Protein; Benzofurans; Biological Assay; Caspase 3; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Neuroblastoma; Parkinson Disease; Proto-Oncogene Proteins c-bcl-6; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction	2010
Protective effect of effective part of Acanthopanacis senticosus on damage of PC12 cells induced by MPP+. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010, Volume: 35, Issue:15 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Araliaceae; Cell Survival; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Malondialdehyde; Neurons; Neuroprotective Agents; Nitric Oxide; Parkinson Disease; PC12 Cells; Rats	2010
Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3β/JNK signaling. Apoptosis : an international journal on programmed cell death, 2010, Volume: 15, Issue:12 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin-Like Growth Factor I; Neuroblastoma; Neurons; Oncogene Protein v-akt; Parkinson Disease; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Signal Transduction; Up-Regulation	2010
Rosmarinic acid antagonized 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in MES23.5 dopaminergic cells. International journal of toxicology, 2010, Volume: 29, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Cell Survival; Cinnamates; Depsides; Dopamine; Electron Transport Complex I; Gene Expression Regulation; Herbicides; Membrane Potential, Mitochondrial; Mice; Neurons; Neuroprotective Agents; Parkinson Disease; Rats; Reactive Oxygen Species; RNA, Messenger; Rosmarinic Acid	2010
Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrite-mediated nitrosative stress and damage of brain mitochondria in vitro: implications for Parkinson's disease. Molecular and cellular biochemistry, 2011, Volume: 347, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Curcumin; Diet; Electron Transport Complex I; Esters; Flavonoids; Glutamates; Mice; Mitochondria; Mitochondrial Proteins; Mitochondrial Swelling; Parkinson Disease; Peroxynitrous Acid; Phenols; Polyphenols; Protective Agents; Tyrosine	2011
Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease. Cell death & disease, 2010, Volume: 1 Topics: 1-Methyl-4-phenylpyridinium; 14-3-3 Proteins; alpha-Synuclein; Animals; Caenorhabditis elegans; Cell Line, Tumor; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Parkinson Disease; Protein Isoforms; Proteins; RNA Interference; RNA, Small Interfering; Rotenone	2010
The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease. Journal of ethnopharmacology, 2011, Mar-24, Volume: 134, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Autophagy; Brain; Cell Differentiation; Dopamine; Male; Medicine, Korean Traditional; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Phytotherapy; Plant Extracts; Proteasome Endopeptidase Complex; Proteins; Rabbits; Rats; Ubiquitin	2011
Protective effect of Chrysanthemum indicum Linne against 1-methyl-4-phenylpridinium ion and lipopolysaccharide-induced cytotoxicity in cellular model of Parkinson's disease. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Base Sequence; Cell Line, Tumor; Chrysanthemum; Cytokines; DNA Primers; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Inflammation Mediators; Lipopolysaccharides; Models, Biological; Oxidative Stress; Parkinson Disease; Plant Extracts; Reactive Oxygen Species	2011
Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. Journal of ethnopharmacology, 2011, Apr-26, Volume: 135, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cytochromes c; Drug Evaluation, Preclinical; Enzyme Inhibitors; Herbicides; Humans; Mitochondria; Neuroblastoma; Neurotoxins; Panax; Parkinson Disease; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species	2011
Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model. The Journal of cell biology, 2011, Mar-07, Volume: 192, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cytoplasm; Disease Models, Animal; Dopamine; Electron Transport Complex I; Mice; Microtubules; NAD; Nerve Degeneration; Parkinson Disease; Reactive Oxygen Species; Rotenone; Substantia Nigra; Vesicular Monoamine Transport Proteins	2011
Neoechinulin a impedes the progression of rotenone-induced cytotoxicity in PC12 cells. Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Alkaloids; Animals; Biological Products; Cell Death; Cytoprotection; Electron Transport Complex I; Fungi; Glucose; Insecticides; Mitochondria; Parkinson Disease; PC12 Cells; Piperazines; Rats; Rotenone	2011
ASICs mediate the modulatory effect by paeoniflorin on α-synuclein autophagic degradation. Brain research, 2011, Jun-17, Volume: 1396 Topics: 1-Methyl-4-phenylpyridinium; Acid Sensing Ion Channels; Acidosis; alpha-Synuclein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Benzoates; Bridged-Ring Compounds; Cytoprotection; Glucosides; Microtubule-Associated Proteins; Monoterpenes; Nerve Tissue Proteins; Neurons; Parkinson Disease; PC12 Cells; Rats; Sodium Channels; Vacuoles	2011
DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging cell, 2011, Volume: 10, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Autophagy; Blotting, Western; Cell Line; Cell Survival; Dynamins; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Fluorescent Dyes; Gene Silencing; Genetic Vectors; GTP Phosphohydrolases; Humans; Image Processing, Computer-Assisted; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Proteins; Neurons; Parkinson Disease; Rats; Reactive Oxygen Species; RNA Interference; Transfection; Tyrosine 3-Monooxygenase	2011
The antioxidative effect of electro-acupuncture in a mouse model of Parkinson's disease. PloS one, 2011, Volume: 6, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Acupuncture Therapy; Animals; Antioxidants; Apoptosis; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Glutathione; Hydrogen Peroxide; Immunoenzyme Techniques; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurons; Oxidative Stress; Parkinson Disease; Substantia Nigra; Superoxide Dismutase	2011
MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 384, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dopamine; Dopaminergic Neurons; Immunohistochemistry; Mesencephalon; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2011
PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis. Neurochemistry international, 2011, Volume: 59, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Drug Administration Schedule; MAP Kinase Signaling System; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A	2011
Similar potency of catechin and its enantiomers in alleviating 1-methyl-4-phenylpyridinium ion cytotoxicity in SH-SY5Y cells. The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Catechin; Cell Line, Tumor; Humans; L-Lactate Dehydrogenase; MAP Kinase Signaling System; MPTP Poisoning; Oxidative Stress; Parkinson Disease; Phosphorylation; Proto-Oncogene Proteins c-jun; Reactive Oxygen Species	2011
Alterations in glutathione S-transferase pi expression following exposure to MPP+ -induced oxidative stress in the blood of Parkinson's disease patients. Parkinsonism & related disorders, 2011, Volume: 17, Issue:10 Topics: 1-Methyl-4-phenylpyridinium; Aged; Aged, 80 and over; Biomarkers; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Female; Glutathione S-Transferase pi; Humans; Leukocytes; Male; Middle Aged; Oxidative Stress; Parkinson Disease	2011
Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease. PloS one, 2011, Volume: 6, Issue:10 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation; Homeostasis; HSP40 Heat-Shock Proteins; Mice; Mitochondria; Molecular Weight; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Long-Evans; Signal Transduction	2011
Brassinosteroids and analogs as neuroprotectors: synthesis and structure-activity relationships. Steroids, 2012, Volume: 77, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Brassinosteroids; Dopaminergic Neurons; Humans; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Structure-Activity Relationship	2012
Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease. Neuropathology and applied neurobiology, 2012, Volume: 38, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Dronabinol; Herbicides; Humans; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Receptor, Cannabinoid, CB1; Tumor Cells, Cultured; Up-Regulation	2012
Astragaloside IV prevents MPP⁺-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production. Molecular and cellular biochemistry, 2012, Volume: 364, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Survival; Dopaminergic Neurons; Gene Expression Regulation; Humans; Neuroblastoma; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Triterpenes	2012
WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity. Molecular neurodegeneration, 2012, Feb-08, Volume: 7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Axons; Cells, Cultured; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutation; NAD; Nerve Tissue Proteins; Neurites; Neuroprotective Agents; Nicotinamide-Nucleotide Adenylyltransferase; Parkinson Disease; Wallerian Degeneration	2012
Use of PC12 cells and rat superior cervical ganglion sympathetic neurons as models for neuroprotective assays relevant to Parkinson's disease. Methods in molecular biology (Clifton, N.J.), 2012, Volume: 846 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Culture Techniques; Cell Survival; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; PC12 Cells; Rats; Superior Cervical Ganglion	2012
Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway. BMC complementary and alternative medicine, 2012, Jun-28, Volume: 12 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Camellia sinensis; Catechin; Cell Survival; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Oxidative Stress; Parkinson Disease; PC12 Cells; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phytotherapy; Plant Extracts; Rats; Reactive Oxygen Species; RNA-Binding Proteins; RNA, Messenger; Signal Transduction; Sirtuin 1; Superoxide Dismutase; Superoxide Dismutase-1; Tea; Transcription Factors; Up-Regulation	2012
Lipid-like components released from degenerating dopaminergic neurons trigger the dynamic migration of microglia. Biochemical and biophysical research communications, 2012, Sep-14, Volume: 426, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Movement; Cells, Cultured; DNA; Dopaminergic Neurons; Lipid Metabolism; Mesencephalon; Microglia; Nerve Degeneration; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA	2012
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America, 2012, Oct-16, Volume: 109, Issue:42 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caenorhabditis elegans; Carbazoles; Dopaminergic Neurons; Dose-Response Relationship, Drug; Hippocampus; Indoles; Mice; Mice, Inbred C57BL; Molecular Structure; Neuroprotective Agents; Parkinson Disease; Substantia Nigra	2012
Induction of Dickkopf-1 contributes to the neurotoxicity of MPP+ in PC12 cells via inhibition of the canonical Wnt signaling pathway. Neuropharmacology, 2013, Volume: 67 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Intercellular Signaling Peptides and Proteins; Parkinson Disease; PC12 Cells; Rats; Wnt Signaling Pathway	2013
Induction of ferroxidase enzymatic activity by copper reduces MPP+-evoked neurotoxicity in rats. Neuroscience research, 2013, Volume: 75, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Ceruloplasmin; Copper; Copper Sulfate; Corpus Striatum; Disease Models, Animal; Male; Mesencephalon; Parkinson Disease; Rats; Rats, Wistar	2013
[Protective effect of six Kaixin San formulas on nerve cells injured by different materials]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:22 Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Drugs, Chinese Herbal; Humans; Neurons; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Peptide Fragments; Rats	2012
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiology of disease, 2002, Volume: 10, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Dopamine; Environmental Exposure; gamma-Aminobutyric Acid; Gliosis; Herbicides; Homovanillic Acid; Humans; Injections, Intraperitoneal; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Parkinsonian Disorders; Risk Factors; Substantia Nigra; Tyrosine 3-Monooxygenase	2002
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proceedings of the National Academy of Sciences of the United States of America, 2002, Oct-29, Volume: 99, Issue:22 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Biogenic Monoamines; Cells, Cultured; Dopamine Agents; Drug Resistance; Electron Transport Complex I; Female; Humans; Male; Mice; Mice, Knockout; NADH, NADPH Oxidoreductases; Nerve Tissue Proteins; Neurons; Parkinson Disease; Synucleins	2002
Tubuloside B from Cistanche salsa rescues the PC12 neuronal cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis and oxidative stress. Planta medica, 2002, Volume: 68, Issue:11 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Apoptosis; Cistanche; DNA Fragmentation; Electrophoresis, Agar Gel; Flow Cytometry; Glucosides; Microscopy, Confocal; Oxidative Stress; Parkinson Disease; PC12 Cells; Phytotherapy; Rats; Reactive Oxygen Species	2002
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Dec-15, Volume: 22, Issue:24 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; eIF-2 Kinase; Endoplasmic Reticulum; Ganglia, Sympathetic; Gene Expression Profiling; Gene Expression Regulation; Mice; Mice, Knockout; Neurons; Oxidopamine; Parkinson Disease; PC12 Cells; Protein Folding; Rats; RNA, Messenger; Rotenone; Sympatholytics; Transcription, Genetic	2002
1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. The Biochemical journal, 2003, Apr-01, Volume: 371, Issue:Pt 1 Topics: 1-Methyl-4-phenylpyridinium; Aconitate Hydratase; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Deferoxamine; Edetic Acid; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Hydrogen Peroxide; Iron; Iron Chelating Agents; Male; Metalloporphyrins; Mitochondria; NADH, NADPH Oxidoreductases; Neurons; Oxidants; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Receptors, Transferrin; Staining and Labeling; Transferrin	2003
Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro. Neuroscience letters, 2003, Feb-06, Volume: 337, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Hydrogen Peroxide; Hydroxydopamines; Neuroblastoma; Neuroprotective Agents; Parkinson Disease; Pyruvic Acid; Tumor Cells, Cultured	2003
1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. The Journal of biological chemistry, 2004, Apr-30, Volume: 279, Issue:18 Topics: 1-Methyl-4-phenylpyridinium; Aconitate Hydratase; Animals; Antioxidants; Apoptosis; Biopterins; Cerebellum; Electron Transport Complex I; Humans; Interneurons; Iron; Mitochondrial Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parkinson Disease; Rats; Reactive Oxygen Species; Receptors, Transferrin; Signal Transduction; Superoxides	2004
The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds. Free radical biology & medicine, 2004, Sep-15, Volume: 37, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apomorphine; Aspirin; Brain; Catalysis; Cell Line, Tumor; Dogs; Dopamine; Erythrocytes; Free Radicals; Herbicides; Humans; Lactoperoxidase; Neurons; Parkinson Disease; Peroxidase; Pyridinium Compounds; Spectrophotometry; Time Factors; Uric Acid	2004
Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Human molecular genetics, 2005, Jul-01, Volume: 14, Issue:13 Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Gene Expression Profiling; Gene Expression Regulation; Herbicides; Mesencephalon; Mice; MPTP Poisoning; Neurons; Oligonucleotide Array Sequence Analysis; Parkinson Disease; PC12 Cells; Rats	2005
Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures. Neurobiology of disease, 2005, Volume: 20, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Brain; Cell Death; Cell Nucleus; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Synergism; Glutamic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase	2005
ATP-sensitive potassium channel opener iptakalim protected against the cytotoxicity of MPP+ on SH-SY5Y cells by decreasing extracellular glutamate level. Journal of neurochemistry, 2005, Volume: 94, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Transport System X-AG; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cytoprotection; Down-Regulation; Extracellular Fluid; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propylamines; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors	2005
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function. Human molecular genetics, 2005, Dec-15, Volume: 14, Issue:24 Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Cells, Cultured; Dopamine; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mutation; Nitric Oxide Donors; Nitroso Compounds; Paraquat; Parkinson Disease; Proteasome Endopeptidase Complex; Reference Values; Rotenone; Solubility; Stress, Physiological; Ubiquitin-Protein Ligases	2005
1-methyl-4-phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase. Journal of neuroscience research, 2006, Feb-01, Volume: 83, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Count; Cell Line, Tumor; Disease Models, Animal; Female; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Immunohistochemistry; Motor Activity; Neuroblastoma; Neurotoxicity Syndromes; Parkinson Disease; Rats; Rotarod Performance Test; Substantia Nigra; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Transgenes; Tyrosine 3-Monooxygenase	2006
6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation. The Journal of biological chemistry, 2006, Apr-07, Volume: 281, Issue:14 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Apoptosis; Disease Models, Animal; Herbicides; Humans; Neuroblastoma; Neurons; Oxidopamine; Parkinson Disease; Phenotype; Proteasome Endopeptidase Complex; Tumor Cells, Cultured	2006
Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Curcumin; Enzyme Inhibitors; Herbicides; Mitochondria; Nitric Oxide Synthase Type II; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species	2006
Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antibodies; Cells, Cultured; Gliosis; Laminin; Mice; Microglia; Neurons; Oligopeptides; Parkinson Disease; Receptors, Laminin; Superoxides	2006
Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells. FEBS letters, 2006, May-29, Volume: 580, Issue:13 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Cells, Cultured; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; Humans; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; RNA, Messenger; Transfection; Ubiquitin	2006
The role of tissue transglutaminase in 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in differentiated human SH-SY5Y neuroblastoma cells. Neuroscience letters, 2006, Sep-11, Volume: 405, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Cell Differentiation; Cell Line, Tumor; Cell Survival; GTP-Binding Proteins; Humans; Imidazoles; Neuroblastoma; Parkinson Disease; Polyamines; Protein Glutamine gamma Glutamyltransferase 2; Putrescine; Transglutaminases	2006
Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells. European journal of pharmacology, 2006, Nov-07, Volume: 549, Issue:1-3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Cell Differentiation; Cell Survival; Cyclic N-Oxides; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Nerve Growth Factor; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Phosphorylation; Rats; Spin Labels	2006
A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free radical biology & medicine, 2006, Nov-15, Volume: 41, Issue:10 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase Inhibitors; Cells, Cultured; Disease Models, Animal; Dopamine; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Oligopeptides; Oxidopamine; Parkinson Disease; Peptides; Poly(ADP-ribose) Polymerases; Protein Kinase C-delta; Protein Kinase Inhibitors; Rats; Tyrosine 3-Monooxygenase	2006
SAG protects human neuroblastoma SH-SY5Y cells against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity via the downregulation of ROS generation and JNK signaling. Neuroscience letters, 2007, Feb-14, Volume: 413, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Enzyme Activation; Gene Expression Regulation; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; Mice; Neuroblastoma; Neurons; Neurotoxins; NIH 3T3 Cells; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; RNA-Binding Proteins; Ubiquitin-Protein Ligases	2007
7-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study. Annals of the New York Academy of Sciences, 2006, Volume: 1089 Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Indazoles; Male; Microdialysis; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra	2006
1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C. Proceedings of the National Academy of Sciences of the United States of America, 2007, Feb-13, Volume: 104, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Axonal Transport; Caspases; Decapodiformes; Disease Models, Animal; Enzyme Activation; Kinetics; Neurons; Parkinson Disease; Protein Kinase C; Protein Kinase C-delta; Synaptic Vesicles	2007
1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCdelta enzymatic activities. Proceedings of the National Academy of Sciences of the United States of America, 2007, Feb-13, Volume: 104, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Caspase 3; Chromosome Pairing; Decapodiformes; Disease Models, Animal; Neurons; Parkinson Disease; Protein Kinase C-delta; Signal Transduction; Synapses; Synaptic Vesicles	2007
The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America, 2007, Feb-27, Volume: 104, Issue:9 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Apoptosis; Chromatography, High Pressure Liquid; E2F1 Transcription Factor; Gene Expression Regulation; Humans; Immunohistochemistry; In Situ Hybridization; Interneurons; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotides, Antisense; Parkinson Disease; Signal Transduction; Substantia Nigra	2007
Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells. Neuroscience letters, 2007, May-17, Volume: 418, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Catalase; Cell Line, Tumor; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Iron; Iron Metabolism Disorders; Mice; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Parkinson Disease; RNA, Messenger; Superoxide Dismutase; Superoxide Dismutase-1; Xanthones	2007
Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models. Biochemical and biophysical research communications, 2007, Jun-08, Volume: 357, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Cell Nucleus; Cell Survival; Cells, Cultured; Cytoplasm; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Neurons; Neuroprotective Agents; Parkinson Disease; Phenanthrenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors	2007
[Protecting effect of Cistanche extracts on MPP+-induced injury of the Parkinson's disease cell model]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2007, Volume: 5, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Antiparkinson Agents; Cell Line; Cistanche; Humans; Models, Biological; Neurons; Neuroprotective Agents; Parkinson Disease; Plant Extracts; RNA, Messenger; Transcription Factor CHOP	2007
Nitration of soluble proteins in organotypic culture models of Parkinson's disease. Neurochemistry international, 2008, Volume: 52, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Mice; Mice, Inbred C57BL; Neurochemistry; Neurotoxins; Nitric Oxide Donors; Nitric Oxide Synthase; Nitro Compounds; Organ Culture Techniques; Oxidative Stress; Parkinson Disease; Proteins; Pterins; Reactive Nitrogen Species; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase; Uncoupling Agents	2008
Dopamine induces TNFalpha and TNF-R1 expression in SH-SY5Y human neuroblastoma cells. Neuroreport, 2007, Oct-29, Volume: 18, Issue:16 Topics: 1-Methyl-4-phenylpyridinium; Antibodies; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Encephalitis; Humans; Neuroblastoma; Neurons; Neurotoxins; Oxidopamine; Parkinson Disease; Receptors, Tumor Necrosis Factor, Type I; Substantia Nigra; Tumor Necrosis Factor-alpha; Up-Regulation	2007
Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons. European journal of pharmacology, 2008, Jan-28, Volume: 579, Issue:1-3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Buddleja; Caspase 3; Cell Death; Cell Survival; Gene Expression Regulation, Enzymologic; Glucosides; Iridoid Glucosides; Iridoids; Medicine, Chinese Traditional; Mesencephalon; Neurons; Neuroprotective Agents; Parkinson Disease; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase	2008
Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells. Neurobiology of aging, 2009, Volume: 30, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase 3; Cation Transport Proteins; Cell Line, Transformed; Gene Expression Regulation; Herbicides; Iron; Membrane Potential, Mitochondrial; Mice; Mitochondrial Diseases; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Reactive Oxygen Species; RNA, Messenger; Up-Regulation	2009
Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's disease. Toxicology, 2008, Mar-12, Volume: 245, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase 3; Cell Differentiation; Cell Survival; Cells, Cultured; DNA Fragmentation; Dopamine; Dose-Response Relationship, Drug; Iron; Iron Chelating Agents; Mesencephalon; Neuroprotective Agents; Parkinson Disease; Phytic Acid; Rats	2008
MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1. The European journal of neuroscience, 2008, Volume: 27, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Death; Cell Line, Tumor; Humans; Male; Neurons; Oxidoreductases; Parkinson Disease; Phosphorylation; Rats; Rats, Sprague-Dawley; Tumor Suppressor Proteins; Tyrosine; WW Domain-Containing Oxidoreductase	2008
Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background. Mitochondrion, 2008, Volume: 8, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Aged; Blood Platelets; Case-Control Studies; Caspase 3; Cell Line, Tumor; Cell Nucleus; Cell Survival; Citrate (si)-Synthase; Cytochromes c; DNA, Mitochondrial; Dose-Response Relationship, Drug; Electron Transport Complex IV; Enzyme Activation; Humans; Hybrid Cells; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Middle Aged; Mitochondria; Neurons; Parkinson Disease; Teratocarcinoma	2008
ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+. Gene therapy, 2008, Volume: 15, Issue:20 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Biomarkers; Calpain; Caspase 3; Gene Expression; Genetic Therapy; HSP70 Heat-Shock Proteins; Immunoblotting; In Situ Nick-End Labeling; Mitochondria; Parkinson Disease; PC12 Cells; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats; Ribonucleotide Reductases; Signal Transduction; Toxins, Biological	2008
Survival of and 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity against dopaminergic neurons in coculture of rat mesencephalon with their target on non-target regions. Neuroscience research, 1995, Volume: 23, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Count; Cell Survival; Cells, Cultured; Corpus Striatum; Dopamine; Mesencephalon; Neurons; Parkinson Disease; Rats; Rats, Wistar	1995
Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuroreport, 1995, May-30, Volume: 6, Issue:8 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Dose-Response Relationship, Drug; Isoquinolines; Ketoglutarate Dehydrogenase Complex; Male; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Parkinson Disease; Rats; Rats, Wistar	1995
Cerebrospinal dopamine metabolites in rats after intrastriatal administration of 6-hydroxydopamine or 1-methyl-4-phenylpyridinium ion. Brain research, 1995, Jan-09, Volume: 669, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Homovanillic Acid; Male; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley	1995
[Serotonin antibodies and their possible role in parkinsonism]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1994, Volume: 94, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Adult; Aged; Animals; Antibodies; Antibody Specificity; Caudate Nucleus; Cluster Analysis; Disease Models, Animal; Electrophysiology; Humans; Immunization; Middle Aged; Parkinson Disease; Rabbits; Serotonin	1994
Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures. Journal of neuroscience research, 1994, Volume: 37, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Cells, Cultured; Corpus Striatum; Dopamine; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Parkinson Disease; Polymerase Chain Reaction; Rats; Receptor, Ciliary Neurotrophic Factor; Receptors, Growth Factor; Substantia Nigra; Tyrosine 3-Monooxygenase	1994
Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease. Journal of neurochemistry, 1994, Volume: 63, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Dose-Response Relationship, Drug; Electron Transport Complex I; NADH, NADPH Oxidoreductases; Necrosis; Parkinson Disease; PC12 Cells; Rats; Rotenone; Substantia Nigra	1994
Differential cytotoxicities of N-methyl-beta-carbolinium analogues of MPP+ in PC12 cells: insights into potential neurotoxicants in Parkinson's disease. Journal of neurochemistry, 1994, Volume: 62, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cations; Cell Death; Culture Media; Energy Metabolism; Harmaline; Kinetics; L-Lactate Dehydrogenase; Methylation; Molecular Structure; Parkinson Disease; PC12 Cells; Rats	1994
Neurotoxicity of nicotinamide derivatives: their role in the aetiology of Parkinson's disease. Biochemical Society transactions, 1993, Volume: 21 ( Pt 3), Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Humans; Isomerism; Kinetics; L-Lactate Dehydrogenase; Neuroblastoma; Neurotoxins; Niacinamide; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rotenone; Tumor Cells, Cultured	1993
Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells. Psychopharmacology, 1995, Volume: 121, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Line; Dose-Response Relationship, Drug; Haloperidol; MPTP Poisoning; Neuroblastoma; Neurotoxins; Parkinson Disease; Time Factors	1995
Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. Journal of neuroscience research, 1996, Jan-01, Volume: 43, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Dizocilpine Maleate; Dopamine; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamic Acid; Mesencephalon; NAD(P)H Dehydrogenase (Quinone); Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Rats; Receptors, N-Methyl-D-Aspartate	1996
beta-Carbolinium cations, endogenous MPP+ analogs, in the lumbar cerebrospinal fluid of patients with Parkinson's disease. Neurology, 1995, Volume: 45, Issue:12 Topics: 1-Methyl-4-phenylpyridinium; Aged; Aged, 80 and over; Carbolines; Cations; Female; Humans; Lumbosacral Region; Male; Middle Aged; Parkinson Disease; Reference Values	1995
Origin and functional consequences of the complex I defect in Parkinson's disease. Annals of neurology, 1996, Volume: 40, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Aged; Apoptosis; Cell Death; DNA, Mitochondrial; Female; Humans; Male; Middle Aged; Muscle, Skeletal; NAD; NAD(P)H Dehydrogenase (Quinone); Parkinson Disease; Point Mutation	1996
Mechanism of resistance to NO-induced neurotoxicity in cultured rat dopaminergic neurons. Journal of neuroscience research, 1996, Nov-15, Volume: 46, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Ascorbic Acid; Cell Survival; Cells, Cultured; Dopamine; Drug Resistance; Mesencephalon; Nerve Tissue Proteins; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Parkinson Disease; Rats; Tyrosine 3-Monooxygenase	1996
Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. Journal of neurochemistry, 1997, Volume: 68, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Aged; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Transformed; Cell Membrane; Cytosol; Dopamine Agents; Endoplasmic Reticulum; Energy Metabolism; Female; Homeostasis; Humans; Ionophores; Kinetics; Male; Middle Aged; Mitochondria; Parkinson Disease; Tumor Cells, Cultured	1997
Apoptosis in neurodegenerative disorders. Journal of neural transmission. Supplementum, 1997, Volume: 50 Topics: 1-Methyl-4-phenylpyridinium; Adult; Age of Onset; Aged; Aged, 80 and over; Animals; Apoptosis; Biomarkers; Brain Diseases; Coculture Techniques; DNA; DNA Nucleotidylexotransferase; Embryo, Mammalian; Humans; Melanins; Mesencephalon; Middle Aged; Neostriatum; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase	1997
Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors. Brain research, 1997, Nov-28, Volume: 777, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Cell Survival; Dopamine; Dopamine Agents; Free Radical Scavengers; Isoquinolines; Ketoglutarate Dehydrogenase Complex; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Neurons; Parkinson Disease; PC12 Cells; Rats; Rotenone; Uncoupling Agents	1997
Quantitative study of mitochondrial complex I in platelets of parkinsonian patients. Movement disorders : official journal of the Movement Disorder Society, 1998, Volume: 13, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Aged; Aged, 80 and over; Blood Platelets; Case-Control Studies; Dopamine Agents; Dose-Response Relationship, Drug; Electron Transport Complex I; Female; Humans; Insecticides; Male; Middle Aged; Mitochondria; NADH, NADPH Oxidoreductases; Neurotoxins; Parkinson Disease; Radioligand Assay; Rotenone	1998
Melatonin protects nigral dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity in rats. Neuroscience letters, 1998, Apr-03, Volume: 245, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Dopamine; Dopamine Agents; Female; Male; Melatonin; Neurons; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra	1998
Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins. Brain research, 1998, Oct-26, Volume: 809, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Coloring Agents; Cyclosporine; Dopamine Agents; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Fluorescent Dyes; In Situ Nick-End Labeling; Intracellular Membranes; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Parkinson Disease; PC12 Cells; Propidium; Rats; Rotenone; Uncoupling Agents	1998
Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease. Journal of neurochemistry, 1999, Volume: 73, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Cysteine; Glutamic Acid; Glutathione; Glycine; Hydrolysis; Hydroxyl Radical; Iron; Kinetics; Male; Microdialysis; Mitochondria; Models, Chemical; Nitro Compounds; Oxygen Consumption; Parkinson Disease; Perfusion; Propionates; Rats; Rats, Sprague-Dawley; Substantia Nigra	1999
Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate. Free radical biology & medicine, 1999, Volume: 27, Issue:9-10 Topics: 1-Methyl-4-phenylpyridinium; Allyl Compounds; Animals; Antioxidants; Butylamines; Corpus Striatum; Dopamine; Free Radical Scavengers; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Injections, Intraperitoneal; Male; Microdialysis; Monoamine Oxidase Inhibitors; Neurotoxins; Parabens; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline	1999
Altered glial function causes neuronal death and increases neuronal susceptibility to 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced toxicity in astrocytic/ventral mesencephalic co-cultures. Journal of neurochemistry, 1999, Volume: 73, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Coculture Techniques; Dizocilpine Maleate; Dopamine; Electron Transport Complex I; Excitatory Amino Acid Antagonists; Glutathione; Lipopolysaccharides; Mesencephalon; NADH, NADPH Oxidoreductases; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley	1999
Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappaB in cellular models of Parkinson's disease. Journal of neurochemistry, 2000, Volume: 74, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Adenine Nucleotides; Benzothiazoles; Electron Transport; Enzyme Activation; Free Radical Scavengers; Herbicides; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; Mitochondria; Mitogen-Activated Protein Kinases; Neuroblastoma; Neurons; NF-kappa B; Oxidative Stress; Parkinson Disease; Peptides; Pramipexole; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Signal Transduction; Superoxide Dismutase; Thiazoles; Tumor Cells, Cultured	2000
Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease. Brain research, 2000, Jan-31, Volume: 854, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Cerebellum; Dopamine; Dopamine Antagonists; Glutathione; Humans; Mice; Nerve Tissue Proteins; Neuroblastoma; Neurons; Neuroprotective Agents; Neurotoxins; Oxidopamine; Parkinson Disease; PC12 Cells; Rats; Tumor Cells, Cultured; Vasoactive Intestinal Peptide	2000
D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America, 2000, May-09, Volume: 97, Issue:10 Topics: 1-Methyl-4-phenylpyridinium; 3-Hydroxybutyric Acid; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Culture Media, Serum-Free; Embryo, Mammalian; Hippocampus; Humans; Ketone Bodies; Mesencephalon; Microtubule-Associated Proteins; Models, Neurological; Neurons; Parkinson Disease; Peptide Fragments; Rats; Tyrosine 3-Monooxygenase	2000
3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells. Brain research, 2000, Jun-23, Volume: 868, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Antioxidants; Dopamine; Energy Metabolism; Enzyme Inhibitors; Estrogens, Non-Steroidal; Fluorenes; Hydantoins; Isoflavones; Mitochondria; Neurons; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; PC12 Cells; Phenylethyl Alcohol; Rats; Rotenone	2000
Disrupted mitochondrial electron transport function increases expression of anti-apoptotic bcl-2 and bcl-X(L) proteins in SH-SY5Y neuroblastoma and in Parkinson disease cybrid cells through oxidative stress. Journal of neuroscience research, 2000, Sep-15, Volume: 61, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; bcl-X Protein; DNA, Mitochondrial; Electron Transport; Gene Expression Regulation; Herbicides; Humans; Hybrid Cells; Microscopy, Confocal; Mitochondria; Neuroblastoma; Neurons; Oxidative Stress; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Tumor Cells, Cultured	2000
Neuroscience. Pesticide causes Parkinson's in rats. Science (New York, N.Y.), 2000, Nov-10, Volume: 290, Issue:5494 Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Disease Models, Animal; Dopamine; Electron Transport Complex I; Free Radicals; Humans; Insecticides; Lewy Bodies; Mitochondria; NADH, NADPH Oxidoreductases; Neurons; Parkinson Disease; Parkinsonian Disorders; Rats; Risk Factors; Rotenone; Uncoupling Agents	2000
Low concentrations of 1-methyl-4-phenylpyridinium ion induce caspase-mediated apoptosis in human SH-SY5Y neuroblastoma cells. Journal of neuroscience research, 2001, Mar-01, Volume: 63, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cyclosporine; Cysteine Proteinase Inhibitors; Cytochrome c Group; DNA Fragmentation; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Humans; Membrane Glycoproteins; Membrane Potentials; Mitochondria; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Osmolar Concentration; Parkinson Disease; Tumor Cells, Cultured	2001
Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease? Journal of neurochemistry, 2001, Volume: 76, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Adult; Aged; Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Cells, Cultured; Dopamine; Embryo, Mammalian; Humans; Intracellular Membranes; Lewy Bodies; Mesencephalon; Mitochondria; Neurons; Parkinson Disease; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reference Values; Substantia Nigra; Tyrosine 3-Monooxygenase	2001
L-Deprenyl prevents the cell hypoxia induced by dopaminergic neurotoxins, MPP(+) and beta-carbolinium: a microdialysis study in rats. Neuroscience letters, 2001, Apr-20, Volume: 302, Issue:2-3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Carbolines; Cell Hypoxia; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Herbicides; Lactic Acid; Male; Microdialysis; Mitochondria; Monoamine Oxidase Inhibitors; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxins; Pargyline; Parkinson Disease; Rats; Rats, Wistar; Selegiline	2001
Prosaptide D5, a retro-inverso 11-mer peptidomimetic, rescued dopaminergic neurons in a model of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:6 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Cytoprotection; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Herbicides; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Neurons; Neuroprotective Agents; Parkinson Disease; Receptors, Dopamine	2001
Nitric oxide enhances MPP(+)-induced hydroxyl radical generation via depolarization activated nitric oxide synthase in rat striatum. Brain research, 2001, Jun-01, Volume: 902, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Allopurinol; Animals; Dopamine; Enzyme Inhibitors; Extracellular Space; Herbicides; Hydroxybenzoates; Hydroxyl Radical; Iron; Iron Chelating Agents; Male; Membrane Potentials; Microdialysis; Neostriatum; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Parkinson Disease; Potassium; Rats; Rats, Wistar	2001
Allopurinol suppresses para-nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical generation in rat striatum. Neuroscience letters, 2001, Jun-22, Volume: 306, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Allopurinol; Animals; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Hazardous Substances; Hydroxyl Radical; Male; Microdialysis; Neostriatum; Nerve Degeneration; Parkinson Disease; Parkinson Disease, Secondary; Phenols; Rats; Rats, Wistar	2001
Decreased expression of the NADH:ubiquinone oxidoreductase (complex I) subunit 4 in 1-methyl-4-phenylpyridinium -treated human neuroblastoma SH-SY5Y cells. Neuroscience letters, 2001, Jun-29, Volume: 306, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Electron Transport Complex I; Gene Expression Regulation, Enzymologic; Herbicides; Humans; Mitochondria; NADH, NADPH Oxidoreductases; Neuroblastoma; Neurons; Parkinson Disease; RNA, Messenger; Tumor Cells, Cultured	2001
GAPDH knockdown rescues mesencephalic dopaminergic neurons from MPP+ -induced apoptosis. Neuroreport, 2001, Jul-03, Volume: 12, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Survival; Cells, Cultured; Dopamine; Fetus; Glyceraldehyde-3-Phosphate Dehydrogenases; Herbicides; Immunohistochemistry; Microtubule-Associated Proteins; Neurons; Oligonucleotides, Antisense; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase	2001
Stimulation of non-alpha7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture. Neuroscience, 2002, Volume: 109, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Death; Dopamine; Female; Immunohistochemistry; Neurons; Neuroprotective Agents; Nicotine; Organ Culture Techniques; Parkinson Disease; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substantia Nigra; Tobacco Use Disorder; Tyrosine 3-Monooxygenase	2002
Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma. Journal of neuroscience research, 2002, Feb-15, Volume: 67, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Amyloid beta-Peptides; Anti-Bacterial Agents; Aristolochic Acids; Benzothiazoles; Bongkrekic Acid; Brain; Caspase Inhibitors; Caspases; Cell Death; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Humans; Neuroblastoma; Neurodegenerative Diseases; Neurons; Parkinson Disease; Peptide Fragments; Phenanthrenes; Pramipexole; Thiazoles; Tumor Cells, Cultured	2002
Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Apr-01, Volume: 22, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Chloromethyl Ketones; Animals; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Mesencephalon; Neurites; Neurons; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase	2002
[Human GDNF cDNA-engineered SH-SY5Y cells' neurotrophic and protective effect on primary dopaminergic neurons of rat]. Zhonghua yi xue za zhi, 2001, Nov-25, Volume: 81, Issue:22 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Coculture Techniques; DNA, Complementary; Dopamine; Genetic Engineering; Genetic Therapy; Glial Cell Line-Derived Neurotrophic Factor; Humans; Mesencephalon; Nerve Growth Factors; Nerve Tissue Proteins; Neuroblastoma; Neurons; Parkinson Disease; Protective Agents; Rats; Rats, Sprague-Dawley; Transfection; Tumor Cells, Cultured	2001
MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells. Brain research, 2002, May-10, Volume: 935, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Brain; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Neuroblastoma; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphorylation; Staurosporine; Synucleins; Tumor Cells, Cultured; Up-Regulation	2002
Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's disease. Journal of neural transmission. Parkinson's disease and dementia section, 1992, Volume: 4, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adult; Aged; Aged, 80 and over; Aging; Blood Platelets; Dopamine Agents; Female; Humans; Ketoglutarate Dehydrogenase Complex; Lymphocytes; Male; Middle Aged; Mitochondria; NAD(P)H Dehydrogenase (Quinone); NADH Dehydrogenase; Parkinson Disease	1992
Search for neurotoxins structurally related to 1-methyl-4-phenylpyridine (MPP+) in the pathogenesis of Parkinson's disease. Brain research, 1992, Mar-20, Volume: 575, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adrenal Glands; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dogs; Enzyme-Linked Immunosorbent Assay; Haplorhini; Humans; Neurotoxins; Parkinson Disease	1992
No relevance to Parkinson's. Nature, 1991, Aug-15, Volume: 352, Issue:6336 Topics: 1-Methyl-4-phenylpyridinium; Dopamine; Humans; Parkinson Disease; Receptors, N-Methyl-D-Aspartate	1991
Change of tyrosine hydroxylase in the parkinsonian brain and in the brain of MPTP-treated mice as revealed by homospecific activity. Neurochemical research, 1990, Volume: 15, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Corpus Striatum; Humans; Mice; Parkinson Disease; Parkinson Disease, Secondary; Rats; Tyrosine 3-Monooxygenase	1990
[Neurobiologic and pharmacologic studies on the pathogenesis of Parkinson disease]. Wiener medizinische Wochenschrift (1946), 1986, Aug-31, Volume: 136, Issue:15-16 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Brain; Corpus Striatum; Disease Models, Animal; Humans; Monoamine Oxidase Inhibitors; Neural Pathways; Neuronal Plasticity; Neurotransmitter Agents; Parkinson Disease; Parkinson Disease, Secondary; Pyridinium Compounds; Receptors, Dopamine; Substantia Nigra; Synapses; Synaptic Transmission	1986
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature, 1988, Jul-28, Volume: 334, Issue:6180 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcholinesterase; Dopamine; Humans; Melanins; Nerve Degeneration; Neurons; Parkinson Disease; Pyridines; Pyridinium Compounds; Tyrosine 3-Monooxygenase	1988
Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin. Science (New York, N.Y.), 1986, Feb-28, Volume: 231, Issue:4741 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Epinephrine; Haplorhini; Humans; Locus Coeruleus; Melanins; Neurotoxins; Norepinephrine; Parkinson Disease; Pyridines; Pyridinium Compounds; Substantia Nigra	1986
Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism. Biochemical and biophysical research communications, 1986, Feb-26, Volume: 135, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cattle; Cell Survival; Corpus Striatum; Cytochrome Reductases; Electron Transport; Intracellular Membranes; Mitochondria; NADH Dehydrogenase; Oxygen Consumption; Parkinson Disease; Pyridinium Compounds; Rats; Substantia Nigra	1986