1-methyl-4-phenylpyridinium has been researched along with Nerve Degeneration in 94 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.13) | 18.7374 |
| 1990's | 11 (11.70) | 18.2507 |
| 2000's | 49 (52.13) | 29.6817 |
| 2010's | 32 (34.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hisatsune, A; Katsuki, H; Kurauchi, Y; Seki, T; Takahashi, S | 1 |
| Cai, J; Iacovitti, L; Kostuk, EW | 1 |
| Capps, J; Virga, DM; Vohra, BPS | 1 |
| Ahn, TB; Baek, JY; Bok, E; Cho, EJ; Chung, YC; Jeong, JY; Jin, BK; Kim, KI; Nam, JH; Shin, WH; Won, SY | 1 |
| Cao, BB; Chen, JN; Gu, TT; Huang, Y; Liu, Z; Peng, YP; Qiu, AW; Qiu, YH; Yang, Y | 1 |
| Ganguly, A; Lee, D; Schultz, BJ; Wiemerslage, L | 1 |
| Hirsch, EC; Michel, PP; Rousseau, E | 1 |
| Choi, MS; Jeon, MT; Jung, UJ; Kim, SR | 1 |
| Anantharam, V; Harischandra, DS; Jin, H; Kanthasamy, A; Rana, A | 1 |
| Lee, D; Wiemerslage, L | 1 |
| Li, Y; Yang, C; Zhang, J | 1 |
| Breckenridge, JM; Macarthur, H; Touchette, JC; Wilken, GH | 1 |
| Bezard, E; Blanchard-Desce, M; Bourdenx, M; Daniel, J; Dehay, B; Genin, E; Soria, FN | 1 |
| Hotta, K; Oka, K; Shindo, Y; Suzuki, K; Yamanaka, R | 1 |
| Chung, KC; Darnell, RB; Hwang, IY; Hwang, JY; Kang, HW; Kim, K; Kim, S; Lee, J; Oh, CK; Oh, YJ; Park, HC; Park, WY; Shin, JH; Um, HD; Um, JW | 1 |
| Cha, DS; Cheon, SM; Jang, I; Jeon, H; Kim, DK; Lee, MH | 1 |
| Chen, H; Ding, JH; Hu, G; Wang, S | 1 |
| Ding, JH; Hu, G; Yang, YJ; Zhang, S; Zhou, F | 1 |
| Ahn, KH; Huh, Y; Jeong, JW; Kim, SY; Kim, YS; Park, C | 1 |
| Hashimoto, T; Ibuki, T; Iwanaga, T; Kishibuchi, R; Kitagawa, H; Mizuguchi, H; Momota, H; Nishihara, S; Onaka, Y; Sado, M; Wada, D; Watanabe, TK; Yamasaki, Y | 1 |
| Le, W; Pu, P | 1 |
| Aguilera, J; Limón, ID; Martínez, I; Mendieta, L; Moreno, N; Patricio, A; Venegas, B | 1 |
| Cai, L; Fei, J; Gao, H; Huang, F; Huang, Y; Liang, M; Lu, S; Yu, M | 1 |
| Chang, PN; Feng, ZW; Wang, L; Xia, YY; Yang, HJ | 1 |
| Liu, L; Wang, X; Wang, Y | 1 |
| Ambrosio, S; Buendía, P; Cano-Jaimez, M; Fariñas, I; Milán, M; Pérez-Sánchez, F | 1 |
| Chen, L; Li, W; Li, Z; Lin, Y; Liu, Z; Lu, XL; Pang, J; Pei, Z; Wang, GL; Xu, Z; Yao, XL; Zeng, J; Zhang, H | 1 |
| Chang, M; Dong, Z; Hu, L; Hu, X; Jiang, H; Li, G; Tian, M; Wang, D; Wang, Y; Xie, H; Zhang, Y | 1 |
| Kidd, SK; Schneider, JS | 1 |
| Chen, J; Kang, X; Li, X; Liang, Q; Sun, X; Tao, L; Ye, X | 1 |
| Bok, E; Chung, ES; Chung, YC; Jin, BK; Jin, M; Kim, SR; Kim, YS; Ko, HW; Park, ES; Park, JY; Park, KW; Won, SY; Yoon, SH | 1 |
| Choi, WS; Palmiter, RD; Xia, Z | 1 |
| Antenor-Dorsey, JA; Kim-Han, JS; O'Malley, KL | 1 |
| Cui, W; Han, R; Han, Y; Hu, S; Li, W; Mak, S; Rong, J; Zhang, H | 1 |
| Li, W; Lu, XL; Wu, WL; Yao, XL; Ye, CH; Zheng, MY | 1 |
| Burdett, TC; Cipriani, S; Desjardins, CA; Schwarzschild, MA; Xu, K; Xu, Y | 1 |
| Krieglstein, K; Ming, M; Spittau, B; Zhou, X | 1 |
| Kim, H; Kim, K; Park, JH | 1 |
| Bähr, M; Frank, T; Koch, JC; Lingor, P; Saal, KA; Szego, ÉM; Tatenhorst, L; Tönges, L; Weishaupt, JH | 1 |
| Cai, J; Iacovitti, L; Jablonski, M; Pelta-Heller, J; Phani, S | 1 |
| Cory-Slechta, DA; Di Monte, DA; Langston, JW; Manning-Bog, AB; McCormack, AL; Thiffault, C; Thiruchelvam, M | 1 |
| Bioulac, B; Fernagut, PO; Ghorayeb, I; Hervier, L; Labattu, B; Tison, F | 1 |
| An, L; Hong, JS; Li, G; Liu, B; Liu, Y; Qin, L; Zhang, W | 1 |
| Anantharam, V; Kanthasamy, A; Kanthasamy, AG; Kaul, S; Kitazawa, M | 1 |
| Hardy, J; Hornykiewicz, O; Kattinger, A; Khorchide, M; Pifl, C; Reither, H | 1 |
| Aguilar Hernández, R; Arriagada, C; Barcia, C; Caviedes, P; Herrero, MT; Sánchez De Las Matas, MJ; Segura-Aguilar, J | 1 |
| Hong, JS; Liu, B; Wang, T; Wilson, B; Zhang, W | 1 |
| Carlson, EC; Ebadi, M; Sharma, SK | 1 |
| Anantharam, V; Kanthasamy, AG; Kaul, S; Yang, Y; Zhang, D | 1 |
| Bähr, M; Kügler, S; Lingor, P; Schöll, U | 1 |
| Bando, Y; Ishibashi, T; Katayama, T; Matsuo, N; Ogawa, S; Taniguchi, M; Tohyama, M | 1 |
| Carrasco, E; Casper, D; Werner, P | 1 |
| Jin, J; Kovacs, M; Wang, Y; Zhang, J; Zhou, Y | 1 |
| Gramsbergen, JB; Jakobsen, B; Møller Dall, A; Rosenblad, C; Zimmer, J | 1 |
| Kress, GJ; Reynolds, IJ | 1 |
| Ding, JH; Hu, G; Hu, LF; Liu, SY; Shi, XR; Sun, YH; Wang, S; Yao, HH | 1 |
| Cappelletti, G; Maci, R; Surrey, T | 1 |
| Beal, MF; Calingasan, NY; Chen, J; Cleren, C; Lorenzo, BJ; Starkov, AA | 1 |
| Halliwell, B; Hyun, DH; Jenner, P; Lee, M | 1 |
| Cao, G; Chen, J; Chu, CT; Signore, A; Wang, S; Zhu, JH | 1 |
| Banerjee, R; Chandra, G; Mohanakumar, KP; Nath De, S; Saravanan, KS; Sreetama, S | 1 |
| Battaglia, G; Biagioni, F; Bruno, V; Busceti, CL; Molinaro, G; Nicoletti, F; Traficante, A | 1 |
| Lim, HS; Lu, XY; Paz, J; Yao, H; Zhang, W | 1 |
| Anantharam, V; Jin, H; Kanthasamy, A; Kanthasamy, AG; Kaul, S; Latchoumycandane, C; Zhang, D | 1 |
| Han, ES; Kim, YJ; Ko, HH; Lee, CS | 2 |
| Amazzal, L; Bagrel, D; Lapôtre, A; Quignon, F | 1 |
| Jiang, H; Song, N; Wang, J; Xie, J; Zhang, S | 1 |
| Hashimoto, T; Nagasao, J; Nishi, K; Oyanagi, K; Tsuji, S | 1 |
| Cardoso, SM; Domingues, AF; Esteves, AR; Oliveira, CR; Swerdlow, RH | 1 |
| Cho, SH; Chung, YH; Kim, DH; Kim, KY; Kim, SS; Lee, DY; Lee, HJ; Lee, JY; Lee, KS; Lee, WB; Noh, YH; Yoon, OJ | 1 |
| Beal, MF; Breakefield, XO; Frim, DM; Galpern, WR; Isacson, O; Uhler, TA | 1 |
| Dringen, R; Eblen, F; Klockgether, T; Löschmann, PA; Schmid, A; Schulz, JB; Turski, L; Wüllner, U | 1 |
| Basit, A; Epstein, CJ; Facca, A; Sanchez-Ramos, JR; Song, S | 1 |
| Mizuno, Y; Mochizuki, H; Mori, H | 1 |
| Beal, MF; Fallon, J; Hyman, BT; Matthews, RT | 1 |
| Beal, MF; Fallon, J; Fedorchak, K; Fishman, MC; Huang, PL; Hyman, BT; Matthews, RT | 1 |
| Chi, S; German, DC; Iacopino, AM; McMahon, A; Ng, MC; Wong, BS | 1 |
| Albers, DS; Moy, LY; Sonsalla, PK | 1 |
| Freed, WJ; Kishikawa, M; Takashima, H; Tsujihata, M | 1 |
| Ambrosio, S; Bermúdez, J; Boada, J; Cutillas, B; Roig, T | 1 |
| Disshon, KA; Dluzen, DE | 1 |
| Annepu, J; Ravindranath, V | 1 |
| Dawson, TM; Dawson, VL; Guo, X | 1 |
| Kubota, S; Obata, T; Yamanaka, Y | 1 |
| Kinemuchi, H; Obata, T; Oreland, L; Yamanaka, Y | 1 |
| Cano, J; Machado, A; Santiago, M | 1 |
| Cappelletti, G; Maci, R; Maggioni, MG; Pedrotti, B | 1 |
| Aoyama, S; Ikeda, K; Kurokawa, M; Kuwana, Y | 1 |
| Callier, S; Di Paolo, T; Le Saux, M; Lhiaubet, AM; Pelaprat, D; Rostène, W | 1 |
| Knigge, MF; Ter Horst, GJ; Van der Wal, A | 1 |
| Corsini, GU; Fascetti, F; Fornai, F; Oberto, G; Vaglini, F; Zuddas, A | 1 |
| Agid, YA; Graybiel, AM; Hirsch, E | 1 |
| Jonsson, G; Luthman, J | 1 |
94 other study(ies) available for 1-methyl-4-phenylpyridinium and Nerve Degeneration
| Article | Year |
|---|---|
Polysulfide protects midbrain dopaminergic neurons from MPP
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Line, Tumor; Dopaminergic Neurons; Dose-Response Relationship, Drug; Glutathione; Humans; Mesencephalon; Nerve Degeneration; Neuroprotective Agents; Rats; Reactive Oxygen Species; Sulfides; Up-Regulation | 2018 |
Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Coculture Techniques; Dopaminergic Neurons; Female; Mesencephalon; Microglia; Nerve Degeneration; Parkinson Disease; Pregnancy; Rats; Rats, Transgenic; Transcription, Genetic | 2018 |
Enteric Neurodegeneration is Mediated Through Independent Neuritic and Somal Mechanisms in Rotenone and MPP+ Toxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Enteric Nervous System; Female; Insecticides; Mice; MPTP Poisoning; Nerve Degeneration; Neurites; Parkinson Disease, Secondary; Parkinsonian Disorders; Pregnancy; Rotenone | 2018 |
Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP⁺ Neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Aged; Animals; Astrocytes; Capsaicin; Cell Survival; Ciliary Neurotrophic Factor; Dopaminergic Neurons; Female; Gene Knockdown Techniques; Humans; Male; Microglia; Models, Biological; Nerve Degeneration; Neuroprotection; Neurotoxicity Syndromes; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Ciliary Neurotrophic Factor; RNA, Small Interfering; Substantia Nigra; TRPV Cation Channels | 2018 |
IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Interleukin-17; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurodegenerative Diseases; Neuroimmunomodulation; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Th17 Cells; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2019 |
Selective degeneration of dopaminergic neurons by MPP(+) and its rescue by D2 autoreceptors in Drosophila primary culture.
Topics: 1-Methyl-4-phenylpyridinium; Action Potentials; Animals; Animals, Genetically Modified; Bromocriptine; Cholinergic Neurons; Dopamine Agonists; Dopaminergic Neurons; Drosophila melanogaster; Drosophila Proteins; Female; GABAergic Neurons; Male; Nerve Degeneration; Parkinsonian Disorders; Primary Cell Culture; Quinpirole; Receptors, Dopamine D2 | 2013 |
The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Binding Sites; Calcium; Cell Death; Cells, Cultured; Dopamine; Focal Adhesion Kinase 1; Glial Cell Line-Derived Neurotrophic Factor; Homeostasis; Humans; Lactoferrin; Mesencephalon; Mitochondria; Nerve Degeneration; Neuroglia; Neurons; Parkinson Disease; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Recombinant Proteins | 2013 |
Silibinin attenuates MPP⁺-induced neurotoxicity in the substantia nigra in vivo.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Female; Inflammation; Interleukin-1beta; Microglia; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide Synthase Type II; Parkinson Disease; Rats; Rats, Sprague-Dawley; Silybin; Silymarin; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2014 |
Targeted toxicants to dopaminergic neuronal cell death.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Mice; Nerve Degeneration; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase | 2015 |
Role of Drosophila calcium channel cacophony in dopaminergic neurodegeneration and neuroprotection.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Calcium Channels; Calcium Chelating Agents; Dopaminergic Neurons; Drosophila; Drosophila Proteins; Edetic Acid; Embryo, Nonmammalian; Mutation; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Primary Cell Culture; Quinpirole; Receptors, Dopamine D2 | 2015 |
UNC-51-like kinase 1 blocks S6k1 phosphorylation contributes to neurodegeneration in Parkinson's disease model in vitro.
Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Substitution; Animals; Autophagy-Related Protein-1 Homolog; Binding Sites; Cell Line; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Gene Knockdown Techniques; Mice; Mutagenesis, Site-Directed; Nerve Degeneration; Parkinsonian Disorders; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger | 2015 |
Direct intranigral injection of dopaminochrome causes degeneration of dopamine neurons.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopaminergic Neurons; Indolequinones; Male; Nerve Degeneration; Parkinson Disease; Pars Compacta; Rats, Sprague-Dawley | 2016 |
Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases.
Topics: 1-Methyl-4-phenylpyridinium; Acids; Alkalies; Animals; Cell Death; Dopaminergic Neurons; Humans; Hydrogen-Ion Concentration; Injections, Intraventricular; Lactic Acid; Lysosomal Storage Diseases; Lysosomes; Mice; Models, Biological; Models, Genetic; Nanoparticles; Neostriatum; Nerve Degeneration; Parkinson Disease; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2016 |
Altered expression of Mg(2+) transport proteins during Parkinson's disease-like dopaminergic cell degeneration in PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cation Transport Proteins; Cell Differentiation; Hydrogen Peroxide; Ion Transport; Magnesium; Membrane Potential, Mitochondrial; Mitochondria; MPTP Poisoning; Nerve Degeneration; Nerve Growth Factor; PC12 Cells; Rats; RNA Interference; RNA, Messenger; RNA, Small Interfering; Rotenone | 2016 |
Proteolytic degradation and potential role of onconeural protein cdr2 in neurodegeneration.
Topics: 1-Methyl-4-phenylpyridinium; Aging; Animals; Calpain; Cell Death; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Mesencephalon; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotection; Parkinson Disease; Postmortem Changes; Proteolysis; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Ubiquitin | 2016 |
Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans.
Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Animals, Genetically Modified; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Survival; Cytoprotection; Dopaminergic Neurons; Dose-Response Relationship, Drug; Feeding Behavior; Longevity; Methanol; Motor Activity; Nerve Degeneration; Neuroprotective Agents; PC12 Cells; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Protein Aggregates; Rats; Solvents; Sorbus; Time Factors | 2017 |
Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Antipyrine; Apoptosis; Astrocytes; Brain; Cells, Cultured; Cytoprotection; Edaravone; Energy Metabolism; Free Radical Scavengers; Mitochondria; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2008 |
Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation.
Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Brain Stem; Cell Death; Cells, Cultured; Decanoic Acids; Diazoxide; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hydroxy Acids; Male; Motor Activity; MPTP Poisoning; Nerve Degeneration; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Potassium Channel Blockers; Propylamines; Random Allocation; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2009 |
Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Cytoprotection; Enzyme Inhibitors; Herbicides; Humans; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Okadaic Acid; Oxidative Stress; Parkinson Disease; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction | 2009 |
Protective effect against Parkinson's disease-related insults through the activation of XBP1.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Cell Death; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dopamine; Endoplasmic Reticulum; Endoribonucleases; Humans; Leupeptins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Regulatory Factor X Transcription Factors; RNA, Messenger; Signal Transduction; Stress, Physiological; Transcription Factors; X-Box Binding Protein 1 | 2009 |
Dopamine neuron degeneration induced by MPP+ is independent of CED-4 pathway in Caenorhabditis elegans.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcium-Binding Proteins; Dendrites; Dopamine; Green Fluorescent Proteins; Mutation; Nerve Degeneration | 2008 |
The carboxyl-terminal domain of the heavy chain of tetanus toxin prevents dopaminergic degeneration and improves motor behavior in rats with striatal MPP(+)-lesions.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Dopamine; Male; Motor Activity; MPTP Poisoning; Nerve Degeneration; Neurons; Peptide Fragments; Rats; Rats, Wistar; Tetanus Toxin | 2009 |
Alteration of NRSF expression exacerbating 1-methyl-4-phenyl-pyridinium ion-induced cell death of SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Cell Line; Cell Line, Tumor; Cell Survival; Gene Expression Regulation; Herbicides; Humans; Models, Biological; Nerve Degeneration; Neurons; Parkinsonian Disorders; Repressor Proteins; RNA Interference; RNA, Messenger; Substantia Nigra | 2009 |
NF-kappaB mediates MPP+-induced apoptotic cell death in neuroblastoma cells SH-EP1 through JNK and c-Jun/AP-1.
Topics: 1-Methyl-4-phenylpyridinium; Active Transport, Cell Nucleus; Apoptosis; Cell Line, Tumor; DNA-Binding Proteins; Enzyme Inhibitors; Herbicides; Humans; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Nerve Degeneration; Neuroblastoma; NF-kappa B; Parkinsonian Disorders; Proto-Oncogene Proteins c-jun; Transcription Factor AP-1; Transcription Factor RelA | 2010 |
HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Apoptosis; Cell Line; Cell Survival; Dopamine; Drug Evaluation, Preclinical; Genetic Predisposition to Disease; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mice; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Rotenone; Substantia Nigra | 2009 |
Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by alpha-synuclein.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Catecholamines; Cell Death; Cells, Cultured; Ganglia, Sympathetic; Mice; Mice, Mutant Strains; Nerve Degeneration; Neurons; Neurotoxins; Parkinsonian Disorders; Sympathetic Fibers, Postganglionic; Tyrosine 3-Monooxygenase | 2010 |
Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Cell Nucleus; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Glutathione; Green Fluorescent Proteins; Intracellular Space; Membrane Potential, Mitochondrial; Nerve Degeneration; Neurons; Neuroprotective Agents; PC12 Cells; Pyrans; Rats; Reactive Oxygen Species | 2010 |
Proteomics analysis of MPP+-induced apoptosis in SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line; Humans; Image Processing, Computer-Assisted; MPTP Poisoning; Nerve Degeneration; Neurons; Neurotoxins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Two-Dimensional Difference Gel Electrophoresis | 2011 |
Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibition.
Topics: 1-Methyl-4-phenylpyridinium; Acetylation; Analysis of Variance; Animals; Apoptosis; Butyric Acid; Cell Line; Cells, Cultured; Dopamine; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Nerve Degeneration; Neurons; Rats; Valproic Acid; Vorinostat | 2010 |
Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Glucosides; Membrane Potential, Mitochondrial; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidative Stress; Parkinsonian Disorders; PC12 Cells; Phenols; Rats; Reactive Oxygen Species; Signal Transduction | 2011 |
Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Count; Coculture Techniques; Corpus Striatum; Cytokines; Dopamine; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning; NADPH Oxidases; Nerve Degeneration; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type II; Oxidative Stress; Recovery of Function; Rotarod Performance Test; Substantia Nigra | 2011 |
Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cytoplasm; Disease Models, Animal; Dopamine; Electron Transport Complex I; Mice; Microtubules; NAD; Nerve Degeneration; Parkinson Disease; Reactive Oxygen Species; Rotenone; Substantia Nigra; Vesicular Monoamine Transport Proteins | 2011 |
The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons.
Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Autophagy; Axonal Transport; Axons; Cell Survival; Dopamine; Mice; Mitochondria; Nerve Degeneration; Neurons; Neurotoxins | 2011 |
PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Drug Administration Schedule; MAP Kinase Signaling System; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2011 |
[Protective effects of Lycium barbarum extract against MPP(+) -induced neurotoxicity in Caenorhabditis elegans and PC12 cells].
Topics: 1-Methyl-4-phenylpyridinium; Animals; Caenorhabditis elegans; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Flow Cytometry; Glutathione; Green Fluorescent Proteins; Lycium; Membrane Potential, Mitochondrial; Mitochondria; Nerve Degeneration; Neurons; Neuroprotective Agents; PC12 Cells; Plant Extracts; Rats; Reactive Oxygen Species | 2011 |
Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Dopaminergic Neurons; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Parkinsonian Disorders; Recombinant Proteins; Tissue Culture Techniques; Urate Oxidase; Uric Acid | 2012 |
IL6 protects MN9D cells and midbrain dopaminergic neurons from MPP+-induced neurodegeneration.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Line, Tumor; Chemokine CXCL10; Cytokines; Dopaminergic Neurons; Interleukin-6; Mesencephalon; Mice; Nerve Degeneration; Nerve Tissue Proteins; Neuroblastoma; Neuroprotective Agents; Primary Cell Culture; Recombinant Proteins; Tyrosine 3-Monooxygenase | 2012 |
Lipid-like components released from degenerating dopaminergic neurons trigger the dynamic migration of microglia.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Movement; Cells, Cultured; DNA; Dopaminergic Neurons; Lipid Metabolism; Mesencephalon; Microglia; Nerve Degeneration; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA | 2012 |
Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-4-phenylpyridinium; Animals; Axons; Behavior, Animal; Cell Survival; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Degeneration; Neurites; Neuroprotective Agents; Parkinson Disease, Secondary; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; rho-Associated Kinases; Substantia Nigra | 2012 |
Gremlin is a novel VTA derived neuroprotective factor for dopamine neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Cell Line, Tumor; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Humans; Intercellular Signaling Peptides and Proteins; Nerve Degeneration; Substantia Nigra; Ventral Tegmental Area | 2013 |
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Dopamine; Environmental Exposure; gamma-Aminobutyric Acid; Gliosis; Herbicides; Homovanillic Acid; Humans; Injections, Intraperitoneal; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Parkinsonian Disorders; Risk Factors; Substantia Nigra; Tyrosine 3-Monooxygenase | 2002 |
A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Forelimb; Herbicides; Intralaminar Thalamic Nuclei; Male; Motor Activity; Motor Cortex; MPTP Poisoning; Multiple System Atrophy; Nerve Degeneration; Parkinsonian Disorders; Rats; Rats, Wistar; Substantia Nigra | 2002 |
Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.
Topics: 1-Methyl-4-phenylpyridinium; Amyloid beta-Peptides; Animals; Cells, Cultured; Dextromethorphan; Drug Interactions; Inflammation; Lipopolysaccharides; Microglia; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Inbred F344; Receptors, Dopamine; Superoxides; Xanthine; Xanthine Oxidase | 2003 |
Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Benzimidazoles; Caspase 3; Caspase 9; Caspase Inhibitors; Caspases; Cell Line; Coumarins; Cytochromes c; DNA Fragmentation; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Free Radical Scavengers; Gene Expression; Herbicides; In Vitro Techniques; Manganese Compounds; Mesencephalon; Metalloporphyrins; Nerve Degeneration; Organometallic Compounds; Oxidative Stress; Precipitin Tests; Protein Kinase C; Protein Kinase C-delta; Rats; Reactive Oxygen Species; Time Factors; Transfection | 2003 |
alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter.
Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Cell Death; Cell Line, Tumor; Cell Survival; Chlorides; Dopamine; Dopamine Plasma Membrane Transport Proteins; Ferrous Compounds; Gene Expression; Herbicides; Humans; Manganese Compounds; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Degeneration; Nerve Tissue Proteins; Neuroblastoma; Synucleins; Transfection | 2004 |
MPP(+)-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Calpain; Cell Death; Cell Line; Chromatography, High Pressure Liquid; Dicumarol; DNA Fragmentation; Dopamine; Dopamine Agents; Enzyme Activation; Enzyme Inhibitors; Melanins; NAD(P)H Dehydrogenase (Quinone); Nerve Degeneration; Oxidation-Reduction; Rats | 2003 |
Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Cyclooxygenase 2; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Inflammation; Isoenzymes; Lipopolysaccharides; Male; Mesencephalon; Microglia; Nerve Degeneration; Neuroglia; Neurons; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 2004 |
Neuroprotective actions of Selegiline in inhibiting 1-methyl, 4-phenyl, pyridinium ion (MPP+)-induced apoptosis in SK-N-SH neurons.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Cell Membrane; Cytoprotection; Dose-Response Relationship, Drug; Free Radicals; Genes, Immediate-Early; Humans; Intracellular Membranes; Microscopy, Electron; Mitochondria; Nerve Degeneration; Neurites; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylserines; Selegiline | 2003 |
Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Dopamine; Enzyme Activation; Enzyme Inhibitors; Nerve Degeneration; Peptide Hydrolases; Protein Kinase C; Protein Kinase C-delta; Rats; RNA, Small Interfering | 2004 |
Functional applications of novel Semliki Forest virus vectors are limited by vector toxicity in cultures of primary neurons in vitro and in the substantia nigra in vivo.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; bcl-X Protein; Cells, Cultured; Disease Models, Animal; Dopamine; Female; Gene Expression Regulation, Viral; Gene Transfer Techniques; Genetic Vectors; Nerve Degeneration; Neurons; Parkinsonian Disorders; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Semliki forest virus; Substantia Nigra; Transduction, Genetic; Transgenes; Treatment Outcome; X-Linked Inhibitor of Apoptosis Protein | 2005 |
RA410/Sly1 suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Adaptation, Physiological; Animals; Apoptosis; Carrier Proteins; Caspases; Cell Survival; Dopamine; Endoplasmic Reticulum; Humans; Immediate-Early Proteins; Microscopy, Electron, Transmission; Munc18 Proteins; Nerve Degeneration; Neurons; Neurotoxins; Oligonucleotides, Antisense; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Rats; Substantia Nigra; Transfection; Tumor Cells, Cultured | 2005 |
Dopaminergic neurotoxicity by 6-OHDA and MPP+: differential requirement for neuronal cyclooxygenase activity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Cells, Cultured; Cyclooxygenase Inhibitors; Dopamine; Ibuprofen; Isoenzymes; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidopamine; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats | 2005 |
Microglial activation induced by neurodegeneration: a proteomic analysis.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Culture Media, Conditioned; Ethylenebis(dithiocarbamates); Membrane Proteins; Microglia; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Organometallic Compounds; Proteome; Proteomics; Rats; Rats, Sprague-Dawley | 2005 |
Characterization of organotypic ventral mesencephalic cultures from embryonic mice and protection against MPP toxicity by GDNF.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Cell Differentiation; Cell Proliferation; Cell Size; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glial Cell Line-Derived Neurotrophic Factor; Mice; Mice, Inbred C57BL; Nerve Degeneration; Nerve Growth Factors; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Parkinsonian Disorders; Recovery of Function; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2005 |
Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Brain; Cell Death; Cell Nucleus; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Synergism; Glutamic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase | 2005 |
ATP-sensitive potassium channel opener iptakalim protected against the cytotoxicity of MPP+ on SH-SY5Y cells by decreasing extracellular glutamate level.
Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Transport System X-AG; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cytoprotection; Down-Regulation; Extracellular Fluid; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propylamines; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors | 2005 |
The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cattle; Cytoskeleton; Herbicides; Humans; Microtubules; Nerve Degeneration; Neurotoxins; Parkinson Disease, Secondary | 2005 |
Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Calcium; Calcium Signaling; Disease Models, Animal; Dopamine; Electron Transport Complex I; Histamine H1 Antagonists; Male; Membrane Potentials; Mice; Mitochondria; Mitochondrial Membranes; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinsonian Disorders; Promethazine; Substantia Nigra | 2005 |
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aldehydes; Apoptosis; Cell Death; Cell Line, Tumor; Drug Resistance; Enzyme Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Guanine; Humans; Hydrogen Peroxide; Mutation; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Tyrosine; Ubiquitin-Protein Ligases | 2005 |
Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells.
Topics: 1-Methyl-4-phenylpyridinium; Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Caspases; Cell Line; DNA Fragmentation; Dopamine; Down-Regulation; Flavoproteins; Membrane Proteins; Mesencephalon; Mice; MPTP Poisoning; Nerve Degeneration; Neurons; Protein Transport; RNA Interference | 2005 |
Intrastriatal infusion of the Parkinsonian neurotoxin, MPP(+), induces damage of striatal cell nuclei in Sprague-Dawley rats.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcholine; Animals; Atrophy; Cell Nucleus; Cholinergic Fibers; Coloring Agents; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Herbicides; Male; Microscopy, Electron, Transmission; Nerve Degeneration; Neurons; Neurotoxins; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2006 |
Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Benzopyrans; Corpus Striatum; Mice; Mice, Inbred C57BL; Mice, Knockout; MPTP Poisoning; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate; Substantia Nigra; Tritium | 2006 |
The neuroprotective role of attractin in neurodegeneration.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Analysis of Variance; Apoptosis Inducing Factor; Cell Line, Tumor; Cell Survival; Cytochromes c; Gene Expression Regulation; Humans; In Situ Hybridization; Membrane Proteins; Nerve Degeneration; Neurotoxins; RNA, Small Interfering; Transfection; Tyrosine 3-Monooxygenase | 2007 |
A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase Inhibitors; Cells, Cultured; Disease Models, Animal; Dopamine; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Oligopeptides; Oxidopamine; Parkinson Disease; Peptides; Poly(ADP-ribose) Polymerases; Protein Kinase C-delta; Protein Kinase Inhibitors; Rats; Tyrosine 3-Monooxygenase | 2006 |
Modulation of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by K(ATP) channel block.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Caspase 3; Cell Death; Cell Membrane Permeability; Cell Nucleus; Cell Survival; Cytochromes c; Decanoic Acids; Glutathione; Glyburide; Herbicides; Hydroxy Acids; Mitochondria; Mitochondrial Membranes; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Potassium Channel Blockers; Potassium Channels; Rats; Reactive Oxygen Species | 2007 |
Lamotrigine inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase 3; Cell Death; Cell Membrane Permeability; Cytochromes c; Electron Transport Complex I; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutathione; Lamotrigine; Membrane Potential, Mitochondrial; Mitochondria; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Rotenone; Triazines | 2007 |
Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Catalase; Cell Line, Tumor; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Iron; Iron Metabolism Disorders; Mice; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Parkinson Disease; RNA, Messenger; Superoxide Dismutase; Superoxide Dismutase-1; Xanthones | 2007 |
Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase 3; Cation Transport Proteins; Cell Line, Transformed; Gene Expression Regulation; Herbicides; Iron; Membrane Potential, Mitochondrial; Mice; Mitochondrial Diseases; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Reactive Oxygen Species; RNA, Messenger; Up-Regulation | 2009 |
Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in dopaminergic neurons.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Dopamine; Immunohistochemistry; In Vitro Techniques; Magnesium; Microscopy, Immunoelectron; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinsonian Disorders; Rats; Tyrosine 3-Monooxygenase | 2008 |
Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Calpain; Caspases; Cell Line, Tumor; DNA, Mitochondrial; Electron Transport Complex I; Humans; Mitochondria; MPTP Poisoning; Nerve Degeneration; Teratocarcinoma | 2008 |
Kynurenic acid attenuates MPP(+)-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; Dopamine; Enzyme Activation; Humans; Kynurenic Acid; Membrane Potential, Mitochondrial; Mitochondria; Nerve Degeneration; Neurons; Time Factors | 2008 |
Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain-Derived Neurotrophic Factor; Cell Line; Cell Survival; Cells, Cultured; Fibroblasts; Genetic Engineering; Male; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Substantia Nigra | 1994 |
Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Buthionine Sulfoximine; Dopamine Agents; Glutathione; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1996 |
Transgenic murine dopaminergic neurons expressing human Cu/Zn superoxide dismutase exhibit increased density in culture, but no resistance to methylphenylpyridinium-induced degeneration.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Count; Cells, Cultured; Dopamine; Dopamine Agents; Drug Resistance; Female; Humans; Male; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Superoxide Dismutase | 1997 |
Apoptosis in neurodegenerative disorders.
Topics: 1-Methyl-4-phenylpyridinium; Adult; Age of Onset; Aged; Aged, 80 and over; Animals; Apoptosis; Biomarkers; Brain Diseases; Coculture Techniques; DNA; DNA Nucleotidylexotransferase; Embryo, Mammalian; Humans; Melanins; Mesencephalon; Middle Aged; Neostriatum; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase | 1997 |
MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Coenzymes; Cyclic N-Oxides; Dopamine Agents; Drug Combinations; Ions; Male; Nerve Degeneration; Niacinamide; Nitrogen Oxides; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Labels; Substantia Nigra; Time Factors; Ubiquinone | 1997 |
MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Male; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1997 |
Calbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Calbindin 1; Calbindins; Calcimycin; Calcium; Culture Media, Serum-Free; Drug Resistance, Neoplasm; Glutamic Acid; Intracellular Fluid; Nerve Degeneration; Nerve Tissue Proteins; PC12 Cells; Rats; S100 Calcium Binding Protein G; Time Factors | 1998 |
Lowering ambient or core body temperature elevates striatal MPP+ levels and enhances toxicity to dopamine neurons in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Agents; Excitatory Amino Acid Antagonists; Methamphetamine; Mice; MPTP Poisoning; Nerve Degeneration; Neurons; Neurotoxins; Serotonin Receptor Agonists; Tyrosine 3-Monooxygenase | 1998 |
Bromocriptine protects dopaminergic neurons from levodopa-induced toxicity by stimulating D(2)receptors.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Antisense Elements (Genetics); Autoreceptors; Bromocriptine; Cell Survival; Cells, Cultured; Dopamine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Fetus; Fluoresceins; Free Radicals; Gene Expression; Levodopa; Mesencephalon; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Sulpiride; Tyrosine 3-Monooxygenase | 1999 |
MPP(+)-induced mitochondrial dysfunction is potentiated by dopamine.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Drug Synergism; In Vitro Techniques; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; NADH Dehydrogenase; Nerve Degeneration; Neurotoxins; Oxygen Consumption; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley | 2000 |
Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Estrogens; Extracellular Space; Female; Herbicides; Male; Microdialysis; Nerve Degeneration; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2000 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced complex I inhibition is reversed by disulfide reductant, dithiothreitol in mouse brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Dithiothreitol; Electron Transport Complex I; Glutathione; Male; Mice; Mitochondria; NADH, NADPH Oxidoreductases; Nerve Degeneration; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Parkinsonian Disorders | 2000 |
Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain Injuries; Cells, Cultured; Dopamine; Immunophilins; Immunosuppressive Agents; Ligands; Mesencephalon; Mice; Mice, Knockout; Nerve Degeneration; Nerve Regeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidopamine; Parkinsonian Disorders; Pyrrolidines; Rats; Rats, Sprague-Dawley; Tacrolimus; Tacrolimus Binding Protein 1A; Tyrosine 3-Monooxygenase | 2001 |
Allopurinol suppresses para-nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical generation in rat striatum.
Topics: 1-Methyl-4-phenylpyridinium; Allopurinol; Animals; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Hazardous Substances; Hydroxyl Radical; Male; Microdialysis; Neostriatum; Nerve Degeneration; Parkinson Disease; Parkinson Disease, Secondary; Phenols; Rats; Rats, Wistar | 2001 |
Release of dopamine by perfusion with 1-methyl-4-phenylpyridinium ion (MPP(+)) into the striatum is associated with hydroxyl free radical generation.
Topics: 1-Methyl-4-phenylpyridinium; Adrenergic Uptake Inhibitors; Animals; Antifungal Agents; Cell Membrane; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Herbicides; Hydroxybenzoates; Hydroxyl Radical; Lipid Peroxidation; Male; Neostriatum; Nerve Degeneration; Neural Pathways; Neurons; Oxidative Stress; Rats; Rats, Wistar; Reserpine; Salicylic Acid; Substantia Nigra | 2001 |
Validity of a quantitative technique to study striatal dopaminergic neurodegeneration by in vivo microdialysis.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Immunohistochemistry; Male; Microdialysis; Neostriatum; Nerve Degeneration; Neurotoxins; Oxidopamine; Parkinsonian Disorders; Presynaptic Terminals; Rats; Rats, Wistar; Reproducibility of Results; Statistics as Topic; Time Factors; Tyrosine 3-Monooxygenase | 2001 |
Microtubule assembly is directly affected by MPP(+)in vitro.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cattle; Dose-Response Relationship, Drug; Microtubules; Nerve Degeneration | 2001 |
Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antineoplastic Agents; Disease Models, Animal; Dopamine; Dopamine Agents; Gliosis; Herbicides; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; PC12 Cells; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Sympatholytics; Tritium | 2002 |
Evaluation of the protective effect of oestradiol against toxicity induced by 6-hydroxydopamine and 1-methyl-4-phenylpyridinium ion (Mpp+) towards dopaminergic mesencephalic neurones in primary culture.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Cell Death; Cells, Cultured; Dopamine; Estradiol; Herbicides; Mesencephalon; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidopamine; Rats; Rats, Wistar; Sympatholytics | 2002 |
Neurochemical lesioning in the rat brain with iontophoretic injection of the 1-methyl-4-phenylpyridinium ion (MPP+).
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Iontophoresis; Male; Nerve Degeneration; Rats; Rats, Wistar; Substantia Nigra; Thalamus | 1992 |
MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Caudate Nucleus; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Macaca fascicularis; Male; Nerve Degeneration; Neurons; Parkinson Disease, Secondary; Putamen; Substantia Nigra | 1992 |
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcholinesterase; Dopamine; Humans; Melanins; Nerve Degeneration; Neurons; Parkinson Disease; Pyridines; Pyridinium Compounds; Tyrosine 3-Monooxygenase | 1988 |
Effects of the parkinsonism-inducing neurotoxin MPTP and its metabolite MPP+ on sympathetic adrenergic nerves in mouse iris and atrium.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adrenergic Fibers; Animals; Biological Transport, Active; Desipramine; Heart; Iris; Male; Mice; Nerve Degeneration; Norepinephrine; Pargyline; Pyridines; Pyridinium Compounds | 1986 |