1-methyl-4-phenylpyridinium has been researched along with MPTP Neurotoxicity Syndrome in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.79) | 18.7374 |
| 1990's | 47 (37.01) | 18.2507 |
| 2000's | 37 (29.13) | 29.6817 |
| 2010's | 39 (30.71) | 24.3611 |
| 2020's | 3 (2.36) | 2.80 |
| Authors | Studies |
|---|---|
| Booth, RG; Caldera, P; Castagnoli, N; Johnson, EA; Lampen, P; Naiman, N; Rollema, H; Trevor, AJ; Youngster, SK | 1 |
| Seo, MH; Yeo, S | 1 |
| Barbariga, M; Gaceb, A; Paul, G | 1 |
| Bai, J; Bai, L; Deng, R; Gu, R; Yan, F; Zhang, X | 1 |
| Chen, Y; Fan, Y; Hao, S; Hu, J; Liu, Y; Qin, X; Yang, B | 1 |
| Mitsumoto, Y; Mori, A | 1 |
| Hayashi, K; Imanishi, T; Iwasaki, A; Kashi, T; Kataoka, Y; Mita, Y; Miyasaka, T; Noguchi, N; Saito, Y | 1 |
| Capps, J; Virga, DM; Vohra, BPS | 1 |
| Araki, M; Kurashige, T; Maruyama, H; Matsumoto, M; Nagano, Y; Nakamura, T; Obayashi, H; Shishido, T; Takahashi, T | 1 |
| Baghi, M; Ghaedi, K; Kiani-Esfahani, A; Nasr-Esfahani, MH; Rostamian Delavar, M; Talepoor Ardakani, M | 1 |
| Wang, YH; Wu, Q; Xi, DZ | 1 |
| Ansah, T; Channon, KM; Charlton, C; Gangula, PR; Hale, A; Kalpana, R; Sampath, C; Srinivasan, S | 1 |
| Chen, R; Wang, H; Wang, X; Zhai, A; Zhu, X | 1 |
| Nakayama, H; Sai, T; Uchida, K | 3 |
| Aguiar, AS; Amar, M; Chevarin, C; de Paula Martins, R; Glaser, V; Lanfumey, L; Latini, A; Mongeau, R; Moreira, EL; Prediger, RD; Raisman-Vozari, R; Tristão, FS | 1 |
| Bai, J; Jia, JJ; Kwon, Y; Wang, SD; Zeng, XS | 1 |
| Amar, M; Brunelle, A; Ferrié, L; Figadère, B; Kadar, H; Le Douaron, G; Raisman-Vozari, R; Touboul, D | 1 |
| Li, WW; Lu, CZ; Zhu, M | 1 |
| Dou, D; Jia, D; Kang, T; Li, D; Liu, Q; Wang, X | 1 |
| Chen, T; Hou, R; Li, C; Wu, C; Xu, S | 1 |
| Kao, YH; Lin, CJ; Lu, YH; Peng, YH; Tsai, TF; Wu, KC; Yang, HT | 1 |
| Adam, M; Bürkle, A; Efremova, L; Gutbier, S; Hanf, B; Leist, M; Pape, R; Schildknecht, S | 1 |
| Guo, H; Hu, L; Li, M; Liu, Q; Shi, F; Yu, B | 1 |
| Dong, Z; Feng, DY; Liu, Y; Shi, M; Wu, R; Zhang, RY; Zhao, G; Zhao, J | 1 |
| Ai, N; Chong, CM; Franklin, RJ; Hou, T; Lee, SM; Li, C; Ma, D; Sa, F; Yu, H; Zhao, C; Zhou, ZY | 1 |
| Chang, YZ; Duan, XL; Li, Z; Shi, ZH; You, LH; Zhao, BL | 1 |
| Hotta, K; Oka, K; Shindo, Y; Suzuki, K; Yamanaka, R | 1 |
| Chen, PC; Chuang, JI; Hsieh, CY; Huang, CY; Pan, IL; Shin, JW | 1 |
| Agim, ZS; Bai, Q; Berman, SB; Bonkowsky, JL; Burton, EA; Cannon, JR; Croix, CM; David, CN; Dukes, AA; Ilin, V; Van Laar, VS; Watkins, SC; Zhou, Y | 1 |
| Cao, X; He, L; Iuvone, PM; Jin, L; Kang, SS; Liu, X; Manfredsson, FP; Sun, YE; Ye, K; Zhang, Z | 1 |
| Brown-Borg, H; Dhanasekaran, M; Jayachandra Babu, R; Karuppagounder, SS; Parameshwaran, K; Suppiramaniam, V; Uthayathas, S; Wold, LE | 1 |
| Jackson, T; Mazzio, E; Soliman, KF; Soliman, Y | 1 |
| Ding, JH; Hu, G; Yang, YJ; Zhang, S; Zhou, F | 1 |
| Kaslin, J; Khrustalyov, D; Panula, P; Reenilä, I; Sallinen, V; Sundvik, M; Torkko, V | 1 |
| Dong, J; Jiang, H; Song, N; Xie, J | 1 |
| Candeletti, S; Cavina, C; Cox, BM; D'Addario, C; Di Benedetto, M; Leoni, G; Romualdi, P | 1 |
| Caramelli, A; Corsini, GU; Pardini, C; Vaglini, F; Viaggi, C | 1 |
| Arumugam, TV; Belal, C; Chan, SL; Chigurupati, S; Kyriazis, GA; Vandermey, M; Wei, Z | 1 |
| Aguilera, J; Limón, ID; Martínez, I; Mendieta, L; Moreno, N; Patricio, A; Venegas, B | 1 |
| Cui, Y; Jia, J; Luo, D; Sun, Z; Wang, H; Wang, X; Yang, J; Yu, F; Zhang, Q; Zheng, Y | 1 |
| Leist, M; Lotharius, J; Matt, F; Nagel, DM; Pöltl, D; Salvo-Vargas, A; Schildknecht, S; Schmieg, N; Scholz, D | 1 |
| Chang, M; Dong, Z; Hu, L; Hu, X; Jiang, H; Li, G; Tian, M; Wang, D; Wang, Y; Xie, H; Zhang, Y | 1 |
| Kim, CS; Lee, DH; Lee, YJ | 1 |
| Bok, E; Chung, ES; Chung, YC; Jin, BK; Jin, M; Kim, SR; Kim, YS; Ko, HW; Park, ES; Park, JY; Park, KW; Won, SY; Yoon, SH | 1 |
| Banerjee, R; Beal, MF; Calingasan, NY; Ho, DJ; Lorenzo, BJ; Starkov, A; Starkova, NN; Thomas, B; Wille, E; Yang, L; Zhang, SF | 1 |
| Jia, J; Liang, X; Pan, Y; Wang, H; Wang, X; Xue, B; Zhao, F | 1 |
| He, XJ; Ito, T; Nakayama, H; Rodríguez, S; Uchida, K | 1 |
| Fan, LL; Fang, HR; Hu, B; Tang, XQ; Zhang, P; Zhou, CF; Zhuang, YY | 1 |
| Chen, RZ; Ruan, HL; Wang, XL; Yang, Y; Zhu, XN | 1 |
| Ito, T; Nakayama, H; Suzuki, K; Uchida, K | 1 |
| Durgadoss, L; Mishra, M; Nidadavolu, P; Ravindranath, V; Saeed, U; Seth, P; Valli, RK | 1 |
| Bähr, M; Frank, T; Koch, JC; Lingor, P; Saal, KA; Szego, ÉM; Tatenhorst, L; Tönges, L; Weishaupt, JH | 1 |
| Obata, T | 2 |
| Bioulac, B; Fernagut, PO; Ghorayeb, I; Hervier, L; Labattu, B; Tison, F | 1 |
| Delgado, M; Ganea, D | 1 |
| Sagi, Y; Weinstock, M; Youdim, MB | 1 |
| Battaglia, G; Biagioni, F; Bruno, V; Busceti, CL; Fornai, F; Molinaro, G; Nicoletti, F; Storto, M | 1 |
| Feldon, J; Ferger, B; Hengerer, B; Leng, A; Mura, A | 1 |
| Hong, JS; Langenbach, R; Lee, C; Liu, B; Miller, DS; Pei, Z; Reece, JM; Wang, T; Wilson, B; Zhang, W | 1 |
| Brooks, A; Chung, CY; Isacson, O; Lin, L; Seo, H; Sonntag, KC | 1 |
| Charlton, CG; Chen, H; Lee, ES; Soliman, KF | 1 |
| Ebadi, M; Fernández-Valverde, F; Franco-Pérez, JE; Rojas, C; Rojas, P; Rojas-Castañeda, J; Serrano-García, N | 1 |
| Chen, LJ; Gao, YQ; Li, XJ; Shen, DH; Sun, FY | 1 |
| Cao, G; Chen, J; Chu, CT; Signore, A; Wang, S; Zhu, JH | 1 |
| Battaglia, G; Biagioni, F; Bruno, V; Busceti, CL; Molinaro, G; Nicoletti, F; Traficante, A | 1 |
| Bringmann, G; Brückner, R; Feineis, D; Hwang, YI; Ott, S; Schwarz, J; Storch, A | 1 |
| Cadet, JL; Chen, J; Deng, X; Freed, WJ; Liu, Y; Rao, MS; Zeng, X | 1 |
| Ago, Y; Baba, A; Ishihara, K; Kawasaki, T; Matsuda, T | 1 |
| Ali, SF; Duhart, HM; Fang, H; Patterson, TA; Wang, J; Xu, Z | 1 |
| Anantharam, V; Kanthasamy, A; Kanthasamy, AG; Kaul, S; Song, C | 1 |
| Le, WD; Pu, P; Wang, YM | 1 |
| Aoyama, K; Matsumura, N; Nakaki, T; Watabe, M | 1 |
| Cardoso, SM; Domingues, AF; Esteves, AR; Oliveira, CR; Swerdlow, RH | 1 |
| Lee, EH; Lu, KT | 1 |
| Pieper, A; Snyder, SH; Zhang, J | 1 |
| Desole, MS; Esposito, G; Fresu, LG; Grella, G; Miele, E; Miele, M; Migheli, R; Sircana, S; Zangani, D | 1 |
| Corsini, GU; Fascetti, F; Fornai, F; Maggio, R; Vaglini, F | 1 |
| Lee, EH; Tsai, MJ | 1 |
| Giovanni, A; Heikkila, RE; Sieber, BA; Sonsalla, PK | 2 |
| Giovanni, A; Heikkila, RE; Sonsalla, PK | 1 |
| Carraro, S; Guarnieri, T; Villani, L; Virgili, M | 1 |
| Budai, G; Kardos, V; Pátfalusi, M; Patthy, M; Sziráki, I | 1 |
| Corsini, GU; Fascetti, F; Piccardi, MP; Zuddas, A | 1 |
| Griffiths, H; Lai, M; Lunec, J; Pall, H; Williams, A | 1 |
| Beal, MF; Brouillet, E | 1 |
| Ali, SF; Freyaldenhoven, TE; Hart, RW | 1 |
| Fang, J; Yu, PH; Zuo, D | 1 |
| Dringen, R; Eblen, F; Klockgether, T; Löschmann, PA; Schmid, A; Schulz, JB; Turski, L; Wüllner, U | 1 |
| Cavalletti, M; Corsini, GU; Fascetti, F; Fornai, F; Tedeschi, D; Vaglini, F | 1 |
| Altomare, C; Carotti, A; Carrupt, PA; Cellamare, S; Jenner, P; Marsden, CD; McNaught, KS; Testa, B; Thull, U | 1 |
| Hung, HC; Lee, EH | 1 |
| Chan, P; Di Monte, DA; Janson, AM; Langston, JW | 1 |
| Cano, J; Machado, A; Matarredona, ER; Santiago, M | 1 |
| Ehrich, M; Jortner, BS; Perkins, S; Song, X | 1 |
| Disshon, KA; Dluzen, DE | 1 |
| Chiueh, CC; Rauhala, P | 1 |
| Alessandrì, MG; Bassi, L; Corsini, GU; Fornai, F; Torracca, MT | 1 |
| Ali, SF; Freyaldenhoven, TE | 1 |
| Samuelsson, EB; Sundström, E | 1 |
| Ebert, MH; Lynn, JC; Schmidt, DE; Whetsell, WO | 1 |
| Albers, DS; Moy, LY; Sonsalla, PK | 1 |
| Beal, MF; Becker, DA; Klivenyi, P; MacGarvey, U; Matthews, RT; Natero, R; Wermer, M; Yang, L | 1 |
| Beal, MF; Hyman, BT; Klockgether, T; Liao, AW; Martinou, JC; Matthews, RT; Penney, JB; Schulz, JB; Yang, L | 1 |
| Aoyama, S; Kaiya, T; Kohda, K; Maruyama, W; Naoi, M; Noda, Y; Sumino, T; Umeda, M | 1 |
| Beal, MF; Ferrante, RJ; Kaddurah-Daouk, R; Klein, AM; Klivenyi, P; Matthews, RT; Mueller, G; Yang, L | 1 |
| Barja, G; Fabre, E; Herrero, A; Leret, ML; Monserrat, J | 1 |
| Andreassen, OA; Beal, MF; Ferrante, RJ; Klivenyi, P; Lancelot, E; Reif, D | 1 |
| Obata, T; Yamanaka, Y | 1 |
| Alcaraz-Zubeldia, M; Montes, S; Ríos, C | 1 |
| Centeno, F; Clemente, N; Fuentes, JM; González-Polo, RA; Mora, A; Sabio, G; Soler, G | 1 |
| Delanney, LE; Di Monte, DA; Irwin, I; Langston, JW; Wu, EY | 1 |
| Basma, A; Geller, HM; Heikkila, RE; Nicklas, WJ; Saporito, M | 1 |
| Kopin, IJ | 1 |
| Daniels, AJ; Miller, DB; O'Callaghan, JP; Reinhard, JF | 1 |
| Jenner, P; Marsden, CD; Walker, MJ | 1 |
| Johannessen, JN | 1 |
| Carmichael, SW; Daniels, AJ; Reinhard, JF | 1 |
| Horng, J; Krishna, G; Kutty, RK; Santostasi, G | 1 |
| Bellomo, G; Di Monte, D; Smith, MT; Wu, EY | 1 |
| Luthman, J; Sundström, E | 1 |
| Fuller, RW; Hemrick-Luecke, SK | 1 |
| Friedman, LK; Mytilineou, C | 1 |
| Barker, JL; Corsini, GU; di Porzio, U; Kopin, IJ; Schinelli, S; Zuddas, A | 1 |
6 review(s) available for 1-methyl-4-phenylpyridinium and MPTP Neurotoxicity Syndrome
| Article | Year |
|---|---|
Dopamine efflux by MPTP and hydroxyl radical generation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Angiotensin-Converting Enzyme Inhibitors; Animals; Dopamine; Humans; Hydroxyl Radical; MPTP Poisoning; Neostriatum; Nitric Oxide; Oxidative Stress; Presynaptic Terminals | 2002 |
[Parkinsonism induced by MPTP and free radical generation].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Dopamine; Humans; Hydroxyl Radical; Iron; Monoamine Oxidase; MPTP Poisoning; Oxidative Stress | 2001 |
Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Cells, Cultured; Dopamine; Female; Herbicides; Humans; Hydroxyl Radical; Iron; Male; MPTP Poisoning; Parkinsonian Disorders | 2002 |
Mitochondrial mechanisms of neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Biotransformation; Brain; Cell Death; Disease Models, Animal; Humans; Mitochondria; MPTP Poisoning; Neurons; Neurotoxins; Parkinson Disease, Secondary | 1992 |
Features of the dopaminergic neurotoxin MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Brain; Calcium; Dopamine; Free Radicals; Humans; MPTP Poisoning; Neurons; Neurotoxins | 1992 |
A model of chronic neurotoxicity: long-term retention of the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) within catecholaminergic neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Basal Ganglia Diseases; Catecholamines; Corpus Striatum; Humans; Models, Neurological; MPTP Poisoning; Neurons; Time Factors | 1991 |
121 other study(ies) available for 1-methyl-4-phenylpyridinium and MPTP Neurotoxicity Syndrome
| Article | Year |
|---|---|
In vivo intracerebral microdialysis studies in rats of MPP+ analogues and related charged species.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Chemical Phenomena; Chemistry; Corpus Striatum; Dialysis; Dopamine; Kinetics; Lactates; Lactic Acid; Male; Molecular Structure; MPTP Poisoning; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1990 |
Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Cell Line; Disease Models, Animal; Male; Mice, Inbred C57BL; MPTP Poisoning; Muscle, Skeletal; Parkinson Disease; Protein Serine-Threonine Kinases | 2021 |
An In Vitro Partial Lesion Model of Differentiated Human Mesencephalic Neurons: Effect of Pericyte Secretome on Phenotypic Markers.
Topics: 1-Methyl-4-phenylpyridinium; Becaplermin; Cell Line; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Dopaminergic Neurons; Exocytosis; Humans; Inhibitory Concentration 50; Mesencephalon; MPTP Poisoning; Oxidopamine; Pericytes; Phenotype | 2020 |
Thioredoxin-1 Rescues MPP
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Line, Tumor; Cell Survival; Ferroptosis; Humans; Male; Mice; Mice, Inbred C57BL; Microinjections; MPTP Poisoning; PC12 Cells; Phospholipid Hydroperoxide Glutathione Peroxidase; Rats; Thioredoxins | 2021 |
Wnt/β-catenin signaling plays an essential role in α7 nicotinic receptor-mediated neuroprotection of dopaminergic neurons in a mouse Parkinson's disease model.
Topics: 1-Methyl-4-phenylpyridinium; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Line; Dopaminergic Neurons; Herbicides; Humans; Immunohistochemistry; Male; Mice, Inbred C57BL; Mice, Knockout; MPTP Poisoning; Nerve Tissue Proteins; Neuroprotection; Parkinson Disease; Random Allocation; RNA Interference; Substantia Nigra; Wnt Signaling Pathway | 2017 |
Acute Restraint Stress Augments 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurotoxicity via Increased Toxin Uptake into the Brain in C57BL/6 Mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurotoxins; Restraint, Physical; Stress, Psychological | 2018 |
Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.
Topics: 1-Methyl-4-phenylpyridinium; Age Factors; Aging; Animals; Brain; Disease Models, Animal; Dopamine; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase; MPTP Poisoning; Muscle, Skeletal; Myocardium; Neurotoxins; Oxidation-Reduction; Protein Deglycase DJ-1 | 2018 |
Enteric Neurodegeneration is Mediated Through Independent Neuritic and Somal Mechanisms in Rotenone and MPP+ Toxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Enteric Nervous System; Female; Insecticides; Mice; MPTP Poisoning; Nerve Degeneration; Neurites; Parkinson Disease, Secondary; Parkinsonian Disorders; Pregnancy; Rotenone | 2018 |
Synphilin-1 has neuroprotective effects on MPP
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Carrier Proteins; Caspase 3; Cell Survival; Cells, Cultured; Cytochromes c; Gene Knockdown Techniques; Humans; MPTP Poisoning; Nerve Tissue Proteins; Neuroprotective Agents; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Transfection; Up-Regulation | 2019 |
Upregulation of miR-200a and miR-204 in MPP
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; MicroRNAs; MPTP Poisoning; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Sirtuin 1; Up-Regulation | 2019 |
MicroRNA-599 regulates the development of Parkinson's disease through mediating LRRK2 expression.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Brain; Cell Line, Tumor; Disease Models, Animal; Down-Regulation; Gene Knockdown Techniques; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lipopolysaccharides; MicroRNAs; MPTP Poisoning; Neurons; Parkinson Disease; Up-Regulation | 2019 |
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Biopterins; Blotting, Western; Colon; Constipation; Disease Models, Animal; Enzyme Inhibitors; Gastric Emptying; Gastrointestinal Motility; Gene Expression Regulation; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; MPTP Poisoning; NF-E2-Related Factor 2; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Parkinson Disease; Parkinsonian Disorders; Tyrosine 3-Monooxygenase | 2019 |
Secalonic acid A protects dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP⁺)-induced cell death via the mitochondrial apoptotic pathway.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Death; Cell Line; Dopaminergic Neurons; Female; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mitochondria; MPTP Poisoning; Neuroprotective Agents; Pregnancy; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Substantia Nigra; Xanthones | 2013 |
Biochemical evaluation of the neurotoxicity of MPTP and MPP⁺ in embryonic and newborn mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Brain; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Female; Homovanillic Acid; Injections, Intraperitoneal; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Monoamine Oxidase; MPTP Poisoning; Pregnancy; Tyrosine 3-Monooxygenase | 2013 |
Six weeks of voluntary exercise don't protect C57BL/6 mice against neurotoxicity of MPTP and MPP(+).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Administration, Intranasal; Animals; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Mice; Mice, Inbred C57BL; Mitochondria; MPTP Poisoning; Physical Conditioning, Animal; Substantia Nigra | 2014 |
The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Caspase 12; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Gene Expression Regulation; Heat-Shock Proteins; MAP Kinase Kinase 4; Mice; Mice, Transgenic; MPTP Poisoning; PC12 Cells; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Thioredoxins; TNF Receptor-Associated Factor 2; Transcription Factor CHOP | 2014 |
MALDI mass spectrometry imaging of 1-methyl-4-phenylpyridinium (MPP+) in mouse brain.
Topics: 1-Methyl-4-phenylpyridinium; Administration, Intranasal; Animals; Brain Chemistry; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP+.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; GTP Phosphohydrolases; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; MPTP Poisoning; Neuroprotective Agents; Parkinsonian Disorders; Rotenone; Uncoupling Agents | 2014 |
Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Brain; Cell Line, Tumor; Cell Survival; Dopamine; Furans; gamma-Aminobutyric Acid; Humans; Lignans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease | 2014 |
MPTP/MPP+ suppresses activation of protein C in Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Antigens, CD; Brain; Cells, Cultured; Dopamine; Endothelial Cells; Endothelial Protein C Receptor; Glial Fibrillary Acidic Protein; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; Microvessels; MPTP Poisoning; Nerve Tissue Proteins; Protein C; Receptors, Cell Surface; RNA, Small Interfering; Sp1 Transcription Factor; Thrombomodulin | 2015 |
Decreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aging; Animals; Blood-Brain Barrier; Brain; Corpus Striatum; Dogs; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Injections, Intraperitoneal; Madin Darby Canine Kidney Cells; Male; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Microvessels; MPTP Poisoning; Octamer Transcription Factor-1; Organic Cation Transport Proteins; Organic Cation Transporter 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2015 |
Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Line; Cells, Cultured; Coculture Techniques; Dopaminergic Neurons; Humans; Isoquinolines; Mice; MPTP Poisoning; Neuroglia; Neuroprotective Agents; Neurotoxins; Poly(ADP-ribose) Polymerase Inhibitors; Rats | 2015 |
Neuroprotective effects of Eucommia ulmoides Oliv. and its bioactive constituent work via ameliorating the ubiquitin-proteasome system.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Dopamine; Eucommiaceae; Male; Mice; Mice, Inbred C57BL; Motor Disorders; MPTP Poisoning; Neuroprotective Agents; Neurotransmitter Agents; Parkinson Disease; Parkinsonian Disorders; Phytotherapy; Plant Extracts; Proteasome Endopeptidase Complex; Ubiquitin | 2015 |
Ginsenoside Rd Protects SH-SY5Y Cells against 1-Methyl-4-phenylpyridinium Induced Injury.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Cell Line, Tumor; Dopaminergic Neurons; Electron Transport Complex I; Ginsenosides; Humans; Mice; Mice, Inbred C57BL; Mitochondria; MPTP Poisoning; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species | 2015 |
Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Blotting, Western; Cells, Cultured; Cerebellum; Dopaminergic Neurons; Herbicides; Humans; Locomotion; Mitochondria; Models, Theoretical; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Pyrimidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rhombencephalon; Tetrazoles; Tyrosine 3-Monooxygenase; Zebrafish | 2015 |
Mitochondrial ferritin suppresses MPTP-induced cell damage by regulating iron metabolism and attenuating oxidative stress.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoferritins; Apoptosis; Brain; Cation Transport Proteins; Cell Survival; Corpus Striatum; Disease Models, Animal; Ferritins; Hippocampus; Iron; Mice; Mice, Knockout; Mitochondria; MPTP Poisoning; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Receptors, Transferrin; Substantia Nigra; Tyrosine 3-Monooxygenase | 2016 |
Altered expression of Mg(2+) transport proteins during Parkinson's disease-like dopaminergic cell degeneration in PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cation Transport Proteins; Cell Differentiation; Hydrogen Peroxide; Ion Transport; Magnesium; Membrane Potential, Mitochondrial; Mitochondria; MPTP Poisoning; Nerve Degeneration; Nerve Growth Factor; PC12 Cells; Rats; RNA Interference; RNA, Messenger; RNA, Small Interfering; Rotenone | 2016 |
Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4-phenylpyridinium treatment.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cerebral Cortex; Dynamins; Melatonin; Mitochondrial Dynamics; MPTP Poisoning; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2016 |
Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Axonal Transport; Axons; Cell Death; Central Nervous System; Dopamine; Dopaminergic Neurons; Mitochondria; Mitochondrial Dynamics; MPTP Poisoning; Neuroimaging; Parkinson Disease; Zebrafish | 2016 |
α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.
Topics: 1-Methyl-4-phenylpyridinium; Adenylate Kinase; Aged; Aged, 80 and over; alpha-Synuclein; Animals; Cell Death; Dopaminergic Neurons; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; Lewy Bodies; Mice; Mice, Inbred C57BL; Mice, Knockout; MPTP Poisoning; Nerve Tissue Proteins; Phosphorylation; Pleckstrin Homology Domains; Protein Aggregation, Pathological; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-fyn | 2017 |
Effect of dopaminergic neurotoxin MPTP/MPP+ on coenzyme Q content.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Line, Tumor; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Dopamine Agents; Humans; Mice; Mice, Inbred C57BL; MPTP Poisoning; Pons; Ubiquinone | 2008 |
The effects of piroxicam in the attenuation of MPP+/MPTP toxicity in vitro and in vivo.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mitochondria; Motor Activity; MPTP Poisoning; Oxygen; Piroxicam | 2009 |
Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation.
Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Brain Stem; Cell Death; Cells, Cultured; Decanoic Acids; Diazoxide; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hydroxy Acids; Male; Motor Activity; MPTP Poisoning; Nerve Degeneration; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Potassium Channel Blockers; Propylamines; Random Allocation; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2009 |
MPTP and MPP+ target specific aminergic cell populations in larval zebrafish.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Behavior, Animal; Biogenic Monoamines; Catecholamines; Cell Count; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Image Processing, Computer-Assisted; Immunohistochemistry; Larva; Locomotion; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Norepinephrine; Selegiline; Swimming; Zebrafish | 2009 |
Ghrelin antagonized 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase 3; Cell Line; Cell Survival; Drug Interactions; Ghrelin; Mice; Mitochondria; MPTP Poisoning; Neurons; Neuroprotective Agents; Oxidative Stress; Receptors, Ghrelin | 2009 |
Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Blotting, Western; Caudate Nucleus; Gene Expression; Glutamate Decarboxylase; Male; MPTP Poisoning; Nociceptin; Nociceptin Receptor; Opioid Peptides; Oxidopamine; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; RNA; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2009 |
MPTP-induced model of Parkinson's disease in cytochrome P450 2E1 knockout mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Cytochrome P-450 CYP2E1; Dopamine; Homovanillic Acid; Male; Mice; Mice, Knockout; MPTP Poisoning; Nerve Tissue Proteins; Neurons; Parkinsonian Disorders; Prodrugs; Substantia Nigra; Tyrosine 3-Monooxygenase | 2009 |
The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neurotoxin model of Parkinson disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Calcium; CCAAT-Enhancer-Binding Proteins; Cell Survival; Endoplasmic Reticulum; Homeostasis; Humans; Membrane Proteins; Mice; MPTP Poisoning; Neurons; PC12 Cells; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Rats; RNA, Small Interfering; Stress, Physiological; Transcription Factor CHOP; Transfection; Ubiquitin | 2009 |
The carboxyl-terminal domain of the heavy chain of tetanus toxin prevents dopaminergic degeneration and improves motor behavior in rats with striatal MPP(+)-lesions.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Dopamine; Male; Motor Activity; MPTP Poisoning; Nerve Degeneration; Neurons; Peptide Fragments; Rats; Rats, Wistar; Tetanus Toxin | 2009 |
Fucoidan protects against dopaminergic neuron death in vivo and in vitro.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Antioxidants; Cell Death; Cell Line; Dopamine; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neostriatum; Neurons; Neuroprotective Agents; Polysaccharides; Tyrosine 3-Monooxygenase | 2009 |
Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Cell Death; Cells, Cultured; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Glutathione; Humans; Lipid Peroxidation; Mesencephalon; Methyltyrosines; Mitochondria; Monoiodotyrosine; MPTP Poisoning; Neurites; Neurons; Time Factors | 2009 |
Proteomics analysis of MPP+-induced apoptosis in SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line; Humans; Image Processing, Computer-Assisted; MPTP Poisoning; Nerve Degeneration; Neurons; Neurotoxins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Two-Dimensional Difference Gel Electrophoresis | 2011 |
Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Caspase 3; Catalase; Cell Line, Tumor; Cytochromes; Enzyme Activation; Enzyme Induction; Fluorescent Antibody Technique, Indirect; Humans; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mitochondria; MPTP Poisoning; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Xanthophylls | 2011 |
Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Count; Coculture Techniques; Corpus Striatum; Cytokines; Dopamine; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning; NADPH Oxidases; Nerve Degeneration; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type II; Oxidative Stress; Recovery of Function; Rotarod Performance Test; Substantia Nigra | 2011 |
Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Apoptosis; Astrocytes; Basal Ganglia; Calcium; Cell Death; Cyclophilins; Disease Models, Animal; Dopaminergic Neurons; Humans; Mice; Mice, Knockout; Microglia; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; MPTP Poisoning; Peptidyl-Prolyl Isomerase F; Substantia Nigra; Tyrosine 3-Monooxygenase | 2012 |
The antioxidative effect of electro-acupuncture in a mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Acupuncture Therapy; Animals; Antioxidants; Apoptosis; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Glutathione; Hydrogen Peroxide; Immunoenzyme Techniques; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurons; Oxidative Stress; Parkinson Disease; Substantia Nigra; Superoxide Dismutase | 2011 |
Resistance of the golden hamster to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-neurotoxicity is not only related with low levels of cerebral monoamine oxidase-B.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Astrocytes; Blood-Brain Barrier; Cerebral Cortex; Cricetinae; Disease Resistance; Dopaminergic Neurons; Endothelial Cells; Female; Fluorescent Antibody Technique; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mesocricetus; Monoamine Oxidase; MPTP Poisoning; Sex Factors | 2013 |
Acute toxicity of MPTP and MPP(+) in the brain of embryo and newborn mice.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Blood-Brain Barrier; Brain; Female; Immunohistochemistry; Maternal Exposure; Mice; Mice, Inbred C57BL; MPTP Poisoning; Organogenesis; Pregnancy; Toxicity Tests, Acute | 2013 |
Involvement of K(ATP)/PI (3)K/AKT/Bcl-2 pathway in hydrogen sulfide-induced neuroprotection against the toxicity of 1-methy-4-phenylpyridinium ion.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Butadienes; Gene Expression Regulation; Genes, bcl-2; Glyburide; Hydrogen Sulfide; In Vitro Techniques; KATP Channels; MAP Kinase Signaling System; MPTP Poisoning; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxins; Nitriles; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium Channel Blockers; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction | 2012 |
Similar potency of catechin and its enantiomers in alleviating 1-methyl-4-phenylpyridinium ion cytotoxicity in SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Catechin; Cell Line, Tumor; Humans; L-Lactate Dehydrogenase; MAP Kinase Signaling System; MPTP Poisoning; Oxidative Stress; Parkinson Disease; Phosphorylation; Proto-Oncogene Proteins c-jun; Reactive Oxygen Species | 2011 |
Different susceptibility to 1-methyl-4-phenylpyridium (MPP(+))-induced nigro-striatal dopaminergic cell loss between C57BL/6 and BALB/c mice is not related to the difference of monoamine oxidase-B (MAO-B).
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Corpus Striatum; Disease Susceptibility; Dopaminergic Neurons; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Monoamine Oxidase; MPTP Poisoning; Species Specificity; Substantia Nigra | 2013 |
Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP, in mouse midbrain, leads to down-regulation of pAkt.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Cells, Cultured; Dopamine; Dopaminergic Neurons; Down-Regulation; Herbicides; Humans; Male; Mesencephalon; Mice; Mice, Inbred C57BL; MPTP Poisoning; Oxidation-Reduction; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins c-akt; Stem Cells; Sulfhydryl Compounds | 2012 |
Involvement of monoamine oxidase-B in the acute neurotoxicity of MPTP in embryonic and newborn mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Dopamine Plasma Membrane Transport Proteins; Embryo, Mammalian; Fluorescent Antibody Technique; Immunohistochemistry; Mice; Mice, Inbred C57BL; Monoamine Oxidase; MPTP Poisoning | 2013 |
Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-4-phenylpyridinium; Animals; Axons; Behavior, Animal; Cell Survival; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Degeneration; Neurites; Neuroprotective Agents; Parkinson Disease, Secondary; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; rho-Associated Kinases; Substantia Nigra | 2012 |
A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Forelimb; Herbicides; Intralaminar Thalamic Nuclei; Male; Motor Activity; Motor Cortex; MPTP Poisoning; Multiple System Atrophy; Nerve Degeneration; Parkinsonian Disorders; Rats; Rats, Wistar; Substantia Nigra | 2002 |
Neuroprotective effect of vasoactive intestinal peptide (VIP) in a mouse model of Parkinson's disease by blocking microglial activation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Dopamine; Dopamine Agents; Gene Expression Regulation; Interleukin-1; Mesencephalon; Mice; MPTP Poisoning; Neuroglia; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Tumor Necrosis Factor-alpha; Vasoactive Intestinal Peptide | 2003 |
Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain Stem; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Dopamine; Enzyme Activation; Indans; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Norepinephrine; Serotonin; Tyrosine 3-Monooxygenase | 2003 |
Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Homovanillic Acid; Mice; Mice, Knockout; MPTP Poisoning; Neuroprotective Agents; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Substantia Nigra; Survival Rate; Synaptosomes | 2004 |
Genetic ablation of tumor necrosis factor-alpha (TNF-alpha) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glial Fibrillary Acidic Protein; Immunosuppressive Agents; Macrophage-1 Antigen; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; MPTP Poisoning; Neostriatum; Nerve Tissue Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Thalidomide; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2004 |
MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Enzyme Activation; Female; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning | 2005 |
Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Gene Expression Profiling; Gene Expression Regulation; Herbicides; Mesencephalon; Mice; MPTP Poisoning; Neurons; Oligonucleotide Array Sequence Analysis; Parkinson Disease; PC12 Cells; Rats | 2005 |
The role of phospholipid methylation in 1-methyl-4-phenyl-pyridinium ion (MPP+)-induced neurotoxicity in PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Lysophosphatidylcholines; Methylation; MPTP Poisoning; PC12 Cells; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Phospholipids; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
Reduction of zinc-positive terminal fields in striatum of mouse after 1-methyl-4-phenylpyridinium neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Dopamine; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; MPTP Poisoning; Sulfides; Zinc; Zinc Compounds | 2005 |
Melatonin protects against MPTP/MPP+ -induced mitochondrial DNA oxidative damage in vivo and in vitro.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adjuvants, Immunologic; Animals; Brain; Brain Chemistry; Cell Death; DNA Damage; DNA, Mitochondrial; Dopamine Agents; Herbicides; Male; Melatonin; Mice; MPTP Poisoning | 2005 |
Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells.
Topics: 1-Methyl-4-phenylpyridinium; Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Caspases; Cell Line; DNA Fragmentation; Dopamine; Down-Regulation; Flavoproteins; Membrane Proteins; Mesencephalon; Mice; MPTP Poisoning; Nerve Degeneration; Neurons; Protein Transport; RNA Interference | 2005 |
Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Benzopyrans; Corpus Striatum; Mice; Mice, Inbred C57BL; Mice, Knockout; MPTP Poisoning; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate; Substantia Nigra; Tritium | 2006 |
Cytotoxicity of chloral-derived beta-carbolines is not specific towards neuronal nor dopaminergic cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain Neoplasms; Carbolines; Cell Line, Tumor; Cell Survival; Data Interpretation, Statistical; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Humans; Mice; MPTP Poisoning; Neuroblastoma; Neurons; Piperazines | 2006 |
An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line; Colony-Forming Units Assay; Cytoprotection; Dopamine; Embryonic Stem Cells; Glial Cell Line-Derived Neurotrophic Factor; Humans; Mice; Models, Biological; MPTP Poisoning; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Reactive Oxygen Species; Substantia Nigra; Toxicology | 2006 |
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antipyrine; Brain; Corpus Striatum; Dopamine; Edaravone; Free Radical Scavengers; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Microglia; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Substantia Nigra; Tyrosine 3-Monooxygenase | 2007 |
Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity study.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Division; Cells, Cultured; Cluster Analysis; Data Interpretation, Statistical; Dopamine Agents; Electric Stimulation; Gene Expression Profiling; Mice; MPTP Poisoning; Neurons; Neurotransmitter Transport Proteins; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Signal Transduction | 2007 |
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Blotting, Western; Caspases; Cell Survival; DNA Fragmentation; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Membrane Glycoproteins; Mesencephalon; MPTP Poisoning; NADPH Oxidase 2; NADPH Oxidases; Neurons; Organic Chemicals; Oxidative Stress; Phosphoproteins; Rats; Reactive Oxygen Species | 2007 |
ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in alpha-synuclein transgenic C. elegans.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; alpha-Synuclein; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Death; Disease Models, Animal; Dopamine; Herbicides; Humans; MPTP Poisoning; Neurons | 2007 |
Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Aspartic Acid; Behavior, Animal; Cysteine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Transporter 1; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Hydroxamic Acids; In Vitro Techniques; Indazoles; Male; Mice; Mice, Inbred C57BL; Movement Disorders; MPTP Poisoning; Neuroprotective Agents; Oxidative Stress; Substantia Nigra | 2008 |
Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Calpain; Caspases; Cell Line, Tumor; DNA, Mitochondrial; Electron Transport Complex I; Humans; Mitochondria; MPTP Poisoning; Nerve Degeneration; Teratocarcinoma | 2008 |
Neurotoxicity of MPTP and uptake of MPPT into dopamine and norepinephrine neurons in mice.
Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Biogenic Monoamines; Corpus Striatum; Dendrites; Dopamine; Drug Administration Schedule; Male; Mice; Mice, Inbred BALB C; Motor Activity; MPTP Poisoning; Neurons; Nomifensine; Norepinephrine; Substantia Nigra | 1995 |
Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage.
Topics: 1-Methyl-4-phenylpyridinium; Amyloid beta-Peptides; Animals; Cell Death; DNA Damage; Enzyme Activation; Hydrogen Peroxide; MPTP Poisoning; Neurotoxins; PC12 Cells; Poly(ADP-ribose) Polymerases; Rats | 1995 |
Neuronal antioxidant system and MPTP-induced oxidative stress in the striatum and brain stem of the rat.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain Stem; Dopamine; Glutathione; Male; MPTP Poisoning; Neostriatum; Neurons; Norepinephrine; Oxidative Stress; PC12 Cells; Rats; Rats, Wistar; Synaptosomes; Uric Acid | 1995 |
(+)MK-801 prevents the DDC-induced enhancement of MPTP toxicity in mice.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Ditiocarb; Dizocilpine Maleate; Dopamine; Drug Synergism; Haplorhini; Homovanillic Acid; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Piperazines; Selegiline; Substantia Nigra; Tyrosine 3-Monooxygenase | 1994 |
Differences in the disposition and toxicity of 1-methyl-4-phenylpyridinium in cultured rat and mouse astrocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Cell Membrane; Cells, Cultured; Drug Resistance; Mice; Monoamine Oxidase; MPTP Poisoning; Rats; Species Specificity; Tissue Distribution | 1994 |
Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 1: Systemic administration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Dopamine; Guanethidine; Male; Mice; Microdialysis; Monoamine Oxidase; MPTP Poisoning; Neostriatum; Neurons; Premedication; Rats; Rats, Sprague-Dawley; Species Specificity; Synaptosomes | 1994 |
Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 2: Central administration of 1-methyl-4-phenylpyridinium.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Dopamine; Dose-Response Relationship, Drug; Guanethidine; Male; Mice; Monoamine Oxidase; MPTP Poisoning; Neostriatum; Premedication; Rats; Rats, Sprague-Dawley; Species Specificity | 1994 |
Quinolinic acid but not MK-801 protects the dopaminergic system from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced toxicity in goldfish retina.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dopamine; Goldfish; Microscopy, Electron; MPTP Poisoning; Necrosis; Neurons; Photoreceptor Cells; Quinolinic Acid; Retina | 1994 |
Methamphetamine protects against MPTP neurotoxicity in C57BL mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amphetamine; Animals; Brain Diseases; Corpus Striatum; Dopamine; Male; Methamphetamine; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurons | 1994 |
In brown Norway rats, MPP+ is accumulated in the nigrostriatal dopaminergic terminals but it is not neurotoxic: a model of natural resistance to MPTP toxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Corpus Striatum; Ditiocarb; Dopamine; Kinetics; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Rats; Rats, Inbred BN; Species Specificity; Stereotyped Behavior; Substantia Nigra; Time Factors; Tissue Distribution | 1994 |
An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Catalase; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lipid Peroxides; MPTP Poisoning; Neurons; Pargyline; Rats; Reactive Oxygen Species; Selegiline; Superoxide Dismutase; Tumor Cells, Cultured | 1993 |
NMDA antagonists partially protect against MPTP induced neurotoxicity in mice.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Binding, Competitive; Dopamine Antagonists; Male; Mice; MPTP Poisoning; N-Methylaspartate; Nervous System | 1993 |
MPTP- and MPP(+)-induced effects on body temperature exhibit age- and strain-dependence in mice.
Topics: 1-Methyl-4-phenylpyridinium; Aging; Analysis of Variance; Animals; Body Temperature Regulation; Dopamine Agents; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Selegiline; Species Specificity | 1995 |
Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Line; Dose-Response Relationship, Drug; Haloperidol; MPTP Poisoning; Neuroblastoma; Neurotoxins; Parkinson Disease; Time Factors | 1995 |
Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Buthionine Sulfoximine; Dopamine Agents; Glutathione; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1996 |
Striatal MPP+ levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetaldehyde; Animals; Chromatography, High Pressure Liquid; Clonidine; Corpus Striatum; Ditiocarb; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Kinetics; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nicotine; Piperazines; Selegiline; Serotonin | 1996 |
Toxicity to PC12 cells of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Catecholamines; Dopamine Agents; Dopamine Uptake Inhibitors; Isoquinolines; L-Lactate Dehydrogenase; MPTP Poisoning; PC12 Cells; Rats; Structure-Activity Relationship | 1996 |
The mesolimbic dopaminergic pathway is more resistant than the nigrostriatal dopaminergic pathway to MPTP and MPP+ toxicity: role of BDNF gene expression.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain-Derived Neurotrophic Factor; Corpus Striatum; Dopamine; Dopamine Agents; Enzyme Induction; Gene Expression Regulation; Limbic System; Male; Mice; Mice, Inbred BALB C; MPTP Poisoning; Nerve Tissue Proteins; Neural Pathways; Nucleus Accumbens; Organ Specificity; Polymerase Chain Reaction; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase | 1996 |
(+)MK-801 does not prevent MPTP-induced loss of nigral neurons in mice.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Male; Mesencephalon; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neuroprotective Agents; Substantia Nigra | 1997 |
Lack of involvement of glutamate-induced excitotoxicity in MPP+ toxicity in striatal dopaminergic terminals: possible involvement of ascorbate.
Topics: 1-Methyl-4-phenylpyridinium; Amino Acids, Essential; Animals; Ascorbic Acid; Aspartic Acid; Dicarboxylic Acids; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Immunohistochemistry; Male; Microdialysis; MPTP Poisoning; Neostriatum; Nerve Endings; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 1997 |
Cytotoxic effects of MPTP on SH-SY5Y human neuroblastoma cells.
Topics: 1-Methyl-4-phenylpyridinium; Brain Neoplasms; Cell Survival; Dopamine Agents; Humans; MPTP Poisoning; NADH Dehydrogenase; Neuroblastoma; Tumor Cells, Cultured | 1997 |
Estrogen as a neuromodulator of MPTP-induced neurotoxicity: effects upon striatal dopamine release.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Dopamine Agents; Estradiol; Estrogens; Female; MPTP Poisoning; Neostriatum; Neurotransmitter Agents; Ovariectomy; Rats; Rats, Sprague-Dawley | 1997 |
Free radicals and MPTP-induced selective destruction of substantia nigra compacta neurons.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Dopamine; Free Radicals; Hydroxyl Radical; Melanins; MPTP Poisoning; Neurons; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Substantia Nigra | 1998 |
Effects of noradrenergic lesions on MPTP/MPP+ kinetics and MPTP-induced nigrostriatal dopamine depletions.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Benzylamines; Brain; Corpus Striatum; Dopamine; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Norepinephrine; Substantia Nigra | 1997 |
Role of heat shock proteins in MPTP-induced neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Body Temperature; Cell Death; Cells, Cultured; CHO Cells; Corpus Striatum; Cricetinae; Dopamine; Dopamine Agents; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurotoxins; Time Factors | 1997 |
Comparison of key steps in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in rodents.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Dopamine; Lactic Acid; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Norepinephrine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
Attenuation of 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity by deprenyl in organotypic canine substantia nigra cultures.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Dogs; Dopamine; Dopamine Agents; Homovanillic Acid; MPTP Poisoning; Neurons; Neuroprotective Agents; Organ Culture Techniques; Selegiline; Substantia Nigra | 1997 |
Lowering ambient or core body temperature elevates striatal MPP+ levels and enhances toxicity to dopamine neurons in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Agents; Excitatory Amino Acid Antagonists; Methamphetamine; Mice; MPTP Poisoning; Nerve Degeneration; Neurons; Neurotoxins; Serotonin Receptor Agonists; Tyrosine 3-Monooxygenase | 1998 |
Azulenyl nitrone spin traps protect against MPTP neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Azulenes; Brain Chemistry; Dopamine; Free Radicals; Glutamic Acid; Male; Mice; MPTP Poisoning; N-Methylaspartate; Neuroprotective Agents; Nitrogen Oxides; Oxidation-Reduction; Sesquiterpenes; Spin Labels | 1998 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Apoptosis; Brain Chemistry; Caspase 2; Caspase Inhibitors; Caspases; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitors; Female; Free Radicals; Gene Expression; Homovanillic Acid; Injections, Intraperitoneal; Male; Mazindol; Mice; Mice, Transgenic; MPTP Poisoning; Neurons; Neurotoxins; Oxidative Stress; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Radioligand Assay; Tritium; Tyrosine | 1998 |
Cytotoxicity of 1-amino-4-phenyl-1,2,3,6-tetrahydropyridine and 1-amino-4-phenylpyridinium ion, 1-amino analogues of MPTP and MPP+, to clonal pheochromocytoma PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antineoplastic Agents; Cell Survival; Dopamine Agents; Monoamine Oxidase Inhibitors; MPTP Poisoning; Oxidation-Reduction; PC12 Cells; Rats | 1998 |
Creatine and cyclocreatine attenuate MPTP neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Administration, Oral; Animals; Creatine; Creatinine; Dopamine; Dopamine Agents; Immunohistochemistry; Male; Mice; MPTP Poisoning; Neurons; Neuroprotective Agents; Nissl Bodies; Substantia Nigra; Tyrosine 3-Monooxygenase | 1999 |
Effect of MPTP on brain mitochondrial H2O2 and ATP production and on dopamine and DOPAC in the striatum.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Adenosine Triphosphate; Animals; Brain; Corpus Striatum; Dopamine; Hydrogen Peroxide; Male; MPTP Poisoning; Oxidative Stress; Rats; Rats, Wistar | 1999 |
Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoquinolines; Male; Mice; MPTP Poisoning; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Substantia Nigra; Tetrahydroisoquinolines; Thiophenes; Tyrosine 3-Monooxygenase | 2000 |
Participation of manganese-superoxide dismutase in the neuroprotection exerted by copper sulfate against 1-methyl 4-phenylpyridinium neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Brain; Copper Sulfate; Drug Administration Schedule; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Sulfates; Superoxide Dismutase | 2001 |
Mechanisms of MPP(+) incorporation into cerebellar granule cells.
Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Transport Systems, Basic; Amino Acids, Basic; Animals; Animals, Newborn; Apoptosis; Carrier Proteins; Cells, Cultured; Cerebellar Cortex; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Herbicides; Male; Membrane Glycoproteins; Membrane Transport Proteins; MPTP Poisoning; Nerve Tissue Proteins; Neurons; Neurotoxins; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2001 |
Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Cell Survival; Cells, Cultured; Energy Metabolism; Mice; Monoamine Oxidase Inhibitors; MPTP Poisoning | 1992 |
Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Catalepsy; Cattle; Corpus Striatum; Ditiocarb; Dopamine; Drug Synergism; Glial Fibrillary Acidic Protein; Hippocampus; Kinetics; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Nervous System; Neurotoxins; Norepinephrine | 1991 |
A redox reaction between MPP+ and MPDP+ to produce superoxide radicals does not impair mitochondrial function.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Free Radicals; Male; Mitochondria; MPTP Poisoning; Oxidation-Reduction; Oxygen Consumption; Pyridinium Compounds; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Superoxide Dismutase; Superoxides | 1991 |
Mechanisms of toxicity and cellular resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in adrenomedullary chromaffin cell cultures.
Topics: 1-Methyl-4-phenylpyridinium; Adrenal Medulla; Animals; Cell Survival; Cells, Cultured; Chromaffin System; Glucose; Lactates; Lactic Acid; MPTP Poisoning; Tyrosine 3-Monooxygenase | 1990 |
MPTP-induced ATP depletion and cell death in neuroblastoma X glioma hybrid NG 108-15 cells: protection by glucose and sensitization by tetraphenylborate.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenine Nucleotides; Adenosine Triphosphate; Cell Survival; Dose-Response Relationship, Drug; Glioma; Glucose; Humans; L-Lactate Dehydrogenase; MPTP Poisoning; Neuroblastoma; Neurons; Tetraphenylborate; Tumor Cells, Cultured | 1991 |
Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Dopamine; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; MPTP Poisoning; Species Specificity | 1991 |
Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Cell Survival; Fluorescent Dyes; Fructose; In Vitro Techniques; Intracellular Membranes; Liver; Male; Membrane Potentials; Mitochondria, Liver; MPTP Poisoning; Rats; Rats, Inbred Strains; Rhodamine 123; Rhodamines; Selegiline | 1990 |
No apparent difference in the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the sympathetic system in NMRI and C57 BL/6 mice.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Heart; Hydroxydopamines; Injections, Subcutaneous; Iris; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Norepinephrine; Oxidopamine; Species Specificity; Sympathetic Nervous System | 1990 |
Tissue concentrations of MPTP and MPP+ after administration of lethal and sublethal doses of MPTP to mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Administration, Oral; Animals; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Interactions; Injections, Subcutaneous; Male; Mice; Monoamine Oxidase; MPTP Poisoning; Selegiline; Tissue Distribution | 1990 |
Neurochemical and toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridine to rat serotonin neurons in dissociated cell cultures.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Mesencephalon; MPTP Poisoning; Neurons; Rats; Serotonin; Tritium | 1990 |
Acetaldehyde directly enhances MPP+ neurotoxicity and delays its elimination from the striatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetaldehyde; Animals; Astrocytes; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning | 1989 |