1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Seizures in 3 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the effect of striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice on kainic acid (KA) evoked seizures." | 7.69 | Motor expression of kainic acid seizures is attenuated by dopamine depletion in mice. ( Bonuccelli, U; Fariello, R; Garant, DS; Maggio, R, 1994) |
| "We studied the effect of striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice on kainic acid (KA) evoked seizures." | 3.69 | Motor expression of kainic acid seizures is attenuated by dopamine depletion in mice. ( Bonuccelli, U; Fariello, R; Garant, DS; Maggio, R, 1994) |
| " The effects of the octapeptide angiotensin II (AT II) on some types of behaviour [threshold of seizures induced by timed intravenous infusion of pentylenetetrazol (PTZ), exploratory behaviour: ambulation, rearing and head-dips on a hole-board, and passive avoidance performance--step-through paradigm] were studied following repeated systemic administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to mice (30 mg/kg, i." | 3.68 | Behavioural effects of angiotensin II in the mouse following MPTP administration. ( Georgiev, V; Kambourova, T, 1991) |
| "Bicuculline and picrotoxin convulsions were not significantly affected by MPTP treatment." | 1.27 | MPTP and convulsive responses in rodents. ( Castorina, M; DeMattei, M; Fariello, RG; Ferraro, TN; Golden, GT, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bonuccelli, U | 1 |
| Garant, DS | 1 |
| Maggio, R | 1 |
| Fariello, R | 1 |
| Georgiev, V | 1 |
| Kambourova, T | 1 |
| Fariello, RG | 1 |
| DeMattei, M | 1 |
| Castorina, M | 1 |
| Ferraro, TN | 1 |
| Golden, GT | 1 |
3 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Seizures
| Article | Year |
|---|---|
Motor expression of kainic acid seizures is attenuated by dopamine depletion in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dihydroxyphenylalanine; Dopa | 1994 |
Behavioural effects of angiotensin II in the mouse following MPTP administration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Angiotensin II; Animals; Avoidance Learning; Behavior, | 1991 |
MPTP and convulsive responses in rodents.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anticonvulsants; Biogenic Amines; Convulsants | 1987 |